Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_015_N22
(855 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P46467|VPS4B_MOUSE Vacuolar sorting protein 4b (SKD1 pro... 349 6e-96
sp|O75351|VPS4B_HUMAN Vacuolar sorting protein 4b (SKD1 pro... 347 3e-95
sp|Q8VEJ9|VPS4A_MOUSE Vacuolar sorting protein 4a 339 7e-93
sp|Q9UN37|VPS4A_HUMAN Vacuolar sorting protein 4a (SKD2 pro... 337 3e-92
sp|Q09803|VPS4_SCHPO Suppressor protein of bem1/bed5 double... 285 1e-76
sp|P52917|VPS4_YEAST Vacuolar protein sorting-associated pr... 274 3e-73
sp|Q5XIK7|KATL1_RAT Katanin p60 ATPase-containing subunit A... 159 7e-39
sp|Q8K0T4|KATL1_MOUSE Katanin p60 ATPase-containing subunit... 159 1e-38
sp|Q9BW62|KATL1_HUMAN Katanin p60 ATPase-containing subunit... 157 5e-38
sp|Q6E0V2|KTNA1_RAT Katanin p60 ATPase-containing subunit A... 151 2e-36
>sp|P46467|VPS4B_MOUSE Vacuolar sorting protein 4b (SKD1 protein)
Length = 444
Score = 349 bits (895), Expect = 6e-96
Identities = 179/265 (67%), Positives = 208/265 (78%)
Frame = +2
Query: 2 QSYLAKAVATEAXXXXXXXXXXXXXXXKWLGESEKLVKSLFEVAREKKPSIIFIDEIDSL 181
+SYLAKAVATEA KWLGESEKLVK+LF++ARE KPSIIFIDEIDSL
Sbjct: 180 KSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSL 239
Query: 182 CSNRGDNDSESAKRIKTEFLVQMQGVSSDNDNVLILAATNIPWALDSAIRRRFEKRIYIA 361
C +R +N+SE+A+RIKTEFLVQMQGV DND +L+L ATNIPW LDSAIRRRFEKRIYI
Sbjct: 240 CGSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIP 299
Query: 362 LPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADISIAVRDALMVPVRKVQ 541
LPEA ARA MF+L +G+ Q+ LT +F ELG ++GYSGADISI VRDALM PVRKVQ
Sbjct: 300 LPEAHARAAMFRLHLGST--QNSLTEADFQELGRKTDGYSGADISIIVRDALMQPVRKVQ 357
Query: 542 TATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDSEKLLEPCVTFADMKLA 721
+ATHF++VRGPS DP+ IV+DLLTPCSPG PGAIEM W V +KLLEP V+ DM +
Sbjct: 358 SATHFKKVRGPSRADPNCIVNDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVSMWDMLRS 417
Query: 722 LSRNKPTVNQKDLEKLIQFTTDFGQ 796
LS KPTVN++DL KL +FT DFGQ
Sbjct: 418 LSSTKPTVNEQDLLKLKKFTEDFGQ 442
>sp|O75351|VPS4B_HUMAN Vacuolar sorting protein 4b (SKD1 protein)
Length = 444
Score = 347 bits (889), Expect = 3e-95
Identities = 178/265 (67%), Positives = 205/265 (77%)
Frame = +2
Query: 2 QSYLAKAVATEAXXXXXXXXXXXXXXXKWLGESEKLVKSLFEVAREKKPSIIFIDEIDSL 181
+SYLAKAVATEA KWLGESEKLVK+LF++ARE KPSIIFIDEIDSL
Sbjct: 180 KSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLARENKPSIIFIDEIDSL 239
Query: 182 CSNRGDNDSESAKRIKTEFLVQMQGVSSDNDNVLILAATNIPWALDSAIRRRFEKRIYIA 361
C +R +N+SE+A+RIKTEFLVQMQGV DND +L+L ATNIPW LDSAIRRRFEKRIYI
Sbjct: 240 CGSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAIRRRFEKRIYIP 299
Query: 362 LPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADISIAVRDALMVPVRKVQ 541
LPE ARA MFKL +G Q+ LT +F ELG ++GYSGADISI VRDALM PVRKVQ
Sbjct: 300 LPEPHARAAMFKLHLGTT--QNSLTEADFRELGRKTDGYSGADISIIVRDALMQPVRKVQ 357
Query: 542 TATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDSEKLLEPCVTFADMKLA 721
+ATHF++VRGPS DP+ +V DLLTPCSPG PGAIEM W V +KLLEP V+ +DM +
Sbjct: 358 SATHFKKVRGPSRADPNHLVDDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVSMSDMLRS 417
Query: 722 LSRNKPTVNQKDLEKLIQFTTDFGQ 796
LS KPTVN+ DL KL +FT DFGQ
Sbjct: 418 LSNTKPTVNEHDLLKLKKFTEDFGQ 442
>sp|Q8VEJ9|VPS4A_MOUSE Vacuolar sorting protein 4a
Length = 437
Score = 339 bits (869), Expect = 7e-93
Identities = 171/265 (64%), Positives = 205/265 (77%)
Frame = +2
Query: 2 QSYLAKAVATEAXXXXXXXXXXXXXXXKWLGESEKLVKSLFEVAREKKPSIIFIDEIDSL 181
+SYLAKAVATEA KWLGESEKLVK+LFE+AR+ KPSIIFIDE+DSL
Sbjct: 173 KSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSL 232
Query: 182 CSNRGDNDSESAKRIKTEFLVQMQGVSSDNDNVLILAATNIPWALDSAIRRRFEKRIYIA 361
C +R +N+SE+A+RIKTEFLVQMQGV ++ND L+L ATNIPW LDSAIRRRFEKRIYI
Sbjct: 233 CGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIP 292
Query: 362 LPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADISIAVRDALMVPVRKVQ 541
LPE ARA+MF+L +G+ P H+LT N EL +EGYSGADISI VRD+LM PVRKVQ
Sbjct: 293 LPEEAARAQMFRLHLGSTP--HNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQ 350
Query: 542 TATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDSEKLLEPCVTFADMKLA 721
+ATHF++V GPS T+PSV++ DLLTPCSPG PGAIEM W V +KLLEP V +DM +
Sbjct: 351 SATHFKKVCGPSRTNPSVMIDDLLTPCSPGDPGAIEMTWMDVPGDKLLEPVVCMSDMLRS 410
Query: 722 LSRNKPTVNQKDLEKLIQFTTDFGQ 796
L+ +PTVN DL K+ +F+ DFGQ
Sbjct: 411 LATTRPTVNADDLLKVKKFSEDFGQ 435
>sp|Q9UN37|VPS4A_HUMAN Vacuolar sorting protein 4a (SKD2 protein) (hVPS4) (VPS4-1)
Length = 437
Score = 337 bits (863), Expect = 3e-92
Identities = 169/265 (63%), Positives = 205/265 (77%)
Frame = +2
Query: 2 QSYLAKAVATEAXXXXXXXXXXXXXXXKWLGESEKLVKSLFEVAREKKPSIIFIDEIDSL 181
+SYLAKAVATEA KWLGESEKLVK+LFE+AR+ KPSIIFIDE+DSL
Sbjct: 173 KSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSL 232
Query: 182 CSNRGDNDSESAKRIKTEFLVQMQGVSSDNDNVLILAATNIPWALDSAIRRRFEKRIYIA 361
C +R +N+SE+A+RIKTEFLVQMQGV ++ND L+L ATNIPW LDSAIRRRFEKRIYI
Sbjct: 233 CGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRIYIP 292
Query: 362 LPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADISIAVRDALMVPVRKVQ 541
LPE ARA+MF+L +G+ P H+LT N EL +EGYSGADISI VRD+LM PVRKVQ
Sbjct: 293 LPEEAARAQMFRLHLGSTP--HNLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQ 350
Query: 542 TATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDSEKLLEPCVTFADMKLA 721
+ATHF++V GPS T+PS+++ DLLTPCSPG PGA+EM W V +KLLEP V +DM +
Sbjct: 351 SATHFKKVCGPSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRS 410
Query: 722 LSRNKPTVNQKDLEKLIQFTTDFGQ 796
L+ +PTVN DL K+ +F+ DFGQ
Sbjct: 411 LATTRPTVNADDLLKVKKFSEDFGQ 435
>sp|Q09803|VPS4_SCHPO Suppressor protein of bem1/bed5 double mutants
Length = 432
Score = 285 bits (728), Expect = 1e-76
Identities = 150/264 (56%), Positives = 185/264 (70%)
Frame = +2
Query: 2 QSYLAKAVATEAXXXXXXXXXXXXXXXKWLGESEKLVKSLFEVAREKKPSIIFIDEIDSL 181
+SYLAKAVATEA KW+GESE+LV+ LFE+ARE+KPSIIFIDEIDSL
Sbjct: 175 KSYLAKAVATEAGSTFFSISSSDLVS-KWMGESERLVRQLFEMAREQKPSIIFIDEIDSL 233
Query: 182 CSNRGDNDSESAKRIKTEFLVQMQGVSSDNDNVLILAATNIPWALDSAIRRRFEKRIYIA 361
C +R + +SES++RIKTEFLVQM GV D VL+L ATNIPW LDSAIRRRFEKRIYI
Sbjct: 234 CGSRSEGESESSRRIKTEFLVQMNGVGKDESGVLVLGATNIPWTLDSAIRRRFEKRIYIP 293
Query: 362 LPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADISIAVRDALMVPVRKVQ 541
LP A ARA MF+L++G P +LT Q+F EL +++GYSG+DISI VRDA+M PVR++
Sbjct: 294 LPNAHARARMFELNVGKIPS--ELTSQDFKELAKMTDGYSGSDISIVVRDAIMEPVRRIH 351
Query: 542 TATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDSEKLLEPCVTFADMKLA 721
TATHF+ V L+TPCSPG P A E +W V+ E ++EP +T D A
Sbjct: 352 TATHFKEVYDNKSN------RTLVTPCSPGDPDAFESSWLEVNPEDIMEPKLTVRDFYSA 405
Query: 722 LSRNKPTVNQKDLEKLIQFTTDFG 793
+ + KPT+N D+EK QFT DFG
Sbjct: 406 VRKVKPTLNAGDIEKHTQFTKDFG 429
>sp|P52917|VPS4_YEAST Vacuolar protein sorting-associated protein VPS4 (END13 protein)
(DOA4-independent degradation protein 6)
Length = 437
Score = 274 bits (700), Expect = 3e-73
Identities = 144/265 (54%), Positives = 188/265 (70%)
Frame = +2
Query: 2 QSYLAKAVATEAXXXXXXXXXXXXXXXKWLGESEKLVKSLFEVAREKKPSIIFIDEIDSL 181
+SYLAKAVATEA KW+GESEKLVK LF +ARE KPSIIFIDE+D+L
Sbjct: 179 KSYLAKAVATEANSTFFSVSSSDLVS-KWMGESEKLVKQLFAMARENKPSIIFIDEVDAL 237
Query: 182 CSNRGDNDSESAKRIKTEFLVQMQGVSSDNDNVLILAATNIPWALDSAIRRRFEKRIYIA 361
RG+ +SE+++RIKTE LVQM GV +D+ VL+L ATNIPW LDSAIRRRFE+RIYI
Sbjct: 238 TGTRGEGESEASRRIKTELLVQMNGVGNDSQGVLVLGATNIPWQLDSAIRRRFERRIYIP 297
Query: 362 LPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADISIAVRDALMVPVRKVQ 541
LP+ AR MF++++G+ P LT +++ LG ++EGYSG+DI++ V+DALM P+RK+Q
Sbjct: 298 LPDLAARTTMFEINVGDTPCV--LTKEDYRTLGAMTEGYSGSDIAVVVKDALMQPIRKIQ 355
Query: 542 TATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDSEKLLEPCVTFADMKLA 721
+ATHF+ V S D + LTPCSPG GAIEM+W +++++L EP +T D A
Sbjct: 356 SATHFKDV---STEDDE---TRKLTPCSPGDDGAIEMSWTDIEADELKEPDLTIKDFLKA 409
Query: 722 LSRNKPTVNQKDLEKLIQFTTDFGQ 796
+ +PTVN+ DL K QFT DFGQ
Sbjct: 410 IKSTRPTVNEDDLLKQEQFTRDFGQ 434
>sp|Q5XIK7|KATL1_RAT Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit
A-like 1) (p60 katanin-like 1)
Length = 488
Score = 159 bits (403), Expect = 7e-39
Identities = 106/271 (39%), Positives = 152/271 (56%), Gaps = 7/271 (2%)
Frame = +2
Query: 2 QSYLAKAVATEAXXXXXXXXXXXXXXXKWLGESEKLVKSLFEVAREKKPSIIFIDEIDSL 181
++ LAKAVATE K+ GESEKLV+ LFE+AR P+ IFIDEIDS+
Sbjct: 252 KTMLAKAVATECGTTFFNVSSSTLTS-KYRGESEKLVRLLFEMARFYAPTTIFIDEIDSI 310
Query: 182 CSNRGDNDS-ESAKRIKTEFLVQMQGVSS--DNDN----VLILAATNIPWALDSAIRRRF 340
CS RG +D E+++R+K+E L+QM GV +ND+ V++LAATN PW +D A+RRR
Sbjct: 311 CSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRL 370
Query: 341 EKRIYIALPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADISIAVRDALM 520
EKRIYI LP A RAE+ K+S+ D+ + ++ +EGYSGADI+ RDA +
Sbjct: 371 EKRIYIPLPTAKGRAELLKISLREVELDPDI---HLEDIAEKTEGYSGADITNICRDASL 427
Query: 521 VPVRKVQTATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDSEKLLEPCVT 700
+ +R RR+ G SP + + S++ L+ VT
Sbjct: 428 MAMR--------RRINGLSPEEIRAL------------------------SKEELQMPVT 455
Query: 701 FADMKLALSRNKPTVNQKDLEKLIQFTTDFG 793
D++LAL + +V+ DLEK ++ +FG
Sbjct: 456 RGDLELALKKIAKSVSAADLEKYEKWMVEFG 486
>sp|Q8K0T4|KATL1_MOUSE Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit
A-like 1) (p60 katanin-like 1)
Length = 488
Score = 159 bits (401), Expect = 1e-38
Identities = 106/271 (39%), Positives = 152/271 (56%), Gaps = 7/271 (2%)
Frame = +2
Query: 2 QSYLAKAVATEAXXXXXXXXXXXXXXXKWLGESEKLVKSLFEVAREKKPSIIFIDEIDSL 181
++ LAKAVATE K+ GESEKLV+ LFE+AR P+ IFIDEIDS+
Sbjct: 252 KTMLAKAVATECGTTFFNVSSSTLTS-KYRGESEKLVRLLFEMARFYAPTTIFIDEIDSI 310
Query: 182 CSNRGDNDS-ESAKRIKTEFLVQMQGVSS--DNDN----VLILAATNIPWALDSAIRRRF 340
CS RG +D E+++R+K+E L+QM GV +ND+ V++LAATN PW +D A+RRR
Sbjct: 311 CSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRL 370
Query: 341 EKRIYIALPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADISIAVRDALM 520
EKRIYI LP A RAE+ K+S+ D+ + ++ +EGYSGADI+ RDA +
Sbjct: 371 EKRIYIPLPTAKGRAELLKISLREVELDPDV---HLEDIADKTEGYSGADITNICRDASL 427
Query: 521 VPVRKVQTATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDSEKLLEPCVT 700
+ +R RR+ G SP + + S++ L+ VT
Sbjct: 428 MAMR--------RRINGLSPEEIRAL------------------------SKEELQMPVT 455
Query: 701 FADMKLALSRNKPTVNQKDLEKLIQFTTDFG 793
D++LAL + +V+ DLEK ++ +FG
Sbjct: 456 RGDLELALKKIAKSVSAADLEKYEKWMVEFG 486
>sp|Q9BW62|KATL1_HUMAN Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit
A-like 1) (p60 katanin-like 1)
Length = 490
Score = 157 bits (396), Expect = 5e-38
Identities = 106/271 (39%), Positives = 151/271 (55%), Gaps = 7/271 (2%)
Frame = +2
Query: 2 QSYLAKAVATEAXXXXXXXXXXXXXXXKWLGESEKLVKSLFEVAREKKPSIIFIDEIDSL 181
++ LAKAVATE K+ GESEKLV+ LFE+AR P+ IFIDEIDS+
Sbjct: 254 KTMLAKAVATECGTTFFNVSSSTLTS-KYRGESEKLVRLLFEMARFYAPTTIFIDEIDSI 312
Query: 182 CSNRGDNDS-ESAKRIKTEFLVQMQGVSS--DNDN----VLILAATNIPWALDSAIRRRF 340
CS RG +D E+++R+K+E L+QM GV +ND+ V++LAATN PW +D A+RRR
Sbjct: 313 CSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRL 372
Query: 341 EKRIYIALPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADISIAVRDALM 520
EKRIYI LP A RAE+ K+++ D+ ++ +E EGYSGADI+ RDA +
Sbjct: 373 EKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAE---KIEGYSGADITNVCRDASL 429
Query: 521 VPVRKVQTATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDSEKLLEPCVT 700
+ +R RR+ G SP + + S++ L+ VT
Sbjct: 430 MAMR--------RRINGLSPEEIRAL------------------------SKEELQMPVT 457
Query: 701 FADMKLALSRNKPTVNQKDLEKLIQFTTDFG 793
D +LAL + +V+ DLEK ++ +FG
Sbjct: 458 KGDFELALKKIAKSVSAADLEKYEKWMVEFG 488
>sp|Q6E0V2|KTNA1_RAT Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1)
(p60 katanin)
Length = 491
Score = 151 bits (382), Expect = 2e-36
Identities = 104/271 (38%), Positives = 148/271 (54%), Gaps = 7/271 (2%)
Frame = +2
Query: 2 QSYLAKAVATEAXXXXXXXXXXXXXXXKWLGESEKLVKSLFEVAREKKPSIIFIDEIDSL 181
++ LAKAVATE K+ GESEKLV+ LFE+AR P+ IFIDEIDS+
Sbjct: 255 KTLLAKAVATECKTTFFNVSSSTLTS-KYRGESEKLVRLLFEMARFYSPATIFIDEIDSI 313
Query: 182 CSNRGDNDS-ESAKRIKTEFLVQMQGV--SSDNDN----VLILAATNIPWALDSAIRRRF 340
CS RG ++ E+++R+K E LVQM GV +S+ND+ V++LAATN PW +D A+RRR
Sbjct: 314 CSRRGTSEEHEASRRVKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRL 373
Query: 341 EKRIYIALPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADISIAVRDALM 520
EKRIYI LP A R E+ ++S+ D+ N + + EGYSGADI+ RDA +
Sbjct: 374 EKRIYIPLPSAKGREELLRISLRELELADDV---NLASIAENMEGYSGADITNVCRDASL 430
Query: 521 VPVRKVQTATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDSEKLLEPCVT 700
+ +R RR+ G LTP + EM+ T T
Sbjct: 431 MAMR--------RRIEG-------------LTPEEIRNLSREEMHMPT-----------T 458
Query: 701 FADMKLALSRNKPTVNQKDLEKLIQFTTDFG 793
D ++AL + +V+ D+E+ ++ +FG
Sbjct: 459 MEDFEMALKKVSKSVSAADIERYEKWIVEFG 489
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,018,563
Number of Sequences: 369166
Number of extensions: 2132303
Number of successful extensions: 7746
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6965
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7469
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8438301375
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)