Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_015_I14
(902 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P21910|LAML2_XENLA Lamin L(II) 142 1e-33
sp|P20700|LAM1_HUMAN Lamin B1 135 1e-31
sp|P14733|LAM1_MOUSE Lamin B1 134 5e-31
sp|P14731|LAM1_CHICK Lamin B1 132 2e-30
sp|P70615|LAM1_RAT Lamin B1 132 2e-30
sp|P14732|LAM2_CHICK Lamin B2 129 9e-30
sp|Q03252|LAM2_HUMAN Lamin B2 129 1e-29
sp|P21619|LAM2_MOUSE Lamin B2 126 9e-29
sp|P11516|LAMC_MOUSE Lamins C and C2 125 1e-28
sp|P48679|LAMA_RAT Lamin A 125 1e-28
>sp|P21910|LAML2_XENLA Lamin L(II)
Length = 623
Score = 142 bits (358), Expect = 1e-33
Identities = 90/313 (28%), Positives = 163/313 (52%), Gaps = 23/313 (7%)
Frame = +3
Query: 6 LSKELERRDLELQALQRKIDSLERDISKQKSDSERYMTLLTQHDTLEKRCAKL------- 164
L+K +++D +L Q +I LE + +++ T L + +LE A L
Sbjct: 120 LNKNYKKKDADLSTAQGRIKDLEALFHRSEAELG---TALGEKRSLEAEVADLRAQLSKT 176
Query: 165 -------SKDLDAEILLRTDIENKNVTLKEQLEFNERLYNEEHTKMKQHQXXXXXXXXDR 323
K L+ E L+R D EN+ +L+E+++F + +Y EE + ++
Sbjct: 177 EDAHRVAKKQLEKETLMRVDFENRMQSLQEEMDFRKNIYEEESRETRKRHERRIVEVDRG 236
Query: 324 KHAEYESKLAEELRSIREETAEEFEGYKLEFEQSFMLRLAELKKSNQQTNENIVKARDEM 503
H +YESKLA+ L +R++ E+ + YK E EQ++ +L +K+S+ ++ A +E+
Sbjct: 237 HHYDYESKLAQALDELRKQHDEQVKMYKEELEQTYQAKLDNIKRSSDHNDKAANTALEEL 296
Query: 504 LIWRSKAEKYEQELAMKASENDTLKKRIKDLESLLSFERNEFEEQLKHFREESDQLRNDL 683
R + E +L+ + + ++RI++LE LLS +R+++ + L E ++R+ +
Sbjct: 297 TERRMRIETLGYQLSGLQKQANAAEERIRELEELLSSDRDKYRKLLDSKEREMAEMRDQM 356
Query: 684 QKRLNDFSNLMSTKIALDQEILMYRKLLESEEARCNINVA---------ADGDTSFSVLN 836
Q++LN++ L+ K+ALD EI YRKLLE EE R ++ + A +S +
Sbjct: 357 QQQLNEYQELLDVKLALDLEINAYRKLLEGEEERLKLSPSPESRVTVSRATSSSSSATRT 416
Query: 837 AGSKRRKVGERGE 875
+ SKRR+V E E
Sbjct: 417 SRSKRRRVEEEYE 429
Score = 36.6 bits (83), Expect = 0.099
Identities = 43/169 (25%), Positives = 70/169 (41%), Gaps = 22/169 (13%)
Frame = +3
Query: 345 KLAEELRSIREETAEEFEGYKLEFEQSFMLRLAELKKSNQQTNENIVKARDEMLIWRSKA 524
+L ++ E T E G K +E LA+ +K +T + + E+ +RS
Sbjct: 62 RLMVKISEKEEVTTREVSGIKNLYESE----LADARKVLDETARERARLQIELGKFRSDL 117
Query: 525 EKYEQELAMKASENDTLKKRIKDLESLLSFERNEFE-----EQLKHFREESDQLRNDLQK 689
++ + K ++ T + RIKDLE+L F R+E E + + E LR L K
Sbjct: 118 DELNKNYKKKDADLSTAQGRIKDLEAL--FHRSEAELGTALGEKRSLEAEVADLRAQLSK 175
Query: 690 RLN-----------------DFSNLMSTKIALDQEILMYRKLLESEEAR 785
+ DF N M + QE + +RK + EE+R
Sbjct: 176 TEDAHRVAKKQLEKETLMRVDFENRMQSL----QEEMDFRKNIYEEESR 220
>sp|P20700|LAM1_HUMAN Lamin B1
Length = 586
Score = 135 bits (341), Expect = 1e-31
Identities = 88/289 (30%), Positives = 144/289 (49%), Gaps = 7/289 (2%)
Frame = +3
Query: 15 ELERRDLELQALQRKIDSLERDISKQKSDSERYMTLLTQHDTLEKRCAKLSKDLDAEILL 194
+++ R+ E AL K +L + +KS L Q LE A K L E LL
Sbjct: 132 QIKLREYEA-ALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLL 190
Query: 195 RTDIENKNVTLKEQLEFNERLYNEEHTKMKQHQXXXXXXXXDRKHAEYESKLAEELRSIR 374
+ D+EN+ +L E LEF + +Y EE + ++ + EYE KLA+ L +R
Sbjct: 191 KVDLENRCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMR 250
Query: 375 EETAEEFEGYKLEFEQSFMLRLAELKKSNQQTNENIVKARDEMLIWRSKAEKYEQELAMK 554
E+ + YK E EQ++ +L + S++ + AR+E++ R + E +L+
Sbjct: 251 EQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNL 310
Query: 555 ASENDTLKKRIKDLESLLSFERNEFEEQLKHFREESDQLRNDLQKRLNDFSNLMSTKIAL 734
E+ +RI++LE LL+ E++ L E ++R+ +Q++LND+ L+ K+AL
Sbjct: 311 QKESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLAL 370
Query: 735 DQEILMYRKLLESEEARCNIN-------VAADGDTSFSVLNAGSKRRKV 860
D EI YRKLLE EE R ++ + +S SV KR++V
Sbjct: 371 DMEISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRSVRTTRGKRKRV 419
>sp|P14733|LAM1_MOUSE Lamin B1
Length = 588
Score = 134 bits (336), Expect = 5e-31
Identities = 86/289 (29%), Positives = 144/289 (49%), Gaps = 7/289 (2%)
Frame = +3
Query: 15 ELERRDLELQALQRKIDSLERDISKQKSDSERYMTLLTQHDTLEKRCAKLSKDLDAEILL 194
+++ R+ E AL K +L + +KS L Q LE + K L E LL
Sbjct: 133 QIKLREYEA-ALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLSAAKKQLADETLL 191
Query: 195 RTDIENKNVTLKEQLEFNERLYNEEHTKMKQHQXXXXXXXXDRKHAEYESKLAEELRSIR 374
+ D+EN+ +L E LEF + +Y EE + ++ + EYE KLA+ L +R
Sbjct: 192 KVDLENRCQSLTEDLEFRKNMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMR 251
Query: 375 EETAEEFEGYKLEFEQSFMLRLAELKKSNQQTNENIVKARDEMLIWRSKAEKYEQELAMK 554
E+ + YK E EQ++ +L + S++ + AR+E++ R + E +L+
Sbjct: 252 EQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNL 311
Query: 555 ASENDTLKKRIKDLESLLSFERNEFEEQLKHFREESDQLRNDLQKRLNDFSNLMSTKIAL 734
E+ +RI++LE +L+ ER+ L E ++R+ +Q++L+D+ L+ K+AL
Sbjct: 312 QKESRACLERIQELEDMLAKERDNSRRMLSDREREMAEIRDQMQQQLSDYEQLLDVKLAL 371
Query: 735 DQEILMYRKLLESEEARCNIN-------VAADGDTSFSVLNAGSKRRKV 860
D EI YRKLLE EE R ++ + +S SV KR++V
Sbjct: 372 DMEISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRSVRTTRGKRKRV 420
>sp|P14731|LAM1_CHICK Lamin B1
Length = 584
Score = 132 bits (331), Expect = 2e-30
Identities = 86/289 (29%), Positives = 145/289 (50%), Gaps = 7/289 (2%)
Frame = +3
Query: 15 ELERRDLELQALQRKIDSLERDISKQKSDSERYMTLLTQHDTLEKRCAKLSKDLDAEILL 194
+++ R+ E AL K +L + ++S E L Q LE A K+L E L
Sbjct: 131 QVKLREFEA-ALNAKEAALATALGDKRSQEEELEDLRDQIAQLEVSLAAAKKELADETLQ 189
Query: 195 RTDIENKNVTLKEQLEFNERLYNEEHTKMKQHQXXXXXXXXDRKHAEYESKLAEELRSIR 374
+ D+EN+ +L E LEF + +Y EE + ++ + EYE KLA+ L+ IR
Sbjct: 190 KVDLENRCQSLIEDLEFRKNVYEEEIKETRRKHETRLVEVDSGRQIEYEYKLAQALKEIR 249
Query: 375 EETAEEFEGYKLEFEQSFMLRLAELKKSNQQTNENIVKARDEMLIWRSKAEKYEQELAMK 554
E+ + + YK E EQ++ +L +++S++ + R+E+ R + E +A
Sbjct: 250 EQHDAQVKLYKEELEQTYSSKLENIRQSSEMHSCTANTVREELHESRMRIETLSSHIADI 309
Query: 555 ASENDTLKKRIKDLESLLSFERNEFEEQLKHFREESDQLRNDLQKRLNDFSNLMSTKIAL 734
E+ + R+ +LE LS ER + + L E ++RN +Q++ +D+ L+ K+AL
Sbjct: 310 QKESRAWQDRVHELEDTLSKERENYRKILAENEREVAEMRNQMQQQFSDYEQLLDVKLAL 369
Query: 735 DQEILMYRKLLESEEARCNIN-------VAADGDTSFSVLNAGSKRRKV 860
D EI YRKLLESEE R ++ + +S SV KR+++
Sbjct: 370 DMEISAYRKLLESEEERLRLSPGPSSRVTVSRASSSRSVRTTRGKRKRI 418
>sp|P70615|LAM1_RAT Lamin B1
Length = 587
Score = 132 bits (331), Expect = 2e-30
Identities = 86/289 (29%), Positives = 142/289 (49%), Gaps = 7/289 (2%)
Frame = +3
Query: 15 ELERRDLELQALQRKIDSLERDISKQKSDSERYMTLLTQHDTLEKRCAKLSKDLDAEILL 194
+++ R+ E AL K +L + +KS L Q LE + K L E LL
Sbjct: 132 QIKLREYEA-ALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLSAAKKQLADETLL 190
Query: 195 RTDIENKNVTLKEQLEFNERLYNEEHTKMKQHQXXXXXXXXDRKHAEYESKLAEELRSIR 374
+ D+EN+ +L E LEF + +Y EE + ++ + EYE KLA+ L +R
Sbjct: 191 KVDLENRCQSLTEDLEFRKNMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMR 250
Query: 375 EETAEEFEGYKLEFEQSFMLRLAELKKSNQQTNENIVKARDEMLIWRSKAEKYEQELAMK 554
E+ + YK E EQ++ +L + S++ + AR M+ R + E +L+
Sbjct: 251 EQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSARGGMMESRMRIESLSSQLSNL 310
Query: 555 ASENDTLKKRIKDLESLLSFERNEFEEQLKHFREESDQLRNDLQKRLNDFSNLMSTKIAL 734
++ +RI++LE +L+ ER+ L E ++R+ +Q++LND+ L+ K+AL
Sbjct: 311 QKDSRACLERIQELEDMLAKERDNSRRMLSDKEREMAEIRDQMQQQLNDYEQLLDVKLAL 370
Query: 735 DQEILMYRKLLESEEARCNIN-------VAADGDTSFSVLNAGSKRRKV 860
D EI YRKLLE EE R ++ + +S SV KR++V
Sbjct: 371 DMEISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRSVRTTRGKRKRV 419
>sp|P14732|LAM2_CHICK Lamin B2
Length = 600
Score = 129 bits (325), Expect = 9e-30
Identities = 79/293 (26%), Positives = 150/293 (51%), Gaps = 14/293 (4%)
Frame = +3
Query: 9 SKELERRDLELQALQRKIDSLERDISKQKSDSERYMTLLTQHDTLEKRCAKL-------- 164
+K +++D +L Q +I LE + +S++E T+L + +LE A L
Sbjct: 111 NKSYKKKDADLSVAQGRIKDLE--VLFHRSEAE-LNTVLNEKRSLEAEVADLRAQLAKAE 167
Query: 165 ------SKDLDAEILLRTDIENKNVTLKEQLEFNERLYNEEHTKMKQHQXXXXXXXXDRK 326
K L+ E L+R D+EN+ +L+E L+F + ++ EE + ++ +
Sbjct: 168 DGHAVAKKQLEKETLMRVDLENRCQSLQEDLDFRKNVFEEEIRETRKRHEHRLVEVDTSR 227
Query: 327 HAEYESKLAEELRSIREETAEEFEGYKLEFEQSFMLRLAELKKSNQQTNENIVKARDEML 506
EYE+K+A+ L +R + E+ + YK+E EQ++ +L ++ Q ++ AR+E+
Sbjct: 228 QQEYENKMAQALEDLRNQHDEQVKLYKMELEQTYQAKLENAILASDQNDKAAGAAREELK 287
Query: 507 IWRSKAEKYEQELAMKASENDTLKKRIKDLESLLSFERNEFEEQLKHFREESDQLRNDLQ 686
R + E +L+ + + RI++L+ ++ ER++F + L E ++R+ +Q
Sbjct: 288 EARMRIESLSHQLSGLQKQASATEDRIRELKETMAGERDKFRKMLDAKEREMTEMRDQMQ 347
Query: 687 KRLNDFSNLMSTKIALDQEILMYRKLLESEEARCNINVAADGDTSFSVLNAGS 845
+L ++ L+ K+ALD EI YRKLLE EE R ++ + + S + S
Sbjct: 348 LQLTEYQELLDVKLALDMEISAYRKLLEGEEERLKLSPSPSSRVTVSRATSSS 400
Score = 32.0 bits (71), Expect = 2.4
Identities = 35/141 (24%), Positives = 62/141 (43%), Gaps = 5/141 (3%)
Frame = +3
Query: 345 KLAEELRSIREETAEEFEGYKLEFEQSFMLRLAELKKSNQQTNENIVKARDEMLIWRSKA 524
+L ++ E T E G K +E LA+ ++ +T + + + E+ R++
Sbjct: 52 RLLVKISEKEEVTTREVSGIKNLYESE----LADARRVLDETAKERARLQIEIGKLRAEL 107
Query: 525 EKYEQELAMKASENDTLKKRIKDLESLLSFERNEFE-----EQLKHFREESDQLRNDLQK 689
E++ + K ++ + RIKDLE L F R+E E + + E LR L K
Sbjct: 108 EEFNKSYKKKDADLSVAQGRIKDLEVL--FHRSEAELNTVLNEKRSLEAEVADLRAQLAK 165
Query: 690 RLNDFSNLMSTKIALDQEILM 752
+ + K L++E LM
Sbjct: 166 AEDGHA---VAKKQLEKETLM 183
>sp|Q03252|LAM2_HUMAN Lamin B2
Length = 600
Score = 129 bits (324), Expect = 1e-29
Identities = 79/291 (27%), Positives = 146/291 (50%), Gaps = 11/291 (3%)
Frame = +3
Query: 6 LSKELERRDLELQALQRKIDSLER-----------DISKQKSDSERYMTLLTQHDTLEKR 152
++K ++R+ EL Q ++ LE +S ++ L Q E
Sbjct: 111 VNKSAKKREGELTVAQGRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDG 170
Query: 153 CAKLSKDLDAEILLRTDIENKNVTLKEQLEFNERLYNEEHTKMKQHQXXXXXXXXDRKHA 332
A K L+ E L+R D+EN+ +L+E+L+F + ++ EE + ++ +
Sbjct: 171 HAVAKKQLEKETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQ 230
Query: 333 EYESKLAEELRSIREETAEEFEGYKLEFEQSFMLRLAELKKSNQQTNENIVKARDEMLIW 512
EY+ K+A+ L +R + E+ YKLE EQ++ +L K S+ Q ++ AR+E+
Sbjct: 231 EYDFKMAQALEELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEA 290
Query: 513 RSKAEKYEQELAMKASENDTLKKRIKDLESLLSFERNEFEEQLKHFREESDQLRNDLQKR 692
R + E +L+ + + RI++LE ++ ER++F + L +E ++R+ +Q++
Sbjct: 291 RMRLESLSYQLSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQ 350
Query: 693 LNDFSNLMSTKIALDQEILMYRKLLESEEARCNINVAADGDTSFSVLNAGS 845
L ++ L+ K+ALD EI YRKLLE EE R ++ + + S + S
Sbjct: 351 LAEYQELLDVKLALDMEINAYRKLLEGEEERLKLSPSPSSRVTVSRATSSS 401
Score = 30.8 bits (68), Expect = 5.4
Identities = 24/96 (25%), Positives = 44/96 (45%)
Frame = +3
Query: 345 KLAEELRSIREETAEEFEGYKLEFEQSFMLRLAELKKSNQQTNENIVKARDEMLIWRSKA 524
+L ++ E T E G K +E LA+ ++ +T + + E+ R++
Sbjct: 53 RLLLKISEKEEVTTREVSGIKALYESE----LADARRVLDETARERARLQIEIGKLRAEL 108
Query: 525 EKYEQELAMKASENDTLKKRIKDLESLLSFERNEFE 632
++ + + E + R+KDLESL F R+E E
Sbjct: 109 DEVNKSAKKREGELTVAQGRVKDLESL--FHRSEVE 142
>sp|P21619|LAM2_MOUSE Lamin B2
Length = 592
Score = 126 bits (316), Expect = 9e-29
Identities = 79/298 (26%), Positives = 147/298 (49%), Gaps = 14/298 (4%)
Frame = +3
Query: 12 KELERRDLELQALQRKIDSLERDISKQKSDSERYMTLLTQHDTLEKRCAKL--------- 164
K ++R+ EL Q ++ LE + +++ T L+ ++ LE A+L
Sbjct: 111 KSAKKREGELTVAQGRVKDLESLFHRSEAE---LATALSDNEGLETEVAELRAQLAKAED 167
Query: 165 -----SKDLDAEILLRTDIENKNVTLKEQLEFNERLYNEEHTKMKQHQXXXXXXXXDRKH 329
K L+ E L+R D+EN+ +L+E+L F++ ++ EE + ++ +
Sbjct: 168 GHAVAKKQLEKETLMRVDLENRCQSLQEELAFSKSVFEEEVRETRRRHERRLVEVDSSRQ 227
Query: 330 AEYESKLAEELRSIREETAEEFEGYKLEFEQSFMLRLAELKKSNQQTNENIVKARDEMLI 509
EY+ K+A+ L +R + E+ Y++E EQ++ +L K + Q ++ AR+E+
Sbjct: 228 QEYDFKMAQALEDLRSQHDEQVRLYRVELEQTYQAKLDNAKLLSDQNDKAAHAAREELKE 287
Query: 510 WRSKAEKYEQELAMKASENDTLKKRIKDLESLLSFERNEFEEQLKHFREESDQLRNDLQK 689
R + E +L + + I +LE L ER++F + L +E ++R+ +Q+
Sbjct: 288 ARMRVESLSYQLLGLQKQASAAENHIHELEEALRGERDKFRKMLDAKEQEMTEVRDRMQQ 347
Query: 690 RLNDFSNLMSTKIALDQEILMYRKLLESEEARCNINVAADGDTSFSVLNAGSKRRKVG 863
+L ++ L+ K+ALD EI YRKLLE EE R ++ + + S + S VG
Sbjct: 348 QLAEYQELLDIKLALDMEISAYRKLLEGEEERLKLSPSPSSRITISRATSSSSSSGVG 405
Score = 40.4 bits (93), Expect = 0.007
Identities = 36/143 (25%), Positives = 67/143 (46%), Gaps = 1/143 (0%)
Frame = +3
Query: 336 YESKLAEELRSIREETAEEFEGYKLEFEQSFMLRLAELKKSNQQTNENIVKARDEMLIWR 515
YES+LA+ R + +ETA E ++E + L E +KS ++ + A+ +
Sbjct: 74 YESELADA-RRVLDETARERARLQIEIGK-VQAELEEARKSAKKREGELTVAQGRVKDLE 131
Query: 516 SKAEKYEQELAMKASENDTLKKRIKDLESLLSFERNEFEEQLKHFREESDQLRNDLQKRL 695
S + E ELA S+N+ L+ + +L + L+ + K +E+ +R DL+ R
Sbjct: 132 SLFHRSEAELATALSDNEGLETEVAELRAQLAKAEDGHAVAKKQLEKET-LMRVDLENRC 190
Query: 696 NDF-SNLMSTKIALDQEILMYRK 761
L +K ++E+ R+
Sbjct: 191 QSLQEELAFSKSVFEEEVRETRR 213
>sp|P11516|LAMC_MOUSE Lamins C and C2
Length = 574
Score = 125 bits (315), Expect = 1e-28
Identities = 79/286 (27%), Positives = 147/286 (51%)
Frame = +3
Query: 6 LSKELERRDLELQALQRKIDSLERDISKQKSDSERYMTLLTQHDTLEKRCAKLSKDLDAE 185
L+ + +DLE L K +L +S++++ L Q LE + K L E
Sbjct: 128 LAAQARLKDLEA-LLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDE 186
Query: 186 ILLRTDIENKNVTLKEQLEFNERLYNEEHTKMKQHQXXXXXXXXDRKHAEYESKLAEELR 365
+L R D EN+ TLKE+L+F + +Y+EE + K+ + K E+ES+LA+ L+
Sbjct: 187 MLRRVDAENRLQTLKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQ 246
Query: 366 SIREETAEEFEGYKLEFEQSFMLRLAELKKSNQQTNENIVKARDEMLIWRSKAEKYEQEL 545
+R + ++ E YK E E+++ +L ++S ++ + + A +E+ R + + +L
Sbjct: 247 ELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQL 306
Query: 546 AMKASENDTLKKRIKDLESLLSFERNEFEEQLKHFREESDQLRNDLQKRLNDFSNLMSTK 725
+ + + +++DLE L+ ER+ L E ++R +Q++L+++ L+ K
Sbjct: 307 SQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIK 366
Query: 726 IALDQEILMYRKLLESEEARCNINVAADGDTSFSVLNAGSKRRKVG 863
+ALD EI YRKLLE EE R ++ + S ++ S + + G
Sbjct: 367 LALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQSQGG 412
Score = 33.5 bits (75), Expect = 0.84
Identities = 42/162 (25%), Positives = 74/162 (45%), Gaps = 25/162 (15%)
Frame = +3
Query: 375 EETAEEFEGYKLEFEQSFMLRLAELKKSNQQTNENIVKARDEMLIWRSKAEKYEQELAMK 554
E + E G K +E AEL + ++T +++ K R + + SK + +EL +
Sbjct: 68 EVVSREVSGIKAAYE-------AELGDA-RKTLDSVAKERARLQLELSKVREEFKELKAR 119
Query: 555 AS--ENDTL--KKRIKDLESLLS----------FERNEFEEQLKHFR-----------EE 659
+ E D L + R+KDLE+LL+ E+ E +L R E
Sbjct: 120 NTKKEGDLLAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEA 179
Query: 660 SDQLRNDLQKRLNDFSNLMSTKIALDQEILMYRKLLESEEAR 785
QL++++ +R++ + L + K LD ++K + SEE R
Sbjct: 180 KKQLQDEMLRRVDAENRLQTLKEELD-----FQKNIYSEELR 216
>sp|P48679|LAMA_RAT Lamin A
Length = 665
Score = 125 bits (315), Expect = 1e-28
Identities = 79/286 (27%), Positives = 147/286 (51%)
Frame = +3
Query: 6 LSKELERRDLELQALQRKIDSLERDISKQKSDSERYMTLLTQHDTLEKRCAKLSKDLDAE 185
L+ + +DLE L K +L +S++++ L Q LE + K L E
Sbjct: 128 LAAQARLKDLEA-LLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDE 186
Query: 186 ILLRTDIENKNVTLKEQLEFNERLYNEEHTKMKQHQXXXXXXXXDRKHAEYESKLAEELR 365
+L R D EN+ TLKE+L+F + +Y+EE + K+ + K E+ES+LA+ L+
Sbjct: 187 MLRRVDAENRLQTLKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQ 246
Query: 366 SIREETAEEFEGYKLEFEQSFMLRLAELKKSNQQTNENIVKARDEMLIWRSKAEKYEQEL 545
+R + ++ E YK E E+++ +L ++S ++ + + A +E+ R + + +L
Sbjct: 247 ELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQL 306
Query: 546 AMKASENDTLKKRIKDLESLLSFERNEFEEQLKHFREESDQLRNDLQKRLNDFSNLMSTK 725
+ + + +++DLE L+ ER+ L E ++R +Q++L+++ L+ K
Sbjct: 307 SQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIK 366
Query: 726 IALDQEILMYRKLLESEEARCNINVAADGDTSFSVLNAGSKRRKVG 863
+ALD EI YRKLLE EE R ++ + S ++ S + + G
Sbjct: 367 LALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQSQGG 412
Score = 33.5 bits (75), Expect = 0.84
Identities = 42/162 (25%), Positives = 74/162 (45%), Gaps = 25/162 (15%)
Frame = +3
Query: 375 EETAEEFEGYKLEFEQSFMLRLAELKKSNQQTNENIVKARDEMLIWRSKAEKYEQELAMK 554
E + E G K +E AEL + ++T +++ K R + + SK + +EL +
Sbjct: 68 EVVSREVSGIKAAYE-------AELGDA-RKTLDSVAKERARLQLELSKVREEFKELKAR 119
Query: 555 AS--ENDTL--KKRIKDLESLLS----------FERNEFEEQLKHFR-----------EE 659
+ E D L + R+KDLE+LL+ E+ E +L R E
Sbjct: 120 NTKKEGDLLAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEA 179
Query: 660 SDQLRNDLQKRLNDFSNLMSTKIALDQEILMYRKLLESEEAR 785
QL++++ +R++ + L + K LD ++K + SEE R
Sbjct: 180 KKQLQDEMLRRVDAENRLQTLKEELD-----FQKNIYSEELR 216
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,650,373
Number of Sequences: 369166
Number of extensions: 1524887
Number of successful extensions: 8927
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 7245
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 8386
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9126484700
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)