Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_015_D13
(622 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Z0Z0|KGP1B_MOUSE cGMP-dependent protein kinase 1, beta... 182 5e-46
sp|P14619|KGP1B_HUMAN cGMP-dependent protein kinase 1, beta... 182 6e-46
sp|P00516|KGP1A_BOVIN cGMP-dependent protein kinase 1, alph... 182 6e-46
sp|Q13976|KGP1A_HUMAN cGMP-dependent protein kinase 1, alph... 182 6e-46
sp|P21136|KGP1B_BOVIN cGMP-dependent protein kinase 1, beta... 182 6e-46
sp|O77676|KGP1A_RABIT cGMP-dependent protein kinase 1, alph... 182 8e-46
sp|P32023|KGP25_DROME cGMP-dependent protein kinase, isozym... 181 1e-45
sp|Q03043|KGP24_DROME cGMP-dependent protein kinase, isozym... 181 1e-45
sp|Q64595|KGP2_RAT cGMP-dependent protein kinase 2 (CGK 2) ... 162 5e-40
sp|Q61410|KGP2_MOUSE cGMP-dependent protein kinase 2 (CGK 2... 162 5e-40
>sp|Q9Z0Z0|KGP1B_MOUSE cGMP-dependent protein kinase 1, beta isozyme (CGK 1 beta)
(cGKI-beta)
Length = 686
Score = 182 bits (463), Expect = 5e-46
Identities = 94/196 (47%), Positives = 126/196 (64%), Gaps = 5/196 (2%)
Frame = +3
Query: 9 IVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAA 188
I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL GHD++A
Sbjct: 495 IIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISA 554
Query: 189 DYWSLGVLIYELLSGRPPFIASTISKTYDLVLIGMDTVEFPRYISK-----MPKI*SKNY 353
DYWSLG+L+YELL+G PPF KTY+++L G+D +EFP+ I+K + K+ N
Sbjct: 555 DYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNP 614
Query: 354 ADQILQID*VMESMV*QNVSSIYGFQISNQMSC*SNNEYPNYTSGSISTDRGNFGNVKPE 533
++++ + ++ + Q GF P S + TD NF + +
Sbjct: 615 SERLGNLKNGVKDI--QKHKWFEGFNWEGLRK--GTLTPPIIPSVASPTDTSNFDSFPED 670
Query: 534 LDDEPDDDVSGWDRDF 581
D+ P DD SGWD DF
Sbjct: 671 SDEPPPDDNSGWDIDF 686
Score = 47.0 bits (110), Expect = 4e-05
Identities = 22/43 (51%), Positives = 28/43 (65%)
Frame = +2
Query: 323 QDAQNLIKKLCRSNPSDRLGYGVDGLTKCFKHLWFSNFKSDEL 451
++A NLIKKLCR NPS+RLG +G+ KH WF F + L
Sbjct: 600 KNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGL 642
>sp|P14619|KGP1B_HUMAN cGMP-dependent protein kinase 1, beta isozyme (cGK 1 beta)
(cGKI-beta)
Length = 686
Score = 182 bits (462), Expect = 6e-46
Identities = 94/196 (47%), Positives = 126/196 (64%), Gaps = 5/196 (2%)
Frame = +3
Query: 9 IVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAA 188
I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL GHD++A
Sbjct: 495 IIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISA 554
Query: 189 DYWSLGVLIYELLSGRPPFIASTISKTYDLVLIGMDTVEFPRYISK-----MPKI*SKNY 353
DYWSLG+L+YELL+G PPF KTY+++L G+D +EFP+ I+K + K+ N
Sbjct: 555 DYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNP 614
Query: 354 ADQILQID*VMESMV*QNVSSIYGFQISNQMSC*SNNEYPNYTSGSISTDRGNFGNVKPE 533
++++ + ++ + Q GF P S + TD NF + +
Sbjct: 615 SERLGNLKNGVKDI--QKHKWFEGFNWEGLRK--GTLTPPIIPSVASPTDTSNFDSFPED 670
Query: 534 LDDEPDDDVSGWDRDF 581
D+ P DD SGWD DF
Sbjct: 671 NDEPPPDDNSGWDIDF 686
Score = 47.0 bits (110), Expect = 4e-05
Identities = 22/43 (51%), Positives = 28/43 (65%)
Frame = +2
Query: 323 QDAQNLIKKLCRSNPSDRLGYGVDGLTKCFKHLWFSNFKSDEL 451
++A NLIKKLCR NPS+RLG +G+ KH WF F + L
Sbjct: 600 KNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGL 642
>sp|P00516|KGP1A_BOVIN cGMP-dependent protein kinase 1, alpha isozyme (CGK 1 alpha)
(CGKI-alpha)
Length = 671
Score = 182 bits (462), Expect = 6e-46
Identities = 94/196 (47%), Positives = 126/196 (64%), Gaps = 5/196 (2%)
Frame = +3
Query: 9 IVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAA 188
I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL GHD++A
Sbjct: 480 IIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISA 539
Query: 189 DYWSLGVLIYELLSGRPPFIASTISKTYDLVLIGMDTVEFPRYISK-----MPKI*SKNY 353
DYWSLG+L+YELL+G PPF KTY+++L G+D +EFP+ I+K + K+ N
Sbjct: 540 DYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNP 599
Query: 354 ADQILQID*VMESMV*QNVSSIYGFQISNQMSC*SNNEYPNYTSGSISTDRGNFGNVKPE 533
++++ + ++ + Q GF P S + TD NF + +
Sbjct: 600 SERLGNLKNGVKDI--QKHKWFEGFNWEGLRK--GTLTPPIIPSVASPTDTSNFDSFPED 655
Query: 534 LDDEPDDDVSGWDRDF 581
D+ P DD SGWD DF
Sbjct: 656 NDEPPPDDNSGWDIDF 671
Score = 47.0 bits (110), Expect = 4e-05
Identities = 22/43 (51%), Positives = 28/43 (65%)
Frame = +2
Query: 323 QDAQNLIKKLCRSNPSDRLGYGVDGLTKCFKHLWFSNFKSDEL 451
++A NLIKKLCR NPS+RLG +G+ KH WF F + L
Sbjct: 585 KNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGL 627
>sp|Q13976|KGP1A_HUMAN cGMP-dependent protein kinase 1, alpha isozyme (CGK 1 alpha)
(cGKI-alpha)
Length = 671
Score = 182 bits (462), Expect = 6e-46
Identities = 94/196 (47%), Positives = 126/196 (64%), Gaps = 5/196 (2%)
Frame = +3
Query: 9 IVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAA 188
I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL GHD++A
Sbjct: 480 IIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISA 539
Query: 189 DYWSLGVLIYELLSGRPPFIASTISKTYDLVLIGMDTVEFPRYISK-----MPKI*SKNY 353
DYWSLG+L+YELL+G PPF KTY+++L G+D +EFP+ I+K + K+ N
Sbjct: 540 DYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNP 599
Query: 354 ADQILQID*VMESMV*QNVSSIYGFQISNQMSC*SNNEYPNYTSGSISTDRGNFGNVKPE 533
++++ + ++ + Q GF P S + TD NF + +
Sbjct: 600 SERLGNLKNGVKDI--QKHKWFEGFNWEGLRK--GTLTPPIIPSVASPTDTSNFDSFPED 655
Query: 534 LDDEPDDDVSGWDRDF 581
D+ P DD SGWD DF
Sbjct: 656 NDEPPPDDNSGWDIDF 671
Score = 47.0 bits (110), Expect = 4e-05
Identities = 22/43 (51%), Positives = 28/43 (65%)
Frame = +2
Query: 323 QDAQNLIKKLCRSNPSDRLGYGVDGLTKCFKHLWFSNFKSDEL 451
++A NLIKKLCR NPS+RLG +G+ KH WF F + L
Sbjct: 585 KNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGL 627
>sp|P21136|KGP1B_BOVIN cGMP-dependent protein kinase 1, beta isozyme (CGK 1 beta)
(cGKI-beta)
Length = 686
Score = 182 bits (462), Expect = 6e-46
Identities = 94/196 (47%), Positives = 126/196 (64%), Gaps = 5/196 (2%)
Frame = +3
Query: 9 IVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAA 188
I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL GHD++A
Sbjct: 495 IIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISA 554
Query: 189 DYWSLGVLIYELLSGRPPFIASTISKTYDLVLIGMDTVEFPRYISK-----MPKI*SKNY 353
DYWSLG+L+YELL+G PPF KTY+++L G+D +EFP+ I+K + K+ N
Sbjct: 555 DYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNP 614
Query: 354 ADQILQID*VMESMV*QNVSSIYGFQISNQMSC*SNNEYPNYTSGSISTDRGNFGNVKPE 533
++++ + ++ + Q GF P S + TD NF + +
Sbjct: 615 SERLGNLKNGVKDI--QKHKWFEGFNWEGLRK--GTLTPPIIPSVASPTDTSNFDSFPED 670
Query: 534 LDDEPDDDVSGWDRDF 581
D+ P DD SGWD DF
Sbjct: 671 NDEPPPDDNSGWDIDF 686
Score = 47.0 bits (110), Expect = 4e-05
Identities = 22/43 (51%), Positives = 28/43 (65%)
Frame = +2
Query: 323 QDAQNLIKKLCRSNPSDRLGYGVDGLTKCFKHLWFSNFKSDEL 451
++A NLIKKLCR NPS+RLG +G+ KH WF F + L
Sbjct: 600 KNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGL 642
>sp|O77676|KGP1A_RABIT cGMP-dependent protein kinase 1, alpha isozyme (CGK 1 alpha)
(cGKI-alpha)
Length = 671
Score = 182 bits (461), Expect = 8e-46
Identities = 94/196 (47%), Positives = 125/196 (63%), Gaps = 5/196 (2%)
Frame = +3
Query: 9 IVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAA 188
I+YRDLKPENL+LDHRGY KL DFGFAK+IG G++TWTFCGTP+YVAPEIIL GHD++A
Sbjct: 480 IIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISA 539
Query: 189 DYWSLGVLIYELLSGRPPFIASTISKTYDLVLIGMDTVEFPRYISK-----MPKI*SKNY 353
DYWSLG+L+YELL+G PPF KTY+++L G+D +EFP+ I+K + K+ N
Sbjct: 540 DYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNP 599
Query: 354 ADQILQID*VMESMV*QNVSSIYGFQISNQMSC*SNNEYPNYTSGSISTDRGNFGNVKPE 533
++++ + ++ + Q GF P S + TD NF +
Sbjct: 600 SERLGNLKNGVKDI--QKHKWFEGFNWEGLRK--GTLTPPIIPSVASPTDTSNFDGFPED 655
Query: 534 LDDEPDDDVSGWDRDF 581
D+ P DD SGWD DF
Sbjct: 656 NDEPPPDDNSGWDIDF 671
Score = 47.0 bits (110), Expect = 4e-05
Identities = 22/43 (51%), Positives = 28/43 (65%)
Frame = +2
Query: 323 QDAQNLIKKLCRSNPSDRLGYGVDGLTKCFKHLWFSNFKSDEL 451
++A NLIKKLCR NPS+RLG +G+ KH WF F + L
Sbjct: 585 KNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGL 627
>sp|P32023|KGP25_DROME cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 (CGK) (Foraging
protein)
Length = 934
Score = 181 bits (460), Expect = 1e-45
Identities = 93/199 (46%), Positives = 129/199 (64%), Gaps = 6/199 (3%)
Frame = +3
Query: 3 RQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDV 182
R I+YRDLKPENLLL+ RGY KL DFGFAK++ +GR+TWTFCGTP+YVAPE+IL GHD+
Sbjct: 741 RNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDI 800
Query: 183 AADYWSLGVLIYELLSGRPPFIASTISKTYDLVLIGMDTVEFPRYISK-----MPKI*SK 347
+ADYWSLGVL++ELL+G PPF S +TY+++L G+D +EFPR I++ + K+
Sbjct: 801 SADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRD 860
Query: 348 NYADQI-LQID*VMESMV*QNVSSIYGFQISNQMSC*SNNEYPNYTSGSISTDRGNFGNV 524
N A+++ Q + E + Y + + N E P + D NF +
Sbjct: 861 NPAERLGYQRGGISEIQKHKWFDGFYWWGLQN-----CTLEPPIKPAVKSVVDTTNFDDY 915
Query: 525 KPELDDEPDDDVSGWDRDF 581
P+ + P DDV+GWD+DF
Sbjct: 916 PPDPEGPPPDDVTGWDKDF 934
>sp|Q03043|KGP24_DROME cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B (CGK)
(Foraging protein)
Length = 1088
Score = 181 bits (460), Expect = 1e-45
Identities = 93/199 (46%), Positives = 129/199 (64%), Gaps = 6/199 (3%)
Frame = +3
Query: 3 RQIVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDV 182
R I+YRDLKPENLLL+ RGY KL DFGFAK++ +GR+TWTFCGTP+YVAPE+IL GHD+
Sbjct: 895 RNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDI 954
Query: 183 AADYWSLGVLIYELLSGRPPFIASTISKTYDLVLIGMDTVEFPRYISK-----MPKI*SK 347
+ADYWSLGVL++ELL+G PPF S +TY+++L G+D +EFPR I++ + K+
Sbjct: 955 SADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRD 1014
Query: 348 NYADQI-LQID*VMESMV*QNVSSIYGFQISNQMSC*SNNEYPNYTSGSISTDRGNFGNV 524
N A+++ Q + E + Y + + N E P + D NF +
Sbjct: 1015 NPAERLGYQRGGISEIQKHKWFDGFYWWGLQN-----CTLEPPIKPAVKSVVDTTNFDDY 1069
Query: 525 KPELDDEPDDDVSGWDRDF 581
P+ + P DDV+GWD+DF
Sbjct: 1070 PPDPEGPPPDDVTGWDKDF 1088
>sp|Q64595|KGP2_RAT cGMP-dependent protein kinase 2 (CGK 2) (cGKII) (Type II
cGMP-dependent protein kinase)
Length = 762
Score = 162 bits (411), Expect = 5e-40
Identities = 86/196 (43%), Positives = 122/196 (62%), Gaps = 5/196 (2%)
Frame = +3
Query: 9 IVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAA 188
I+YRDLKPENL+LD GY KL DFGFAK+IGSG++TWTFCGTP+YVAPE+IL GHD +
Sbjct: 572 IIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSV 631
Query: 189 DYWSLGVLIYELLSGRPPFIASTISKTYDLVLIGMDTVEFPRYISKMP-----KI*SKNY 353
D+WSLG+L+YELL+G PPF TY+L+L G++ ++FPR I++ P ++ +N
Sbjct: 632 DFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNP 691
Query: 354 ADQILQID*VMESMV*QNVSSIYGFQISNQMSC*SNNEYPNYTSGSISTDRGNFGNVKPE 533
+++ + + + + + GF + + SG I D F PE
Sbjct: 692 TERLGNLKNGINDI--KKHRWLNGFNWEGLKARSLPSPLRRELSGPI--DHSYFDKYPPE 747
Query: 534 LDDEPDDDVSGWDRDF 581
P D++SGWD+DF
Sbjct: 748 -KGVPPDEMSGWDKDF 762
Score = 39.3 bits (90), Expect = 0.008
Identities = 16/40 (40%), Positives = 26/40 (65%)
Frame = +2
Query: 332 QNLIKKLCRSNPSDRLGYGVDGLTKCFKHLWFSNFKSDEL 451
++LI++LCR NP++RLG +G+ KH W + F + L
Sbjct: 680 EDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGL 719
>sp|Q61410|KGP2_MOUSE cGMP-dependent protein kinase 2 (CGK 2) (cGKII) (Type II
cGMP-dependent protein kinase)
Length = 762
Score = 162 bits (411), Expect = 5e-40
Identities = 86/196 (43%), Positives = 122/196 (62%), Gaps = 5/196 (2%)
Frame = +3
Query: 9 IVYRDLKPENLLLDHRGYCKLTDFGFAKRIGSGRRTWTFCGTPDYVAPEIILYSGHDVAA 188
I+YRDLKPENL+LD GY KL DFGFAK+IGSG++TWTFCGTP+YVAPE+IL GHD +
Sbjct: 572 IIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSV 631
Query: 189 DYWSLGVLIYELLSGRPPFIASTISKTYDLVLIGMDTVEFPRYISKMP-----KI*SKNY 353
D+WSLG+L+YELL+G PPF TY+L+L G++ ++FPR I++ P ++ +N
Sbjct: 632 DFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNP 691
Query: 354 ADQILQID*VMESMV*QNVSSIYGFQISNQMSC*SNNEYPNYTSGSISTDRGNFGNVKPE 533
+++ + + + + + GF + + SG I D F PE
Sbjct: 692 TERLGNLKNGINDI--KKHRWLNGFNWEGLKARSLPSPLRRELSGPI--DHSYFDKYPPE 747
Query: 534 LDDEPDDDVSGWDRDF 581
P D++SGWD+DF
Sbjct: 748 -KGVPPDEMSGWDKDF 762
Score = 39.3 bits (90), Expect = 0.008
Identities = 16/40 (40%), Positives = 26/40 (65%)
Frame = +2
Query: 332 QNLIKKLCRSNPSDRLGYGVDGLTKCFKHLWFSNFKSDEL 451
++LI++LCR NP++RLG +G+ KH W + F + L
Sbjct: 680 EDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGL 719
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,327,495
Number of Sequences: 369166
Number of extensions: 1430732
Number of successful extensions: 6544
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4729
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5042
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 4877307000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)