Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_016_B08
(611 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8IZP0|ABI1_HUMAN Abl-interactor 1 (Abelson interactor 1... 69 7e-12
sp|Q9NYB9|ABI2_HUMAN Abl-interactor 2 (Abelson interactor 2... 69 7e-12
sp|P62484|ABI2_MOUSE Abl-interactor 2 (Abelson interactor 2... 69 9e-12
sp|Q8CBW3|ABI1_MOUSE Abl-interactor 1 (Abelson interactor 1... 67 3e-11
sp|Q9QZM5|ABI1_RAT Abl-interactor 1 (Abelson interactor 1) ... 67 3e-11
sp|Q9P2A4|ABI3_HUMAN ABI gene family member 3 (New molecule... 60 3e-09
sp|Q8BYZ1|ABI3_MOUSE ABI gene family member 3 (New molecule... 53 7e-07
sp|Q9NZM3|ITSN2_HUMAN Intersectin-2 (SH3 domain-containing ... 50 6e-06
sp|Q9Z0R6|ITSN2_MOUSE Intersectin-2 (SH3 domain-containing ... 50 6e-06
sp|Q9WVE9|ITSN1_RAT Intersectin-1 (EH domain and SH3 domain... 42 0.001
>sp|Q8IZP0|ABI1_HUMAN Abl-interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3
domain-binding protein 1) (Eps8 SH3 domain-binding
protein) (Eps8-binding protein) (e3B1) (Nap1-binding
protein) (Nap1BP) (Abl-binding protein 4) (AblBP4)
Length = 508
Score = 69.3 bits (168), Expect = 7e-12
Identities = 38/100 (38%), Positives = 52/100 (52%), Gaps = 1/100 (1%)
Frame = +1
Query: 178 PPPPNVEQFQ-RPPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAPSQ 354
PPP ++ F PP +D Y + + PY + D WAP
Sbjct: 399 PPPDDIPMFDDSPPPPPPPPVD-----YEDEEAAVVQYND-PY------ADGDPAWAPKN 446
Query: 355 YICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGWWGG 474
YI KVV +Y Y ++K+DELSF+E +IYV +KNDDGW+ G
Sbjct: 447 YIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEG 486
Score = 30.4 bits (67), Expect = 3.7
Identities = 13/17 (76%), Positives = 13/17 (76%)
Frame = +2
Query: 470 EGVMNGKAGLFPGNYVE 520
EGV N GLFPGNYVE
Sbjct: 485 EGVCNRVTGLFPGNYVE 501
>sp|Q9NYB9|ABI2_HUMAN Abl-interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding
protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)
Length = 513
Score = 69.3 bits (168), Expect = 7e-12
Identities = 39/99 (39%), Positives = 52/99 (52%)
Frame = +1
Query: 178 PPPPNVEQFQRPPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAPSQY 357
PPPP VE+ P +E Y + + PY ++ D WAP Y
Sbjct: 403 PPPPPVEE---PVFDESPPPPPPPEDYEEEEAAVVEYSD-PY------AEEDPPWAPRSY 452
Query: 358 ICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGWWGG 474
+ KVV +Y Y ++KEDELSF E +IYV +KNDDGW+ G
Sbjct: 453 LEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEG 491
Score = 35.8 bits (81), Expect = 0.089
Identities = 15/17 (88%), Positives = 15/17 (88%)
Frame = +2
Query: 470 EGVMNGKAGLFPGNYVE 520
EGVMNG GLFPGNYVE
Sbjct: 490 EGVMNGVTGLFPGNYVE 506
>sp|P62484|ABI2_MOUSE Abl-interactor 2 (Abelson interactor 2) (Abi-2)
Length = 446
Score = 68.9 bits (167), Expect = 9e-12
Identities = 39/99 (39%), Positives = 52/99 (52%)
Frame = +1
Query: 178 PPPPNVEQFQRPPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAPSQY 357
PPPP VE+ P +E Y + + PY ++ D WAP Y
Sbjct: 336 PPPPPVEE---PVFDESPPPPPPPEDYEEEEAAVVEYSD-PY------AEEDPPWAPRAY 385
Query: 358 ICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGWWGG 474
+ KVV +Y Y ++KEDELSF E +IYV +KNDDGW+ G
Sbjct: 386 LEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEG 424
Score = 35.8 bits (81), Expect = 0.089
Identities = 15/17 (88%), Positives = 15/17 (88%)
Frame = +2
Query: 470 EGVMNGKAGLFPGNYVE 520
EGVMNG GLFPGNYVE
Sbjct: 423 EGVMNGVTGLFPGNYVE 439
>sp|Q8CBW3|ABI1_MOUSE Abl-interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3
domain-binding protein 1) (Eps8 SH3 domain-binding
protein) (Eps8-binding protein) (e3B1) (Ablphilin-1)
Length = 481
Score = 67.4 bits (163), Expect = 3e-11
Identities = 37/102 (36%), Positives = 52/102 (50%), Gaps = 3/102 (2%)
Frame = +1
Query: 178 PPPPNVEQFQR---PPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAP 348
PPP ++ F PP ++ + + + S PY + D WAP
Sbjct: 372 PPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYS--------DPY------ADGDPAWAP 417
Query: 349 SQYICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGWWGG 474
YI KVV +Y Y ++K+DELSF E +IYV +KNDDGW+ G
Sbjct: 418 KNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDDGWFEG 459
Score = 30.4 bits (67), Expect = 3.7
Identities = 13/17 (76%), Positives = 13/17 (76%)
Frame = +2
Query: 470 EGVMNGKAGLFPGNYVE 520
EGV N GLFPGNYVE
Sbjct: 458 EGVCNRVTGLFPGNYVE 474
>sp|Q9QZM5|ABI1_RAT Abl-interactor 1 (Abelson interactor 1) (Abi-1) (Eps8 SH3 domain
binding protein) (Eps8 binding protein) (e3B1)
Length = 476
Score = 67.4 bits (163), Expect = 3e-11
Identities = 37/102 (36%), Positives = 52/102 (50%), Gaps = 3/102 (2%)
Frame = +1
Query: 178 PPPPNVEQFQR---PPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAP 348
PPP ++ F PP ++ + + + S PY + D WAP
Sbjct: 367 PPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYS--------DPY------ADGDPAWAP 412
Query: 349 SQYICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGWWGG 474
YI KVV +Y Y ++K+DELSF E +IYV +KNDDGW+ G
Sbjct: 413 KNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDDGWFEG 454
Score = 30.4 bits (67), Expect = 3.7
Identities = 13/17 (76%), Positives = 13/17 (76%)
Frame = +2
Query: 470 EGVMNGKAGLFPGNYVE 520
EGV N GLFPGNYVE
Sbjct: 453 EGVCNRVTGLFPGNYVE 469
>sp|Q9P2A4|ABI3_HUMAN ABI gene family member 3 (New molecule including SH3) (Nesh)
Length = 366
Score = 60.5 bits (145), Expect = 3e-09
Identities = 36/105 (34%), Positives = 53/105 (50%), Gaps = 6/105 (5%)
Frame = +1
Query: 178 PPPPNVEQFQRPPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIK------SQSDEV 339
PPP VE FQRPP+ E+++ + + + + P D L + +
Sbjct: 245 PPPAAVEVFQRPPTLEELS-PPPPDEELPLPLDLPPPPPLDGDELGLPPPPPGFGPDEPS 303
Query: 340 WAPSQYICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGWWGG 474
W P+ Y+ KVVTLY Y K++ELSF E +I V ++ DGW G
Sbjct: 304 WVPASYLEKVVTLYPYTSQKDNELSFSEGTVICVTRRYSDGWCEG 348
>sp|Q8BYZ1|ABI3_MOUSE ABI gene family member 3 (New molecule including SH3) (Nesh)
Length = 367
Score = 52.8 bits (125), Expect = 7e-07
Identities = 32/100 (32%), Positives = 49/100 (49%)
Frame = +1
Query: 175 LPPPPNVEQFQRPPSNEQINIDKNQNRYISDSVGIAHLQPTPYDVLRIKSQSDEVWAPSQ 354
LPPPP + +PP ++ + D +G+ P + + W P+
Sbjct: 259 LPPPPL--EVSQPPLEAELPLPPPP-ALEGDELGLLPPPPPGF------GPDEPSWVPAS 309
Query: 355 YICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGWWGG 474
Y+ KVVTLY Y + K++ELSF E +I V ++ DGW G
Sbjct: 310 YLEKVVTLYPYTRQKDNELSFSEGTVICVIRRYSDGWCEG 349
>sp|Q9NZM3|ITSN2_HUMAN Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18)
(SH3P18-like WASP associated protein)
Length = 1696
Score = 49.7 bits (117), Expect = 6e-06
Identities = 23/60 (38%), Positives = 35/60 (58%), Gaps = 1/60 (1%)
Frame = +1
Query: 298 PYDVLRIKSQSDEVWAPSQY-ICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGWWGG 474
P +++ S E P+ + +C+V+ +Y Y N EDELSF + +LI V K+D WW G
Sbjct: 1107 PASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG 1166
Score = 31.2 bits (69), Expect = 2.2
Identities = 11/30 (36%), Positives = 18/30 (60%)
Frame = +1
Query: 385 YLQNKEDELSFLENELIYVKQKNDDGWWGG 474
Y+ + ++LS +LI + +KN GWW G
Sbjct: 1063 YVASGSEQLSLAPGQLILILKKNTSGWWQG 1092
Score = 29.6 bits (65), Expect = 6.3
Identities = 14/35 (40%), Positives = 20/35 (57%)
Frame = +1
Query: 370 VTLYKYLQNKEDELSFLENELIYVKQKNDDGWWGG 474
+ LY Y + +L+F E E I V QK+ + WW G
Sbjct: 986 IALYPYSSVEPGDLTFTEGEEILVTQKDGE-WWTG 1019
>sp|Q9Z0R6|ITSN2_MOUSE Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains
protein 2) (EH domain and SH3 domain regulator of
endocytosis 2)
Length = 1658
Score = 49.7 bits (117), Expect = 6e-06
Identities = 22/60 (36%), Positives = 36/60 (60%), Gaps = 1/60 (1%)
Frame = +1
Query: 298 PYDVLRIKSQSDEVWAPSQY-ICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGWWGG 474
P +++ S E P+ + +C+V+ +Y Y+ N EDEL+F + +LI V K+D WW G
Sbjct: 1068 PASHVKLLGPSSERTMPTFHAVCQVIAMYDYMANNEDELNFSKGQLINVMNKDDPDWWQG 1127
Score = 30.4 bits (67), Expect = 3.7
Identities = 14/38 (36%), Positives = 20/38 (52%)
Frame = +1
Query: 370 VTLYKYLQNKEDELSFLENELIYVKQKNDDGWWGGCHE 483
+ LY Y + +L+F E E I V QK+ + W G E
Sbjct: 947 IALYSYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGE 984
Score = 30.0 bits (66), Expect = 4.9
Identities = 11/30 (36%), Positives = 17/30 (56%)
Frame = +1
Query: 385 YLQNKEDELSFLENELIYVKQKNDDGWWGG 474
Y + ++LS +LI + +KN GWW G
Sbjct: 1024 YAASGTEQLSLAPGQLILILKKNTSGWWQG 1053
>sp|Q9WVE9|ITSN1_RAT Intersectin-1 (EH domain and SH3 domain regulator of endocytosis 1)
Length = 1217
Score = 42.0 bits (97), Expect = 0.001
Identities = 15/39 (38%), Positives = 24/39 (61%)
Frame = +1
Query: 358 ICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGWWGG 474
+C+V+ +Y Y +DEL+F + ++I V K D WW G
Sbjct: 1154 VCQVIGMYDYTAQNDDELAFSKGQIINVLSKEDPDWWKG 1192
Score = 30.0 bits (66), Expect = 4.9
Identities = 16/59 (27%), Positives = 31/59 (52%)
Frame = +1
Query: 298 PYDVLRIKSQSDEVWAPSQYICKVVTLYKYLQNKEDELSFLENELIYVKQKNDDGWWGG 474
P + R+ S + + P + + V +Y Y ++ +L+F + +I V +K+ D WW G
Sbjct: 984 PSSLKRVASPAAKPAIPGE---EFVAMYTYESSEHGDLTFQQGHVIVVTKKDGD-WWTG 1038
Score = 29.6 bits (65), Expect = 6.3
Identities = 10/30 (33%), Positives = 17/30 (56%)
Frame = +1
Query: 385 YLQNKEDELSFLENELIYVKQKNDDGWWGG 474
Y ++L+ +LI +++KN GWW G
Sbjct: 1082 YTATGPEQLTLAPGQLILIRKKNPGGWWEG 1111
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,566,733
Number of Sequences: 369166
Number of extensions: 941001
Number of successful extensions: 3403
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3086
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3389
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4797864890
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)