Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_016_A14
(531 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P50093|PHB2_CAEEL Mitochondrial prohibitin complex prote... 126 3e-29
sp|O35129|PHB2_MOUSE Prohibitin-2 (B-cell receptor-associat... 123 3e-28
sp|Q5XIH7|PHB2_RAT Prohibitin-2 (B-cell receptor-associated... 123 3e-28
sp|P50085|PHB2_YEAST Prohibitin-2 112 7e-25
sp|P67778|PHB_MOUSE Prohibitin (B-cell receptor associated ... 105 7e-23
sp|P35232|PHB_HUMAN Prohibitin 103 2e-22
sp|P40961|PHB_YEAST Prohibitin 100 2e-21
sp|P24156|L2CC_DROME L(2)37Cc protein 100 4e-21
sp|Q9BKU4|PHB1_CAEEL Mitochondrial prohibitin complex prote... 93 4e-19
sp|O13432|SYFB_CANAL Phenylalanyl-tRNA synthetase beta chai... 32 1.3
>sp|P50093|PHB2_CAEEL Mitochondrial prohibitin complex protein 2 (Prohibitin-2)
Length = 286
Score = 126 bits (317), Expect = 3e-29
Identities = 73/142 (51%), Positives = 101/142 (71%), Gaps = 2/142 (1%)
Frame = +1
Query: 19 IYKSLGEDYDERVLPSISNEVLKAVVAKFNAGQLITQREQVSLLIRKLLIERAKDFNIIV 198
IY++LG++++ERVLPSI NEVLK VVAKFNA QLITQR+QVS+L+RK LIERA DFNII+
Sbjct: 111 IYRTLGQNWEERVLPSICNEVLKGVVAKFNASQLITQRQQVSMLVRKTLIERALDFNIIL 170
Query: 199 DDVSITDLSFSIVQRSS*TKAD--FPTRSSTSSIYRNASKTRKTAEIVNAEGRSASCNID 372
DDVS+T+L+FS Q S+ +A + ++ Y +K +K +IV AEG + S +
Sbjct: 171 DDVSLTELAFS-PQYSAAVEAKQVAAQEAQRATFYVERAKQQKQEKIVQAEGEAESAKLL 229
Query: 373 WVMLWSQGSGYLKLRKIKSCRK 438
+ G+LKLRKI++ +K
Sbjct: 230 GEAM-KNDPGFLKLRKIRAAQK 250
Score = 79.3 bits (194), Expect = 5e-15
Identities = 46/99 (46%), Positives = 63/99 (63%)
Frame = +2
Query: 227 SRSYSVAVERKQISQQEAQRAQFIVMRAKQERQQKLLMLRGEAQAAILIG*CFGRKVPVI 406
S YS AVE KQ++ QEAQRA F V RAKQ++Q+K++ GEA++A L+G + P
Sbjct: 181 SPQYSAAVEAKQVAAQEAQRATFYVERAKQQKQEKIVQAEGEAESAKLLGEAM-KNDPGF 239
Query: 407 *N*GK*KAAEKIARTLSTAQNKAYLNANTLMMNINDKTF 523
K +AA+KIAR +S + NK YL LM+NI D +
Sbjct: 240 LKLRKIRAAQKIARIVSESGNKTYLPTGGLMLNIADTDY 278
>sp|O35129|PHB2_MOUSE Prohibitin-2 (B-cell receptor-associated protein BAP37) (Repressor
of estrogen receptor activity)
sp|Q99623|PHB2_HUMAN Prohibitin-2 (B-cell receptor-associated protein BAP37) (Repressor
of estrogen receptor activity) (D-prohibitin)
Length = 299
Score = 123 bits (308), Expect = 3e-28
Identities = 73/153 (47%), Positives = 101/153 (66%), Gaps = 1/153 (0%)
Frame = +1
Query: 7 KIPTIYKSLGEDYDERVLPSISNEVLKAVVAKFNAGQLITQREQVSLLIRKLLIERAKDF 186
++P++Y+ LG DY+ERVLPSI NEVLK+VVAKFNA QLITQR QVSLLIR+ L ERAKDF
Sbjct: 116 ELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDF 175
Query: 187 NIIVDDVSITDLSFSIVQRSS-*TKADFPTRSSTSSIYRNASKTRKTAEIVNAEGRSASC 363
++I+DDV+IT+LSFS ++ K + + +K + +IV AEG + +
Sbjct: 176 SLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAA 235
Query: 364 NIDWVMLWSQGSGYLKLRKIKSCRKNRKNSVNS 462
+ L S+ GY+KLRKI++ + K S
Sbjct: 236 KMLGEAL-SKNPGYIKLRKIRAAQNISKTIATS 267
>sp|Q5XIH7|PHB2_RAT Prohibitin-2 (B-cell receptor-associated protein BAP37) (BAP-37)
Length = 299
Score = 123 bits (308), Expect = 3e-28
Identities = 73/153 (47%), Positives = 101/153 (66%), Gaps = 1/153 (0%)
Frame = +1
Query: 7 KIPTIYKSLGEDYDERVLPSISNEVLKAVVAKFNAGQLITQREQVSLLIRKLLIERAKDF 186
++P++Y+ LG DY+ERVLPSI NEVLK+VVAKFNA QLITQR QVSLLIR+ L ERAKDF
Sbjct: 116 ELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDF 175
Query: 187 NIIVDDVSITDLSFSIVQRSS-*TKADFPTRSSTSSIYRNASKTRKTAEIVNAEGRSASC 363
++I+DDV+IT+LSFS ++ K + + +K + +IV AEG + +
Sbjct: 176 SLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAA 235
Query: 364 NIDWVMLWSQGSGYLKLRKIKSCRKNRKNSVNS 462
+ L S+ GY+KLRKI++ + K S
Sbjct: 236 KMLGEAL-SKNPGYIKLRKIRAAQNISKTIATS 267
>sp|P50085|PHB2_YEAST Prohibitin-2
Length = 315
Score = 112 bits (279), Expect = 7e-25
Identities = 64/148 (43%), Positives = 97/148 (65%), Gaps = 5/148 (3%)
Frame = +1
Query: 7 KIPTIYKSLGEDYDERVLPSISNEVLKAVVAKFNAGQLITQREQVSLLIRKLLIERAKDF 186
++PTIY++LG+DYDERVLPSI NEVLKAVVA+FNA QLITQRE+VS LIR+ L+ RA F
Sbjct: 133 QLPTIYRTLGQDYDERVLPSIVNEVLKAVVAQFNASQLITQREKVSRLIRENLVRRASKF 192
Query: 187 NIIVDDVSITDLSFS-----IVQRSS*TKADFPTRSSTSSIYRNASKTRKTAEIVNAEGR 351
NI++DDVSIT ++FS V+ + D + ++ + ++ K +V A+G
Sbjct: 193 NILLDDVSITYMTFSPEFTNAVEAKQIAQQD----AQRAAFVVDKARQEKQGMVVRAQGE 248
Query: 352 SASCNIDWVMLWSQGSGYLKLRKIKSCR 435
+ S + + + Y++L+++ + R
Sbjct: 249 AKSAELIGEAI-KKSRDYVELKRLDTAR 275
>sp|P67778|PHB_MOUSE Prohibitin (B-cell receptor associated protein 32) (BAP 32)
sp|P67779|PHB_RAT Prohibitin
Length = 272
Score = 105 bits (262), Expect = 7e-23
Identities = 60/143 (41%), Positives = 91/143 (63%), Gaps = 1/143 (0%)
Frame = +1
Query: 4 NKIPTIYKSLGEDYDERVLPSISNEVLKAVVAKFNAGQLITQREQVSLLIRKLLIERAKD 183
+++P IY S+GEDYDERVLPSI+ E+LK+VVA+F+AG+LITQRE VS + L ERA
Sbjct: 101 SQLPRIYTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAAT 160
Query: 184 FNIIVDDVSITDLSF-SIVQRSS*TKADFPTRSSTSSIYRNASKTRKTAEIVNAEGRSAS 360
F +I+DDVS+T L+F + K + + ++ +K A I++AEG S +
Sbjct: 161 FGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKA 220
Query: 361 CNIDWVMLWSQGSGYLKLRKIKS 429
+ L + G G ++LRK+++
Sbjct: 221 AELIANSLATAGDGLIELRKLEA 243
>sp|P35232|PHB_HUMAN Prohibitin
Length = 272
Score = 103 bits (258), Expect = 2e-22
Identities = 59/143 (41%), Positives = 91/143 (63%), Gaps = 1/143 (0%)
Frame = +1
Query: 4 NKIPTIYKSLGEDYDERVLPSISNEVLKAVVAKFNAGQLITQREQVSLLIRKLLIERAKD 183
+++P I+ S+GEDYDERVLPSI+ E+LK+VVA+F+AG+LITQRE VS + L ERA
Sbjct: 101 SQLPRIFTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAAT 160
Query: 184 FNIIVDDVSITDLSF-SIVQRSS*TKADFPTRSSTSSIYRNASKTRKTAEIVNAEGRSAS 360
F +I+DDVS+T L+F + K + + ++ +K A I++AEG S +
Sbjct: 161 FGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKA 220
Query: 361 CNIDWVMLWSQGSGYLKLRKIKS 429
+ L + G G ++LRK+++
Sbjct: 221 AELIANSLATAGDGLIELRKLEA 243
>sp|P40961|PHB_YEAST Prohibitin
Length = 287
Score = 100 bits (250), Expect = 2e-21
Identities = 59/158 (37%), Positives = 93/158 (58%), Gaps = 5/158 (3%)
Frame = +1
Query: 7 KIPTIYKSLGEDYDERVLPSISNEVLKAVVAKFNAGQLITQREQVSLLIRKLLIERAKDF 186
++P IY++LG DYDERVLPSI NEVLK++VA+F+A +LITQRE +S IRK L RA +F
Sbjct: 104 QLPAIYQNLGLDYDERVLPSIGNEVLKSIVAQFDAAELITQREIISQKIRKELSTRANEF 163
Query: 187 NIIVDDVSITDLSF-----SIVQRSS*TKADFPTRSSTSSIYRNASKTRKTAEIVNAEGR 351
I ++DVSIT ++F V++ + D + + ++ + A ++ AEG
Sbjct: 164 GIKLEDVSITHMTFGPEFTKAVEQKQIAQQD----AERAKFLVEKAEQERQASVIRAEGE 219
Query: 352 SASCNIDWVMLWSQGSGYLKLRKIKSCRKNRKNSVNSA 465
+ S L G G L +R++++ + + NS+
Sbjct: 220 AESAEFISKALAKVGDGLLLIRRLEASKDIAQTLANSS 257
>sp|P24156|L2CC_DROME L(2)37Cc protein
Length = 276
Score = 99.8 bits (247), Expect = 4e-21
Identities = 58/143 (40%), Positives = 88/143 (61%), Gaps = 1/143 (0%)
Frame = +1
Query: 4 NKIPTIYKSLGEDYDERVLPSISNEVLKAVVAKFNAGQLITQREQVSLLIRKLLIERAKD 183
+++P IY LG+DYDERVLPSI+ EVLKAVVA+F+AG+LITQRE VS + + L RAK
Sbjct: 101 DQLPKIYTILGQDYDERVLPSIAPEVLKAVVAQFDAGELITQREMVSQRVSQELTVRAKQ 160
Query: 184 FNIIVDDVSITDLSFS-IVQRSS*TKADFPTRSSTSSIYRNASKTRKTAEIVNAEGRSAS 360
F I+DD+S+T L+F + K + + ++ +K A I++AEG + +
Sbjct: 161 FGFILDDISLTHLTFGREFTLAVEMKQVAQQEAEKARFVVEKAEQQKLASIISAEGDAEA 220
Query: 361 CNIDWVMLWSQGSGYLKLRKIKS 429
+ G G ++LR+I++
Sbjct: 221 AGLLAKSFGEAGDGLVELRRIEA 243
>sp|Q9BKU4|PHB1_CAEEL Mitochondrial prohibitin complex protein 1 (Prohibitin-1)
Length = 275
Score = 93.2 bits (230), Expect = 4e-19
Identities = 55/146 (37%), Positives = 86/146 (58%), Gaps = 1/146 (0%)
Frame = +1
Query: 4 NKIPTIYKSLGEDYDERVLPSISNEVLKAVVAKFNAGQLITQREQVSLLIRKLLIERAKD 183
+++P IY ++G DY ERVLPSI+NEVLKAVVA+F+A ++ITQRE VS L ERA
Sbjct: 104 DRLPNIYLNIGLDYAERVLPSITNEVLKAVVAQFDAHEMITQREVVSQRASVALRERAAQ 163
Query: 184 FNIIVDDVSITDLSFSIVQRSS*TKADFPTRSSTSSIYR-NASKTRKTAEIVNAEGRSAS 360
F +++DD++IT L+F + + + + Y ++ K A + AEG + +
Sbjct: 164 FGLLLDDIAITHLNFGREFTEAVEMKQVAQQEAEKARYLVEKAEQMKIAAVTTAEGDAQA 223
Query: 361 CNIDWVMLWSQGSGYLKLRKIKSCRK 438
+ S G G ++LRKI++ +
Sbjct: 224 AKLLAKAFASAGDGLVELRKIEAAEE 249
>sp|O13432|SYFB_CANAL Phenylalanyl-tRNA synthetase beta chain (Phenylalanine--tRNA ligase
beta chain) (PheRS)
Length = 592
Score = 31.6 bits (70), Expect = 1.3
Identities = 29/124 (23%), Positives = 55/124 (44%), Gaps = 1/124 (0%)
Frame = +1
Query: 46 DERVLPSISNEVLKAVVAKFNAGQ-LITQREQVSLLIRKLLIERAKDFNIIVDDVSITDL 222
+ RV P+I+ KA ++ N+ L E++S L++K+ ++ ++ I D+
Sbjct: 284 ETRVCPNITPRTAKAEISYINSCVGLNYSGEEISKLLKKMSLDATPS----TEERDILDV 339
Query: 223 SFSIVQRSS*TKADFPTRSSTSSIYRNASKTRKTAEIVNAEGRSASCNIDWVMLWSQGSG 402
I + + D + Y N KT+ AE + A + D + L S +G
Sbjct: 340 KIPITRSDILHQCDIMEDVAIGYGYDNLKKTKPQAESLVAAPLPVNKVADILRLASSQAG 399
Query: 403 YLKL 414
YL++
Sbjct: 400 YLEV 403
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,143,915
Number of Sequences: 369166
Number of extensions: 722794
Number of successful extensions: 2272
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2206
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2253
length of database: 68,354,980
effective HSP length: 103
effective length of database: 49,327,275
effective search space used: 3600891075
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)