Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_015_N21
(834 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q7T339|CHMP5_BRARE Charged multivesicular body protein 5... 212 9e-55
sp|Q5FW29|CHMP5_XENTR Charged multivesicular body protein 5... 201 2e-51
sp|Q6DD52|CHMP5_XENLA Charged multivesicular body protein 5... 197 2e-50
sp|Q9D7S9|CHMP5_MOUSE Charged multivesicular body protein 5... 196 5e-50
sp|Q5RBR3|CHMP5_PONPY Charged multivesicular body protein 5... 196 9e-50
sp|Q03390|VPS60_YEAST Vacuolar protein sorting-associated p... 88 3e-17
sp|Q503V0|CHMP6_BRARE Charged multivesicular body protein 6... 63 9e-10
sp|Q753W3|SNF7_ASHGO Vacuolar sorting protein SNF7 (Vacuola... 62 2e-09
sp|Q6CJL0|SNF7_KLULA Vacuolar sorting protein SNF7 (Vacuola... 61 4e-09
sp|Q6FW96|SNF7_CANGA Vacuolar sorting protein SNF7 (Vacuola... 60 6e-09
>sp|Q7T339|CHMP5_BRARE Charged multivesicular body protein 5 (Chromatin modifying protein
5)
Length = 220
Score = 212 bits (540), Expect = 9e-55
Identities = 101/218 (46%), Positives = 151/218 (69%), Gaps = 6/218 (2%)
Frame = +1
Query: 58 MNSLFGRGITNQPSTNINNVILNIDNSGKSIDRKIKKLDVELTNYREQMIRMSDGAAKNM 237
MN +FGRG P N+ + I +D+ +S+D+KI +LD EL Y++QM +M DG +KNM
Sbjct: 1 MNRIFGRGKPKGPPPNLTDCISGVDSRAESVDKKIARLDAELMKYKDQMKKMRDGPSKNM 60
Query: 238 IKQKALRVLQQKRIYENQRKQLSNQSLNLEQMDFAIQTVKYTKSQVDAMKIGVKSFQKEF 417
+KQKA+RVL+QKR+YE QR QL QS N+EQ ++ IQT+K TK+ V+AMKIG K +K +
Sbjct: 61 VKQKAMRVLKQKRMYEGQRDQLMQQSFNMEQANYTIQTLKDTKTTVEAMKIGAKEMKKAY 120
Query: 418 RNMNLDKIKDLQDELHDIIEQTNKIQEVLGRTFVMPDVNEADLEAAFDALGYNIGIGEG- 594
+N+ +D+I+DLQD+L D++E N++QE L R++ P+++E DLEA DALG + + +
Sbjct: 121 KNVKIDQIEDLQDQLEDMMEDANEVQEALSRSYGTPEIDEDDLEAELDALGDELLLDDDN 180
Query: 595 -----ALNVPGVPSTSPGESTVAPDDLVIHEFGLPQTP 693
A + P +P +PG+ T D +++ EFGLPQ P
Sbjct: 181 SYLDEASSAPAIPEGAPGDRTTNRDGVLVDEFGLPQIP 218
>sp|Q5FW29|CHMP5_XENTR Charged multivesicular body protein 5 (Chromatin modifying protein
5)
Length = 219
Score = 201 bits (511), Expect = 2e-51
Identities = 99/218 (45%), Positives = 149/218 (68%), Gaps = 6/218 (2%)
Frame = +1
Query: 58 MNSLFGRGITNQPSTNINNVILNIDNSGKSIDRKIKKLDVELTNYREQMIRMSDGAAKNM 237
MN LFG+ P + + + I N+D+ +SID+KI +LD EL Y++QM +M +G +KNM
Sbjct: 1 MNRLFGKSKPKVPPSTLTDCISNVDSRSESIDKKISRLDAELVKYKDQMKKMREGPSKNM 60
Query: 238 IKQKALRVLQQKRIYENQRKQLSNQSLNLEQMDFAIQTVKYTKSQVDAMKIGVKSFQKEF 417
+KQKALRVL+QKR+YE QR L+ QS N+EQ ++AIQ++K TK+ VDAMK+G K +K +
Sbjct: 61 VKQKALRVLKQKRMYEQQRDNLNQQSFNMEQTNYAIQSLKDTKTTVDAMKVGAKEMKKAY 120
Query: 418 RNMNLDKIKDLQDELHDIIEQTNKIQEVLGRTFVMPDVNEADLEAAFDALGYNIGIGEG- 594
+ + +D+I+DLQD+L D++E N+IQE L R++ P+++E DLEA DALG + + +
Sbjct: 121 KQVKIDQIEDLQDQLEDMMENANEIQEALSRSYGTPEIDEDDLEAELDALGDELLLDDDT 180
Query: 595 -----ALNVPGVPSTSPGESTVAPDDLVIHEFGLPQTP 693
A + P +P P +S D +++ EFGLPQ P
Sbjct: 181 SYLDEAASAPAIPEGVPNDSK-NKDGVLVDEFGLPQIP 217
>sp|Q6DD52|CHMP5_XENLA Charged multivesicular body protein 5 (Chromatin modifying protein
5)
Length = 219
Score = 197 bits (502), Expect = 2e-50
Identities = 97/218 (44%), Positives = 146/218 (66%), Gaps = 6/218 (2%)
Frame = +1
Query: 58 MNSLFGRGITNQPSTNINNVILNIDNSGKSIDRKIKKLDVELTNYREQMIRMSDGAAKNM 237
MN +FG+ P + + I N+D +SI++KI +LD EL Y++QM +M +G +KNM
Sbjct: 1 MNRIFGKSKPKVPPPTLTDCITNVDGRAESIEKKISRLDAELIKYKDQMKKMREGPSKNM 60
Query: 238 IKQKALRVLQQKRIYENQRKQLSNQSLNLEQMDFAIQTVKYTKSQVDAMKIGVKSFQKEF 417
+KQKALRVL+QKR+YE QR L+ QS N+EQ ++ IQT+K TK+ VDAMK+G K +K +
Sbjct: 61 VKQKALRVLKQKRMYEQQRDNLNQQSFNMEQANYTIQTLKDTKTTVDAMKVGAKEMKKAY 120
Query: 418 RNMNLDKIKDLQDELHDIIEQTNKIQEVLGRTFVMPDVNEADLEAAFDALGYNIGIGEG- 594
+ + +D+I+DLQD+L D++E N+IQE L R++ P+++E DLEA DALG + + +
Sbjct: 121 KQVKIDQIEDLQDQLEDMMENANEIQEALSRSYGTPEIDEDDLEAELDALGDELLLDDDT 180
Query: 595 -----ALNVPGVPSTSPGESTVAPDDLVIHEFGLPQTP 693
A + P +P P +S D +++ EFGLPQ P
Sbjct: 181 SYLDEAASAPAIPEGVPNDSK-NKDGVLVDEFGLPQIP 217
>sp|Q9D7S9|CHMP5_MOUSE Charged multivesicular body protein 5 (Chromatin modifying protein
5) (SNF7 domain-containing protein 2)
sp|Q4QQV8|CHMP5_RAT Charged multivesicular body protein 5 (Chromatin modifying protein
5)
Length = 219
Score = 196 bits (499), Expect = 5e-50
Identities = 99/218 (45%), Positives = 147/218 (67%), Gaps = 6/218 (2%)
Frame = +1
Query: 58 MNSLFGRGITNQPSTNINNVILNIDNSGKSIDRKIKKLDVELTNYREQMIRMSDGAAKNM 237
MN FG+ P ++ + I +D+ +SID+KI +LD EL Y++Q+ +M +G AKNM
Sbjct: 1 MNRFFGKAKPKAPPPSLTDCIGTVDSRAESIDKKISRLDAELVKYKDQIKKMREGPAKNM 60
Query: 238 IKQKALRVLQQKRIYENQRKQLSNQSLNLEQMDFAIQTVKYTKSQVDAMKIGVKSFQKEF 417
+KQKALRVL+QKR+YE QR L+ QS N+EQ ++ IQ++K TK+ VDAMK+GVK +K +
Sbjct: 61 VKQKALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKTTVDAMKLGVKEMKKAY 120
Query: 418 RNMNLDKIKDLQDELHDIIEQTNKIQEVLGRTFVMPDVNEADLEAAFDALGYNIGIGEG- 594
+ + +D+I+DLQD+L D++E N+IQE LGR++ P+++E DLEA DALG + E
Sbjct: 121 KEVKIDQIEDLQDQLEDMMEDANEIQEALGRSYGTPELDEDDLEAELDALGDELLADEDS 180
Query: 595 -----ALNVPGVPSTSPGESTVAPDDLVIHEFGLPQTP 693
A + P +P P + T D +++ EFGLPQ P
Sbjct: 181 SYLDEAASAPAIPEGVPTD-TKNKDGVLVDEFGLPQIP 217
>sp|Q5RBR3|CHMP5_PONPY Charged multivesicular body protein 5 (Chromatin modifying protein
5)
sp|Q9NZZ3|CHMP5_HUMAN Charged multivesicular body protein 5 (Chromatin modifying protein
5) (Vacuolar protein sorting 60) (Vps60) (hVps60) (SNF7
domain-containing protein 2)
Length = 219
Score = 196 bits (497), Expect = 9e-50
Identities = 99/218 (45%), Positives = 147/218 (67%), Gaps = 6/218 (2%)
Frame = +1
Query: 58 MNSLFGRGITNQPSTNINNVILNIDNSGKSIDRKIKKLDVELTNYREQMIRMSDGAAKNM 237
MN LFG+ P ++ + I +D+ +SID+KI +LD EL Y++Q+ +M +G AKNM
Sbjct: 1 MNRLFGKAKPKAPPPSLTDCIGTVDSRAESIDKKISRLDAELVKYKDQIKKMREGPAKNM 60
Query: 238 IKQKALRVLQQKRIYENQRKQLSNQSLNLEQMDFAIQTVKYTKSQVDAMKIGVKSFQKEF 417
+KQKALRVL+QKR+YE QR L+ QS N+EQ ++ IQ++K TK+ VDAMK+GVK +K +
Sbjct: 61 VKQKALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDTKTTVDAMKLGVKEMKKAY 120
Query: 418 RNMNLDKIKDLQDELHDIIEQTNKIQEVLGRTFVMPDVNEADLEAAFDALGYNIGIGEG- 594
+ + +D+I+DLQD+L D++E N+IQE L R++ P+++E DLEA DALG + E
Sbjct: 121 KQVKIDQIEDLQDQLEDMMEDANEIQEALSRSYGTPELDEDDLEAELDALGDELLADEDS 180
Query: 595 -----ALNVPGVPSTSPGESTVAPDDLVIHEFGLPQTP 693
A + P +P P + T D +++ EFGLPQ P
Sbjct: 181 SYLDEAASAPAIPEGVPTD-TKNKDGVLVDEFGLPQIP 217
>sp|Q03390|VPS60_YEAST Vacuolar protein sorting-associated protein VPS60
Length = 262
Score = 88.2 bits (217), Expect = 3e-17
Identities = 51/192 (26%), Positives = 110/192 (57%), Gaps = 10/192 (5%)
Frame = +1
Query: 22 FKFFKLIFRSVLMNSLFGRG-------ITNQPSTNINNVILNIDNSGKSIDRKIKKLDVE 180
+K FK I MN +FG G + + + ++N ++ N +D +I +L+ +
Sbjct: 27 YKLFKAI-----MNRIFGYGNKKSHDQLLQESNQSMNQAQQSLSNRISQLDTQIAQLNFQ 81
Query: 181 LTNYREQMIRMSDGAAKNMIKQKALRVLQQKRIYENQRKQLSNQSLNLEQMDFAIQTVKY 360
L N ++ + R ++ + ++++AL++L +++ EN + L +QS ++ Q ++
Sbjct: 82 LQNIQKNLQRSNN--KQPSLRKQALKILNKRKQLENMKDSLDSQSWSMTQAQLTNDNLQN 139
Query: 361 TKSQVDAMKIGVKSFQKEFRNMNLDKIKDLQDELHDIIEQTNKIQEVL---GRTFVMPDV 531
T ++A+K + + ++ +N+DK++D+QDE+ D+IEQ +++QEVL + + D+
Sbjct: 140 TMITINALKQTNNAMKAQYGKINIDKLQDMQDEMLDLIEQGDELQEVLAMNNNSGELDDI 199
Query: 532 NEADLEAAFDAL 567
++A+L+A DAL
Sbjct: 200 SDAELDAELDAL 211
>sp|Q503V0|CHMP6_BRARE Charged multivesicular body protein 6 (Chromatin modifying protein
6)
Length = 206
Score = 63.2 bits (152), Expect = 9e-10
Identities = 47/189 (24%), Positives = 91/189 (48%), Gaps = 2/189 (1%)
Frame = +1
Query: 58 MNSLFGRGITNQPSTNINNVILNIDNSGKSIDRKIKKLDVELTNYREQMIRMSDGAAKNM 237
M +LFG+ + T + +L + + + K++ +++ R+ ++ K+
Sbjct: 1 MGNLFGKKKATRV-TEQDRAVLQLKQQRDKLKQYQKRITLQMDKERQ----LAKQLLKDG 55
Query: 238 IKQKALRVLQQKRIYENQRKQLSNQSLNLEQMDFAIQTVKYTKSQVDAMKIGVKSFQKEF 417
K KAL +L++KR + ++ NQ NLE+M I+ + ++ +K+G +K
Sbjct: 56 KKDKALLLLKKKRYQDQLLEKTENQISNLERMVQDIEFAQIEMKVIEGLKVGNDCLKKMH 115
Query: 418 RNMNLDKIKDLQDELHDIIEQTNKIQEVLGRTFVMPDVNE--ADLEAAFDALGYNIGIGE 591
+++++++ + DE HD IE +I E+L + D A+LEA I GE
Sbjct: 116 EVLSIEEVEKIMDETHDAIEYQKQIDEMLAGSLTQEDEEAVLAELEA--------ITQGE 167
Query: 592 GALNVPGVP 618
L +P VP
Sbjct: 168 ADLELPEVP 176
>sp|Q753W3|SNF7_ASHGO Vacuolar sorting protein SNF7 (Vacuolar protein sorting-associated
protein VPS32)
Length = 237
Score = 62.0 bits (149), Expect = 2e-09
Identities = 47/214 (21%), Positives = 92/214 (42%), Gaps = 6/214 (2%)
Frame = +1
Query: 67 LFGRGITNQPSTNINNVILNIDNSGKSIDRKIKKLDVELTNYREQMIRMSDGAAKNMIKQ 246
LFG G Q IL + + + +K L ++T+ E KNM K
Sbjct: 5 LFGSGNAKQKKELPKKAILELREHIQLLSKKQAHLQTQMTSQEESARHFLSKGNKNMAKA 64
Query: 247 KALRVLQQKRIYENQRKQLSNQSLNLEQMDFAIQTVKYTKSQVDAMKIGVKSFQKEFRNM 426
L++K+++E+Q ++ Q +LEQ ++I+ + AMK G + + +
Sbjct: 65 ----ALKRKKVFESQLLKIDKQVDSLEQQLYSIENANLNLETMKAMKQGASAMKHIHEGL 120
Query: 427 NLDKIKDLQDELHDIIEQTNKIQEVLGRTFV--MPDVNEADLEAAFDALGY----NIGIG 588
+++++ + DE+ + +E +I E + R + +++E +L+ D L +
Sbjct: 121 DVERVDETMDEIREQVELGEEISEAISRPLYTGVNEIDEDELDEELDMLAQEEVARKVME 180
Query: 589 EGALNVPGVPSTSPGESTVAPDDLVIHEFGLPQT 690
GA P+T +V D+ + G P T
Sbjct: 181 PGAAVPAAAPATKVSLPSVPSSDMPQQDRGQPVT 214
>sp|Q6CJL0|SNF7_KLULA Vacuolar sorting protein SNF7 (Vacuolar protein sorting-associated
protein VPS32)
Length = 232
Score = 60.8 bits (146), Expect = 4e-09
Identities = 32/137 (23%), Positives = 72/137 (52%), Gaps = 1/137 (0%)
Frame = +1
Query: 160 IKKLDVELTNYREQMIRMSDGAAKNMIKQKALRVLQQKRIYENQRKQLSNQSLNLEQMDF 339
+ K L +Q +++ + ++ K A L++K++YE+Q +L +Q +L+Q +
Sbjct: 30 LNKKQAHLQTQIDQQQQLAKKSLQSGNKNNAKTYLKKKKLYESQLDKLQSQIDSLDQQLY 89
Query: 340 AIQTVKYTKSQVDAMKIGVKSFQKEFRNMNLDKIKDLQDELHDIIEQTNKIQEVLGRTFV 519
+I+ + AMK G + + + ++LDK+ D DE+ + +E +I E + + +
Sbjct: 90 SIENANLNLETLKAMKQGASAMKNIHKGLDLDKVDDTMDEIREQVELNQEISEAISKPLI 149
Query: 520 MPD-VNEADLEAAFDAL 567
+ D ++E +L+ + L
Sbjct: 150 LQDELDEDELDQELELL 166
>sp|Q6FW96|SNF7_CANGA Vacuolar sorting protein SNF7 (Vacuolar protein sorting-associated
protein VPS32)
Length = 228
Score = 60.5 bits (145), Expect = 6e-09
Identities = 45/202 (22%), Positives = 91/202 (45%), Gaps = 13/202 (6%)
Frame = +1
Query: 73 GRGITNQPSTNINNVILNIDNSGKSIDRKIKKLDVELTNYREQMIRMSDGAAKNMIKQKA 252
G+G TN+ I+ + + +K L ++T + + K M K
Sbjct: 8 GKGNTNKELPK--KAIIELREHINLLSKKQAHLQGQITAQENEARKFLTRGNKTMAKN-- 63
Query: 253 LRVLQQKRIYENQRKQLSNQSLNLEQMDFAIQTVKYTKSQVDAMKIGVKSFQKEFRNMNL 432
L++K++YE Q +L +Q +LEQ F+I++ + AMK G K+ + +++
Sbjct: 64 --ALKKKKVYEGQLVKLESQMDSLEQQLFSIESANLNLETMRAMKQGAKAMKSIHSGLDI 121
Query: 433 DKIKDLQDELHDIIEQTNKIQEVLGRTFV--MPDVNEADLEAAFDALGYN---------- 576
D++ + DE+ + +E +I + + R +++E +L+ D L
Sbjct: 122 DRVDETMDEIREQVELGEEISDAISRPLYTGANEIDEDELDEELDMLAQETEPQVATKEQ 181
Query: 577 -IGIGEGALNVPGVPSTSPGES 639
+ + AL++P +P+T ES
Sbjct: 182 ALPESKQALSMPNIPNTKIDES 203
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,269,614
Number of Sequences: 369166
Number of extensions: 1494948
Number of successful extensions: 5332
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5110
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5313
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8100769320
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)