Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_015_O10
(793 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q93088|BHMT_HUMAN Betaine--homocysteine S-methyltransferase 316 5e-86
sp|O35490|BHMT_MOUSE Betaine--homocysteine S-methyltransferase 310 4e-84
sp|O09171|BHMT_RAT Betaine--homocysteine S-methyltransferase 298 1e-80
sp|Q95332|BHMT_PIG Betaine--homocysteine S-methyltransferase 143 5e-34
sp|P74240|RIR1_SYNY3 Ribonucleoside-diphosphate reductase a... 38 0.036
sp|Q55786|METH_SYNY3 Methionine synthase (5-methyltetrahydr... 35 0.18
sp|Q5E735|NANE_VIBF1 Putative N-acetylmannosamine-6-phospha... 34 0.40
sp|Q49775|METH_MYCLE Methionine synthase (5-methyltetrahydr... 34 0.52
sp|Q99707|METH_HUMAN Methionine synthase (5-methyltetrahydr... 32 2.0
sp|O33259|METH_MYCTU Methionine synthase (5-methyltetrahydr... 32 2.6
>sp|Q93088|BHMT_HUMAN Betaine--homocysteine S-methyltransferase
Length = 406
Score = 316 bits (809), Expect = 5e-86
Identities = 144/222 (64%), Positives = 174/222 (78%)
Frame = +2
Query: 20 VACSLCIGPEGDMKNVPTGECAVRLVKAGADIVGINCHHDPFIVLKAMKIMISAVKAAGL 199
VA ++CIGPEGD+ VP GECAVRLVKAGA I+G+NCH DP I LK +K+M ++AA L
Sbjct: 181 VAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAAQL 240
Query: 200 KAHFMIQPLGYMTPDASKQGFIDLPEFPFALEPRICTRFDMQKYAREAYEAGIRYIGGCC 379
KAH M QPL Y TPD +KQGFIDLPEFPF LEPR+ TR+D+QKYAREAY G+RYIGGCC
Sbjct: 241 KAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCC 300
Query: 380 GFEAYHIRAVAEELAKERGRFPAGSEKHEPWGEGLKMHTKPWVRARAKREYWEKLCPCTG 559
GFE YHIRA+AEELA ERG P SEKH WG GL MHTKPWVRARA++EYWE L +G
Sbjct: 301 GFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASG 360
Query: 560 RPYSASLAVPDQWGVTAGHEELKQQSAKTDDKEIEDLYKQLK 685
RPY+ S++ PD WGVT G EL QQ T ++++++L+++ K
Sbjct: 361 RPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFEKQK 402
>sp|O35490|BHMT_MOUSE Betaine--homocysteine S-methyltransferase
Length = 407
Score = 310 bits (793), Expect = 4e-84
Identities = 140/222 (63%), Positives = 172/222 (77%)
Frame = +2
Query: 20 VACSLCIGPEGDMKNVPTGECAVRLVKAGADIVGINCHHDPFIVLKAMKIMISAVKAAGL 199
VA ++CIGPEGD+ VP GECAVRLVKAGA IVG+NCH DP + L+ +K+M ++AA L
Sbjct: 181 VAATMCIGPEGDLHGVPPGECAVRLVKAGASIVGVNCHFDPSVSLQTVKLMKEGLEAARL 240
Query: 200 KAHFMIQPLGYMTPDASKQGFIDLPEFPFALEPRICTRFDMQKYAREAYEAGIRYIGGCC 379
KA+ M QPL Y TPD KQGFIDLPEFPF LEPR+ TR+D+QKYAREAY G+RYIGGCC
Sbjct: 241 KAYLMSQPLAYHTPDCGKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCC 300
Query: 380 GFEAYHIRAVAEELAKERGRFPAGSEKHEPWGEGLKMHTKPWVRARAKREYWEKLCPCTG 559
GFE YHIRA+AEELA ERG P SEKH WG GL MHTKPW+RARA++EYW+ L +G
Sbjct: 301 GFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARKEYWQNLRIASG 360
Query: 560 RPYSASLAVPDQWGVTAGHEELKQQSAKTDDKEIEDLYKQLK 685
RPY+ S++ PD WGVT G EL QQ T ++++ +L+++ K
Sbjct: 361 RPYNPSMSRPDAWGVTKGAAELMQQKEATTEQQLRELFEKQK 402
>sp|O09171|BHMT_RAT Betaine--homocysteine S-methyltransferase
Length = 407
Score = 298 bits (762), Expect = 1e-80
Identities = 136/222 (61%), Positives = 167/222 (75%)
Frame = +2
Query: 20 VACSLCIGPEGDMKNVPTGECAVRLVKAGADIVGINCHHDPFIVLKAMKIMISAVKAAGL 199
+A ++CIGPEGD+ V GECAVRLVKAGA IVG+NCH DP L+ +K+M ++AA L
Sbjct: 181 IAATMCIGPEGDLHGVSPGECAVRLVKAGAAIVGVNCHFDPSTSLQTIKLMKEGLEAARL 240
Query: 200 KAHFMIQPLGYMTPDASKQGFIDLPEFPFALEPRICTRFDMQKYAREAYEAGIRYIGGCC 379
KA+ M L Y TPD KQGFIDLPEFPF LEPR+ TR+D+QKYAREAY G+RYIGGCC
Sbjct: 241 KAYLMSHALAYHTPDCGKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCC 300
Query: 380 GFEAYHIRAVAEELAKERGRFPAGSEKHEPWGEGLKMHTKPWVRARAKREYWEKLCPCTG 559
GFE YHIRA+AEELA ERG P SEKH WG GL MHTKPW+RARA++EYW+ L +G
Sbjct: 301 GFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARKEYWQNLRIASG 360
Query: 560 RPYSASLAVPDQWGVTAGHEELKQQSAKTDDKEIEDLYKQLK 685
RPY+ S++ PD WGVT G EL QQ T ++++ L+++ K
Sbjct: 361 RPYNPSMSKPDAWGVTKGAAELMQQKEATTEQQLRALFEKQK 402
>sp|Q95332|BHMT_PIG Betaine--homocysteine S-methyltransferase
Length = 278
Score = 143 bits (361), Expect = 5e-34
Identities = 66/98 (67%), Positives = 77/98 (78%)
Frame = +2
Query: 20 VACSLCIGPEGDMKNVPTGECAVRLVKAGADIVGINCHHDPFIVLKAMKIMISAVKAAGL 199
VA ++CIGPEGD+ V G+CAVRLVKAGA IVG+NCH DP I L+ +K+M ++AAGL
Sbjct: 181 VAATMCIGPEGDLHGVTPGQCAVRLVKAGASIVGVNCHFDPTISLQTVKLMKEGLQAAGL 240
Query: 200 KAHFMIQPLGYMTPDASKQGFIDLPEFPFALEPRICTR 313
KAH M QPL Y TPD KQGFIDLPEFPF LEPR+ TR
Sbjct: 241 KAHLMSQPLAYHTPDCGKQGFIDLPEFPFGLEPRVATR 278
>sp|P74240|RIR1_SYNY3 Ribonucleoside-diphosphate reductase alpha subunit (Ribonucleotide
reductase)
Length = 767
Score = 37.7 bits (86), Expect = 0.036
Identities = 25/48 (52%), Positives = 31/48 (64%), Gaps = 5/48 (10%)
Frame = +2
Query: 416 ELAKERGRFPA--GSEKHEPWGEGLKMHTKP--WVRAR-AKREYWEKL 544
ELAKERG +PA GS+ W +GL + +KP W +A AK E WEKL
Sbjct: 569 ELAKERGAYPAFPGSD----WQKGLLIGSKPVSWFQANAAKPERWEKL 612
>sp|Q55786|METH_SYNY3 Methionine synthase (5-methyltetrahydrofolate--homocysteine
methyltransferase) (Methionine synthase, vitamin-B12
dependent isozyme) (MS)
Length = 1195
Score = 35.4 bits (80), Expect = 0.18
Identities = 28/114 (24%), Positives = 49/114 (42%), Gaps = 7/114 (6%)
Frame = +2
Query: 110 DIVGINCHHDPFIVLKAMKIM-------ISAVKAAGLKAHFMIQPLGYMTPDASKQGFID 268
DI+G+NC P ++ + +K + +S + AGL + Q +TP + +
Sbjct: 222 DILGLNCATGPDLMKEHVKYLSEHSPFVVSCIPNAGLPENVGGQAFYRLTPMELQMSLMH 281
Query: 269 LPEFPFALEPRICTRFDMQKYAREAYEAGIRYIGGCCGFEAYHIRAVAEELAKE 430
E + G++ IGGCCG HI+A+A ++AK+
Sbjct: 282 FIE-----------------------DLGVQVIGGCCGTRPDHIKALA-DIAKD 311
>sp|Q5E735|NANE_VIBF1 Putative N-acetylmannosamine-6-phosphate 2-epimerase (ManNAc-6-P
epimerase)
Length = 235
Score = 34.3 bits (77), Expect = 0.40
Identities = 36/127 (28%), Positives = 55/127 (43%), Gaps = 24/127 (18%)
Frame = +2
Query: 47 EGDMKNVPTGECAVRLVKAGADIVGINCHHDPFIV-----------LKAMKIMISAVKAA 193
+ +++ P E + L +AGADI+ I+ H P V L + + S+
Sbjct: 78 DSEVRITPYIEDVIALKEAGADIIAIDATHRPRPVPVEELVKKIQSLGCLVMADSSTYEE 137
Query: 194 GLKAHFMIQPL------GYMTPDASKQGFIDLPEFPF--ALEPRIC-----TRFDMQKYA 334
G+ H + + GY TP K+ P+FPF L + C RF+ + A
Sbjct: 138 GMFCHGLGVEIIGTTLSGYTTPVTPKE-----PDFPFIQQLANQGCFVMAEGRFNSPQLA 192
Query: 335 REAYEAG 355
REA EAG
Sbjct: 193 REAIEAG 199
>sp|Q49775|METH_MYCLE Methionine synthase (5-methyltetrahydrofolate--homocysteine
methyltransferase) (Methionine synthase, vitamin-B12
dependent isozyme) (MS)
Length = 1206
Score = 33.9 bits (76), Expect = 0.52
Identities = 37/128 (28%), Positives = 53/128 (41%), Gaps = 8/128 (6%)
Frame = +2
Query: 104 GADIVGINCHHDPFIVL-------KAMKIMISAVKAAGLKAHFMIQPLGYMTPDASKQGF 262
G D++G+NC P + K +I +S + AGL P +G
Sbjct: 225 GVDMIGLNCATGPAEMSEHLRHLSKHARIPVSVMPNAGL-------------PVLGAKG- 270
Query: 263 IDLPEFPFALEPRICTRFDMQKYAREAYEAGIRYIGGCCGFEAYHIRAVAEELAK-ERGR 439
E+P L+P + A E G+ +GGCCG HIR VA +A+ G
Sbjct: 271 ---AEYP--LQPDELA----EALAGFIAEFGLSLVGGCCGTTPDHIREVAAAVARCNDGT 321
Query: 440 FPAGSEKH 463
P G E+H
Sbjct: 322 VPRG-ERH 328
>sp|Q99707|METH_HUMAN Methionine synthase (5-methyltetrahydrofolate--homocysteine
methyltransferase) (Methionine synthase, vitamin-B12
dependent) (MS)
Length = 1265
Score = 32.0 bits (71), Expect = 2.0
Identities = 15/43 (34%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Frame = +2
Query: 320 MQKYARE-AYEAGIRYIGGCCGFEAYHIRAVAEELAKERGRFP 445
M K+ ++ A + + +GGCCG HIR +AE + + R P
Sbjct: 304 MAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVP 346
>sp|O33259|METH_MYCTU Methionine synthase (5-methyltetrahydrofolate--homocysteine
methyltransferase) (Methionine synthase, vitamin-B12
dependent isozyme) (MS)
Length = 1192
Score = 31.6 bits (70), Expect = 2.6
Identities = 36/147 (24%), Positives = 54/147 (36%), Gaps = 8/147 (5%)
Frame = +2
Query: 8 RHEAVACSLCIGPEGDMK-NVPTGECAVRLVKAGADIVGINCHHDPFIVLKAMK------ 166
RH V + + G M G + G D++G+NC P + + ++
Sbjct: 190 RHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSEHLRHLSRHA 249
Query: 167 -IMISAVKAAGLKAHFMIQPLGYMTPDASKQGFIDLPEFPFALEPRICTRFDMQKYAREA 343
I +S + AGL P +G + P P L + A
Sbjct: 250 RIPVSVMPNAGL-------------PVLGAKG-AEYPLLPDELAEAL---------AGFI 286
Query: 344 YEAGIRYIGGCCGFEAYHIRAVAEELA 424
E G+ +GGCCG HIR VA +A
Sbjct: 287 AEFGLSLVGGCCGTTPAHIREVAAAVA 313
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,555,620
Number of Sequences: 369166
Number of extensions: 1797675
Number of successful extensions: 5187
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5026
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5185
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7425705210
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)