Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_016_D13
(499 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q3TZA2|CDKL4_MOUSE Cyclin-dependent kinase-like 4 268 7e-72
sp|Q5MAI5|CDKL4_HUMAN Cyclin-dependent kinase-like 4 262 4e-70
sp|Q8CEQ0|CDKL1_MOUSE Cyclin-dependent kinase-like 1 256 2e-68
sp|Q66HE7|CDKL1_RAT Cyclin-dependent kinase-like 1 253 2e-67
sp|Q9TTK0|CDKL2_RABIT Cyclin-dependent kinase-like 2 (Serin... 227 1e-59
sp|Q5R754|CDKL2_PONPY Cyclin-dependent kinase-like 2 223 2e-58
sp|Q92772|CDKL2_HUMAN Cyclin-dependent kinase-like 2 (Serin... 222 4e-58
sp|Q4R7T5|CDKL2_MACFA Cyclin-dependent kinase-like 2 221 6e-58
sp|Q8BLF2|CDKL3_MOUSE Cyclin-dependent kinase-like 3 198 5e-51
sp|Q9JM01|CDKL3_RAT Cyclin-dependent kinase-like 3 (Serine/... 197 9e-51
>sp|Q3TZA2|CDKL4_MOUSE Cyclin-dependent kinase-like 4
Length = 342
Score = 268 bits (684), Expect = 7e-72
Identities = 120/166 (72%), Positives = 141/166 (84%)
Frame = +1
Query: 1 RKRRLHLVFQYIDHTLLNELEQKPNGLDRDRICKITSQLLLAIRFCHQHNCIHRDVKPEN 180
RKR++HLVF+Y DHTLLNELE+ PNG+ I + Q L A+ FCH+HNCIHRDVKPEN
Sbjct: 72 RKRKMHLVFEYCDHTLLNELERNPNGVSDGVIKSVLWQTLQALNFCHKHNCIHRDVKPEN 131
Query: 181 ILVTKSGQVKLCDFGFARILSPGDEYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCVF 360
IL+TK G +K+CDFGFARIL PGD YTDYVATRWYRAPELLVGDT+YG VDVWA+GCVF
Sbjct: 132 ILITKQGMIKICDFGFARILIPGDAYTDYVATRWYRAPELLVGDTKYGSSVDVWAVGCVF 191
Query: 361 AEMLRGQPLWPGMSDLDQIYLIIKTLGDLLPRFKEIFQNNSFFRGI 498
AE+L GQPLWPG SD+DQ+YLII+TLG L+PR + IF++N FFRGI
Sbjct: 192 AELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFRSNQFFRGI 237
>sp|Q5MAI5|CDKL4_HUMAN Cyclin-dependent kinase-like 4
Length = 315
Score = 262 bits (669), Expect = 4e-70
Identities = 118/166 (71%), Positives = 139/166 (83%)
Frame = +1
Query: 1 RKRRLHLVFQYIDHTLLNELEQKPNGLDRDRICKITSQLLLAIRFCHQHNCIHRDVKPEN 180
RKR++HLVF+Y DHTLLNELE+ PNG+ I + Q L A+ FCH HNCIHRD+KPEN
Sbjct: 72 RKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIKPEN 131
Query: 181 ILVTKSGQVKLCDFGFARILSPGDEYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCVF 360
IL+TK G +K+CDFGFA+IL PGD YTDYVATRWYRAPELLVGDTQYG VD+WAIGCVF
Sbjct: 132 ILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVF 191
Query: 361 AEMLRGQPLWPGMSDLDQIYLIIKTLGDLLPRFKEIFQNNSFFRGI 498
AE+L GQPLWPG SD+DQ+YLII+TLG L+PR + IF++N FF GI
Sbjct: 192 AELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGI 237
>sp|Q8CEQ0|CDKL1_MOUSE Cyclin-dependent kinase-like 1
Length = 352
Score = 256 bits (655), Expect = 2e-68
Identities = 116/167 (69%), Positives = 139/167 (83%), Gaps = 1/167 (0%)
Frame = +1
Query: 1 RKRRLHLVFQYIDHTLLNELEQKPNGLDRDRICKITSQLLLAIRFCHQHNCIHRDVKPEN 180
RKRRLHLVF+Y DHT+L+EL++ G+ + IT Q L A+ FCH+HNCIHRDVKPEN
Sbjct: 72 RKRRLHLVFEYCDHTVLHELDRYQRGVPEPLVKNITWQTLQAVNFCHKHNCIHRDVKPEN 131
Query: 181 ILVTKSGQVKLCDFGFARILS-PGDEYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCV 357
IL+TK +KLCDFGFAR+L+ PGD YTDYVATRWYR+PELLVGDTQYGPPVDVWAIGCV
Sbjct: 132 ILITKQSAIKLCDFGFARLLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCV 191
Query: 358 FAEMLRGQPLWPGMSDLDQIYLIIKTLGDLLPRFKEIFQNNSFFRGI 498
FAE+L G PLWPG SD+DQ+YLI KTLGDL+PR +++F N +F G+
Sbjct: 192 FAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSMNQYFSGV 238
>sp|Q66HE7|CDKL1_RAT Cyclin-dependent kinase-like 1
Length = 352
Score = 253 bits (646), Expect = 2e-67
Identities = 115/167 (68%), Positives = 138/167 (82%), Gaps = 1/167 (0%)
Frame = +1
Query: 1 RKRRLHLVFQYIDHTLLNELEQKPNGLDRDRICKITSQLLLAIRFCHQHNCIHRDVKPEN 180
RKRRLHLVF+Y HT+L+EL++ G+ + IT Q L A+ FCH+HNCIHRDVKPEN
Sbjct: 72 RKRRLHLVFEYCHHTVLHELDRYQRGVPEPLVKNITWQTLQAVNFCHKHNCIHRDVKPEN 131
Query: 181 ILVTKSGQVKLCDFGFARILS-PGDEYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCV 357
IL+TK +KLCDFGFAR+L+ PGD YTDYVATRWYR+PELLVGDTQYGPPVDVWAIGCV
Sbjct: 132 ILITKHSVIKLCDFGFARLLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCV 191
Query: 358 FAEMLRGQPLWPGMSDLDQIYLIIKTLGDLLPRFKEIFQNNSFFRGI 498
FAE+L G PLWPG SD+DQ+YLI KTLGDL+PR +++F N +F G+
Sbjct: 192 FAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSMNQYFSGV 238
>sp|Q9TTK0|CDKL2_RABIT Cyclin-dependent kinase-like 2 (Serine/threonine-protein kinase
KKIAMRE)
Length = 566
Score = 227 bits (578), Expect = 1e-59
Identities = 104/167 (62%), Positives = 134/167 (80%), Gaps = 1/167 (0%)
Frame = +1
Query: 1 RKRRLHLVFQYIDHTLLNELEQKPNGLDRDRICKITSQLLLAIRFCHQHNCIHRDVKPEN 180
+K+R +LVF+++DHT+L++LE PNGLD + K Q++ I FCH HN IHRD+KPEN
Sbjct: 72 KKKRWYLVFEFVDHTILDDLELFPNGLDDQVVQKYLFQIINGIGFCHSHNIIHRDIKPEN 131
Query: 181 ILVTKSGQVKLCDFGFARILS-PGDEYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCV 357
ILV++SG VKLCDFGFAR L+ PG+ YTDYVATRWYRAPELLVGD +YG VDVWAIGC+
Sbjct: 132 ILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCL 191
Query: 358 FAEMLRGQPLWPGMSDLDQIYLIIKTLGDLLPRFKEIFQNNSFFRGI 498
EML G+PL+PG SD+DQ+YLI++ LG+L+PR +E+F N F G+
Sbjct: 192 VTEMLMGEPLFPGDSDIDQLYLIMRCLGNLIPRHQELFYKNPVFAGV 238
>sp|Q5R754|CDKL2_PONPY Cyclin-dependent kinase-like 2
Length = 493
Score = 223 bits (568), Expect = 2e-58
Identities = 103/167 (61%), Positives = 131/167 (78%), Gaps = 1/167 (0%)
Frame = +1
Query: 1 RKRRLHLVFQYIDHTLLNELEQKPNGLDRDRICKITSQLLLAIRFCHQHNCIHRDVKPEN 180
+K+R +LVF+++DHT+L++LE PNGLD + K Q++ I FCH HN IHRD+KPEN
Sbjct: 72 KKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPEN 131
Query: 181 ILVTKSGQVKLCDFGFARILS-PGDEYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCV 357
ILV+KSG VKLCDFGFAR L+ PG+ YTDYVATRWYRAPELLVGD +YG VDVWAIGC+
Sbjct: 132 ILVSKSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCL 191
Query: 358 FAEMLRGQPLWPGMSDLDQIYLIIKTLGDLLPRFKEIFQNNSFFRGI 498
EM G+PL+PG SD+DQ+Y I+ LG+L+PR +E+F N F G+
Sbjct: 192 VTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFYKNPVFAGV 238
>sp|Q92772|CDKL2_HUMAN Cyclin-dependent kinase-like 2 (Serine/threonine-protein kinase
KKIAMRE) (Protein kinase p56 KKIAMRE)
Length = 493
Score = 222 bits (565), Expect = 4e-58
Identities = 102/167 (61%), Positives = 131/167 (78%), Gaps = 1/167 (0%)
Frame = +1
Query: 1 RKRRLHLVFQYIDHTLLNELEQKPNGLDRDRICKITSQLLLAIRFCHQHNCIHRDVKPEN 180
+K+R +LVF+++DHT+L++LE PNGLD + K Q++ I FCH HN IHRD+KPEN
Sbjct: 72 KKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPEN 131
Query: 181 ILVTKSGQVKLCDFGFARILS-PGDEYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCV 357
ILV++SG VKLCDFGFAR L+ PG+ YTDYVATRWYRAPELLVGD +YG VDVWAIGC+
Sbjct: 132 ILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCL 191
Query: 358 FAEMLRGQPLWPGMSDLDQIYLIIKTLGDLLPRFKEIFQNNSFFRGI 498
EM G+PL+PG SD+DQ+Y I+ LG+L+PR +E+F N F G+
Sbjct: 192 VTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGV 238
>sp|Q4R7T5|CDKL2_MACFA Cyclin-dependent kinase-like 2
Length = 570
Score = 221 bits (564), Expect = 6e-58
Identities = 102/167 (61%), Positives = 131/167 (78%), Gaps = 1/167 (0%)
Frame = +1
Query: 1 RKRRLHLVFQYIDHTLLNELEQKPNGLDRDRICKITSQLLLAIRFCHQHNCIHRDVKPEN 180
+K+R +LVF+++DHT+L++LE PNGLD + K Q++ I FCH HN IHRD+KPEN
Sbjct: 72 KKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPEN 131
Query: 181 ILVTKSGQVKLCDFGFARILS-PGDEYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCV 357
ILV++SG VKLCDFGFAR L+ PG+ YTDYVATRWYRAPELLVGD +YG VDVWAIGC+
Sbjct: 132 ILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCL 191
Query: 358 FAEMLRGQPLWPGMSDLDQIYLIIKTLGDLLPRFKEIFQNNSFFRGI 498
EM G+PL+PG SD+DQ+Y I+ LG+L+PR +E+F N F G+
Sbjct: 192 VTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFYKNPVFAGV 238
>sp|Q8BLF2|CDKL3_MOUSE Cyclin-dependent kinase-like 3
Length = 595
Score = 198 bits (504), Expect = 5e-51
Identities = 91/167 (54%), Positives = 122/167 (73%), Gaps = 1/167 (0%)
Frame = +1
Query: 1 RKRRLHLVFQYIDHTLLNELEQKPNGLDRDRICKITSQLLLAIRFCHQHNCIHRDVKPEN 180
+K+++HLVF++IDHT+L+EL+ +GL+ R+ K Q+L AI + H +N IHRD+KPEN
Sbjct: 71 QKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIEYLHNNNIIHRDIKPEN 130
Query: 181 ILVTKSGQVKLCDFGFARILS-PGDEYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCV 357
ILV++SG KLCDFGFAR L+ PGD YTDYVATRWYRAPEL++ DT YG PVD+WA+GC+
Sbjct: 131 ILVSQSGITKLCDFGFARTLAAPGDVYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCM 190
Query: 358 FAEMLRGQPLWPGMSDLDQIYLIIKTLGDLLPRFKEIFQNNSFFRGI 498
EM G P P SDLD ++ I+ +G+L P IF + F G+
Sbjct: 191 IIEMATGHPFLPSSSDLDLLHKIVLKVGNLTPHLHNIFSKSPIFAGV 237
>sp|Q9JM01|CDKL3_RAT Cyclin-dependent kinase-like 3 (Serine/threonine protein kinase
NKIATRE)
Length = 593
Score = 197 bits (502), Expect = 9e-51
Identities = 91/167 (54%), Positives = 122/167 (73%), Gaps = 1/167 (0%)
Frame = +1
Query: 1 RKRRLHLVFQYIDHTLLNELEQKPNGLDRDRICKITSQLLLAIRFCHQHNCIHRDVKPEN 180
+K+++HLVF++IDHT+L+EL+ +GL+ R+ K Q+L AI + H +N IHRD+KPEN
Sbjct: 71 QKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIEYLHNNNIIHRDIKPEN 130
Query: 181 ILVTKSGQVKLCDFGFARILS-PGDEYTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCV 357
ILV++SG KLCDFGFAR L+ PGD YTDYVATRWYRAPEL++ DT YG PVD+WA+GC+
Sbjct: 131 ILVSQSGITKLCDFGFARTLAAPGDVYTDYVATRWYRAPELVLKDTTYGKPVDIWALGCM 190
Query: 358 FAEMLRGQPLWPGMSDLDQIYLIIKTLGDLLPRFKEIFQNNSFFRGI 498
EM G P P SDLD ++ I+ +G+L P IF + F G+
Sbjct: 191 IIEMATGNPYLPSSSDLDLLHKIVLKVGNLTPHLHNIFSKSPIFAGV 237
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,230,518
Number of Sequences: 369166
Number of extensions: 1162017
Number of successful extensions: 5500
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4101
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4277
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 3119256630
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)