Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_014_P07
(849 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O00560|SDCB1_HUMAN Syntenin-1 (Syndecan binding protein ... 277 2e-74
sp|Q9JI92|SDCB1_RAT Syntenin-1 (Syndecan binding protein 1) 275 2e-73
sp|O08992|SDCB1_MOUSE Syntenin-1 (Syndecan binding protein ... 273 4e-73
sp|Q99JZ0|SDCB2_MOUSE Syntenin-2 (Syndecan binding protein 2) 247 3e-65
sp|Q9H190|SDCB2_HUMAN Syntenin-2 (Syndecan binding protein 2) 241 2e-63
sp|O35430|APBA1_RAT Amyloid beta A4 precursor protein-bindi... 61 3e-09
sp|Q02410|APBA1_HUMAN Amyloid beta A4 precursor protein-bin... 60 6e-09
sp|Q99767|APBA2_HUMAN Amyloid beta A4 precursor protein-bin... 55 2e-07
sp|Q5RD33|APBA2_PONPY Amyloid beta A4 precursor protein-bin... 55 2e-07
sp|P98084|APBA2_MOUSE Amyloid beta A4 precursor protein-bin... 55 2e-07
>sp|O00560|SDCB1_HUMAN Syntenin-1 (Syndecan binding protein 1) (Melanoma
differentiation-associated protein 9) (MDA-9) (Scaffold
protein Pbp1) (Pro-TGF-alpha cytoplasmic
domain-interacting protein 18) (TACIP18)
Length = 298
Score = 277 bits (709), Expect = 2e-74
Identities = 145/288 (50%), Positives = 194/288 (67%), Gaps = 18/288 (6%)
Frame = +2
Query: 35 LYPTLEDLKVDELKSVQHNFINTVVNEPTGSQGS------------LYPALDDYLGLDMR 178
LYP+LEDLKVD++ Q F N S+ S LYP L Y+GL +
Sbjct: 3 LYPSLEDLKVDKVIQAQTAFSANPANPAILSEASAPIPHDGNLYPRLYPELSQYMGLSLN 62
Query: 179 AAQ---NQMVQSYGNSVVGYGWRQNTSV---VAPVTKNDVGISRAEIKQGLRRAVLCKDS 340
+ N V S G + G + +S+ VAPVT NDVGI RAEIKQG+R +LCKD
Sbjct: 63 EEEIRANVAVVS-GAPLQGQLVARPSSINYMVAPVTGNDVGIRRAEIKQGIREVILCKDQ 121
Query: 341 KGIIGLRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA 520
G IGLR+++++ GIFV V NSPAS+ GLRFGDQ+L++N + AGW+++K HK K A
Sbjct: 122 DGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQA 181
Query: 521 GSNNITVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEI 700
IT+ +RDRPFERTITM+KDS G++GF+FKNG IT +VKDSSAARNGLL +H + EI
Sbjct: 182 FGEKITMTIRDRPFERTITMHKDSTGHVGFIFKNGKITSIVKDSSAARNGLLTEHNICEI 241
Query: 701 NGQNVIGLKDKEIQKIIDKTPNIVTVTIMPMFVYEHMVKTLSSDLLKN 844
NGQNVIGLKD +I I+ + +VT+TIMP F++EH++K ++ ++K+
Sbjct: 242 NGQNVIGLKDSQIADILSTSGTVVTITIMPAFIFEHIIKRMAPSIMKS 289
>sp|Q9JI92|SDCB1_RAT Syntenin-1 (Syndecan binding protein 1)
Length = 300
Score = 275 bits (702), Expect = 2e-73
Identities = 145/290 (50%), Positives = 195/290 (67%), Gaps = 20/290 (6%)
Frame = +2
Query: 35 LYPTLEDLKVDELKSVQH-------------NFINTVVNEPTGS-QGSLYPALDDYLGLD 172
LYP+LEDLKVD++ Q N +++ P G+ LYP L Y+GL
Sbjct: 3 LYPSLEDLKVDKVIQAQTASSANPASQAFFLNVVDSAAFPPGGNLYPKLYPELSQYMGLS 62
Query: 173 MRAAQ---NQMVQSYGNSVVGYGWRQNTSV---VAPVTKNDVGISRAEIKQGLRRAVLCK 334
+ A+ N V S G G + +SV VAPVT ND GI RAEIKQG+R +LCK
Sbjct: 63 LSEAEICENMPVVS-GAPTQGQLVARPSSVNYMVAPVTGNDAGIRRAEIKQGIREVILCK 121
Query: 335 DSKGIIGLRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFK 514
D G IGLR+++V+ GIFV V NSPAS+ GLRFGDQ+L++N + AGW+++K HK K
Sbjct: 122 DQDGKIGLRLKSVDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLK 181
Query: 515 AAGSNNITVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLI 694
A IT+ +RDRPFERT+TM+KDS+G++GF+FK+G IT +VKDSSAARNGLL DH +
Sbjct: 182 QAFGEKITMTIRDRPFERTVTMHKDSSGHVGFIFKSGKITSIVKDSSAARNGLLTDHHIC 241
Query: 695 EINGQNVIGLKDKEIQKIIDKTPNIVTVTIMPMFVYEHMVKTLSSDLLKN 844
EINGQNVIGLKD +I I+ +VT+TIMP F++EH++K ++ ++K+
Sbjct: 242 EINGQNVIGLKDAQIADILSTAGTVVTITIMPAFIFEHIIKRMAPSIMKS 291
>sp|O08992|SDCB1_MOUSE Syntenin-1 (Syndecan binding protein 1) (Scaffold protein Pbp1)
Length = 299
Score = 273 bits (698), Expect = 4e-73
Identities = 141/288 (48%), Positives = 192/288 (66%), Gaps = 18/288 (6%)
Frame = +2
Query: 35 LYPTLEDLKVDELKSVQHNFINTVVNE------------PTGS-QGSLYPALDDYLGLDM 175
LYP+LEDLKVD++ Q + ++ P G+ LYP L Y+GL +
Sbjct: 3 LYPSLEDLKVDKVIQAQTAYSANPASQAFVLVDASAALPPDGNLYPKLYPELSQYMGLSL 62
Query: 176 RAAQ--NQMVQSYGNSVVGYGWRQNTSV---VAPVTKNDVGISRAEIKQGLRRAVLCKDS 340
A+ M G G + +SV VAPVT ND GI RAEIKQG+R +LCKD
Sbjct: 63 NEAEICESMPMVSGAPAQGQLVARPSSVNYMVAPVTGNDAGIRRAEIKQGIREVILCKDQ 122
Query: 341 KGIIGLRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA 520
G IGLR+++++ GIFV V NSPAS+ GLRFGDQ+L++N + AGW+++K HK K A
Sbjct: 123 DGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQA 182
Query: 521 GSNNITVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEI 700
IT+ +RDRPFERT+TM+KDS+G++GF+FK+G IT +VKDSSAARNGLL DH + EI
Sbjct: 183 FGEKITMTIRDRPFERTVTMHKDSSGHVGFIFKSGKITSIVKDSSAARNGLLTDHHICEI 242
Query: 701 NGQNVIGLKDKEIQKIIDKTPNIVTVTIMPMFVYEHMVKTLSSDLLKN 844
NGQNVIGLKD +I I+ +VT+TIMP F++EH++K ++ ++K+
Sbjct: 243 NGQNVIGLKDAQIADILSTAGTVVTITIMPTFIFEHIIKRMAPSIMKS 290
>sp|Q99JZ0|SDCB2_MOUSE Syntenin-2 (Syndecan binding protein 2)
Length = 292
Score = 247 bits (630), Expect = 3e-65
Identities = 137/286 (47%), Positives = 184/286 (64%), Gaps = 15/286 (5%)
Frame = +2
Query: 26 MSRLYPTLEDLKVDELKSVQHNFINTVVNEPTGSQGS-----LYP---ALDDYLGLDMRA 181
MS LYP+LEDLKV ++ Q T+ P + LYP L+ Y+GL + +
Sbjct: 1 MSVLYPSLEDLKVGQVIQAQGRASPTMPTLPAPMASAPPLSELYPNLAELESYMGLSLSS 60
Query: 182 AQNQ----MVQSYGNSVV---GYGWRQNTSVVAPVTKNDVGISRAEIKQGLRRAVLCKDS 340
+ Q + N VV G G VVAPV+ N++GI RAEIK G+R LCKD
Sbjct: 61 QEVQKNLTQIPDSDNMVVTSPGPG-----QVVAPVSGNNLGILRAEIKPGVREIHLCKDE 115
Query: 341 KGIIGLRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA 520
+G GLR+QAV+KG+FV V N+PAS+ GLRFGDQIL+++ AGW T K HK K A
Sbjct: 116 RGKTGLRLQAVDKGLFVQLVQANTPASLVGLRFGDQILQIDGCDCAGWNTHKAHKVLKKA 175
Query: 521 GSNNITVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEI 700
+ I + +RDRPF+RT+TM+KDS+G +GF K G I +VK SSAARNGLL +H + E+
Sbjct: 176 SAEKIVMVIRDRPFQRTVTMHKDSSGQVGFSIKKGKIVSVVKGSSAARNGLLTNHYVCEV 235
Query: 701 NGQNVIGLKDKEIQKIIDKTPNIVTVTIMPMFVYEHMVKTLSSDLL 838
NGQNVIGLKDK++ +I+ +++T+TI+P +YEHM+K LS LL
Sbjct: 236 NGQNVIGLKDKKVTEILTTAGDVITLTIIPTVIYEHMIKRLSPLLL 281
>sp|Q9H190|SDCB2_HUMAN Syntenin-2 (Syndecan binding protein 2)
Length = 292
Score = 241 bits (614), Expect = 2e-63
Identities = 133/284 (46%), Positives = 184/284 (64%), Gaps = 13/284 (4%)
Frame = +2
Query: 26 MSRLYPTLEDLKVDELKSVQHNFINTVVNEPTGSQGS-----LYP---ALDDYLGLDMRA 181
MS LYP+LEDLKVD+ Q + P + LYP L++Y+GL + +
Sbjct: 1 MSSLYPSLEDLKVDQAIQAQVRASPKMPALPVQATAISPPPVLYPNLAELENYMGLSLSS 60
Query: 182 AQNQ-----MVQSYGNSVVGYGWRQNTSVVAPVTKNDVGISRAEIKQGLRRAVLCKDSKG 346
+ Q + + +V G G Q +VAPVT +G+ RAEIK G+R LCKD +G
Sbjct: 61 QEVQESLLQIPEGDSTAVSGPGPGQ---MVAPVTGYSLGVRRAEIKPGVREIHLCKDERG 117
Query: 347 IIGLRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAAGS 526
GLR++ V++G+FV V N+PAS+ GLRFGDQ+L+++ + AGW++ K H+ K A
Sbjct: 118 KTGLRLRKVDQGLFVQLVQANTPASLVGLRFGDQLLQIDGRDCAGWSSHKAHQVVKKASG 177
Query: 527 NNITVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEING 706
+ I V +RDRPF+RT+TM+KDS G++GFV K G I LVK SSAARNGLL +H + E++G
Sbjct: 178 DKIVVVVRDRPFQRTVTMHKDSMGHVGFVIKKGKIVSLVKGSSAARNGLLTNHYVCEVDG 237
Query: 707 QNVIGLKDKEIQKIIDKTPNIVTVTIMPMFVYEHMVKTLSSDLL 838
QNVIGLKDK+I +I+ N+VT+TI+P +YEHMVK L LL
Sbjct: 238 QNVIGLKDKKIMEILATAGNVVTLTIIPSVIYEHMVKKLPPVLL 281
>sp|O35430|APBA1_RAT Amyloid beta A4 precursor protein-binding family A member 1
(Neuron-specific X11 protein) (Neuronal
Munc18-1-interacting protein 1) (Mint-1) (Adapter protein
X11alpha)
Length = 839
Score = 61.2 bits (147), Expect = 3e-09
Identities = 38/144 (26%), Positives = 68/144 (47%), Gaps = 4/144 (2%)
Frame = +2
Query: 383 IFVSFVNENSPASMAG-LRFGDQILEVNNQVVAGW---TTEKVHKFFKAAGSNNITVALR 550
+ ++ + PA +G L GDQI+ +N + G T + + K K + + +R
Sbjct: 685 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNI-VR 743
Query: 551 DRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKD 730
P + D +GF +NG I L++ A R G+ + H++IEINGQ+V+
Sbjct: 744 CPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPH 803
Query: 731 KEIQKIIDKTPNIVTVTIMPMFVY 802
++I I+ + + MP +Y
Sbjct: 804 EKIVHILSNAVGEIHMKTMPAAMY 827
>sp|Q02410|APBA1_HUMAN Amyloid beta A4 precursor protein-binding family A member 1
(Neuron-specific X11 protein) (Neuronal
Munc18-1-interacting protein 1) (Mint-1) (Adapter protein
X11alpha)
Length = 837
Score = 60.5 bits (145), Expect = 6e-09
Identities = 39/144 (27%), Positives = 64/144 (44%), Gaps = 4/144 (2%)
Frame = +2
Query: 383 IFVSFVNENSPASMAG-LRFGDQILEVNNQVVAGWTTEKVHKFFKAAGSNNITVAL---R 550
+ ++ + PA +G L GDQI+ +N + G K N V L R
Sbjct: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGL-ENQSRVKLNIVR 741
Query: 551 DRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKD 730
P + D +GF +NG I L++ A R G+ + H++IEINGQ+V+
Sbjct: 742 CPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPH 801
Query: 731 KEIQKIIDKTPNIVTVTIMPMFVY 802
++I I+ + + MP +Y
Sbjct: 802 EKIVHILSNAVGEIHMKTMPAAMY 825
>sp|Q99767|APBA2_HUMAN Amyloid beta A4 precursor protein-binding family A member 2
(Neuron-specific X11L protein) (Neuronal
Munc18-1-interacting protein 2) (Mint-2) (Adapter protein
X11beta)
Length = 749
Score = 55.5 bits (132), Expect = 2e-07
Identities = 34/142 (23%), Positives = 64/142 (45%), Gaps = 2/142 (1%)
Frame = +2
Query: 383 IFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA-GSNNITVALRDRP 559
I + +N A L GDQI+ +N + G K + + + P
Sbjct: 596 ILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCP 655
Query: 560 FERTITMNKDSNGY-IGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKDKE 736
T+ + + Y +GF +NG I L++ A R G+ + H++IEINGQ+V+ ++
Sbjct: 656 PVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEK 715
Query: 737 IQKIIDKTPNIVTVTIMPMFVY 802
I + + + + + MP ++
Sbjct: 716 IVQALSNSVGEIHMKTMPAAMF 737
>sp|Q5RD33|APBA2_PONPY Amyloid beta A4 precursor protein-binding family A member 2
Length = 749
Score = 55.5 bits (132), Expect = 2e-07
Identities = 34/142 (23%), Positives = 64/142 (45%), Gaps = 2/142 (1%)
Frame = +2
Query: 383 IFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA-GSNNITVALRDRP 559
I + +N A L GDQI+ +N + G K + + + P
Sbjct: 596 ILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCP 655
Query: 560 FERTITMNKDSNGY-IGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKDKE 736
T+ + + Y +GF +NG I L++ A R G+ + H++IEINGQ+V+ ++
Sbjct: 656 PVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEK 715
Query: 737 IQKIIDKTPNIVTVTIMPMFVY 802
I + + + + + MP ++
Sbjct: 716 IVQALSNSVGEIHMKTMPAAMF 737
>sp|P98084|APBA2_MOUSE Amyloid beta A4 precursor protein-binding family A member 2
(Neuron-specific X11L protein) (Neuronal
Munc18-1-interacting protein 2) (Mint-2) (Adapter protein
X11beta)
Length = 750
Score = 55.5 bits (132), Expect = 2e-07
Identities = 34/142 (23%), Positives = 64/142 (45%), Gaps = 2/142 (1%)
Frame = +2
Query: 383 IFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA-GSNNITVALRDRP 559
I + +N A L GDQI+ +N + G K + + + P
Sbjct: 597 ILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCP 656
Query: 560 FERTITMNKDSNGY-IGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKDKE 736
T+ + + Y +GF +NG I L++ A R G+ + H++IEINGQ+V+ ++
Sbjct: 657 PVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEK 716
Query: 737 IQKIIDKTPNIVTVTIMPMFVY 802
I + + + + + MP ++
Sbjct: 717 IVQALSNSVGEIHMKTMPAAMF 738
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,286,240
Number of Sequences: 369166
Number of extensions: 1968648
Number of successful extensions: 5644
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5274
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5607
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8341863645
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)