Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_016_C11
(713 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q29092|ENPL_PIG Endoplasmin precursor (94 kDa glucose-re... 289 4e-78
sp|P41148|ENPL_CANFA Endoplasmin precursor (94 kDa glucose-... 289 4e-78
sp|Q95M18|ENPL_BOVIN Endoplasmin precursor (94 kDa glucose-... 288 8e-78
sp|P08113|ENPL_MOUSE Endoplasmin precursor (Endoplasmic ret... 288 1e-77
sp|P14625|ENPL_HUMAN Endoplasmin precursor (94 kDa glucose-... 286 4e-77
sp|P08110|ENPL_CHICK Endoplasmin precursor (Heat shock 108 ... 286 5e-77
sp|O18750|ENPL_RABIT Endoplasmin (94 kDa glucose-regulated ... 268 1e-71
sp|P36183|ENPL_HORVU Endoplasmin homolog precursor (GRP94 h... 239 5e-63
sp|P34058|HS90B_RAT Heat shock protein HSP 90-beta (HSP 84) 234 2e-61
sp|O02192|HSP83_DROAV Heat shock protein 83 (HSP 82) 233 3e-61
>sp|Q29092|ENPL_PIG Endoplasmin precursor (94 kDa glucose-regulated protein) (GRP94)
(GP96 homolog) (98 kDa protein kinase) (PPK 98) (ppk98)
Length = 804
Score = 289 bits (740), Expect = 4e-78
Identities = 144/241 (59%), Positives = 184/241 (76%), Gaps = 4/241 (1%)
Frame = +2
Query: 2 IWTRKTSEIKDEEYNDFYKSFGKTSENPLAKIHFTAEGEVTFKSILFVPAKPP---FNYY 172
IW R + E++D+EY FYKSF K S++P+A IHFTAEGEVTFKSILFVP P F+ Y
Sbjct: 342 IWQRPSKEVEDDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEY 401
Query: 173 QNPESHRDNIKMYVRRVFITDDFHDMMPKYLSFIVGIVDSDDLPLNVSRETLQQNXXXXX 352
+ +S D IK+YVRRVFITDDFHDMMPKYL+F+ G+VDSDDLPLNVSRETLQQ+
Sbjct: 402 GSKKS--DYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKV 459
Query: 353 XXXXXXXXXXDMLKKMSEEDF-DKFWKEFSTSLKLGVVEDVSNRTRLAKLLRFWTSHNDK 529
DM+KK+++E + D FWKEF T++KLGV+ED SNRTRLAKLLRF +SH+
Sbjct: 460 IRKKLVRKTLDMIKKIADEKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPS 519
Query: 530 KQSTLTDYVSRMKEKQDVIYYIAGQSKEELIKSPLVEKVLKKGFEVVYMIDPVDEYVVQS 709
++L YV RMKEKQD IY++AG S++E SP VE++LKKG+EV+Y+ +PVDEY +Q+
Sbjct: 520 DITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQA 579
Query: 710 V 712
+
Sbjct: 580 L 580
>sp|P41148|ENPL_CANFA Endoplasmin precursor (94 kDa glucose-regulated protein) (GRP94)
Length = 804
Score = 289 bits (740), Expect = 4e-78
Identities = 144/241 (59%), Positives = 184/241 (76%), Gaps = 4/241 (1%)
Frame = +2
Query: 2 IWTRKTSEIKDEEYNDFYKSFGKTSENPLAKIHFTAEGEVTFKSILFVPAKPP---FNYY 172
IW R + E++D+EY FYKSF K S++P+A IHFTAEGEVTFKSILFVP P F+ Y
Sbjct: 342 IWQRPSKEVEDDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEY 401
Query: 173 QNPESHRDNIKMYVRRVFITDDFHDMMPKYLSFIVGIVDSDDLPLNVSRETLQQNXXXXX 352
+ +S D IK+YVRRVFITDDFHDMMPKYL+F+ G+VDSDDLPLNVSRETLQQ+
Sbjct: 402 GSKKS--DYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKV 459
Query: 353 XXXXXXXXXXDMLKKMSEEDF-DKFWKEFSTSLKLGVVEDVSNRTRLAKLLRFWTSHNDK 529
DM+KK+++E + D FWKEF T++KLGV+ED SNRTRLAKLLRF +SH+
Sbjct: 460 IRKKLVRKTLDMIKKIADEKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPS 519
Query: 530 KQSTLTDYVSRMKEKQDVIYYIAGQSKEELIKSPLVEKVLKKGFEVVYMIDPVDEYVVQS 709
++L YV RMKEKQD IY++AG S++E SP VE++LKKG+EV+Y+ +PVDEY +Q+
Sbjct: 520 DITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQA 579
Query: 710 V 712
+
Sbjct: 580 L 580
>sp|Q95M18|ENPL_BOVIN Endoplasmin precursor (94 kDa glucose-regulated protein) (GRP94)
Length = 804
Score = 288 bits (738), Expect = 8e-78
Identities = 143/241 (59%), Positives = 184/241 (76%), Gaps = 4/241 (1%)
Frame = +2
Query: 2 IWTRKTSEIKDEEYNDFYKSFGKTSENPLAKIHFTAEGEVTFKSILFVPAKPP---FNYY 172
IW R + E++++EY FYKSF K S++P+A IHFTAEGEVTFKSILFVP P F+ Y
Sbjct: 342 IWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEY 401
Query: 173 QNPESHRDNIKMYVRRVFITDDFHDMMPKYLSFIVGIVDSDDLPLNVSRETLQQNXXXXX 352
+ +S D IK+YVRRVFITDDFHDMMPKYL+F+ G+VDSDDLPLNVSRETLQQ+
Sbjct: 402 GSKKS--DYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKV 459
Query: 353 XXXXXXXXXXDMLKKMSEEDF-DKFWKEFSTSLKLGVVEDVSNRTRLAKLLRFWTSHNDK 529
DM+KK+++E + D FWKEF T++KLGV+ED SNRTRLAKLLRF +SH+
Sbjct: 460 IRKKLVRKTLDMIKKIADEKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPS 519
Query: 530 KQSTLTDYVSRMKEKQDVIYYIAGQSKEELIKSPLVEKVLKKGFEVVYMIDPVDEYVVQS 709
++L YV RMKEKQD IY++AG S++E SP VE++LKKG+EV+Y+ +PVDEY +Q+
Sbjct: 520 DMTSLDQYVERMKEKQDKIYFMAGASRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQA 579
Query: 710 V 712
+
Sbjct: 580 L 580
>sp|P08113|ENPL_MOUSE Endoplasmin precursor (Endoplasmic reticulum protein 99) (94 kDa
glucose-regulated protein) (GRP94) (ERP99) (Polymorphic
tumor rejection antigen 1) (Tumor rejection antigen gp96)
Length = 802
Score = 288 bits (736), Expect = 1e-77
Identities = 143/241 (59%), Positives = 184/241 (76%), Gaps = 4/241 (1%)
Frame = +2
Query: 2 IWTRKTSEIKDEEYNDFYKSFGKTSENPLAKIHFTAEGEVTFKSILFVPAKPP---FNYY 172
IW R + E++++EY FYKSF K S++P+A IHFTAEGEVTFKSILFVP P F+ Y
Sbjct: 342 IWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEY 401
Query: 173 QNPESHRDNIKMYVRRVFITDDFHDMMPKYLSFIVGIVDSDDLPLNVSRETLQQNXXXXX 352
+ +S D IK+YVRRVFITDDFHDMMPKYL+F+ G+VDSDDLPLNVSRETLQQ+
Sbjct: 402 GSKKS--DYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKV 459
Query: 353 XXXXXXXXXXDMLKKMSEEDF-DKFWKEFSTSLKLGVVEDVSNRTRLAKLLRFWTSHNDK 529
DM+KK+++E + D FWKEF T++KLGV+ED SNRTRLAKLLRF +SH+
Sbjct: 460 IRKKLVRKTLDMIKKIADEKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHST 519
Query: 530 KQSTLTDYVSRMKEKQDVIYYIAGQSKEELIKSPLVEKVLKKGFEVVYMIDPVDEYVVQS 709
++L YV RMKEKQD IY++AG S++E SP VE++LKKG+EV+Y+ +PVDEY +Q+
Sbjct: 520 DITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQA 579
Query: 710 V 712
+
Sbjct: 580 L 580
>sp|P14625|ENPL_HUMAN Endoplasmin precursor (94 kDa glucose-regulated protein) (GRP94)
(gp96 homolog) (Tumor rejection antigen 1)
Length = 803
Score = 286 bits (732), Expect = 4e-77
Identities = 142/241 (58%), Positives = 184/241 (76%), Gaps = 4/241 (1%)
Frame = +2
Query: 2 IWTRKTSEIKDEEYNDFYKSFGKTSENPLAKIHFTAEGEVTFKSILFVPAKPP---FNYY 172
IW R + E++++EY FYKSF K S++P+A IHFTAEGEVTFKSILFVP P F+ Y
Sbjct: 342 IWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEY 401
Query: 173 QNPESHRDNIKMYVRRVFITDDFHDMMPKYLSFIVGIVDSDDLPLNVSRETLQQNXXXXX 352
+ +S D IK+YVRRVFITDDFHDMMPKYL+F+ G+VDSDDLPLNVSRETLQQ+
Sbjct: 402 GSKKS--DYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKV 459
Query: 353 XXXXXXXXXXDMLKKMSEEDF-DKFWKEFSTSLKLGVVEDVSNRTRLAKLLRFWTSHNDK 529
DM+KK++++ + D FWKEF T++KLGV+ED SNRTRLAKLLRF +SH+
Sbjct: 460 IRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPT 519
Query: 530 KQSTLTDYVSRMKEKQDVIYYIAGQSKEELIKSPLVEKVLKKGFEVVYMIDPVDEYVVQS 709
++L YV RMKEKQD IY++AG S++E SP VE++LKKG+EV+Y+ +PVDEY +Q+
Sbjct: 520 DITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQA 579
Query: 710 V 712
+
Sbjct: 580 L 580
>sp|P08110|ENPL_CHICK Endoplasmin precursor (Heat shock 108 kDa protein) (HSP108) (HSP 108)
(Transferrin-binding protein)
Length = 795
Score = 286 bits (731), Expect = 5e-77
Identities = 142/241 (58%), Positives = 184/241 (76%), Gaps = 4/241 (1%)
Frame = +2
Query: 2 IWTRKTSEIKDEEYNDFYKSFGKTSENPLAKIHFTAEGEVTFKSILFVPAKPP---FNYY 172
IW R + E++++EY FYK+F K ++P+A IHFTAEGEVTFKSILFVP P F+ Y
Sbjct: 341 IWQRPSKEVEEDEYKAFYKTFSKEHDDPMAYIHFTAEGEVTFKSILFVPNSAPRGLFDEY 400
Query: 173 QNPESHRDNIKMYVRRVFITDDFHDMMPKYLSFIVGIVDSDDLPLNVSRETLQQNXXXXX 352
+ +S D IK+YVRRVFITDDFHDMMPKYL+F+ G+VDSDDLPLNVSRETLQQ+
Sbjct: 401 GSKKS--DFIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKV 458
Query: 353 XXXXXXXXXXDMLKKMSEEDF-DKFWKEFSTSLKLGVVEDVSNRTRLAKLLRFWTSHNDK 529
DM+KK++EE + D FWKEF T++KLGV+ED SNRTRLAKLLRF +SH++
Sbjct: 459 IRKKLVRKTLDMIKKIAEEKYNDTFWKEFGTNVKLGVIEDHSNRTRLAKLLRFQSSHHES 518
Query: 530 KQSTLTDYVSRMKEKQDVIYYIAGQSKEELIKSPLVEKVLKKGFEVVYMIDPVDEYVVQS 709
++L YV RMKEKQD IY++AG S++E SP VE++LKKG+EV+Y+ +PVDEY +Q+
Sbjct: 519 NLTSLDQYVERMKEKQDKIYFMAGASRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQA 578
Query: 710 V 712
+
Sbjct: 579 L 579
>sp|O18750|ENPL_RABIT Endoplasmin (94 kDa glucose-regulated protein) (GRP94)
Length = 716
Score = 268 bits (685), Expect = 1e-71
Identities = 139/242 (57%), Positives = 180/242 (74%), Gaps = 5/242 (2%)
Frame = +2
Query: 2 IWTRKTSEIKDEEYNDFYKSFGKTSENPLAKIHFTAEGEVTFKSILFVPAKPP---FNYY 172
IW R + E++++EY FYKSF K S++P+A IHFTAE E TFKSILFVP P F+ Y
Sbjct: 263 IWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAE-ESTFKSILFVPTSAPRGLFDEY 321
Query: 173 QNPESHRDNIKMYVRRVFITDDFHDMMPKYLSFIVGIVDSDDLPLNVSRETLQQNXXXXX 352
+ +S D IK+YVRRVFITDDFHDMMPKYL+F+ G+VDSDDLPLNVSRETLQQ+
Sbjct: 322 GSKKS--DYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKV 379
Query: 353 XXXXXXXXXXDMLKKMSEEDF--DKFWKEFSTSLKLGVVEDVSNRTRLAKLLRFWTSHND 526
DM+KK+++E + D FWK T++KLGV+ED SNRTRLAKLLRF +SH+
Sbjct: 380 IRKKLVRKTLDMIKKIADEKYNDDTFWK--GTNIKLGVIEDHSNRTRLAKLLRFQSSHHP 437
Query: 527 KKQSTLTDYVSRMKEKQDVIYYIAGQSKEELIKSPLVEKVLKKGFEVVYMIDPVDEYVVQ 706
++L YV RMKEKQD IY++AG S++E SP VE++LKKG+EV+Y+ +PVDEY +Q
Sbjct: 438 TDITSLDQYVERMKEKQDKIYFMAGASRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQ 497
Query: 707 SV 712
++
Sbjct: 498 AL 499
>sp|P36183|ENPL_HORVU Endoplasmin homolog precursor (GRP94 homolog)
Length = 809
Score = 239 bits (610), Expect = 5e-63
Identities = 122/261 (46%), Positives = 170/261 (65%), Gaps = 26/261 (9%)
Frame = +2
Query: 2 IWTRKTSEIKDEEYNDFYKSFGKT--SENPLAKIHFTAEGEVTFKSILFVPAKPPFNYYQ 175
+W R E+ +EEY FY S K + P++ HF+AEG+V FK++LFVP K P + Y+
Sbjct: 345 VWLRSPKEVTEEEYAKFYHSLAKDFGDDKPMSWSHFSAEGDVEFKALLFVPPKAPHDLYE 404
Query: 176 NP-ESHRDNIKMYVRRVFITDDFHDMMPKYLSFIVGIVDSDDLPLNVSRETLQQNXXXXX 352
+ +++ N+K+YVRRVFI+D+F D++PKYLSF++GIVDSD LPLNVSRE LQQ+
Sbjct: 405 SYYNANKSNLKLYVRRVFISDEFDDLLPKYLSFLMGIVDSDTLPLNVSREMLQQHSSLKT 464
Query: 353 XXXXXXXXXXDMLKKMSEEDFD-----------------------KFWKEFSTSLKLGVV 463
DM++K++EED D KFW EF S+KLG++
Sbjct: 465 IKKKLIRKALDMIRKLAEEDPDEYSNKEKTDDEKSAMEEKKGQYAKFWNEFGKSVKLGII 524
Query: 464 EDVSNRTRLAKLLRFWTSHNDKKQSTLTDYVSRMKEKQDVIYYIAGQSKEELIKSPLVEK 643
ED +NR RLAKLLRF +S +D K +L +Y+SRMK Q I+Y+ G SKE+L KSP +E+
Sbjct: 525 EDATNRNRLAKLLRFESSKSDGKLVSLDEYISRMKSGQKDIFYLTGSSKEQLEKSPFLEQ 584
Query: 644 VLKKGFEVVYMIDPVDEYVVQ 706
+ KK +EV+Y DPVDEY++Q
Sbjct: 585 LTKKNYEVIYFTDPVDEYLMQ 605
>sp|P34058|HS90B_RAT Heat shock protein HSP 90-beta (HSP 84)
Length = 724
Score = 234 bits (596), Expect = 2e-61
Identities = 114/239 (47%), Positives = 169/239 (70%), Gaps = 2/239 (0%)
Frame = +2
Query: 2 IWTRKTSEIKDEEYNDFYKSFGKTSENPLAKIHFTAEGEVTFKSILFVPAKPPFNYYQNP 181
IWTR +I EEY +FYKS E+ LA HF+ EG++ F+++LF+P + PF+ ++N
Sbjct: 288 IWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENK 347
Query: 182 ESHRDNIKMYVRRVFITDDFHDMMPKYLSFIVGIVDSDDLPLNVSRETLQQNXXXXXXXX 361
+ ++NIK+YVRRVFI D D++P+YL+FI G+VDS+DLPLN+SRE LQQ+
Sbjct: 348 KK-KNNIKLYVRRVFIMDSCDDLIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRK 406
Query: 362 XXXXXXXDMLKKMSE--EDFDKFWKEFSTSLKLGVVEDVSNRTRLAKLLRFWTSHNDKKQ 535
++ +++E E++ KF++ FS +LKLG+ ED +NR RL++LLR+ TS + +
Sbjct: 407 NIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEM 466
Query: 536 STLTDYVSRMKEKQDVIYYIAGQSKEELIKSPLVEKVLKKGFEVVYMIDPVDEYVVQSV 712
++L++YVSRMKE Q IYYI G+SKE++ S VE+V K+GFEVVYM +P+DEY VQ +
Sbjct: 467 TSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQL 525
>sp|O02192|HSP83_DROAV Heat shock protein 83 (HSP 82)
Length = 716
Score = 233 bits (595), Expect = 3e-61
Identities = 114/237 (48%), Positives = 167/237 (70%), Gaps = 2/237 (0%)
Frame = +2
Query: 2 IWTRKTSEIKDEEYNDFYKSFGKTSENPLAKIHFTAEGEVTFKSILFVPAKPPFNYYQNP 181
IWTR +I EEY +FYKS E+ LA HF+ EG++ F+++LF+P + PF+ ++N
Sbjct: 280 IWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRTPFDLFEN- 338
Query: 182 ESHRDNIKMYVRRVFITDDFHDMMPKYLSFIVGIVDSDDLPLNVSRETLQQNXXXXXXXX 361
+ R+NIK+YVRRVFI D+ D++P+YL+FI G+VDS+DLPLN+SRE LQQN
Sbjct: 339 QKKRNNIKLYVRRVFIMDNCEDLIPEYLNFIKGVVDSEDLPLNISREMLQQNKVLKVIRK 398
Query: 362 XXXXXXXDMLKKMSE--EDFDKFWKEFSTSLKLGVVEDVSNRTRLAKLLRFWTSHNDKKQ 535
+++++++E E++ KF+ +FS +LKLGV ED +NR +LA LRF TS +
Sbjct: 399 NLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLADFLRFHTSASGDDF 458
Query: 536 STLTDYVSRMKEKQDVIYYIAGQSKEELIKSPLVEKVLKKGFEVVYMIDPVDEYVVQ 706
+L+DYVSRMKE Q +Y+I G+SK+++ S VE+V +GFEVVYM +P+DEYV+Q
Sbjct: 459 CSLSDYVSRMKENQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPIDEYVIQ 515
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,910,623
Number of Sequences: 369166
Number of extensions: 1451721
Number of successful extensions: 4807
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4336
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4493
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6316483550
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)