Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_016_F01
(906 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9WTR6|XCT_MOUSE Cystine/glutamate transporter (Amino ac... 185 1e-46
sp|Q9UPY5|XCT_HUMAN Cystine/glutamate transporter (Amino ac... 181 3e-45
sp|Q63016|LAT1_RAT Large neutral amino acids transporter sm... 181 3e-45
sp|Q9Z127|LAT1_MOUSE Large neutral amino acids transporter ... 179 7e-45
sp|Q01650|LAT1_HUMAN Large neutral amino acids transporter ... 175 2e-43
sp|Q9WVR6|LAT2_RAT Large neutral amino acids transporter sm... 158 2e-38
sp|Q9UHI5|LAT2_HUMAN Large neutral amino acids transporter ... 157 3e-38
sp|Q9QXW9|LAT2_MOUSE Large neutral amino acids transporter ... 157 5e-38
sp|Q9NS82|AAA1_HUMAN Asc-type amino acid transporter 1 (Asc-1) 148 2e-35
sp|P63116|AAA1_RAT Asc-type amino acid transporter 1 (Asc-1... 146 9e-35
>sp|Q9WTR6|XCT_MOUSE Cystine/glutamate transporter (Amino acid transport system xc-) (xCT)
Length = 502
Score = 185 bits (470), Expect = 1e-46
Identities = 103/279 (36%), Positives = 147/279 (52%)
Frame = +2
Query: 26 FVDAFSGSNYKTASLPMAFYQGFWAYSGWNYLNFLTNEMKNPEKNLPLAIIISLTLITXX 205
F DAFSG + LP+AFY G +AY+GW YLNF+T E+ NPEK +PLAI IS+ +IT
Sbjct: 221 FKDAFSGRDTSLMGLPLAFYYGMYAYAGWFYLNFITEEVDNPEKTIPLAICISMAIITVG 280
Query: 206 XXXXXXXXXXXXSPQEMLLIGQSSAAIAVNFADRTMGVMSWVMPIFVGMSVFGSMNSELL 385
S +E+L S+A+AV F++R +G S +PIFV +S FGSMN +
Sbjct: 281 YVLTNVAYFTTISAEELL----QSSAVAVTFSERLLGKFSLAVPIFVALSCFGSMNGGVF 336
Query: 386 SLSRLTHTGAEENQMPKILAMVSHKYLTPMPAVIVITMLTIVFQLYQNAFYLIELAGFAF 565
++SRL + + E +P+IL+M+ TP+PAVIV+ LT+V + + L+ FA
Sbjct: 337 AVSRLFYVASREGHLPEILSMIHVHKHTPLPAVIVLHPLTMVMLFSGDLYSLLNFLSFAR 396
Query: 566 SVIAVMSVCSLLYLRYKHPEXXXXXXXXXXXXXXXXXXXXXXCGLTVYQQPFDXXXXXXX 745
+ ++V L+YLRYK P+ L++Y PF
Sbjct: 397 WLFMGLAVAGLIYLRYKRPDMHRPFKVPLFIPALFSFTCLFMVVLSLYSDPFSTGVGFLI 456
Query: 746 XXXXXPVYIIFISWKNKPTSMTNLIDKITLNIQKLLNVV 862
P Y +FI W KP L D+IT +Q +L VV
Sbjct: 457 TLTGVPAYYLFIVWDKKPKWFRRLSDRITRTLQIILEVV 495
>sp|Q9UPY5|XCT_HUMAN Cystine/glutamate transporter (Amino acid transport system xc-) (xCT)
(Calcium channel blocker resistance protein CCBR1)
Length = 501
Score = 181 bits (458), Expect = 3e-45
Identities = 100/280 (35%), Positives = 149/280 (53%)
Frame = +2
Query: 23 SFVDAFSGSNYKTASLPMAFYQGFWAYSGWNYLNFLTNEMKNPEKNLPLAIIISLTLITX 202
+F DAFSG + LP+AFY G +AY+GW YLNF+T E++NPEK +PLAI IS+ ++T
Sbjct: 220 NFKDAFSGRDSSITRLPLAFYYGMYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTI 279
Query: 203 XXXXXXXXXXXXXSPQEMLLIGQSSAAIAVNFADRTMGVMSWVMPIFVGMSVFGSMNSEL 382
+ +E+LL S A+AV F++R +G S +PIFV +S FGSMN +
Sbjct: 280 GYVLTNVAYFTTINAEELLL----SNAVAVTFSERLLGNFSLAVPIFVALSCFGSMNGGV 335
Query: 383 LSLSRLTHTGAEENQMPKILAMVSHKYLTPMPAVIVITMLTIVFQLYQNAFYLIELAGFA 562
++SRL + + E +P+IL+M+ + TP+PAVIV+ LT++ + L+ FA
Sbjct: 336 FAVSRLFYVASREGHLPEILSMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFA 395
Query: 563 FSVIAVMSVCSLLYLRYKHPEXXXXXXXXXXXXXXXXXXXXXXCGLTVYQQPFDXXXXXX 742
+ ++V L+YLRYK P+ L++Y PF
Sbjct: 396 RWLFIGLAVAGLIYLRYKCPDMHRPFKVPLFIPALFSFTCLFMVALSLYSDPFSTGIGFV 455
Query: 743 XXXXXXPVYIIFISWKNKPTSMTNLIDKITLNIQKLLNVV 862
P Y +FI W KP + +KIT +Q +L VV
Sbjct: 456 ITLTGVPAYYLFIIWDKKPRWFRIMSEKITRTLQIILEVV 495
>sp|Q63016|LAT1_RAT Large neutral amino acids transporter small subunit 1 (L-type amino
acid transporter 1) (4F2 light chain) (4F2 LC) (4F2LC)
(Integral membrane protein E16) (TA1 protein)
Length = 512
Score = 181 bits (458), Expect = 3e-45
Identities = 92/276 (33%), Positives = 150/276 (54%)
Frame = +2
Query: 35 AFSGSNYKTASLPMAFYQGFWAYSGWNYLNFLTNEMKNPEKNLPLAIIISLTLITXXXXX 214
+F G+N ++ +A Y G +AY GWNYLNF+T EM NP +NLPLAIIISL ++T
Sbjct: 237 SFEGTNLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVL 296
Query: 215 XXXXXXXXXSPQEMLLIGQSSAAIAVNFADRTMGVMSWVMPIFVGMSVFGSMNSELLSLS 394
S +ML +S A+AV+F + +GVMSW++P+FVG+S FGS+N L + S
Sbjct: 297 TNLAYFTTLSTNQML----TSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSS 352
Query: 395 RLTHTGAEENQMPKILAMVSHKYLTPMPAVIVITMLTIVFQLYQNAFYLIELAGFAFSVI 574
RL G+ E +P IL+M+ + LTP+P+++ ++T+++ ++ F +I F +
Sbjct: 353 RLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLMYAFSRDIFSIINFFSFFNWLC 412
Query: 575 AVMSVCSLLYLRYKHPEXXXXXXXXXXXXXXXXXXXXXXCGLTVYQQPFDXXXXXXXXXX 754
+++ +++LR+K PE ++ ++ P +
Sbjct: 413 VALAIIGMMWLRFKKPELERPIKVNLALPVFFILACLFLIAVSFWKTPLECGIGFAIILS 472
Query: 755 XXPVYIIFISWKNKPTSMTNLIDKITLNIQKLLNVV 862
PVY + WKNKP + +I +T+ QKL+ VV
Sbjct: 473 GLPVYFFGVWWKNKPKWILQVIFSVTVLCQKLMQVV 508
>sp|Q9Z127|LAT1_MOUSE Large neutral amino acids transporter small subunit 1 (L-type amino
acid transporter 1) (4F2 light chain) (4F2 LC) (4F2LC)
Length = 512
Score = 179 bits (455), Expect = 7e-45
Identities = 91/276 (32%), Positives = 149/276 (53%)
Frame = +2
Query: 35 AFSGSNYKTASLPMAFYQGFWAYSGWNYLNFLTNEMKNPEKNLPLAIIISLTLITXXXXX 214
+F G+N ++ +A Y G +AY GWNYLNF+T EM NP +NLPLAIIISL ++T
Sbjct: 237 SFEGTNLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVL 296
Query: 215 XXXXXXXXXSPQEMLLIGQSSAAIAVNFADRTMGVMSWVMPIFVGMSVFGSMNSELLSLS 394
S +ML +S A+AV+F + +GVMSW++P+FVG+S FGS+N L + S
Sbjct: 297 TNLAYFTTLSTNQML----TSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSS 352
Query: 395 RLTHTGAEENQMPKILAMVSHKYLTPMPAVIVITMLTIVFQLYQNAFYLIELAGFAFSVI 574
RL G+ E +P +L+M+ + LTP+P+++ ++T+++ ++ F +I F +
Sbjct: 353 RLFFVGSREGHLPSVLSMIHPQLLTPVPSLVFTCIMTLMYAFSRDIFSIINFFSFFNWLC 412
Query: 575 AVMSVCSLLYLRYKHPEXXXXXXXXXXXXXXXXXXXXXXCGLTVYQQPFDXXXXXXXXXX 754
+++ +++LR+K PE ++ ++ P +
Sbjct: 413 VALAIIGMMWLRFKKPELERPIKVNLALPVFFILACLFLIAVSFWKTPMECGIGFAIILS 472
Query: 755 XXPVYIIFISWKNKPTSMTNLIDKITLNIQKLLNVV 862
PVY + WKNKP + I +T+ QKL+ VV
Sbjct: 473 GLPVYFFGVWWKNKPKWILQAIFSVTVLCQKLMQVV 508
>sp|Q01650|LAT1_HUMAN Large neutral amino acids transporter small subunit 1 (L-type amino
acid transporter 1) (4F2 light chain) (4F2 LC) (4F2LC)
(CD98 light chain) (Integral membrane protein E16)
(hLAT1)
Length = 507
Score = 175 bits (443), Expect = 2e-43
Identities = 91/276 (32%), Positives = 148/276 (53%)
Frame = +2
Query: 35 AFSGSNYKTASLPMAFYQGFWAYSGWNYLNFLTNEMKNPEKNLPLAIIISLTLITXXXXX 214
+F G+ ++ +A Y G +AY GWNYLNF+T EM NP +NLPLAIIISL ++T
Sbjct: 232 SFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVL 291
Query: 215 XXXXXXXXXSPQEMLLIGQSSAAIAVNFADRTMGVMSWVMPIFVGMSVFGSMNSELLSLS 394
S ++ML SS A+AV+F + +GVMSW++P+FVG+S FGS+N L + S
Sbjct: 292 TNLAYFTTLSTEQML----SSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSS 347
Query: 395 RLTHTGAEENQMPKILAMVSHKYLTPMPAVIVITMLTIVFQLYQNAFYLIELAGFAFSVI 574
RL G+ E +P IL+M+ + LTP+P+++ ++T+++ ++ F +I F +
Sbjct: 348 RLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLC 407
Query: 575 AVMSVCSLLYLRYKHPEXXXXXXXXXXXXXXXXXXXXXXCGLTVYQQPFDXXXXXXXXXX 754
+++ +++LR++ PE ++ ++ P +
Sbjct: 408 VALAIIGMIWLRHRKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILS 467
Query: 755 XXPVYIIFISWKNKPTSMTNLIDKITLNIQKLLNVV 862
PVY + WKNKP + I T+ QKL+ VV
Sbjct: 468 GLPVYFFGVWWKNKPKWLLQGIFSTTVLCQKLMQVV 503
>sp|Q9WVR6|LAT2_RAT Large neutral amino acids transporter small subunit 2 (L-type amino
acid transporter 2)
Length = 533
Score = 158 bits (399), Expect = 2e-38
Identities = 86/263 (32%), Positives = 136/263 (51%)
Frame = +2
Query: 74 MAFYQGFWAYSGWNYLNFLTNEMKNPEKNLPLAIIISLTLITXXXXXXXXXXXXXXSPQE 253
+AF QG +AY GWN+LN++T E+ +P KNLP AI IS+ L+T SPQE
Sbjct: 237 LAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANIAYVTAMSPQE 296
Query: 254 MLLIGQSSAAIAVNFADRTMGVMSWVMPIFVGMSVFGSMNSELLSLSRLTHTGAEENQMP 433
+L +S A+AV F ++ +GVM+W+MPI V +S FG +N L + SRL GA E +P
Sbjct: 297 LL----ASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLP 352
Query: 434 KILAMVSHKYLTPMPAVIVITMLTIVFQLYQNAFYLIELAGFAFSVIAVMSVCSLLYLRY 613
+LAM+ K TP+PA++ + T++ + + + LI GF + ++V + LR+
Sbjct: 353 SVLAMIHVKRCTPIPALLFTCLSTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRW 412
Query: 614 KHPEXXXXXXXXXXXXXXXXXXXXXXCGLTVYQQPFDXXXXXXXXXXXXPVYIIFISWKN 793
K P+ +++ +P PVY + + W++
Sbjct: 413 KKPDIPRPIKISLLFPIIYLLFWAFLLIFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQH 472
Query: 794 KPTSMTNLIDKITLNIQKLLNVV 862
KP + I+ +TL QK+ VV
Sbjct: 473 KPKCFNDFIESLTLVSQKMCVVV 495
>sp|Q9UHI5|LAT2_HUMAN Large neutral amino acids transporter small subunit 2 (L-type amino
acid transporter 2) (hLAT2)
Length = 535
Score = 157 bits (398), Expect = 3e-38
Identities = 86/263 (32%), Positives = 137/263 (52%)
Frame = +2
Query: 74 MAFYQGFWAYSGWNYLNFLTNEMKNPEKNLPLAIIISLTLITXXXXXXXXXXXXXXSPQE 253
+AF QG +AY GWN+LN++T E+ +P KNLP AI IS+ L+T SPQE
Sbjct: 236 LAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQE 295
Query: 254 MLLIGQSSAAIAVNFADRTMGVMSWVMPIFVGMSVFGSMNSELLSLSRLTHTGAEENQMP 433
+L +S A+AV F ++ +GVM+W+MPI V +S FG +N L + SRL GA E +P
Sbjct: 296 LL----ASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLP 351
Query: 434 KILAMVSHKYLTPMPAVIVITMLTIVFQLYQNAFYLIELAGFAFSVIAVMSVCSLLYLRY 613
+LAM+ K TP+PA++ + T++ + + + LI GF + ++V + LR+
Sbjct: 352 SVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRW 411
Query: 614 KHPEXXXXXXXXXXXXXXXXXXXXXXCGLTVYQQPFDXXXXXXXXXXXXPVYIIFISWKN 793
K P+ +++ +P PVY + + W++
Sbjct: 412 KKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQH 471
Query: 794 KPTSMTNLIDKITLNIQKLLNVV 862
KP ++ I+ +TL QK+ VV
Sbjct: 472 KPKCFSDFIELLTLVSQKMCVVV 494
>sp|Q9QXW9|LAT2_MOUSE Large neutral amino acids transporter small subunit 2 (L-type amino
acid transporter 2)
Length = 531
Score = 157 bits (396), Expect = 5e-38
Identities = 86/263 (32%), Positives = 135/263 (51%)
Frame = +2
Query: 74 MAFYQGFWAYSGWNYLNFLTNEMKNPEKNLPLAIIISLTLITXXXXXXXXXXXXXXSPQE 253
+AF QG +AY GWN+LN++T E+ +P KNLP AI IS+ L+T SPQE
Sbjct: 235 LAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANIAYVTAMSPQE 294
Query: 254 MLLIGQSSAAIAVNFADRTMGVMSWVMPIFVGMSVFGSMNSELLSLSRLTHTGAEENQMP 433
+L +S A+AV F ++ +GVM+W+MPI V +S FG +N L + SRL GA E +P
Sbjct: 295 LL----ASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLP 350
Query: 434 KILAMVSHKYLTPMPAVIVITMLTIVFQLYQNAFYLIELAGFAFSVIAVMSVCSLLYLRY 613
+LAM+ K TP+PA++ + T++ + + + LI GF + ++V + LR+
Sbjct: 351 SVLAMIHVKRCTPIPALLFTCLSTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRW 410
Query: 614 KHPEXXXXXXXXXXXXXXXXXXXXXXCGLTVYQQPFDXXXXXXXXXXXXPVYIIFISWKN 793
K P+ +++ +P PVY + + W++
Sbjct: 411 KKPDIPRPIKVSLLFPIIYLLFWAFLLIFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQH 470
Query: 794 KPTSMTNLIDKITLNIQKLLNVV 862
KP + I +TL QK+ VV
Sbjct: 471 KPKCFNDFIKSLTLVSQKMCVVV 493
>sp|Q9NS82|AAA1_HUMAN Asc-type amino acid transporter 1 (Asc-1)
Length = 523
Score = 148 bits (373), Expect = 2e-35
Identities = 85/265 (32%), Positives = 132/265 (49%)
Frame = +2
Query: 68 LPMAFYQGFWAYSGWNYLNFLTNEMKNPEKNLPLAIIISLTLITXXXXXXXXXXXXXXSP 247
L +AF QG +A+SGWN+LN++T EM + KNLP AI IS+ L+T SP
Sbjct: 234 LALAFLQGSFAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSP 293
Query: 248 QEMLLIGQSSAAIAVNFADRTMGVMSWVMPIFVGMSVFGSMNSELLSLSRLTHTGAEENQ 427
QE+L SS A+AV F ++ +G SWVMP+ V +S FG +N L + SRL +GA E
Sbjct: 294 QELL----SSNAVAVTFGEKLLGYFSWVMPVSVALSTFGGINGYLFTYSRLCFSGAREGH 349
Query: 428 MPKILAMVSHKYLTPMPAVIVITMLTIVFQLYQNAFYLIELAGFAFSVIAVMSVCSLLYL 607
+P +LAM+ ++ TP+PA++V T V L + + LI F + +++ LL L
Sbjct: 350 LPSLLAMIHVRHCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLLL 409
Query: 608 RYKHPEXXXXXXXXXXXXXXXXXXXXXXCGLTVYQQPFDXXXXXXXXXXXXPVYIIFISW 787
R++ P + +P P++ + + W
Sbjct: 410 RWRRPALHRPIKVNLLIPVAYLVFWAFLLVFSFISEPMVCGVGVIIILTGVPIFFLGVFW 469
Query: 788 KNKPTSMTNLIDKITLNIQKLLNVV 862
++KP + L + +T Q+L VV
Sbjct: 470 RSKPKCVHRLTESMTHWGQELCFVV 494
>sp|P63116|AAA1_RAT Asc-type amino acid transporter 1 (Asc-1) (D-serine transporter)
sp|P63115|AAA1_MOUSE Asc-type amino acid transporter 1 (Asc-1) (D-serine transporter)
Length = 530
Score = 146 bits (368), Expect = 9e-35
Identities = 84/265 (31%), Positives = 130/265 (49%)
Frame = +2
Query: 68 LPMAFYQGFWAYSGWNYLNFLTNEMKNPEKNLPLAIIISLTLITXXXXXXXXXXXXXXSP 247
L +AF QG +A+SGWN+LN++T E+ +P KNLP AI IS+ L+T SP
Sbjct: 240 LALAFLQGSFAFSGWNFLNYVTEELVDPRKNLPRAIFISIPLVTFVYTFTNVAYFTAMSP 299
Query: 248 QEMLLIGQSSAAIAVNFADRTMGVMSWVMPIFVGMSVFGSMNSELLSLSRLTHTGAEENQ 427
QE+L SS A+AV F ++ +G SWVMP+ V +S FG +N L + SRL +GA E
Sbjct: 300 QELL----SSNAVAVTFGEKLLGYFSWVMPVSVALSTFGGINGYLFTSSRLCFSGAREGH 355
Query: 428 MPKILAMVSHKYLTPMPAVIVITMLTIVFQLYQNAFYLIELAGFAFSVIAVMSVCSLLYL 607
+P LAM+ + TP+PA++V T V L + + LI F + +++ LL L
Sbjct: 356 LPSFLAMIHVRRCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLVL 415
Query: 608 RYKHPEXXXXXXXXXXXXXXXXXXXXXXCGLTVYQQPFDXXXXXXXXXXXXPVYIIFISW 787
R++ P + +P P++ + + W
Sbjct: 416 RWRRPALHRPIKVNLLVPVVYLVFWAFLLVFSFISEPMVCGVGIIIILTGVPIFFLGVFW 475
Query: 788 KNKPTSMTNLIDKITLNIQKLLNVV 862
++KP + + +T Q+L VV
Sbjct: 476 RSKPKCVHRFTESMTRWGQELCFVV 500
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,059,728
Number of Sequences: 369166
Number of extensions: 1741794
Number of successful extensions: 3805
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3644
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3769
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9174518830
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)