Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_016_E04
(500 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P31153|METK_HUMAN S-adenosylmethionine synthetase gamma ... 156 3e-38
sp|P18298|METK_RAT S-adenosylmethionine synthetase gamma fo... 155 4e-38
sp|P13444|METL_RAT S-adenosylmethionine synthetase alpha an... 147 1e-35
sp|Q00266|METL_HUMAN S-adenosylmethionine synthetase alpha ... 145 7e-35
sp|P50306|METL_CAEEL Probable S-adenosylmethionine syntheta... 144 1e-34
sp|P50305|METK_CAEEL Probable S-adenosylmethionine syntheta... 144 1e-34
sp|O17680|METM_CAEEL Probable S-adenosylmethionine syntheta... 144 2e-34
sp|Q27522|METN_CAEEL Probable S-adenosylmethionine syntheta... 140 1e-33
sp|P43282|METM_LYCES S-adenosylmethionine synthetase 3 (Met... 139 3e-33
sp|P50301|METK_ACTCH S-adenosylmethionine synthetase 1 (Met... 137 1e-32
>sp|P31153|METK_HUMAN S-adenosylmethionine synthetase gamma form (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-II)
Length = 395
Score = 156 bits (394), Expect = 3e-38
Identities = 75/105 (71%), Positives = 89/105 (84%)
Frame = +3
Query: 3 ERSDEDVGAGDQGLMFGYATDETEELMPLTVVLAHGLNMKLAECRRNGTLPYLRPDTKTQ 182
+R++ED+GAGDQGLMFGYATDETEE MPLT+VLAH LN KLAE RRNGTLP+LRPD+KTQ
Sbjct: 124 DRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQ 183
Query: 183 VTVLYKSVQGACVPIRVHTVVISTQHDENVSLDQLREDLMCHVVK 317
VTV Y +GA +PIRVHT+VIS QHDE V LD++R+ L V+K
Sbjct: 184 VTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIK 228
Score = 45.1 bits (105), Expect = 1e-04
Identities = 32/63 (50%), Positives = 36/63 (57%), Gaps = 5/63 (7%)
Frame = +2
Query: 314 KTVIPEIYLDANTIYHLTLS-RFVI---EDLKRCRYWRKSCDTYGD-GERTGRAFSGKDY 478
K V+P YLD +TIYHL S RFVI + + DTYG G G AFSGKDY
Sbjct: 228 KAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY 287
Query: 479 TKV 487
TKV
Sbjct: 288 TKV 290
>sp|P18298|METK_RAT S-adenosylmethionine synthetase gamma form (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-II)
Length = 395
Score = 155 bits (393), Expect = 4e-38
Identities = 74/105 (70%), Positives = 89/105 (84%)
Frame = +3
Query: 3 ERSDEDVGAGDQGLMFGYATDETEELMPLTVVLAHGLNMKLAECRRNGTLPYLRPDTKTQ 182
+R++ED+GAGDQGLMFGYATDETEE MPLT+VLAH LN KLAE RRNGTLP+LRPD+KTQ
Sbjct: 124 DRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQ 183
Query: 183 VTVLYKSVQGACVPIRVHTVVISTQHDENVSLDQLREDLMCHVVK 317
VTV Y +GA +PIRVHT+VIS QHDE V LD++R+ L ++K
Sbjct: 184 VTVQYMQDRGAVIPIRVHTIVISVQHDEEVCLDEMRDALKEKLIK 228
Score = 45.1 bits (105), Expect = 1e-04
Identities = 32/63 (50%), Positives = 36/63 (57%), Gaps = 5/63 (7%)
Frame = +2
Query: 314 KTVIPEIYLDANTIYHLTLS-RFVI---EDLKRCRYWRKSCDTYGD-GERTGRAFSGKDY 478
K V+P YLD +TIYHL S RFVI + + DTYG G G AFSGKDY
Sbjct: 228 KAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDY 287
Query: 479 TKV 487
TKV
Sbjct: 288 TKV 290
>sp|P13444|METL_RAT S-adenosylmethionine synthetase alpha and beta forms (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-I/III)
Length = 397
Score = 147 bits (371), Expect = 1e-35
Identities = 80/166 (48%), Positives = 112/166 (67%), Gaps = 5/166 (3%)
Frame = +3
Query: 3 ERSDEDVGAGDQGLMFGYATDETEELMPLTVVLAHGLNMKLAECRRNGTLPYLRPDTKTQ 182
+R++EDVGAGDQGLMFGYATDETEE MPLT+VLAH LN ++A+ RR+G LP+LRPD+KTQ
Sbjct: 125 DRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRMADLRRSGVLPWLRPDSKTQ 184
Query: 183 VTVLYKSVQGACVPIRVHTVVISTQHDENVSLDQLREDLMCHVVKQLF-QRYISMLIPFT 359
VTV Y GA +P+RVHT+VIS QH+E+++L+ +RE L V+K + +Y+ +
Sbjct: 185 VTVQYVQDNGAVIPVRVHTIVISVQHNEDITLEAMREALKEQVIKAVVPAKYLDEDTIYH 244
Query: 360 I*PSADLLLRISR-DAVIGANHV---THMEMGSARGGRFPEKTIQK 485
+ PS ++ + DA + + T+ G+ GG F K K
Sbjct: 245 LQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTK 290
Score = 45.1 bits (105), Expect = 1e-04
Identities = 32/63 (50%), Positives = 36/63 (57%), Gaps = 5/63 (7%)
Frame = +2
Query: 314 KTVIPEIYLDANTIYHLTLS-RFVI---EDLKRCRYWRKSCDTYGD-GERTGRAFSGKDY 478
K V+P YLD +TIYHL S RFVI + + DTYG G G AFSGKDY
Sbjct: 229 KAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDY 288
Query: 479 TKV 487
TKV
Sbjct: 289 TKV 291
>sp|Q00266|METL_HUMAN S-adenosylmethionine synthetase alpha and beta forms (Methionine
adenosyltransferase) (AdoMet synthetase) (MAT-I/III)
Length = 395
Score = 145 bits (365), Expect = 7e-35
Identities = 76/166 (45%), Positives = 112/166 (67%), Gaps = 5/166 (3%)
Frame = +3
Query: 3 ERSDEDVGAGDQGLMFGYATDETEELMPLTVVLAHGLNMKLAECRRNGTLPYLRPDTKTQ 182
+R++EDVGAGDQGLMFGYATDETEE MPLT++LAH LN ++A+ RR+G LP+LRPD+KTQ
Sbjct: 124 DRNEEDVGAGDQGLMFGYATDETEECMPLTIILAHKLNARMADLRRSGLLPWLRPDSKTQ 183
Query: 183 VTVLYKSVQGACVPIRVHTVVISTQHDENVSLDQLREDLMCHVVKQLF-QRYISMLIPFT 359
VTV Y GA +P+R+HT+VIS QH+E+++L+++R L V++ + +Y+ +
Sbjct: 184 VTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEEMRRALKEQVIRAVVPAKYLDEDTVYH 243
Query: 360 I*PSADLLLRISR-DAVIGANHV---THMEMGSARGGRFPEKTIQK 485
+ PS ++ + DA + + T+ G+ GG F K K
Sbjct: 244 LQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTK 289
Score = 43.5 bits (101), Expect = 3e-04
Identities = 30/63 (47%), Positives = 36/63 (57%), Gaps = 5/63 (7%)
Frame = +2
Query: 314 KTVIPEIYLDANTIYHLTLS-RFVI---EDLKRCRYWRKSCDTYGD-GERTGRAFSGKDY 478
+ V+P YLD +T+YHL S RFVI + + DTYG G G AFSGKDY
Sbjct: 228 RAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDY 287
Query: 479 TKV 487
TKV
Sbjct: 288 TKV 290
>sp|P50306|METL_CAEEL Probable S-adenosylmethionine synthetase C06E7.3 (Methionine
adenosyltransferase) (AdoMet synthetase)
Length = 404
Score = 144 bits (363), Expect = 1e-34
Identities = 68/105 (64%), Positives = 87/105 (82%)
Frame = +3
Query: 3 ERSDEDVGAGDQGLMFGYATDETEELMPLTVVLAHGLNMKLAECRRNGTLPYLRPDTKTQ 182
++ +DVGAGDQG+MFGYATDETEE MPLT++L+H LN KL E RR+G L ++RPD+KTQ
Sbjct: 112 DKDSDDVGAGDQGIMFGYATDETEEAMPLTLLLSHKLNRKLHELRRSGELEWVRPDSKTQ 171
Query: 183 VTVLYKSVQGACVPIRVHTVVISTQHDENVSLDQLREDLMCHVVK 317
VT+ Y S GACVP+RVHTVVISTQH ++SLD LR++L+ V+K
Sbjct: 172 VTIEYASEGGACVPLRVHTVVISTQHSPDISLDDLRKELIEKVIK 216
Score = 32.7 bits (73), Expect = 0.49
Identities = 29/63 (46%), Positives = 31/63 (49%), Gaps = 5/63 (7%)
Frame = +2
Query: 314 KTVIPEIYLDANTIYHLT-LSRFVIEDLKRCR--YWRKSC-DTYGD-GERTGRAFSGKDY 478
K VIP +D TIYHL F+I RK DTYG G G AFSGKD
Sbjct: 216 KAVIPANLIDDKTIYHLNPCGSFIIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDP 275
Query: 479 TKV 487
TKV
Sbjct: 276 TKV 278
>sp|P50305|METK_CAEEL Probable S-adenosylmethionine synthetase C06E7.1 (Methionine
adenosyltransferase) (AdoMet synthetase)
Length = 404
Score = 144 bits (363), Expect = 1e-34
Identities = 68/105 (64%), Positives = 87/105 (82%)
Frame = +3
Query: 3 ERSDEDVGAGDQGLMFGYATDETEELMPLTVVLAHGLNMKLAECRRNGTLPYLRPDTKTQ 182
++ +DVGAGDQG+MFGYATDETEE MPLT++L+H LN KL E RR+G L ++RPD+KTQ
Sbjct: 112 DKDSDDVGAGDQGIMFGYATDETEEAMPLTLLLSHKLNRKLHELRRSGELEWVRPDSKTQ 171
Query: 183 VTVLYKSVQGACVPIRVHTVVISTQHDENVSLDQLREDLMCHVVK 317
VT+ Y S GACVP+RVHTVVISTQH ++SLD LR++L+ V+K
Sbjct: 172 VTIEYASEGGACVPLRVHTVVISTQHSPDISLDDLRKELIEKVIK 216
Score = 32.7 bits (73), Expect = 0.49
Identities = 29/63 (46%), Positives = 31/63 (49%), Gaps = 5/63 (7%)
Frame = +2
Query: 314 KTVIPEIYLDANTIYHLT-LSRFVIEDLKRCR--YWRKSC-DTYGD-GERTGRAFSGKDY 478
K VIP +D TIYHL F+I RK DTYG G G AFSGKD
Sbjct: 216 KAVIPANLIDDKTIYHLNPCGSFIIGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDP 275
Query: 479 TKV 487
TKV
Sbjct: 276 TKV 278
>sp|O17680|METM_CAEEL Probable S-adenosylmethionine synthetase C49F5.1 (Methionine
adenosyltransferase) (AdoMet synthetase)
Length = 403
Score = 144 bits (362), Expect = 2e-34
Identities = 64/106 (60%), Positives = 90/106 (84%)
Frame = +3
Query: 6 RSDEDVGAGDQGLMFGYATDETEELMPLTVVLAHGLNMKLAECRRNGTLPYLRPDTKTQV 185
+ EDVGAGDQG+MFGYATDETEE MPLT++L+H +N +L + RRNGTLP++RPD+K+QV
Sbjct: 112 KDGEDVGAGDQGIMFGYATDETEETMPLTLILSHKINAELHKLRRNGTLPWVRPDSKSQV 171
Query: 186 TVLYKSVQGACVPIRVHTVVISTQHDENVSLDQLREDLMCHVVKQL 323
T+ Y+S GA +P+RVHTVV+STQH +V+L++LRE ++ V+K++
Sbjct: 172 TIEYESRHGATIPLRVHTVVVSTQHSPDVTLEKLRETILADVIKKV 217
Score = 31.2 bits (69), Expect = 1.4
Identities = 26/63 (41%), Positives = 32/63 (50%), Gaps = 5/63 (7%)
Frame = +2
Query: 314 KTVIPEIYLDANTIYHLT-LSRFVIEDLKRCR--YWRKSC-DTYGD-GERTGRAFSGKDY 478
K VIP LD +T++H+ F++ RK DTYG G G AFSGKD
Sbjct: 215 KKVIPASLLDESTVFHINPCGTFIVGGPMGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDP 274
Query: 479 TKV 487
TKV
Sbjct: 275 TKV 277
>sp|Q27522|METN_CAEEL Probable S-adenosylmethionine synthetase T13A10.11 (Methionine
adenosyltransferase) (AdoMet synthetase)
Length = 404
Score = 140 bits (354), Expect = 1e-33
Identities = 67/100 (67%), Positives = 84/100 (84%)
Frame = +3
Query: 18 DVGAGDQGLMFGYATDETEELMPLTVVLAHGLNMKLAECRRNGTLPYLRPDTKTQVTVLY 197
DVGAGDQG+MFGYATDETEE MPLT++L+H LN KL E RR+G L ++RPD+KTQVT+ Y
Sbjct: 117 DVGAGDQGIMFGYATDETEEAMPLTLLLSHKLNYKLHELRRSGELEWVRPDSKTQVTIEY 176
Query: 198 KSVQGACVPIRVHTVVISTQHDENVSLDQLREDLMCHVVK 317
S GACVP+RVHTVVISTQH ++SL+ LR++L+ V+K
Sbjct: 177 SSEGGACVPLRVHTVVISTQHSPDISLEDLRKELIEKVIK 216
Score = 32.3 bits (72), Expect = 0.65
Identities = 28/63 (44%), Positives = 32/63 (50%), Gaps = 5/63 (7%)
Frame = +2
Query: 314 KTVIPEIYLDANTIYHLT-LSRFVIEDLKRCR--YWRKSC-DTYGD-GERTGRAFSGKDY 478
K VIP +D +T+YHL FV+ RK DTYG G G AFSGKD
Sbjct: 216 KVVIPGNLIDNDTVYHLNPCGSFVVGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDP 275
Query: 479 TKV 487
TKV
Sbjct: 276 TKV 278
>sp|P43282|METM_LYCES S-adenosylmethionine synthetase 3 (Methionine adenosyltransferase
3) (AdoMet synthetase 3)
Length = 390
Score = 139 bits (351), Expect = 3e-33
Identities = 74/128 (57%), Positives = 91/128 (71%), Gaps = 1/128 (0%)
Frame = +3
Query: 6 RSDEDVGAGDQGLMFGYATDETEELMPLTVVLAHGLNMKLAECRRNGTLPYLRPDTKTQV 185
+ E++GAGDQG MFGYATDET ELMPLT VLA L KL E R+N T P+LRPD KTQV
Sbjct: 113 KKPEEIGAGDQGHMFGYATDETPELMPLTHVLATKLGAKLTEVRKNKTCPWLRPDGKTQV 172
Query: 186 TVLYKSVQGACVPIRVHTVVISTQHDENVSLDQLREDLMCHVVKQLF-QRYISMLIPFTI 362
TV YK+ GA VPIRVHTV+ISTQHDE V+ DQ+ +DL HV+K + +Y+ F +
Sbjct: 173 TVEYKNDNGAMVPIRVHTVLISTQHDETVTNDQIAQDLKEHVIKPVIPAKYLDENTIFHL 232
Query: 363 *PSADLLL 386
PS ++
Sbjct: 233 NPSGRFVI 240
Score = 41.2 bits (95), Expect = 0.001
Identities = 32/63 (50%), Positives = 34/63 (53%), Gaps = 5/63 (7%)
Frame = +2
Query: 314 KTVIPEIYLDANTIYHLTLS-RFVI---EDLKRCRYWRKSCDTYGD-GERTGRAFSGKDY 478
K VIP YLD NTI+HL S RFVI + DTYG G G AFSGKD
Sbjct: 216 KPVIPAKYLDENTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDP 275
Query: 479 TKV 487
TKV
Sbjct: 276 TKV 278
>sp|P50301|METK_ACTCH S-adenosylmethionine synthetase 1 (Methionine adenosyltransferase
1) (AdoMet synthetase 1)
Length = 390
Score = 137 bits (345), Expect = 1e-32
Identities = 69/104 (66%), Positives = 80/104 (76%)
Frame = +3
Query: 6 RSDEDVGAGDQGLMFGYATDETEELMPLTVVLAHGLNMKLAECRRNGTLPYLRPDTKTQV 185
+ E++GAGDQG MFGYATDET ELMPLT VLA L KL E R+N T P+LRPD KTQV
Sbjct: 113 KKPEEIGAGDQGHMFGYATDETPELMPLTHVLATKLGAKLTEVRKNSTCPWLRPDGKTQV 172
Query: 186 TVLYKSVQGACVPIRVHTVVISTQHDENVSLDQLREDLMCHVVK 317
TV Y++ GA VPIRVHTV+ISTQHDE V+ DQ+ DL HV+K
Sbjct: 173 TVEYRNEGGAMVPIRVHTVLISTQHDETVTNDQIANDLKKHVIK 216
Score = 40.4 bits (93), Expect = 0.002
Identities = 31/63 (49%), Positives = 34/63 (53%), Gaps = 5/63 (7%)
Frame = +2
Query: 314 KTVIPEIYLDANTIYHLTLS-RFVI---EDLKRCRYWRKSCDTYGD-GERTGRAFSGKDY 478
K V+P YLD NTI+HL S RFVI + DTYG G G AFSGKD
Sbjct: 216 KPVVPAQYLDDNTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDP 275
Query: 479 TKV 487
TKV
Sbjct: 276 TKV 278
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,579,079
Number of Sequences: 369166
Number of extensions: 1139659
Number of successful extensions: 3210
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2760
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2998
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 3168768640
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)