Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_015_I18
(662 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P53634|CATC_HUMAN Dipeptidyl-peptidase I precursor (DPP-... 210 3e-54
sp|P97821|CATC_MOUSE Dipeptidyl-peptidase I precursor (DPP-... 208 1e-53
sp|Q60HG6|CATC_MACFA Dipeptidyl-peptidase I precursor (DPP-... 204 1e-52
sp|P80067|CATC_RAT Dipeptidyl-peptidase I precursor (DPP-I)... 202 6e-52
sp|O97578|CATC_CANFA Dipeptidyl-peptidase I precursor (DPP-... 202 8e-52
sp|Q26563|CATC_SCHMA Cathepsin C precursor 152 6e-37
sp|Q90686|CATK_CHICK Cathepsin K precursor (JTAP-1) 60 4e-09
sp|O17473|CATL_BRUPA Cathepsin L-like precursor 58 2e-08
sp|P43296|RD19A_ARATH Cysteine proteinase RD19a precursor (... 58 3e-08
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 57 3e-08
>sp|P53634|CATC_HUMAN Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 463
Score = 210 bits (534), Expect = 3e-54
Identities = 107/228 (46%), Positives = 137/228 (60%), Gaps = 9/228 (3%)
Frame = +2
Query: 5 AVDEFGNYGKWTLIYNQGFEVTITNKKYFGFFDYKKINSTYTISYCDRLQPNWFHDVLIR 184
A D+ GN G +T+IYNQGFE+ + + K+F FF YK+ S T +YC+ W HDVL R
Sbjct: 74 AYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVT-TYCNETMTGWVHDVLGR 132
Query: 185 QWQCFKAQRITTLKE---------KNNVLPHSNIFALTSLRYGSQKRIVDKINLENNGWT 337
W CF +++ T E KN+ +SN Y V IN WT
Sbjct: 133 NWACFTGKKVGTASENVYVNTAHLKNSQEKYSNRL------YKYDHNFVKAINAIQKSWT 186
Query: 338 AKDYPEFHEKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGVNYV 517
A Y E+ TL ++I +GG K+ RPKPAP+T I + +P S+DWRNV+G+N+V
Sbjct: 187 ATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFV 246
Query: 518 SPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPY 661
SPVRNQ CGSCYSFAS GMLEAR RI +NN+ PILSPQ+VV CS Y
Sbjct: 247 SPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQY 294
>sp|P97821|CATC_MOUSE Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 462
Score = 208 bits (529), Expect = 1e-53
Identities = 110/226 (48%), Positives = 139/226 (61%), Gaps = 7/226 (3%)
Frame = +2
Query: 5 AVDEFGNYGKWTLIYNQGFEVTITNKKYFGFFDYKKINSTYTISYCDRLQPNWFHDVLIR 184
A DE GN G +TLIYNQGFE+ + + K+F FF Y+ T ISYC W HDVL R
Sbjct: 74 AYDELGNSGHFTLIYNQGFEIVLNDYKWFAFFKYEVRGHT-AISYCHETMTGWVHDVLGR 132
Query: 185 QWQCFKAQRITTLKEKNNVLPHSNIFALTSLR-------YGSQKRIVDKINLENNGWTAK 343
W CF +++ + EK N+ N L L+ Y V IN WTA
Sbjct: 133 NWACFVGKKVESHIEKVNM----NAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTAT 188
Query: 344 DYPEFHEKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGVNYVSP 523
Y E+ + +L ++I +G S+ ++ RPKPAP+T I + +P+S+DWRNV GVNYVSP
Sbjct: 189 AYKEYEKMSLRDLIRRSGHSQ-RIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSP 247
Query: 524 VRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPY 661
VRNQ CGSCYSFAS GMLEAR RI +NN+ PILSPQ+VV CSPY
Sbjct: 248 VRNQESCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPY 293
>sp|Q60HG6|CATC_MACFA Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 463
Score = 204 bits (520), Expect = 1e-52
Identities = 105/228 (46%), Positives = 134/228 (58%), Gaps = 9/228 (3%)
Frame = +2
Query: 5 AVDEFGNYGKWTLIYNQGFEVTITNKKYFGFFDYKKINSTYTISYCDRLQPNWFHDVLIR 184
A D+ GN G +T+IYNQGFE+ + + K+F FF YK+ TI YC+ W HDVL R
Sbjct: 74 AYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGIKVTI-YCNETMTGWVHDVLGR 132
Query: 185 QWQCFKAQRITTLKE---------KNNVLPHSNIFALTSLRYGSQKRIVDKINLENNGWT 337
W CF +++ T E KN+ +SN Y V IN WT
Sbjct: 133 NWACFTGKKVGTASENVYVNTAHLKNSQEKYSNRL------YKYDHNFVKAINAIQKSWT 186
Query: 338 AKDYPEFHEKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGVNYV 517
A Y E+ TL ++I +GG K+ RPKP P+T I + +P S+DWRNV+G+N+V
Sbjct: 187 ATTYMEYETLTLGDMIKRSGGHSRKIPRPKPTPLTAEIQQKILHLPTSWDWRNVHGINFV 246
Query: 518 SPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPY 661
SPVRNQ CGSCYSFAS GMLEAR RI +NN+ PILS Q+VV CS Y
Sbjct: 247 SPVRNQASCGSCYSFASVGMLEARIRILTNNSQTPILSSQEVVSCSQY 294
>sp|P80067|CATC_RAT Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 462
Score = 202 bits (514), Expect = 6e-52
Identities = 105/226 (46%), Positives = 136/226 (60%), Gaps = 7/226 (3%)
Frame = +2
Query: 5 AVDEFGNYGKWTLIYNQGFEVTITNKKYFGFFDYKKINSTYTISYCDRLQPNWFHDVLIR 184
A DE GN G +TLIYNQGFE+ + + K+F FF Y+ + + ISYC W HD L R
Sbjct: 74 AYDEVGNSGYFTLIYNQGFEIVLNDYKWFAFFKYE-VKGSRAISYCHETMTGWVHDYLGR 132
Query: 185 QWQCFKAQRITTLKEKNNVLPHSNIFALTSLR-------YGSQKRIVDKINLENNGWTAK 343
W CF +++ EK V N+ L L+ Y V IN WTA
Sbjct: 133 NWACFVGKKMANHSEKVYV----NVAHLGGLQEKYSERLYSHHHNFVKAINSVQKSWTAT 188
Query: 344 DYPEFHEKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGVNYVSP 523
Y + + ++ ++I +G S ++ RPKPAPIT I + +P+S+DWRNV G+N+VSP
Sbjct: 189 TYRRYEKLSIRDLIRRSGHS-GRILRPKPAPITDEIQQQILSLPESWDWRNVRGINFVSP 247
Query: 524 VRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPY 661
VRNQ CGSCYSFAS GMLEAR RI +NN+ PILSPQ+VV CSPY
Sbjct: 248 VRNQESCGSCYSFASIGMLEARIRILTNNSQTPILSPQEVVSCSPY 293
>sp|O97578|CATC_CANFA Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain 1;
Dipeptidyl-peptidase I heavy chain 2;
Dipeptidyl-peptidase I heavy chain 3;
Dipeptidyl-peptidase I heavy chain 4;
Dipeptidyl-peptidase I light chain]
Length = 435
Score = 202 bits (513), Expect = 8e-52
Identities = 105/226 (46%), Positives = 131/226 (57%), Gaps = 7/226 (3%)
Frame = +2
Query: 5 AVDEFGNYGKWTLIYNQGFEVTITNKKYFGFFDYKKINSTYTISYCDRLQPNWFHDVLIR 184
A D FGN G +T+IYNQGFE+ + + K+F FF YK+ T SYC+ W HDVL R
Sbjct: 49 AYDNFGNTGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGHKVT-SYCNETMTGWVHDVLGR 107
Query: 185 QWQCFKAQRITTLKEKNNV-------LPHSNIFALTSLRYGSQKRIVDKINLENNGWTAK 343
W CF ++ T EK V L +N L Y V IN WTA
Sbjct: 108 NWACFTGTKMGTTSEKAKVNTKHIERLQENNSNRLYKYNY----EFVKAINTIQKSWTAT 163
Query: 344 DYPEFHEKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGVNYVSP 523
Y E+ TL +++ GG K+ RPKP P+T I + + +P S+DWRNV G N+VSP
Sbjct: 164 RYIEYETLTLRDMMTRVGGR--KIPRPKPTPLTAEIHEEISRLPTSWDWRNVRGTNFVSP 221
Query: 524 VRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPY 661
VRNQ CGSCY+FAS MLEAR RI +NNT PILSPQ++V CS Y
Sbjct: 222 VRNQASCGSCYAFASTAMLEARIRILTNNTQTPILSPQEIVSCSQY 267
>sp|Q26563|CATC_SCHMA Cathepsin C precursor
Length = 454
Score = 152 bits (385), Expect = 6e-37
Identities = 94/225 (41%), Positives = 121/225 (53%), Gaps = 6/225 (2%)
Frame = +2
Query: 5 AVDEFGNYGKWTLIYNQGFEVTITNKKYFGFFDYKKINSTYTISYCDRLQPNWFHDVLIR 184
A+DEFGN G WTLIYNQGFEVTI ++K+ F YK N + C + P W HD LI
Sbjct: 66 AIDEFGNRGHWTLIYNQGFEVTINHRKWLVIFAYKS-NGEFN---CHKSMPMWTHDTLID 121
Query: 185 QWQCFKAQRITTLKEKNNVLPHSNIFALTSLRYGSQKRIVDKINLENNGWTAKDYPEFHE 364
+ K N L S F T Y V KIN W + YPE +
Sbjct: 122 SGSVCSGKIGVHDKFHINKLFGSKSFGRTL--YHINPSFVGKINAHQKSWRGEIYPELSK 179
Query: 365 KTLYEVINMAGGSRSKLERP----KPAPITKSILDSVKLIPKSFDWRNV--NGVNYVSPV 526
T+ E+ N AGG +S + RP + P +K ++ +P FDW + + V+P+
Sbjct: 180 YTIDELRNRAGGVKSMVTRPSVLNRKTP-SKELISLTGNLPLEFDWTSPPDGSRSPVTPI 238
Query: 527 RNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPY 661
RNQG CGSCY+ SA LEAR R+ SN + +PILSPQ VV+CSPY
Sbjct: 239 RNQGICGSCYASPSAAALEARIRLVSNFSEQPILSPQTVVDCSPY 283
>sp|Q90686|CATK_CHICK Cathepsin K precursor (JTAP-1)
Length = 334
Score = 60.5 bits (145), Expect = 4e-09
Identities = 36/97 (37%), Positives = 53/97 (54%)
Frame = +2
Query: 362 EKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGVNYVSPVRNQGG 541
+ T EV+ G R RP+P T + D P + DWR YV+PV++QG
Sbjct: 85 DMTSEEVVRTMTGLRVPRSRPRPNG-TLYVPDWSSRAPAAVDWRRKG---YVTPVKDQGQ 140
Query: 542 CGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVEC 652
CGSC++F+S G LE + + R+ + LSPQ++V C
Sbjct: 141 CGSCWAFSSVGALEGQLKRRTGKLLS--LSPQNLVYC 175
>sp|O17473|CATL_BRUPA Cathepsin L-like precursor
Length = 395
Score = 58.2 bits (139), Expect = 2e-08
Identities = 29/67 (43%), Positives = 42/67 (62%)
Frame = +2
Query: 455 DSVKLIPKSFDWRNVNGVNYVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSP 634
D + +P DWR V +PVRNQG CGSCY+FA+A LEA ++ + + LSP
Sbjct: 177 DKSERLPDQVDWRTKGAV---TPVRNQGECGSCYAFATAAALEAYHKQMTGRLLD--LSP 231
Query: 635 QDVVECS 655
Q++V+C+
Sbjct: 232 QNIVDCT 238
>sp|P43296|RD19A_ARATH Cysteine proteinase RD19a precursor (RD19)
Length = 368
Score = 57.8 bits (138), Expect = 3e-08
Identities = 36/100 (36%), Positives = 54/100 (54%)
Frame = +2
Query: 353 EFHEKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGVNYVSPVRN 532
+F + T E G RS + PK A K+ + + +P+ FDWR+ V +PV+N
Sbjct: 98 QFSDLTRSEFRKKHLGVRSGFKLPKDA--NKAPILPTENLPEDFDWRDHGAV---TPVKN 152
Query: 533 QGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVEC 652
QG CGSC+SF++ G LE + + V LS Q +V+C
Sbjct: 153 QGSCGSCWSFSATGALEGANFLATGKLVS--LSEQQLVDC 190
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 57.4 bits (137), Expect = 3e-08
Identities = 29/62 (46%), Positives = 41/62 (66%)
Frame = +2
Query: 470 IPKSFDWRNVNGVNYVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVE 649
IPKS DWR YV+PV+NQG CGSC++F++ G LE + ++ V LS Q++V+
Sbjct: 114 IPKSVDWREKG---YVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVS--LSEQNLVD 168
Query: 650 CS 655
CS
Sbjct: 169 CS 170
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,661,329
Number of Sequences: 369166
Number of extensions: 1614633
Number of successful extensions: 4242
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4002
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4148
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5560129980
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)