Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_015_I20
(723 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 235 1e-61
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 231 1e-60
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 230 3e-60
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 228 1e-59
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 224 2e-58
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 219 4e-57
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 217 3e-56
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 216 4e-56
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 214 2e-55
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 214 2e-55
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 235 bits (599), Expect = 1e-61
Identities = 123/235 (52%), Positives = 150/235 (63%), Gaps = 1/235 (0%)
Frame = +3
Query: 21 LNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMT 200
L +W +K R Y + RR +WE+N+K I+ HN EY GKH++++ +N F DMT
Sbjct: 25 LEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMT 84
Query: 201 NEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFS 380
+EEF+ G KP +G + P P SVDWR+KGYVTPVKNQ QCGSCW+FS
Sbjct: 85 SEEFRQVMNGFQNRKPR-KGKVFQEPLFYEA-PRSVDWREKGYVTPVKNQGQCGSCWAFS 142
Query: 381 ATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDY 557
ATG+LEGQ FRK RLIS SEQ LVDCS LMD AF+Y++D G++SE Y
Sbjct: 143 ATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESY 202
Query: 558 PYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 722
PY AT+ +CK NP V TGF DI Q E L AVATVGP+SVAIDAGH SF
Sbjct: 203 PYEATEESCKYNPKYSVANDTGFVDIPKQ-EKALMKAVATVGPISVAIDAGHESF 256
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 231 bits (590), Expect = 1e-60
Identities = 116/238 (48%), Positives = 152/238 (63%), Gaps = 1/238 (0%)
Frame = +3
Query: 12 NSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFA 191
+ L+ +W +K T R Y + RR +WE+N+K I+ HN EY GKH +++ +N F
Sbjct: 22 DQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFG 81
Query: 192 DMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCW 371
DMTNEEF+ + +G + + +G + P + LP SVDWR+KGYVTPVKNQ+QCGSCW
Sbjct: 82 DMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCW 139
Query: 372 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESE 548
+FSATG+LEGQ FRK +L+S SEQ LVDCS M AF+Y+K+ G++SE
Sbjct: 140 AFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSE 199
Query: 549 GDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 722
YPY A D CK P V TGFT + E L AVATVGP+SVA+DAGH+SF
Sbjct: 200 ESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSF 257
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 230 bits (587), Expect = 3e-60
Identities = 121/239 (50%), Positives = 148/239 (61%), Gaps = 2/239 (0%)
Frame = +3
Query: 12 NSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFA 191
+ LN +W +K T R Y + RR +WE+N+K I+ HN EY GKH +++ +N F
Sbjct: 22 DQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELHNREYSQGKHGFTMAMNAFG 81
Query: 192 DMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCW 371
DMTNEEF+ G K +G + P +P SVDWR+KGYVTPVKNQ QCGSCW
Sbjct: 82 DMTNEEFRQVMNGFQNQKHK-KGKMFQEPL-FAEIPKSVDWREKGYVTPVKNQGQCGSCW 139
Query: 372 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESE 548
+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAFRY+KD G++SE
Sbjct: 140 AFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDSE 199
Query: 549 GDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 722
YPY D TC P TGF D+ Q E L AVAT+GP+SVAIDAGH SF
Sbjct: 200 ESYPYLGRDTETCNYKPECSAANDTGFVDL-PQREKALMKAVATLGPISVAIDAGHQSF 257
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 228 bits (581), Expect = 1e-59
Identities = 123/240 (51%), Positives = 147/240 (61%), Gaps = 2/240 (0%)
Frame = +3
Query: 9 VNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQF 188
++ L+ W +K T R Y + RR +WE+N K I HN EY GKH + + +N F
Sbjct: 21 LDPNLDAHWHQWKATHRRLYGMNEEEWRRAVWEKNKKIIDLHNQEYSEGKHAFRMAMNAF 80
Query: 189 ADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSC 368
DMTNEEF+ G K +G + P + V P SVDW +KGYVTPVKNQ QCGSC
Sbjct: 81 GDMTNEEFRQVMNGFQNQKHK-KGKLFHEPLLVDV-PKSVDWTKKGYVTPVKNQGQCGSC 138
Query: 369 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIES 545
W+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+YIKD G++S
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDS 198
Query: 546 EGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 722
E YPY ATD +C P TGF DI Q E L AVATVGP+SVAIDAGH SF
Sbjct: 199 EESYPYLATDTNSCNYKPECSAANDTGFVDI-PQREKALMKAVATVGPISVAIDAGHTSF 257
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 224 bits (571), Expect = 2e-58
Identities = 119/240 (49%), Positives = 150/240 (62%), Gaps = 2/240 (0%)
Frame = +3
Query: 9 VNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQF 188
++ L+ +W +K T GR Y + RR +WE+N+K I+ HN EY GKH +S+ +N F
Sbjct: 21 LDQNLDADWYKWKATHGRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHGFSMAMNAF 80
Query: 189 ADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSC 368
DMTNEEF+ G K +G + + V P SVDWR+KGYVT VKNQ QCGSC
Sbjct: 81 GDMTNEEFRQVMNGFQNQKHK-KGKVFHESLVLEV-PKSVDWREKGYVTAVKNQGQCGSC 138
Query: 369 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIES 545
W+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+Y+KD G+++
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGLMDNAFQYVKDNGGLDT 198
Query: 546 EGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 722
E YPY + +C P TGF DI Q E L AVATVGP+SVAIDAGH+SF
Sbjct: 199 EESYPYLGRETNSCTYKPECSAANDTGFVDI-PQREKALMKAVATVGPISVAIDAGHSSF 257
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 219 bits (559), Expect = 4e-57
Identities = 106/224 (47%), Positives = 140/224 (62%)
Frame = +3
Query: 33 WETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEF 212
W +K + ++Y+ D RR IWE+N+K+IQ+HNL +DLG TY+LGLNQF DMT EEF
Sbjct: 21 WHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEF 80
Query: 213 KAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGS 392
KAKYL M + N +P +DWR+ GYVT VK+Q CGSCW+FS TG+
Sbjct: 81 KAKYLTEMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGT 140
Query: 393 LEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQGIESEGDYPYTAT 572
+EGQY + ISFSEQQLVDCS LM+NA++Y+K G+E+E YPYTA
Sbjct: 141 MEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYTAV 200
Query: 573 DGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAID 704
+G C+ N V K TG+ + S +E +L N V P +VA+D
Sbjct: 201 EGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRPAAVAVD 244
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 217 bits (552), Expect = 3e-56
Identities = 118/231 (51%), Positives = 144/231 (62%), Gaps = 1/231 (0%)
Frame = +3
Query: 30 EWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEE 209
EW +K+T R Y + RR IWE+N++ IQ HN EY G+H +S+ +N F DMTNEE
Sbjct: 28 EWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEE 87
Query: 210 FKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATG 389
F+ G K +G + P + + P SVDWR+KG VTPVKNQ QCGSCW+FSA+G
Sbjct: 88 FRQVVNGYRHQKHK-KGRLFQEPLMLKI-PKSVDWREKGCVTPVKNQGQCGSCWAFSASG 145
Query: 390 SLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYT 566
LEGQ F K +LIS SEQ LVDCS LMD AF+YIK+ G++SE YPY
Sbjct: 146 CLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYE 205
Query: 567 ATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHAS 719
A DG+CK V TGF DI Q E L AVATVGP+SVA+DA H S
Sbjct: 206 AKDGSCKYRAEFAVANDTGFVDI-PQQEKALMKAVATVGPISVAMDASHPS 255
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 216 bits (551), Expect = 4e-56
Identities = 116/233 (49%), Positives = 145/233 (62%), Gaps = 1/233 (0%)
Frame = +3
Query: 24 NEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTN 203
N +W +K+T R Y + RR +WE+N++ IQ HN EY GKH +++ +N F DMTN
Sbjct: 26 NAQWHQWKSTHRRLYGTNEEEWRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTN 85
Query: 204 EEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSA 383
EEF+ G K +G + P + + P +VDWR+KG VTPVKNQ QCGSCW+FSA
Sbjct: 86 EEFRQIVNGYRHQKHK-KGRLFQEPLMLQI-PKTVDWREKGCVTPVKNQGQCGSCWAFSA 143
Query: 384 TGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYP 560
+G LEGQ F K +LIS SEQ LVDCS LMD AF+YIK+ G++SE YP
Sbjct: 144 SGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYP 203
Query: 561 YTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHAS 719
Y A DG+CK V TGF DI Q E L AVATVGP+SVA+DA H S
Sbjct: 204 YEAKDGSCKYRAEYAVANDTGFVDI-PQQEKALMKAVATVGPISVAMDASHPS 255
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 214 bits (545), Expect = 2e-55
Identities = 115/238 (48%), Positives = 150/238 (63%), Gaps = 4/238 (1%)
Frame = +3
Query: 21 LNEEWETYKTTFGRKYDELTD-ITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADM 197
L+ +WE +K T+ ++Y+ D I+RRLIWE+NLK+I HNLE LG HTY L +N DM
Sbjct: 22 LDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDM 81
Query: 198 TNEEFKAKYLGIMKTKPTLEGS--TYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCW 371
T+EE K G+ K P+ S T P+ G P S+D+R+KGYVTPVKNQ QCGSCW
Sbjct: 82 TSEEVVQKMTGL-KVPPSRSHSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCW 140
Query: 372 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI-KDQGIESE 548
+FS+ G+LEGQ +K +L++ S Q LVDC M NAF+Y+ +++GI+SE
Sbjct: 141 AFSSVGALEGQLKKKTGKLLNLSPQNLVDC--VSENYGCGGGYMTNAFQYVQRNRGIDSE 198
Query: 549 GDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 722
YPY D +C NP+ KC G+ +I NE L AVA VGPVSVAIDA SF
Sbjct: 199 DAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSF 256
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 214 bits (545), Expect = 2e-55
Identities = 115/237 (48%), Positives = 146/237 (61%), Gaps = 3/237 (1%)
Frame = +3
Query: 21 LNEEWETYKTTFGRKYDELTD-ITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADM 197
L+ WE +K T ++Y+ D I+RRLIWE+NLKYI HNLE LG HTY L +N DM
Sbjct: 22 LDTHWELWKKTHRKQYNSKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDM 81
Query: 198 TNEEFKAKYLGI-MKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWS 374
TNEE K G+ + + T P+ G P SVD+R+KGYVTPVKNQ QCGSCW+
Sbjct: 82 TNEEVVQKMTGLKVPASHSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWA 141
Query: 375 FSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI-KDQGIESEG 551
FS+ G+LEGQ +K +L++ S Q LVDC M NAF+Y+ K++GI+SE
Sbjct: 142 FSSVGALEGQLKKKTGKLLNLSPQNLVDC--VSENDGCGGGYMTNAFQYVQKNRGIDSED 199
Query: 552 DYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 722
YPY + +C NP+ KC G+ +I NE L AVA VGPVSVAIDA SF
Sbjct: 200 AYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSF 256
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,841,937
Number of Sequences: 369166
Number of extensions: 1491140
Number of successful extensions: 4347
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3912
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4028
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6462248555
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)