Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_015_E24
(501 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 243 1e-64
sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 237 1e-62
sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 237 1e-62
sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 235 5e-62
sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 223 2e-58
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 214 9e-56
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 197 1e-50
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 180 1e-45
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precu... 175 6e-44
sp|P19092|CYSP1_HAECO Cathepsin B-like cysteine proteinase ... 172 3e-43
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 243 bits (621), Expect = 1e-64
Identities = 108/167 (64%), Positives = 128/167 (76%)
Frame = +1
Query: 1 VEAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEY 180
VEAI+DR CIHSNG +SAED+LTCCG CGDGCNGGFPSGAW++W GLV+GG Y
Sbjct: 114 VEAISDRICIHSNGRVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLY 173
Query: 181 GAHLGCQDYAFPKCSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVD 360
+H+GC+ Y+ P C HHV G P CTGE TPKC K C+ GYS +Y EDK +G SSYSV
Sbjct: 174 NSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCNKTCEPGYSPSYKEDKHFGCSSYSVA 233
Query: 361 SNQQAIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVTGGMLGGHAI 501
+N++ IM EI NGPVE AFSVY+DF YKSGVYQHV+G ++GGHAI
Sbjct: 234 NNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAI 280
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B
light chain; Cathepsin B heavy chain]
Length = 339
Score = 237 bits (604), Expect = 1e-62
Identities = 102/167 (61%), Positives = 125/167 (74%)
Frame = +1
Query: 1 VEAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEY 180
VEA++DR CIH+NG +SAEDLLTCCG +CGDGCNGG+PSGAW++W GLV+GG Y
Sbjct: 114 VEAMSDRICIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVY 173
Query: 181 GAHLGCQDYAFPKCSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVD 360
+H+GC Y P C HHV G P CTGE TPKC K C+AGYS +Y EDK YG +SYSV
Sbjct: 174 NSHIGCLPYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVS 233
Query: 361 SNQQAIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVTGGMLGGHAI 501
+++ IM EI NGPVE AF+V++DF YKSGVY+H G ++GGHAI
Sbjct: 234 DSEKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMGGHAI 280
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS)
[Contains: Cathepsin B light chain; Cathepsin B heavy
chain]
Length = 339
Score = 237 bits (604), Expect = 1e-62
Identities = 105/167 (62%), Positives = 127/167 (76%)
Frame = +1
Query: 1 VEAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEY 180
VEAI+DR CIH+N + +SAEDLLTCCG CGDGCNGG+P+ AW++W GLV+GG Y
Sbjct: 114 VEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLY 173
Query: 181 GAHLGCQDYAFPKCSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVD 360
+H+GC+ Y+ P C HHV G P CTGE TPKC K C+ GYS TY +DK YG +SYSV
Sbjct: 174 ESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVS 233
Query: 361 SNQQAIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVTGGMLGGHAI 501
++++ IM EI NGPVE AFSVY+DF YKSGVYQHVTG M+GGHAI
Sbjct: 234 NSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAI 280
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 339
Score = 235 bits (599), Expect = 5e-62
Identities = 102/167 (61%), Positives = 125/167 (74%)
Frame = +1
Query: 1 VEAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEY 180
VEAI+DR CIH+NG +SAEDLLTCCG +CGDGCNGG+PSGAW +W GLV+GG Y
Sbjct: 114 VEAISDRTCIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWSFWTKKGLVSGGVY 173
Query: 181 GAHLGCQDYAFPKCSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVD 360
+H+GC Y P C HHV G P CTGE TP+C K+C+AGYS +Y EDK +G +SYSV
Sbjct: 174 NSHVGCLPYTIPPCEHHVNGSRPPCTGEGDTPRCNKSCEAGYSPSYKEDKHFGYTSYSVS 233
Query: 361 SNQQAIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVTGGMLGGHAI 501
++ + IM EI NGPVE AF+V++DF YKSGVY+H G M+GGHAI
Sbjct: 234 NSVKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDMMGGHAI 280
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 340
Score = 223 bits (568), Expect = 2e-58
Identities = 100/168 (59%), Positives = 121/168 (72%), Gaps = 1/168 (0%)
Frame = +1
Query: 1 VEAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEY 180
VEAI+DR C+H+N + +SAEDLL+CCGF CG GCNGG+PSGAW YW GLV+GG Y
Sbjct: 114 VEAISDRICVHTNAKVSVEVSAEDLLSCCGFECGMGCNGGYPSGAWRYWTERGLVSGGLY 173
Query: 181 GAHLGCQDYAFPKCSHHVIGPYPNCTGE-FPTPKCKKACQAGYSKTYAEDKQYGKSSYSV 357
+H+GC+ Y P C HHV G P CTGE TP+C + C+ GYS +Y EDK YG +SY V
Sbjct: 174 DSHVGCRAYTIPPCEHHVNGSRPPCTGEGGETPRCSRHCEPGYSPSYKEDKHYGITSYGV 233
Query: 358 DSNQQAIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVTGGMLGGHAI 501
+++ IM EI NGPVE AF VY DF YKSGVYQHV+G +GGHAI
Sbjct: 234 PRSEKEIMAEIYKNGPVEGAFIVYEDFLMYKSGVYQHVSGEQVGGHAI 281
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31)
Length = 342
Score = 214 bits (545), Expect = 9e-56
Identities = 97/168 (57%), Positives = 118/168 (70%), Gaps = 1/168 (0%)
Frame = +1
Query: 1 VEAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEY 180
VEA+TDR CI S G Q+ +SA DL++CC CGDGC GGFP AW YWV G+VTGG
Sbjct: 124 VEAMTDRICIQSGGGQSAELSALDLISCCK-DCGDGCQGGFPGVAWDYWVKRGIVTGGSK 182
Query: 181 GAHLGCQDYAFPKCSHHVIGPYPNC-TGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSV 357
H GCQ Y FPKC HH G YP C T + TP+CK+ CQ GY Y +DK YG SY+V
Sbjct: 183 ENHTGCQPYPFPKCEHHTKGKYPACGTKIYKTPQCKQTCQKGYKTPYEQDKHYGDESYNV 242
Query: 358 DSNQQAIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVTGGMLGGHAI 501
+N++ I ++I+ GPVEAAF VY DF NYKSG+Y+HVTG ++GGHAI
Sbjct: 243 QNNEKVIQRDIMMYGPVEAAFDVYEDFLNYKSGIYRHVTGSIVGGHAI 290
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31)
Length = 340
Score = 197 bits (501), Expect = 1e-50
Identities = 91/168 (54%), Positives = 114/168 (67%), Gaps = 1/168 (0%)
Frame = +1
Query: 1 VEAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEY 180
VEA++DR CI S G Q +SA DLLTCC CG GC GG AW YWV +G+VT
Sbjct: 123 VEAMSDRSCIQSGGKQNVELSAVDLLTCCE-SCGLGCEGGILGPAWDYWVKEGIVTASSK 181
Query: 181 GAHLGCQDYAFPKCSHHVIGPYPNCTGE-FPTPKCKKACQAGYSKTYAEDKQYGKSSYSV 357
H GC+ Y FPKC HH G YP C + + TP+CK+ CQ Y Y +DK GKSSY+V
Sbjct: 182 ENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNV 241
Query: 358 DSNQQAIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVTGGMLGGHAI 501
++++AI +EI+ GPVEA+F+VY DF NYKSG+Y+H+TG LGGHAI
Sbjct: 242 KNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAI 289
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine
protease-related 6)
Length = 379
Score = 180 bits (457), Expect = 1e-45
Identities = 88/172 (51%), Positives = 114/172 (66%), Gaps = 5/172 (2%)
Frame = +1
Query: 1 VEAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEY 180
VEA++DR CI S+G +SA+DLL+CC CG GCNGG P AW YWV DG+VTG Y
Sbjct: 139 VEAMSDRICIASHGELQVTLSADDLLSCCK-SCGFGCNGGDPLAAWRYWVKDGIVTGSNY 197
Query: 181 GAHLGCQDYAFPKCSHHV----IGPYPNCTGEFPTPKCKKACQAGYS-KTYAEDKQYGKS 345
A+ GC+ Y FP C HH P P+ +PTPKC+K C + Y+ KTY+EDK +G S
Sbjct: 198 TANNGCKPYPFPPCEHHSKKTHFDPCPHDL--YPTPKCEKKCVSDYTDKTYSEDKFFGAS 255
Query: 346 SYSVDSNQQAIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVTGGMLGGHAI 501
+Y V + +AI +E++T+GP+E AF VY DF NY GVY H G + GGHA+
Sbjct: 256 AYGVKDDVEAIQKELMTHGPLEIAFEVYEDFLNYDGGVYVHTGGKLGGGHAV 307
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor
Length = 329
Score = 175 bits (443), Expect = 6e-44
Identities = 86/166 (51%), Positives = 106/166 (63%)
Frame = +1
Query: 4 EAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYG 183
E I+DR CI + G Q P IS +DLL+CCG CG+GC GG+P A +W + G+VTGG+Y
Sbjct: 120 EMISDRTCIETKGAQQPIISPDDLLSCCGSSCGNGCEGGYPIQALRWWDSKGVVTGGDYH 179
Query: 184 AHLGCQDYAFPKCSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDS 363
GC+ Y C+ NC E TP C +CQ+GYS YA+DK +G S+Y+V
Sbjct: 180 G-AGCKPYPIAPCTSG------NCP-ESKTPSCSMSCQSGYSTAYAKDKHFGVSAYAVPK 231
Query: 364 NQQAIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVTGGMLGGHAI 501
N +I EI NGPVEAAFSVY DF YKSGVY+H G LGGHAI
Sbjct: 232 NAASIQAEIYANGPVEAAFSVYEDFYKYKSGVYKHTAGKYLGGHAI 277
>sp|P19092|CYSP1_HAECO Cathepsin B-like cysteine proteinase 1 precursor
Length = 342
Score = 172 bits (437), Expect = 3e-43
Identities = 81/166 (48%), Positives = 105/166 (63%), Gaps = 1/166 (0%)
Frame = +1
Query: 7 AITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGA 186
AI+DR CI S + ISA D++TCC +CGDGC GG+P AW Y++ DG+V+GGEY
Sbjct: 122 AISDRICIASKAEKQVNISATDIMTCCRPQCGDGCEGGWPIEAWKYFIYDGVVSGGEYLT 181
Query: 187 HLGCQDYAFPKCSHHVIGPY-PNCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDS 363
C+ Y C HH Y C G PTP CK+ C+ G K Y DK+YGK +Y V
Sbjct: 182 KDVCRPYPIHPCGHHGNDTYYGECRGTAPTPPCKRKCRPGVRKMYRIDKRYGKDAYIVKQ 241
Query: 364 NQQAIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVTGGMLGGHAI 501
+ +AI EIL NGPV A+F+VY DF +YKSG+Y+H G + G HA+
Sbjct: 242 SVKAIQSEILRNGPVVASFAVYEDFRHYKSGIYKHTAGELRGYHAV 287
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,865,837
Number of Sequences: 369166
Number of extensions: 1439105
Number of successful extensions: 4757
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4445
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4693
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 3168768640
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)