Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_015_E06
(697 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 330 2e-90
sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 325 9e-89
sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 323 3e-88
sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 318 9e-87
sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 306 3e-83
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 285 6e-77
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 276 3e-74
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 258 8e-69
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5... 254 2e-67
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precu... 250 3e-66
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 330 bits (846), Expect = 2e-90
Identities = 144/213 (67%), Positives = 167/213 (78%)
Frame = +1
Query: 1 TDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHL 180
+DR CIHSNG +SAED+LTCCG CGDGCNGGFPSGAW++W GLV+GG Y +H+
Sbjct: 118 SDRICIHSNGRVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHV 177
Query: 181 GCQDYAFPKCSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQ 360
GC+ Y+ P C HHV G P CTGE TPKC K C+ GYS +Y EDK +G SSYSV +N++
Sbjct: 178 GCRPYSIPPCEHHVNGSRPPCTGEGDTPKCNKTCEPGYSPSYKEDKHFGCSSYSVANNEK 237
Query: 361 AIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLVA 540
IM EI NGPVE AFSVY+DF YKSGVYQHVSG ++GGHAI+ILGWGVEN TPYWLV
Sbjct: 238 EIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVG 297
Query: 541 NSWNPTWGDNGYFKILRGSDECGIEDEVVAGIP 639
NSWN WGDNG+FKILRG D CGIE E+VAG+P
Sbjct: 298 NSWNTDWGDNGFFKILRGQDHCGIESEIVAGMP 330
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS)
[Contains: Cathepsin B light chain; Cathepsin B heavy
chain]
Length = 339
Score = 325 bits (832), Expect = 9e-89
Identities = 142/214 (66%), Positives = 168/214 (78%)
Frame = +1
Query: 1 TDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHL 180
+DR CIH+N + +SAEDLLTCCG CGDGCNGG+P+ AW++W GLV+GG Y +H+
Sbjct: 118 SDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHV 177
Query: 181 GCQDYAFPKCSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQ 360
GC+ Y+ P C HHV G P CTGE TPKC K C+ GYS TY +DK YG +SYSV ++++
Sbjct: 178 GCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEK 237
Query: 361 AIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLVA 540
IM EI NGPVE AFSVY+DF YKSGVYQHV+G M+GGHAI+ILGWGVEN TPYWLVA
Sbjct: 238 DIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVA 297
Query: 541 NSWNPTWGDNGYFKILRGSDECGIEDEVVAGIPK 642
NSWN WGDNG+FKILRG D CGIE EVVAGIP+
Sbjct: 298 NSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPR 331
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B
light chain; Cathepsin B heavy chain]
Length = 339
Score = 323 bits (827), Expect = 3e-88
Identities = 137/214 (64%), Positives = 166/214 (77%)
Frame = +1
Query: 1 TDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHL 180
+DR CIH+NG +SAEDLLTCCG +CGDGCNGG+PSGAW++W GLV+GG Y +H+
Sbjct: 118 SDRICIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHI 177
Query: 181 GCQDYAFPKCSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQ 360
GC Y P C HHV G P CTGE TPKC K C+AGYS +Y EDK YG +SYSV +++
Sbjct: 178 GCLPYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEK 237
Query: 361 AIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLVA 540
IM EI NGPVE AF+V++DF YKSGVY+H +G ++GGHAI+ILGWG+EN PYWLVA
Sbjct: 238 EIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMGGHAIRILGWGIENGVPYWLVA 297
Query: 541 NSWNPTWGDNGYFKILRGSDECGIEDEVVAGIPK 642
NSWN WGDNG+FKILRG + CGIE E+VAGIP+
Sbjct: 298 NSWNVDWGDNGFFKILRGENHCGIESEIVAGIPR 331
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 339
Score = 318 bits (815), Expect = 9e-87
Identities = 136/214 (63%), Positives = 165/214 (77%)
Frame = +1
Query: 1 TDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHL 180
+DR CIH+NG +SAEDLLTCCG +CGDGCNGG+PSGAW +W GLV+GG Y +H+
Sbjct: 118 SDRTCIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHV 177
Query: 181 GCQDYAFPKCSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQ 360
GC Y P C HHV G P CTGE TP+C K+C+AGYS +Y EDK +G +SYSV ++ +
Sbjct: 178 GCLPYTIPPCEHHVNGSRPPCTGEGDTPRCNKSCEAGYSPSYKEDKHFGYTSYSVSNSVK 237
Query: 361 AIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLVA 540
IM EI NGPVE AF+V++DF YKSGVY+H +G M+GGHAI+ILGWGVEN PYWL A
Sbjct: 238 EIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDMMGGHAIRILGWGVENGVPYWLAA 297
Query: 541 NSWNPTWGDNGYFKILRGSDECGIEDEVVAGIPK 642
NSWN WGDNG+FKILRG + CGIE E+VAGIP+
Sbjct: 298 NSWNLDWGDNGFFKILRGENHCGIESEIVAGIPR 331
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 340
Score = 306 bits (784), Expect = 3e-83
Identities = 134/216 (62%), Positives = 160/216 (74%), Gaps = 1/216 (0%)
Frame = +1
Query: 1 TDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHL 180
+DR C+H+N + +SAEDLL+CCGF CG GCNGG+PSGAW YW GLV+GG Y +H+
Sbjct: 118 SDRICVHTNAKVSVEVSAEDLLSCCGFECGMGCNGGYPSGAWRYWTERGLVSGGLYDSHV 177
Query: 181 GCQDYAFPKCSHHVIGPYPNCTGEF-PTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQ 357
GC+ Y P C HHV G P CTGE TP+C + C+ GYS +Y EDK YG +SY V ++
Sbjct: 178 GCRAYTIPPCEHHVNGSRPPCTGEGGETPRCSRHCEPGYSPSYKEDKHYGITSYGVPRSE 237
Query: 358 QAIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLV 537
+ IM EI NGPVE AF VY DF YKSGVYQHVSG +GGHAI+ILGWGVEN TPYWL
Sbjct: 238 KEIMAEIYKNGPVEGAFIVYEDFLMYKSGVYQHVSGEQVGGHAIRILGWGVENGTPYWLA 297
Query: 538 ANSWNPTWGDNGYFKILRGSDECGIEDEVVAGIPKL 645
ANSWN WG G+FKILRG D CGIE E+VAG+P++
Sbjct: 298 ANSWNTDWGITGFFKILRGEDHCGIESEIVAGVPRM 333
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31)
Length = 342
Score = 285 bits (730), Expect = 6e-77
Identities = 125/215 (58%), Positives = 155/215 (72%), Gaps = 1/215 (0%)
Frame = +1
Query: 1 TDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHL 180
TDR CI S G Q+ +SA DL++CC CGDGC GGFP AW YWV G+VTGG H
Sbjct: 128 TDRICIQSGGGQSAELSALDLISCCK-DCGDGCQGGFPGVAWDYWVKRGIVTGGSKENHT 186
Query: 181 GCQDYAFPKCSHHVIGPYPNC-TGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQ 357
GCQ Y FPKC HH G YP C T + TP+CK+ CQ GY Y +DK YG SY+V +N+
Sbjct: 187 GCQPYPFPKCEHHTKGKYPACGTKIYKTPQCKQTCQKGYKTPYEQDKHYGDESYNVQNNE 246
Query: 358 QAIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLV 537
+ I ++I+ GPVEAAF VY DF NYKSG+Y+HV+G ++GGHAI+I+GWGVE TPYWL+
Sbjct: 247 KVIQRDIMMYGPVEAAFDVYEDFLNYKSGIYRHVTGSIVGGHAIRIIGWGVEKRTPYWLI 306
Query: 538 ANSWNPTWGDNGYFKILRGSDECGIEDEVVAGIPK 642
ANSWN WG+ G F+++RG DEC IE +VVAG+ K
Sbjct: 307 ANSWNEDWGEKGLFRMVRGRDECSIESDVVAGLIK 341
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31)
Length = 340
Score = 276 bits (707), Expect = 3e-74
Identities = 122/212 (57%), Positives = 152/212 (71%), Gaps = 1/212 (0%)
Frame = +1
Query: 1 TDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHL 180
+DR CI S G Q +SA DLLTCC CG GC GG AW YWV +G+VT H
Sbjct: 127 SDRSCIQSGGKQNVELSAVDLLTCCE-SCGLGCEGGILGPAWDYWVKEGIVTASSKENHT 185
Query: 181 GCQDYAFPKCSHHVIGPYPNCTGE-FPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQ 357
GC+ Y FPKC HH G YP C + + TP+CK+ CQ Y Y +DK GKSSY+V +++
Sbjct: 186 GCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKSSYNVKNDE 245
Query: 358 QAIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLV 537
+AI +EI+ GPVEA+F+VY DF NYKSG+Y+H++G LGGHAI+I+GWGVEN TPYWL+
Sbjct: 246 KAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGWGVENKTPYWLI 305
Query: 538 ANSWNPTWGDNGYFKILRGSDECGIEDEVVAG 633
ANSWN WG+NGYF+I+RG DEC IE EV+AG
Sbjct: 306 ANSWNEDWGENGYFRIVRGRDECSIESEVIAG 337
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine
protease-related 6)
Length = 379
Score = 258 bits (660), Expect = 8e-69
Identities = 119/220 (54%), Positives = 153/220 (69%), Gaps = 5/220 (2%)
Frame = +1
Query: 1 TDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHL 180
+DR CI S+G +SA+DLL+CC CG GCNGG P AW YWV DG+VTG Y A+
Sbjct: 143 SDRICIASHGELQVTLSADDLLSCCK-SCGFGCNGGDPLAAWRYWVKDGIVTGSNYTANN 201
Query: 181 GCQDYAFPKCSHHV----IGPYPNCTGEFPTPKCKKACQAGYS-KTYAEDKQYGKSSYSV 345
GC+ Y FP C HH P P+ +PTPKC+K C + Y+ KTY+EDK +G S+Y V
Sbjct: 202 GCKPYPFPPCEHHSKKTHFDPCPHDL--YPTPKCEKKCVSDYTDKTYSEDKFFGASAYGV 259
Query: 346 DSNQQAIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTP 525
+ +AI +E++T+GP+E AF VY DF NY GVY H G + GGHA+K++GWG+++ P
Sbjct: 260 KDDVEAIQKELMTHGPLEIAFEVYEDFLNYDGGVYVHTGGKLGGGHAVKLIGWGIDDGIP 319
Query: 526 YWLVANSWNPTWGDNGYFKILRGSDECGIEDEVVAGIPKL 645
YW VANSWN WG++G+F+ILRG DECGIE VV GIPKL
Sbjct: 320 YWTVANSWNTDWGEDGFFRILRGVDECGIESGVVGGIPKL 359
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 precursor (Cysteine
protease-related 5)
Length = 344
Score = 254 bits (649), Expect = 2e-67
Identities = 118/221 (53%), Positives = 148/221 (66%), Gaps = 6/221 (2%)
Frame = +1
Query: 1 TDRYCIHSNGTQTPRISAEDLLTCCG--FRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGA 174
+DR CI SNG +S+EDLL+CC F CG+GC GG+P AW +WV GLVTGG Y
Sbjct: 120 SDRTCIASNGAVNTLLSSEDLLSCCTGMFSCGNGCEGGYPIQAWKWWVKHGLVTGGSYET 179
Query: 175 HLGCQDYAFPKCSHHVIG-PYPNCTGEF-PTPKCKKACQA--GYSKTYAEDKQYGKSSYS 342
GC+ Y+ C V G +P C + PTPKC +C + Y+ Y +DK +G ++Y+
Sbjct: 180 QFGCKPYSIAPCGETVNGVKWPACPEDTEPTPKCVDSCTSKNNYATPYLQDKHFGSTAYA 239
Query: 343 VDSNQQAIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNT 522
V + I EILTNGP+E AF+VY DF Y +GVY H +G LGGHA+KILGWGV+N T
Sbjct: 240 VGKKVEQIQTEILTNGPIEVAFTVYEDFYQYTTGVYVHTAGASLGGHAVKILGWGVDNGT 299
Query: 523 PYWLVANSWNPTWGDNGYFKILRGSDECGIEDEVVAGIPKL 645
PYWLVANSWN WG+ GYF+I+RG +ECGIE VAGIP L
Sbjct: 300 PYWLVANSWNVAWGEKGYFRIIRGLNECGIEHSAVAGIPDL 340
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor
Length = 329
Score = 250 bits (638), Expect = 3e-66
Identities = 117/215 (54%), Positives = 146/215 (67%)
Frame = +1
Query: 1 TDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHL 180
+DR CI + G Q P IS +DLL+CCG CG+GC GG+P A +W + G+VTGG+Y
Sbjct: 123 SDRTCIETKGAQQPIISPDDLLSCCGSSCGNGCEGGYPIQALRWWDSKGVVTGGDYHG-A 181
Query: 181 GCQDYAFPKCSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQ 360
GC+ Y C+ NC E TP C +CQ+GYS YA+DK +G S+Y+V N
Sbjct: 182 GCKPYPIAPCTSG------NCP-ESKTPSCSMSCQSGYSTAYAKDKHFGVSAYAVPKNAA 234
Query: 361 AIMQEILTNGPVEAAFSVYADFPNYKSGVYQHVSGGMLGGHAIKILGWGVENNTPYWLVA 540
+I EI NGPVEAAFSVY DF YKSGVY+H +G LGGHAIKI+GWG E+ +PYWLVA
Sbjct: 235 SIQAEIYANGPVEAAFSVYEDFYKYKSGVYKHTAGKYLGGHAIKIIGWGTESGSPYWLVA 294
Query: 541 NSWNPTWGDNGYFKILRGSDECGIEDEVVAGIPKL 645
NSW WG++G+FKI RG D+CGIE VVAG K+
Sbjct: 295 NSWGVNWGESGFFKIYRGDDQCGIESAVVAGKAKV 329
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,386,163
Number of Sequences: 369166
Number of extensions: 2078245
Number of successful extensions: 6530
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5986
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6406
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6024953540
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)