Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_015_A02
(674 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P26267|ODPA_ASCSU Pyruvate dehydrogenase E1 component al... 186 4e-47
sp|P26268|ODPT_ASCSU Pyruvate dehydrogenase E1 component al... 184 2e-46
sp|P52899|ODPA_CAEEL Probable pyruvate dehydrogenase E1 com... 170 4e-42
sp|P08559|ODPA_HUMAN Pyruvate dehydrogenase E1 component al... 164 1e-40
sp|Q5R490|ODPA_PONPY Pyruvate dehydrogenase E1 component al... 164 1e-40
sp|Q8HXW9|ODPA_MACFA Pyruvate dehydrogenase E1 component al... 164 1e-40
sp|P26284|ODPA_RAT Pyruvate dehydrogenase E1 component alph... 163 3e-40
sp|P35486|ODPA_MOUSE Pyruvate dehydrogenase E1 component al... 163 3e-40
sp|P29803|ODPAT_HUMAN Pyruvate dehydrogenase E1 component a... 162 7e-40
sp|P52900|ODPA_SMIMA Pyruvate dehydrogenase E1 component al... 162 7e-40
>sp|P26267|ODPA_ASCSU Pyruvate dehydrogenase E1 component alpha subunit type I,
mitochondrial precursor (PDHE1-A)
Length = 396
Score = 186 bits (473), Expect = 4e-47
Identities = 90/141 (63%), Positives = 109/141 (77%)
Frame = +3
Query: 6 MGTSAKRSSASVTYYTRGDYVPGIWVDGMDVLTVREALRFATKWCRDGLGPLVIEMETYR 185
MGT+A RSSAS YYTRGDYVPGIWVDGMDVL VR+A+R+A +WC G GPL+IEM TYR
Sbjct: 225 MGTAAARSSASTDYYTRGDYVPGIWVDGMDVLAVRQAVRWAKEWCNAGKGPLMIEMATYR 284
Query: 186 YSGHSMSDPGTSYRTREEVQAVRKEKDPITLFSRALQTAGLLDDEASKRIEKEVKDEVNA 365
YSGHSMSDPGTSYRTREEVQ VRK +DPIT F + TAGL+ ++ K I+K+V+ E++A
Sbjct: 285 YSGHSMSDPGTSYRTREEVQEVRKTRDPITGFKDKIVTAGLVTEDEIKEIDKQVRKEIDA 344
Query: 366 AMEQCKIDPEPKVEETYKHVY 428
A++Q D E VE +Y
Sbjct: 345 AVKQAHTDKESPVELMLTDIY 365
>sp|P26268|ODPT_ASCSU Pyruvate dehydrogenase E1 component alpha subunit type II,
mitochondrial precursor (PDHE1-A)
Length = 391
Score = 184 bits (467), Expect = 2e-46
Identities = 87/141 (61%), Positives = 106/141 (75%)
Frame = +3
Query: 6 MGTSAKRSSASVTYYTRGDYVPGIWVDGMDVLTVREALRFATKWCRDGLGPLVIEMETYR 185
MGTSA RSSAS YYTRGDYVPG WVDGMDVL VR+A+R+ +WC G GPL+IEM TYR
Sbjct: 220 MGTSAARSSASTDYYTRGDYVPGFWVDGMDVLAVRQAIRWGKEWCNAGKGPLMIEMATYR 279
Query: 186 YSGHSMSDPGTSYRTREEVQAVRKEKDPITLFSRALQTAGLLDDEASKRIEKEVKDEVNA 365
Y GHSMSDPGTSYRTREE+Q VRK +DPIT F + TAGL+ ++ K ++KE++ EV+A
Sbjct: 280 YGGHSMSDPGTSYRTREEIQEVRKTRDPITGFKDKIVTAGLVTEDELKEVDKEIRKEVDA 339
Query: 366 AMEQCKIDPEPKVEETYKHVY 428
A++Q D E VE +Y
Sbjct: 340 AVKQAHTDKEAPVEMLLTDIY 360
>sp|P52899|ODPA_CAEEL Probable pyruvate dehydrogenase E1 component alpha subunit,
mitochondrial precursor (PDHE1-A)
Length = 397
Score = 170 bits (430), Expect = 4e-42
Identities = 83/144 (57%), Positives = 105/144 (72%)
Frame = +3
Query: 6 MGTSAKRSSASVTYYTRGDYVPGIWVDGMDVLTVREALRFATKWCRDGLGPLVIEMETYR 185
MGT+A+RSSAS YYTRGDYVPGIWVDGMD+L VREA ++A ++C G GPL++EM TYR
Sbjct: 223 MGTTAERSSASTEYYTRGDYVPGIWVDGMDILAVREATKWAKEYCDSGKGPLMMEMATYR 282
Query: 186 YSGHSMSDPGTSYRTREEVQAVRKEKDPITLFSRALQTAGLLDDEASKRIEKEVKDEVNA 365
Y GHSMSDPGTSYRTREE+Q VRK +DPIT F + T+ L +E K I+KEV+ EV+
Sbjct: 283 YHGHSMSDPGTSYRTREEIQEVRKTRDPITGFKDRIITSSLATEEELKAIDKEVRKEVDE 342
Query: 366 AMEQCKIDPEPKVEETYKHVYSSS 437
A++ D E Y +Y ++
Sbjct: 343 ALKIATSDGVLPPEALYADIYHNT 366
>sp|P08559|ODPA_HUMAN Pyruvate dehydrogenase E1 component alpha subunit, somatic form,
mitochondrial precursor (PDHE1-A type I)
Length = 390
Score = 164 bits (416), Expect = 1e-40
Identities = 81/158 (51%), Positives = 106/158 (67%), Gaps = 1/158 (0%)
Frame = +3
Query: 6 MGTSAKRSSASVTYYTRGDYVPGIWVDGMDVLTVREALRFATKWCRDGLGPLVIEMETYR 185
MGTS +R++AS YY RGD++PG+ VDGMD+L VREA RFA +CR G GP+++E++TYR
Sbjct: 229 MGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYR 288
Query: 186 YSGHSMSDPGTSYRTREEVQAVRKEKDPITLFSRALQTAGLLDDEASKRIEKEVKDEVNA 365
Y GHSMSDPG SYRTREE+Q VR + DPI L + + L E K I+ EV+ E+
Sbjct: 289 YHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIED 348
Query: 366 AMEQCKIDPEPKVEETYKHVYSSS-NVPIRGCDSMTWI 476
A + DPEP +EE H+YSS +RG + WI
Sbjct: 349 AAQFATADPEPPLEELGYHIYSSDPPFEVRGANQ--WI 384
>sp|Q5R490|ODPA_PONPY Pyruvate dehydrogenase E1 component alpha subunit, somatic form,
mitochondrial precursor (PDHE1-A type I)
Length = 390
Score = 164 bits (416), Expect = 1e-40
Identities = 81/158 (51%), Positives = 106/158 (67%), Gaps = 1/158 (0%)
Frame = +3
Query: 6 MGTSAKRSSASVTYYTRGDYVPGIWVDGMDVLTVREALRFATKWCRDGLGPLVIEMETYR 185
MGTS +R++AS YY RGD++PG+ VDGMD+L VREA RFA +CR G GP+++E++TYR
Sbjct: 229 MGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYR 288
Query: 186 YSGHSMSDPGTSYRTREEVQAVRKEKDPITLFSRALQTAGLLDDEASKRIEKEVKDEVNA 365
Y GHSMSDPG SYRTREE+Q VR + DPI L + + L E K I+ EV+ E+
Sbjct: 289 YHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIED 348
Query: 366 AMEQCKIDPEPKVEETYKHVYSSS-NVPIRGCDSMTWI 476
A + DPEP +EE H+YSS +RG + WI
Sbjct: 349 AAQFATADPEPPLEELGYHIYSSDPPFEVRGANQ--WI 384
>sp|Q8HXW9|ODPA_MACFA Pyruvate dehydrogenase E1 component alpha subunit, somatic form,
mitochondrial precursor (PDHE1-A type I)
Length = 390
Score = 164 bits (416), Expect = 1e-40
Identities = 81/158 (51%), Positives = 106/158 (67%), Gaps = 1/158 (0%)
Frame = +3
Query: 6 MGTSAKRSSASVTYYTRGDYVPGIWVDGMDVLTVREALRFATKWCRDGLGPLVIEMETYR 185
MGTS +R++AS YY RGD++PG+ VDGMD+L VREA RFA +CR G GP+++E++TYR
Sbjct: 229 MGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYR 288
Query: 186 YSGHSMSDPGTSYRTREEVQAVRKEKDPITLFSRALQTAGLLDDEASKRIEKEVKDEVNA 365
Y GHSMSDPG SYRTREE+Q VR + DPI L + + L E K I+ EV+ E+
Sbjct: 289 YHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIED 348
Query: 366 AMEQCKIDPEPKVEETYKHVYSSS-NVPIRGCDSMTWI 476
A + DPEP +EE H+YSS +RG + WI
Sbjct: 349 AAQFATADPEPPLEELGYHIYSSDPPFEVRGANQ--WI 384
>sp|P26284|ODPA_RAT Pyruvate dehydrogenase E1 component alpha subunit, somatic form,
mitochondrial precursor (PDHE1-A type I)
Length = 390
Score = 163 bits (413), Expect = 3e-40
Identities = 80/158 (50%), Positives = 106/158 (67%), Gaps = 1/158 (0%)
Frame = +3
Query: 6 MGTSAKRSSASVTYYTRGDYVPGIWVDGMDVLTVREALRFATKWCRDGLGPLVIEMETYR 185
MGTS +R++AS YY RGD++PG+ VDGMD+L VREA +FA +CR G GP+++E++TYR
Sbjct: 229 MGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATKFAAAYCRSGKGPILMELQTYR 288
Query: 186 YSGHSMSDPGTSYRTREEVQAVRKEKDPITLFSRALQTAGLLDDEASKRIEKEVKDEVNA 365
Y GHSMSDPG SYRTREE+Q VR + DPI L + + L E K I+ EV+ E+
Sbjct: 289 YHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIED 348
Query: 366 AMEQCKIDPEPKVEETYKHVYSSS-NVPIRGCDSMTWI 476
A + DPEP +EE H+YSS +RG + WI
Sbjct: 349 AAQFATADPEPPLEELGYHIYSSDPPFEVRGANQ--WI 384
>sp|P35486|ODPA_MOUSE Pyruvate dehydrogenase E1 component alpha subunit, somatic form,
mitochondrial precursor (PDHE1-A type I)
Length = 390
Score = 163 bits (413), Expect = 3e-40
Identities = 80/158 (50%), Positives = 106/158 (67%), Gaps = 1/158 (0%)
Frame = +3
Query: 6 MGTSAKRSSASVTYYTRGDYVPGIWVDGMDVLTVREALRFATKWCRDGLGPLVIEMETYR 185
MGTS +R++AS YY RGD++PG+ VDGMD+L VREA +FA +CR G GP+++E++TYR
Sbjct: 229 MGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATKFAAAYCRSGKGPILMELQTYR 288
Query: 186 YSGHSMSDPGTSYRTREEVQAVRKEKDPITLFSRALQTAGLLDDEASKRIEKEVKDEVNA 365
Y GHSMSDPG SYRTREE+Q VR + DPI L + + L E K I+ EV+ E+
Sbjct: 289 YHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIED 348
Query: 366 AMEQCKIDPEPKVEETYKHVYSSS-NVPIRGCDSMTWI 476
A + DPEP +EE H+YSS +RG + WI
Sbjct: 349 AAQFATADPEPPLEELGYHIYSSDPPFEVRGANQ--WI 384
>sp|P29803|ODPAT_HUMAN Pyruvate dehydrogenase E1 component alpha subunit, testis-specific
form, mitochondrial precursor (PDHE1-A type II)
Length = 388
Score = 162 bits (410), Expect = 7e-40
Identities = 80/158 (50%), Positives = 109/158 (68%), Gaps = 1/158 (0%)
Frame = +3
Query: 6 MGTSAKRSSASVTYYTRGDYVPGIWVDGMDVLTVREALRFATKWCRDGLGPLVIEMETYR 185
MGTS +R++AS YY RG+++PG+ VDGMDVL VREA +FA +CR G GP+++E++TYR
Sbjct: 227 MGTSTERAAASPDYYKRGNFIPGLKVDGMDVLCVREATKFAANYCRSGKGPILMELQTYR 286
Query: 186 YSGHSMSDPGTSYRTREEVQAVRKEKDPITLFSRALQTAGLLDDEASKRIEKEVKDEVNA 365
Y GHSMSDPG SYRTREE+Q VR ++DPI + + + L E K I EV+ E++
Sbjct: 287 YHGHSMSDPGVSYRTREEIQEVRSKRDPIIILQDRMVNSKLATVEELKEIGAEVRKEIDD 346
Query: 366 AMEQCKIDPEPKVEETYKHVYSS-SNVPIRGCDSMTWI 476
A + DPEP +EE H+YSS S+ +RG + WI
Sbjct: 347 AAQFATTDPEPHLEELGHHIYSSDSSFEVRGAN--PWI 382
>sp|P52900|ODPA_SMIMA Pyruvate dehydrogenase E1 component alpha subunit, mitochondrial
precursor (PDHE1-A)
Length = 363
Score = 162 bits (410), Expect = 7e-40
Identities = 77/142 (54%), Positives = 98/142 (69%)
Frame = +3
Query: 6 MGTSAKRSSASVTYYTRGDYVPGIWVDGMDVLTVREALRFATKWCRDGLGPLVIEMETYR 185
MGTS +R++AS YY RGD++PGI VDGMDVL VREA +FA +CR G GP+++E++TYR
Sbjct: 202 MGTSVERAAASTDYYKRGDFIPGIMVDGMDVLCVREATKFAAAYCRSGKGPMLMELQTYR 261
Query: 186 YSGHSMSDPGTSYRTREEVQAVRKEKDPITLFSRALQTAGLLDDEASKRIEKEVKDEVNA 365
Y GHSMSDPG SYRTREE+Q VR + DPI L + L E K I+ EV+ E+
Sbjct: 262 YHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNNNLASIEELKEIDVEVRKEIED 321
Query: 366 AMEQCKIDPEPKVEETYKHVYS 431
A + DPEP +EE H+YS
Sbjct: 322 AAQFATADPEPPLEELGYHIYS 343
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,144,629
Number of Sequences: 369166
Number of extensions: 1420845
Number of successful extensions: 3366
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3267
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3353
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5684835195
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)