Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_015_O17
(570 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 171 2e-42
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 170 2e-42
sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 169 3e-42
sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 168 1e-41
sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 156 3e-38
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 141 1e-33
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 138 1e-32
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precu... 130 3e-30
sp|P43507|CPR3_CAEEL Cathepsin B-like cysteine proteinase 3... 121 1e-27
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 120 2e-27
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 339
Score = 171 bits (432), Expect = 2e-42
Identities = 85/164 (51%), Positives = 102/164 (62%), Gaps = 6/164 (3%)
Frame = +1
Query: 25 KLPKRKPLLNRVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSN 204
KLP R + LP TFDAR QW C +IG+IRDQ +CGSCWAFGAVEAI+DR CIH+N
Sbjct: 67 KLPGRVAFGEDIDLPETFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDRTCIHTN 126
Query: 205 GTQTPRISAEDLLTCCGFRCGDGCN------EVLFTCMALLVTDGLLLVENTEHI*DVRI 366
G +SAEDLLTCCG +CGDGCN F LV+ G+ H+ +
Sbjct: 127 GRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWSFWTKKGLVSGGVY----NSHVGCLPY 182
Query: 367 MPS*CSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYG 498
C HHV G P CTGE TP+C K+C+AGYS +Y EDK +G
Sbjct: 183 TIPPCEHHVNGSRPPCTGEGDTPRCNKSCEAGYSPSYKEDKHFG 226
Score = 28.9 bits (63), Expect = 9.4
Identities = 13/26 (50%), Positives = 18/26 (69%)
Frame = +2
Query: 491 NMGKSSYSVDSNQQAIMQEILTNGPV 568
+ G +SYSV ++ + IM EI NGPV
Sbjct: 224 HFGYTSYSVSNSVKEIMAEIYKNGPV 249
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 170 bits (431), Expect = 2e-42
Identities = 87/164 (53%), Positives = 99/164 (60%), Gaps = 6/164 (3%)
Frame = +1
Query: 25 KLPKRKPLLNRVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSN 204
KLP+R V LP +FDAR QWP C +I EIRDQ +CGSCWAFGAVEAI+DR CIHSN
Sbjct: 67 KLPQRDAFAADVVLPESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSN 126
Query: 205 GTQTPRISAEDLLTCCGFRCGDGCNEVL------FTCMALLVTDGLLLVENTEHI*DVRI 366
G +SAED+LTCCG CGDGCN F LV+ GL H+
Sbjct: 127 GRVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLY----NSHVGCRPY 182
Query: 367 MPS*CSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYG 498
C HHV G P CTGE TPKC K C+ GYS +Y EDK +G
Sbjct: 183 SIPPCEHHVNGSRPPCTGEGDTPKCNKTCEPGYSPSYKEDKHFG 226
Score = 32.3 bits (72), Expect = 0.85
Identities = 15/26 (57%), Positives = 19/26 (73%)
Frame = +2
Query: 491 NMGKSSYSVDSNQQAIMQEILTNGPV 568
+ G SSYSV +N++ IM EI NGPV
Sbjct: 224 HFGCSSYSVANNEKEIMAEIYKNGPV 249
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B
light chain; Cathepsin B heavy chain]
Length = 339
Score = 169 bits (429), Expect = 3e-42
Identities = 87/172 (50%), Positives = 104/172 (60%), Gaps = 6/172 (3%)
Frame = +1
Query: 1 VMKDPNNFKLPKRKPLLNRVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAIT 180
V+ PN LP+R + LP +FDAR QW C +I +IRDQ +CGSCWAFGAVEA++
Sbjct: 62 VLGGPN---LPERVGFSEDINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMS 118
Query: 181 DRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNEVL------FTCMALLVTDGLLLVENT 342
DR CIH+NG +SAEDLLTCCG +CGDGCN F LV+ G+
Sbjct: 119 DRICIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVY----N 174
Query: 343 EHI*DVRIMPS*CSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYG 498
HI + C HHV G P CTGE TPKC K C+AGYS +Y EDK YG
Sbjct: 175 SHIGCLPYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYG 226
Score = 29.6 bits (65), Expect = 5.5
Identities = 13/24 (54%), Positives = 17/24 (70%)
Frame = +2
Query: 497 GKSSYSVDSNQQAIMQEILTNGPV 568
G +SYSV +++ IM EI NGPV
Sbjct: 226 GYTSYSVSDSEKEIMAEIYKNGPV 249
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS)
[Contains: Cathepsin B light chain; Cathepsin B heavy
chain]
Length = 339
Score = 168 bits (425), Expect = 1e-41
Identities = 87/164 (53%), Positives = 102/164 (62%), Gaps = 6/164 (3%)
Frame = +1
Query: 25 KLPKRKPLLNRVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSN 204
K P+R ++LP +FDAR QWP+C +I EIRDQ +CGSCWAFGAVEAI+DR CIH+N
Sbjct: 67 KPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTN 126
Query: 205 GTQTPRISAEDLLTCCGFRCGDGCNEVL------FTCMALLVTDGLLLVENTEHI*DVRI 366
+ +SAEDLLTCCG CGDGCN F LV+ G L E+ I
Sbjct: 127 AHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGG--LYESHVGCRPYSI 184
Query: 367 MPS*CSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYG 498
P C HHV G P CTGE TPKC K C+ GYS TY +DK YG
Sbjct: 185 PP--CEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYG 226
Score = 29.6 bits (65), Expect = 5.5
Identities = 13/24 (54%), Positives = 18/24 (75%)
Frame = +2
Query: 497 GKSSYSVDSNQQAIMQEILTNGPV 568
G +SYSV ++++ IM EI NGPV
Sbjct: 226 GYNSYSVSNSEKDIMAEIYKNGPV 249
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 340
Score = 156 bits (395), Expect = 3e-38
Identities = 80/165 (48%), Positives = 97/165 (58%), Gaps = 7/165 (4%)
Frame = +1
Query: 25 KLPKRKPLLNRVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSN 204
K P+R + LP TFD R QWP C +I EIRDQ +CGSCWAFGAVEAI+DR C+H+N
Sbjct: 67 KAPERVDFAEDMDLPDTFDTRKQWPNCPTISEIRDQGSCGSCWAFGAVEAISDRICVHTN 126
Query: 205 GTQTPRISAEDLLTCCGFRCGDGCNEVL------FTCMALLVTDGLLLVENTEHI*DVRI 366
+ +SAEDLL+CCGF CG GCN + LV+ GL H+
Sbjct: 127 AKVSVEVSAEDLLSCCGFECGMGCNGGYPSGAWRYWTERGLVSGGLY----DSHVGCRAY 182
Query: 367 MPS*CSHHVIGPYPNCTGEF-PTPKCKKACQAGYSKTYAEDKQYG 498
C HHV G P CTGE TP+C + C+ GYS +Y EDK YG
Sbjct: 183 TIPPCEHHVNGSRPPCTGEGGETPRCSRHCEPGYSPSYKEDKHYG 227
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31)
Length = 342
Score = 141 bits (355), Expect = 1e-33
Identities = 73/152 (48%), Positives = 92/152 (60%), Gaps = 3/152 (1%)
Frame = +1
Query: 58 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 237
V +P+ FD+R +WP CKSI +IRDQS CGSCWAFGAVEA+TDR CI S G Q+ +SA D
Sbjct: 88 VEIPSQFDSRKKWPHCKSISQIRDQSRCGSCWAFGAVEAMTDRICIQSGGGQSAELSALD 147
Query: 238 LLTCCGFRCGDGCNEVL-FTCMALLVTDGLLLVENTEHI*DVRIMP-S*CSHHVIGPYPN 411
L++CC CGDGC V G++ + E+ + P C HH G YP
Sbjct: 148 LISCCK-DCGDGCQGGFPGVAWDYWVKRGIVTGGSKENHTGCQPYPFPKCEHHTKGKYPA 206
Query: 412 C-TGEFPTPKCKKACQAGYSKTYAEDKQYGKE 504
C T + TP+CK+ CQ GY Y +DK YG E
Sbjct: 207 CGTKIYKTPQCKQTCQKGYKTPYEQDKHYGDE 238
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31)
Length = 340
Score = 138 bits (347), Expect = 1e-32
Identities = 73/163 (44%), Positives = 95/163 (58%), Gaps = 7/163 (4%)
Frame = +1
Query: 34 KRKPLLNR----VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHS 201
KR+P ++ V +P+ FD+R +WP CKSI IRDQS CGSCW+FGAVEA++DR CI S
Sbjct: 75 KRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQS 134
Query: 202 NGTQTPRISAEDLLTCCGFRCGDGC-NEVLFTCMALLVTDGLLLVENTEHI*DVRIMP-S 375
G Q +SA DLLTCC CG GC +L V +G++ + E+ P
Sbjct: 135 GGKQNVELSAVDLLTCCE-SCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFP 193
Query: 376 *CSHHVIGPYPNCTGE-FPTPKCKKACQAGYSKTYAEDKQYGK 501
C HH G YP C + + TP+CK+ CQ Y Y +DK GK
Sbjct: 194 KCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGK 236
Score = 31.2 bits (69), Expect = 1.9
Identities = 13/24 (54%), Positives = 20/24 (83%)
Frame = +2
Query: 497 GKSSYSVDSNQQAIMQEILTNGPV 568
GKSSY+V ++++AI +EI+ GPV
Sbjct: 235 GKSSYNVKNDEKAIQKEIMKYGPV 258
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor
Length = 329
Score = 130 bits (326), Expect = 3e-30
Identities = 69/147 (46%), Positives = 88/147 (59%), Gaps = 2/147 (1%)
Frame = +1
Query: 64 LPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLL 243
+P TFD+R QW +CKSI IRDQ+ CGSCWAFGA E I+DR CI + G Q P IS +DLL
Sbjct: 85 VPATFDSRTQWSECKSIKLIRDQATCGSCWAFGAAEMISDRTCIETKGAQQPIISPDDLL 144
Query: 244 TCCGFRCGDGCNEVLFTCMALLVTDGLLLVENTEHI*DVRIMPS*CSHHVIGPYP--NCT 417
+CCG CG+GC E + AL D +V ++ + C + I P NC
Sbjct: 145 SCCGSSCGNGC-EGGYPIQALRWWDSKGVVTGGDY------HGAGCKPYPIAPCTSGNCP 197
Query: 418 GEFPTPKCKKACQAGYSKTYAEDKQYG 498
E TP C +CQ+GYS YA+DK +G
Sbjct: 198 -ESKTPSCSMSCQSGYSTAYAKDKHFG 223
>sp|P43507|CPR3_CAEEL Cathepsin B-like cysteine proteinase 3 precursor (Cysteine
protease-related 3)
Length = 370
Score = 121 bits (304), Expect = 1e-27
Identities = 67/152 (44%), Positives = 82/152 (53%), Gaps = 7/152 (4%)
Frame = +1
Query: 64 LPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLL 243
LP TFDAR +WP C +I IR+Q+ CGSCWAFGA E I+DR CI SNGTQ P IS ED+L
Sbjct: 92 LPDTFDAREKWPDCNTIKLIRNQATCGSCWAFGAAEVISDRVCIQSNGTQQPVISVEDIL 151
Query: 244 TCCGFRCGDGCN------EVLFTCMALLVTDGLLLVENTEHI*DVRIMPS*CSHHVIGPY 405
+CCG CG GC + F + VT G + H C + P
Sbjct: 152 SCCGTTCGYGCKGGYSIEALRFWASSGAVTGG----DYGGHG---------CMPYSFAPC 198
Query: 406 PNCTGEFPTPKCKKACQAGY-SKTYAEDKQYG 498
E TP CK CQ+ Y ++ Y +DK YG
Sbjct: 199 TKNCPESTTPSCKTTCQSSYKTEEYKKDKHYG 230
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine
protease-related 6)
Length = 379
Score = 120 bits (302), Expect = 2e-27
Identities = 70/152 (46%), Positives = 90/152 (59%), Gaps = 7/152 (4%)
Frame = +1
Query: 64 LPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLL 243
+P +FD+R WPKC SI IRDQS+CGSCWAFGAVEA++DR CI S+G +SA+DLL
Sbjct: 105 IPESFDSRDNWPKCDSIKVIRDQSSCGSCWAFGAVEAMSDRICIASHGELQVTLSADDLL 164
Query: 244 TCCGFRCGDGCN-EVLFTCMALLVTDGLLLVENTEHI*DVRIMP-S*CSHHV----IGPY 405
+CC CG GCN V DG++ N + P C HH P
Sbjct: 165 SCCK-SCGFGCNGGDPLAAWRYWVKDGIVTGSNYTANNGCKPYPFPPCEHHSKKTHFDPC 223
Query: 406 PNCTGEFPTPKCKKACQAGYS-KTYAEDKQYG 498
P+ +PTPKC+K C + Y+ KTY+EDK +G
Sbjct: 224 PH--DLYPTPKCEKKCVSDYTDKTYSEDKFFG 253
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,708,084
Number of Sequences: 369166
Number of extensions: 1454528
Number of successful extensions: 4112
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3935
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4075
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 4177115900
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)