Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_015_E01
(768 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9H1P3|OSR2_HUMAN Oxysterol binding protein-related prot... 174 3e-43
sp|Q9BXW6|OSR1_HUMAN Oxysterol binding protein-related prot... 171 2e-42
sp|Q8BX94|OSR2_MOUSE Oxysterol binding protein-related prot... 167 4e-41
sp|Q91XL9|OSR1_MOUSE Oxysterol binding protein-related prot... 164 2e-40
sp|Q9BZF3|OSR6_HUMAN Oxysterol binding protein-related prot... 117 3e-26
sp|Q8BXR9|OSR6_MOUSE Oxysterol binding protein-related prot... 116 6e-26
sp|Q969R2|OSB2_HUMAN Oxysterol-binding protein 2 (Oxysterol... 103 7e-22
sp|O14340|YB35_SCHPO Oxysterol-binding protein homolog C2F1... 102 1e-21
sp|Q12451|OSH2_YEAST Oxysterol-binding protein homolog 2 99 1e-20
sp|Q9H4L5|OSR3_HUMAN Oxysterol binding protein-related prot... 99 1e-20
>sp|Q9H1P3|OSR2_HUMAN Oxysterol binding protein-related protein 2 (OSBP-related protein
2) (ORP-2)
Length = 480
Score = 174 bits (440), Expect = 3e-43
Identities = 97/231 (41%), Positives = 127/231 (54%), Gaps = 1/231 (0%)
Frame = +3
Query: 3 SVVINPKGNLTLELLPWDEVYTWQNVTCTVHNVIIGKIWIEHSGPMRIINHSNNCIADLT 182
SV P+G +TLELL +E YTW N TC VHNVIIGK+WIE G + I+NH L
Sbjct: 210 SVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVIIGKLWIEQYGTVEILNHRTGHKCVLH 269
Query: 183 FHSVGWFGKNMHRVDGDIYYGQRKSKHVERKIYGKWTEALFSVSPDVWNXXXXXXXXXXX 362
F G FGK +H+V+G I Q K+K IYGKWTE L+ + P +
Sbjct: 270 FKPCGLFGKELHKVEGHI---QDKNKKKLFMIYGKWTECLWGIDPVSYESFKKQERRGDH 326
Query: 363 XXXQITNVEKGDINENDIDD-PLPQDNTPCDMKLLNQRLIWKAKSRPENSPIFYNFTSFT 539
+ + G + + DD P+ Q+ + +L+W+ +RP NS YNFTSFT
Sbjct: 327 LRKAKLDEDSGKADSDVADDVPVAQETV---QVIPGSKLLWRINTRPPNSAQMYNFTSFT 383
Query: 540 MGLNQLNDNFKNELPPTDSRFRQDMRYMENGLLDDAAGAKTYLEEKQRAKR 692
+ LN+L + LPPTD R R D+R MENG +D A+ K LEEKQR R
Sbjct: 384 VSLNELETGMEKTLPPTDCRLRPDIRGMENGNMDLASQEKERLEEKQREAR 434
>sp|Q9BXW6|OSR1_HUMAN Oxysterol binding protein-related protein 1 (OSBP-related protein 1)
(ORP-1)
Length = 950
Score = 171 bits (434), Expect = 2e-42
Identities = 97/233 (41%), Positives = 128/233 (54%), Gaps = 3/233 (1%)
Frame = +3
Query: 3 SVVINPKGNLTLELLPWDEVYTWQNVTCTVHNVIIGKIWIEHSGPMRIINHSNNCIADLT 182
SV PKG +TLELL +E YTW N TC VHN+I+GK+WIE G + IINH L
Sbjct: 683 SVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLN 742
Query: 183 FHSVGWFGKNMHRVDGDIYYGQRKSKHVERKIYGKWTEALFSVSP---DVWNXXXXXXXX 353
F G FGK +H+V+G Y Q KSK +YGKWTE L+SV P D +
Sbjct: 743 FKPCGLFGKELHKVEG---YIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTE 799
Query: 354 XXXXXXQITNVEKGDINENDIDDPLPQDNTPCDMKLLNQRLIWKAKSRPENSPIFYNFTS 533
Q++ E+ D +P ++ + L+W+ RP NS YNFTS
Sbjct: 800 EKKNSKQMSTSEE--------LDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTS 851
Query: 534 FTMGLNQLNDNFKNELPPTDSRFRQDMRYMENGLLDDAAGAKTYLEEKQRAKR 692
F M LN+++ + ++ +P TD R R D+R MENG +D A+ K LEEKQRA R
Sbjct: 852 FAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAAR 904
>sp|Q8BX94|OSR2_MOUSE Oxysterol binding protein-related protein 2 (OSBP-related protein
2) (ORP-2)
Length = 484
Score = 167 bits (422), Expect = 4e-41
Identities = 95/235 (40%), Positives = 126/235 (53%), Gaps = 5/235 (2%)
Frame = +3
Query: 3 SVVINPKGNLTLELLPWDEVYTWQNVTCTVHNVIIGKIWIEHSGPMRIINHSNNCIADLT 182
SV P+G +TLELL +E YTW N TC VHNVI+G++WIE G + I+NH L
Sbjct: 210 SVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVILGQLWIEQYGIVEIVNHRTGDKCILH 269
Query: 183 FHSVGWFGKNMHRVDGDIYYGQRKSKHVERKIYGKWTEALFSVSPDVWNXXXXXXXXXXX 362
F G FGK +HRV+G I RK + +YGKWTE L+ + P +
Sbjct: 270 FKPCGLFGKELHRVEGYIQDKNRKKLFI---MYGKWTECLWGIDPASYE--SFKKQEKRG 324
Query: 363 XXXQITNVEKGDINEN-----DIDDPLPQDNTPCDMKLLNQRLIWKAKSRPENSPIFYNF 527
+ ++ G N D+ D +P + + +L+W+ SRP NS YNF
Sbjct: 325 DQARKAKMDDGPEKANSDVPGDVADDVPVAQETVQV-IPGSKLLWRINSRPPNSAQMYNF 383
Query: 528 TSFTMGLNQLNDNFKNELPPTDSRFRQDMRYMENGLLDDAAGAKTYLEEKQRAKR 692
TSFT+ LN+L + LPPTD R R D+R MENG +D A+ K LEEKQR R
Sbjct: 384 TSFTVSLNELESGMEKTLPPTDCRLRPDIRGMENGNMDLASQEKERLEEKQREAR 438
>sp|Q91XL9|OSR1_MOUSE Oxysterol binding protein-related protein 1 (OSBP-related protein
1) (ORP-1)
Length = 437
Score = 164 bits (416), Expect = 2e-40
Identities = 94/233 (40%), Positives = 125/233 (53%), Gaps = 3/233 (1%)
Frame = +3
Query: 3 SVVINPKGNLTLELLPWDEVYTWQNVTCTVHNVIIGKIWIEHSGPMRIINHSNNCIADLT 182
SV PKG +TLEL +E YTW N TC V N+I+GK+WIE G + II H L
Sbjct: 170 SVKAEPKGTITLELFVHNEAYTWTNPTCCVQNIIVGKLWIEQYGNVEIITHKTGDKCVLN 229
Query: 183 FHSVGWFGKNMHRVDGDIYYGQRKSKHVERKIYGKWTEALFSVSP---DVWNXXXXXXXX 353
F+ G FGK +H+V+G I Q KSK +YGKWTE L+SV P D +
Sbjct: 230 FNPCGLFGKELHKVEGSI---QDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTE 286
Query: 354 XXXXXXQITNVEKGDINENDIDDPLPQDNTPCDMKLLNQRLIWKAKSRPENSPIFYNFTS 533
Q ++ E+ D +P ++ + L+W+ RP NS YNFTS
Sbjct: 287 EKKNSKQTSSSEE--------SDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTS 338
Query: 534 FTMGLNQLNDNFKNELPPTDSRFRQDMRYMENGLLDDAAGAKTYLEEKQRAKR 692
F M LN+++ ++ +P TD R R D+R MENG +D A+ K LEEKQRA R
Sbjct: 339 FAMVLNEVDKEMESVIPKTDCRLRPDIRAMENGEIDLASEEKKRLEEKQRAAR 391
>sp|Q9BZF3|OSR6_HUMAN Oxysterol binding protein-related protein 6 (OSBP-related protein 6)
(ORP-6)
Length = 934
Score = 117 bits (294), Expect = 3e-26
Identities = 73/232 (31%), Positives = 110/232 (47%), Gaps = 2/232 (0%)
Frame = +3
Query: 3 SVVINPKGNLTLELLPWDEVYTWQNVTCTVHNVIIGKIWIEHSGPMRIIN-HSNNCIADL 179
S+ I P G L + L + + Y W VT +HN++ G+ WIEH G + I N S+ CI L
Sbjct: 704 SMEILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKL 763
Query: 180 TFHSVGWFGKNMHRVDGDIYYGQRKSKHVERKIYGKWTEALF-SVSPDVWNXXXXXXXXX 356
TF V ++ NM+ V G + + K+ + +++GKW E L+ V+P
Sbjct: 764 TFVKVNYWNSNMNEVQGVVIDQEGKAVY---RLFGKWHEGLYCGVAPSA----------- 809
Query: 357 XXXXXQITNVEKGDINENDIDDPLPQDNTPCDMKLLNQRLIWKAKSRPENSPIFYNFTSF 536
+ IW+ S P N ++Y FT F
Sbjct: 810 --------------------------------------KCIWRPGSMPTNYELYYGFTRF 831
Query: 537 TMGLNQLNDNFKNELPPTDSRFRQDMRYMENGLLDDAAGAKTYLEEKQRAKR 692
+ LN+L+ K+ LPPTD+RFR D R++E G L+ AA K +EE QR++R
Sbjct: 832 AIELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAASEKQRVEELQRSRR 883
>sp|Q8BXR9|OSR6_MOUSE Oxysterol binding protein-related protein 6 (OSBP-related protein 6)
(ORP-6)
Length = 959
Score = 116 bits (291), Expect = 6e-26
Identities = 72/232 (31%), Positives = 109/232 (46%), Gaps = 2/232 (0%)
Frame = +3
Query: 3 SVVINPKGNLTLELLPWDEVYTWQNVTCTVHNVIIGKIWIEHSGPMRIIN-HSNNCIADL 179
S+ I P G L + L + + Y W VT +HN++ G+ WIEH G + + N S+ CI L
Sbjct: 729 SMEILPVGTLNVTLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTLRNTKSSVCICKL 788
Query: 180 TFHSVGWFGKNMHRVDGDIYYGQRKSKHVERKIYGKWTEALF-SVSPDVWNXXXXXXXXX 356
TF V ++ N++ V G + + K H +++GKW E L+ V+P
Sbjct: 789 TFVKVNYWNSNVNEVQGVVIDQEGKVVH---RLFGKWHEGLYCGVAPSA----------- 834
Query: 357 XXXXXQITNVEKGDINENDIDDPLPQDNTPCDMKLLNQRLIWKAKSRPENSPIFYNFTSF 536
+ IW+ S P N ++Y FT F
Sbjct: 835 --------------------------------------KCIWRPGSLPTNYELYYGFTRF 856
Query: 537 TMGLNQLNDNFKNELPPTDSRFRQDMRYMENGLLDDAAGAKTYLEEKQRAKR 692
+ LN+L+ K+ LPPTD+RFR D R++E G L+ AA K +EE QR++R
Sbjct: 857 AVELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAAAEKQRVEELQRSRR 908
>sp|Q969R2|OSB2_HUMAN Oxysterol-binding protein 2 (Oxysterol binding protein-related
protein 4) (OSBP-related protein 4) (ORP-4)
Length = 878
Score = 103 bits (256), Expect = 7e-22
Identities = 70/230 (30%), Positives = 98/230 (42%), Gaps = 1/230 (0%)
Frame = +3
Query: 6 VVINPKGNLTLELLPWDEVYTWQNVTCTVHNVIIGKIWIEHSGPMRIINHSNNCIADLTF 185
+ I P G + LE Y W+ T TVHN+I+GK+WI+ SG + I+NH N L F
Sbjct: 620 ISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTNDRCQLKF 679
Query: 186 HSVGWFGKNMHR-VDGDIYYGQRKSKHVERKIYGKWTEALFSVSPDVWNXXXXXXXXXXX 362
+F K R V G + Q K+ +V + G W E
Sbjct: 680 LPYSYFSKEAARKVTGVVSDSQGKAHYV---LSGSWDE---------------------- 714
Query: 363 XXXQITNVEKGDINENDIDDPLPQDNTPCDMKLLNQRLIWKAKSRPENSPIFYNFTSFTM 542
+E + + P + L+ +L+WK PEN+ Y F+ +
Sbjct: 715 ------QMECSKVMHSSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMYYFSELAL 768
Query: 543 GLNQLNDNFKNELPPTDSRFRQDMRYMENGLLDDAAGAKTYLEEKQRAKR 692
LN+ + + PTDSR R D R ME G D+A K LEEKQR R
Sbjct: 769 TLNEHEEG----VAPTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSR 814
>sp|O14340|YB35_SCHPO Oxysterol-binding protein homolog C2F12.05c
Length = 1310
Score = 102 bits (253), Expect = 1e-21
Identities = 77/232 (33%), Positives = 100/232 (43%), Gaps = 5/232 (2%)
Frame = +3
Query: 12 INPKGNLTLELL-PWDEV--YTWQNVTCTVHNVIIGKIWIEHSGPMRIINHSN--NCIAD 176
I+P G LEL P EV YTW+ VT +V +I+G +++ G M I+NHS+ NC+ D
Sbjct: 1073 ISPLGTWFLELRHPSGEVELYTWKKVTSSVVGIILGSPSVDNYGQMHIVNHSSGINCVLD 1132
Query: 177 LTFHSVGWFGKNMHRVDGDIYYGQRKSKHVERKIYGKWTEALFSVSPDVWNXXXXXXXXX 356
F GW G N H V G + K + + G W + +F P+
Sbjct: 1133 --FKPRGWRGTNAHEVKGSVQSTDDTPKWM---VNGHWNDKIFGQQPNG----------- 1176
Query: 357 XXXXXQITNVEKGDINENDIDDPLPQDNTPCDMKLLNQRLIWKAKSRPENSPIFYNFTSF 536
N+ L+W+ RP P +N T F
Sbjct: 1177 ------------------------------------NKILLWQNHERP---PRPFNLTPF 1197
Query: 537 TMGLNQLNDNFKNELPPTDSRFRQDMRYMENGLLDDAAGAKTYLEEKQRAKR 692
+ LN L K LPPTD+R R D R MENG D AA K LEEKQR KR
Sbjct: 1198 AISLNALTPQLKPWLPPTDTRLRPDQRAMENGQYDLAASEKNRLEEKQRKKR 1249
>sp|Q12451|OSH2_YEAST Oxysterol-binding protein homolog 2
Length = 1283
Score = 99.4 bits (246), Expect = 1e-20
Identities = 65/213 (30%), Positives = 96/213 (45%)
Frame = +3
Query: 54 DEVYTWQNVTCTVHNVIIGKIWIEHSGPMRIINHSNNCIADLTFHSVGWFGKNMHRVDGD 233
+E+YTW+ TV ++IG +++ G + ++NH+ L F + GW + + G+
Sbjct: 1051 EELYTWKKPNNTVIGILIGNPQVDNHGEVNVVNHTTGDHCKLYFKARGWRSSGAYEITGE 1110
Query: 234 IYYGQRKSKHVERKIYGKWTEALFSVSPDVWNXXXXXXXXXXXXXXQITNVEKGDINEND 413
+Y K K + G W EA+F+ V+ GD++
Sbjct: 1111 VY---NKKKQKVWILGGHWNEAIFAKKV----------------------VKDGDLSLEK 1145
Query: 414 IDDPLPQDNTPCDMKLLNQRLIWKAKSRPENSPIFYNFTSFTMGLNQLNDNFKNELPPTD 593
N P D + LIWKA RPE +N T F + LN + LPPTD
Sbjct: 1146 TRTAASAGNGPTDDG--TKFLIWKANDRPEEP---FNLTPFAITLNAPQPHLLPWLPPTD 1200
Query: 594 SRFRQDMRYMENGLLDDAAGAKTYLEEKQRAKR 692
+R R D R ME+G D+A K +EEKQRA R
Sbjct: 1201 TRLRPDQRAMEDGRYDEAGDEKFRVEEKQRAAR 1233
>sp|Q9H4L5|OSR3_HUMAN Oxysterol binding protein-related protein 3 (OSBP-related protein 3)
(ORP-3)
Length = 887
Score = 99.0 bits (245), Expect = 1e-20
Identities = 62/235 (26%), Positives = 106/235 (45%), Gaps = 5/235 (2%)
Frame = +3
Query: 3 SVVINPKGNLTLELLPWDEVYTWQNVTCTVHNVIIGKIWIEHSGPMRIIN-HSNNCIADL 179
S+ I P G + L + + + W VT +HN++ G+ WIEH G + I N H ++C +
Sbjct: 661 SMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCYCKV 720
Query: 180 TFHSVGWFGKNMHRVDGDIYYGQRKSKHVERKIYGKWTEALF----SVSPDVWNXXXXXX 347
F ++ N H ++G ++ K+ H +++GKW E+++ S S VW
Sbjct: 721 NFIKAKYWSTNAHEIEGTVFDRSGKAVH---RLFGKWHESIYCGGGSSSACVW------- 770
Query: 348 XXXXXXXXQITNVEKGDINENDIDDPLPQDNTPCDMKLLNQRLIWKAKSRPENSPIFYNF 527
+A P+ +Y+F
Sbjct: 771 ---------------------------------------------RANPMPKGYEQYYSF 785
Query: 528 TSFTMGLNQLNDNFKNELPPTDSRFRQDMRYMENGLLDDAAGAKTYLEEKQRAKR 692
T F + LN+++ + K+ LPPTD+RFR D R++E G L++A K +E+ QR +R
Sbjct: 786 TQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQLQRERR 840
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,328,449
Number of Sequences: 369166
Number of extensions: 1723398
Number of successful extensions: 3748
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3643
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3730
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7115329200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)