Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_014_P04
(813 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 206 8e-53
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 200 3e-51
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 198 1e-50
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 196 5e-50
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 194 2e-49
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 193 5e-49
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 192 1e-48
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 192 1e-48
sp|O35186|CATK_RAT Cathepsin K precursor 192 1e-48
sp|Q9R014|CATJ_MOUSE Cathepsin J precursor (Cathepsin P) (C... 192 1e-48
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 206 bits (523), Expect = 8e-53
Identities = 104/238 (43%), Positives = 147/238 (61%), Gaps = 5/238 (2%)
Frame = +3
Query: 18 KNDDLSRNDFITTPNNIKLPDSWDWREKGAVSPVGNQRNNCCGYAFAAAGALEGQNFNLT 197
+N + P + LP S DWR+KG V+PV NQ+ +AF+A GALEGQ F T
Sbjct: 96 RNQKFRKGKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKT 155
Query: 198 KTLEILSKQQIIDCSIYYGNSNCYSGCILSKAYAYLADYGS-ELDEDYPFVGYNSNCKYD 374
L LS+Q ++DCS GN C +G +++A+ Y+ + G + +E YP+V + CKY
Sbjct: 156 GKLVSLSEQNLVDCSRPQGNQGC-NGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYR 214
Query: 375 KSLATVKPYGFKYVSRGKEADLMNAVYNIGPISAAIDASPNTFKQYKTGIYDDTSCSSNN 554
+ GF V+ GKE LM AV +GPIS A+DA ++F+ YK+GIY + CSS N
Sbjct: 215 PENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKN 274
Query: 555 VNHAVLVIGYGEESGQS----FWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVP 716
++H VLV+GYG E S +W++KNSWG +WG GY+K+++D NN CGIA+ AS P
Sbjct: 275 LDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYP 332
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 200 bits (509), Expect = 3e-51
Identities = 94/242 (38%), Positives = 152/242 (62%), Gaps = 2/242 (0%)
Frame = +3
Query: 3 NKHINKNDDLSRNDFITTPNNIKLPDSWDWREKGAVSPVGNQRNNCCGYAFAAAGALEGQ 182
+K + D+ + +P ++ LP S DWR KGAV+ V +Q + +AF++ GALEGQ
Sbjct: 101 HKQLRAADESFKGVTFISPAHVTLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQ 160
Query: 183 NFNLTKTLEILSKQQIIDCSIYYGNSNCYSGCILSKAYAYLADYGS-ELDEDYPFVGYNS 359
+F + L LS+Q ++DCS YGN+ C G ++ A+ Y+ D G + ++ YP+ +
Sbjct: 161 HFRKSGVLVSLSEQNLVDCSTKYGNNGCNGG-LMDNAFRYIKDNGGIDTEKSYPYEAIDD 219
Query: 360 NCKYDKSLATVKPYGFKYVSRGKEADLMNAVYNIGPISAAIDASPNTFKQYKTGIYDDTS 539
+C ++K GF + +G E + AV +GP+S AIDAS +F+ Y G+Y++
Sbjct: 220 SCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQ 279
Query: 540 CSSNNVNHAVLVIGYG-EESGQSFWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVP 716
C + N++H VLV+G+G +ESG+ +W++KNSWG+ WG KG++K+ R+ N CGIAS +S P
Sbjct: 280 CDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYP 339
Query: 717 LL 722
L+
Sbjct: 340 LV 341
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 198 bits (504), Expect = 1e-50
Identities = 92/222 (41%), Positives = 143/222 (64%), Gaps = 2/222 (0%)
Frame = +3
Query: 57 PNNIKLPDSWDWREKGAVSPVGNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIID 236
P ++ +P S DWRE GAV+ V +Q + +AF++ GALEGQ+F L LS+Q ++D
Sbjct: 117 PAHVTVPKSVDWREHGAVTGVKDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVD 176
Query: 237 CSIYYGNSNCYSGCILSKAYAYLADYGS-ELDEDYPFVGYNSNCKYDKSLATVKPYGFKY 413
CS YGN+ C G ++ A+ Y+ D G + ++ YP+ G + +C ++K+ GF
Sbjct: 177 CSTKYGNNGCNGG-LMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVD 235
Query: 414 VSRGKEADLMNAVYNIGPISAAIDASPNTFKQYKTGIYDDTSCSSNNVNHAVLVIGYG-E 590
+ G E + AV +GP+S AIDAS +F+ Y G+Y++ C N++H VLV+GYG +
Sbjct: 236 IPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVGYGTD 295
Query: 591 ESGQSFWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVP 716
ESG +W++KNSWG+ WG +GY+K++R+ NN CGIA+ +S P
Sbjct: 296 ESGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIATASSYP 337
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 196 bits (499), Expect = 5e-50
Identities = 92/223 (41%), Positives = 136/223 (60%)
Frame = +3
Query: 60 NNIKLPDSWDWREKGAVSPVGNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDC 239
NN +PD DWRE G V+ V +Q N +AF+ G +EGQ +T S+QQ++DC
Sbjct: 104 NNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDC 163
Query: 240 SIYYGNSNCYSGCILSKAYAYLADYGSELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVS 419
S +GN+ C SG ++ AY YL +G E + YP+ C+Y+K L K G+ V
Sbjct: 164 SGPWGNNGC-SGGLMENAYQYLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGYYTVH 222
Query: 420 RGKEADLMNAVYNIGPISAAIDASPNTFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEESG 599
G E +L N V P + A+D + F Y++GIY +CS VNHAVL +GYG + G
Sbjct: 223 SGSEVELKNLVGARRPAAVAVDVESD-FMMYRSGIYQSQTCSPLRVNHAVLAVGYGTQGG 281
Query: 600 QSFWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVPLLKK 728
+WI+KNSWG+ WG +GY++++R+ N+CGIAS+AS+P++ +
Sbjct: 282 TDYWIVKNSWGTYWGERGYIRMARNRGNMCGIASLASLPMVAR 324
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 194 bits (494), Expect = 2e-49
Identities = 104/238 (43%), Positives = 144/238 (60%), Gaps = 5/238 (2%)
Frame = +3
Query: 18 KNDDLSRNDFITTPNNIKLPDSWDWREKGAVSPVGNQRNNCCGYAFAAAGALEGQNFNLT 197
+N + P ++P S DWREKG V+PV NQ +AF+A GALEGQ F T
Sbjct: 96 QNQKHKKGKMFQEPLFAEIPKSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKT 155
Query: 198 KTLEILSKQQIIDCSIYYGNSNCYSGCILSKAYAYLADYGS-ELDEDYPFVGYNS-NCKY 371
L LS+Q ++DCS GN C +G ++ A+ Y+ D G + +E YP++G ++ C Y
Sbjct: 156 GKLVSLSEQNLVDCSRAQGNEGC-NGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNY 214
Query: 372 DKSLATVKPYGFKYVSRGKEADLMNAVYNIGPISAAIDASPNTFKQYKTGIYDDTSCSSN 551
+ GF + + +E LM AV +GPIS AIDA +F+ YK+GIY D CSS
Sbjct: 215 KPECSAANDTGFVDLPQ-REKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSK 273
Query: 552 NVNHAVLVIGYGEE---SGQSFWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVP 716
+++H VLV+GYG E S FWI+KNSWG +WG GY+K+++D NN CGIA+ AS P
Sbjct: 274 DLDHGVLVVGYGFEGTDSNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYP 331
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 193 bits (490), Expect = 5e-49
Identities = 98/227 (43%), Positives = 147/227 (64%), Gaps = 5/227 (2%)
Frame = +3
Query: 57 PNNIKLPDSWDWREKGAVSPVGNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIID 236
P +K+P S DWREKG V+PV NQ +AF+A+G LEGQ F T L LS+Q ++D
Sbjct: 109 PLMLKIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVD 168
Query: 237 CSIYYGNSNCYSGCILSKAYAYLADYGS-ELDEDYPFVGYNSNCKYDKSLATVKPYGFKY 413
CS GN C +G ++ A+ Y+ + G + +E YP+ + +CKY A GF
Sbjct: 169 CSHAQGNQGC-NGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVD 227
Query: 414 VSRGKEADLMNAVYNIGPISAAIDASPNTFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEE 593
+ + ++A LM AV +GPIS A+DAS + + Y +GIY + +CSS N++H VL++GYG E
Sbjct: 228 IPQQEKA-LMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYE 286
Query: 594 SGQS----FWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVPLL 722
S +W++KNSWGS+WGM+GY+K+++D +N CG+A+ AS P++
Sbjct: 287 GTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 192 bits (487), Expect = 1e-48
Identities = 101/219 (46%), Positives = 138/219 (63%), Gaps = 5/219 (2%)
Frame = +3
Query: 75 PDSWDWREKGAVSPVGNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYG 254
P S DWREKG V+PV NQ +AF+A GALEGQ F T L LS+Q ++DCS G
Sbjct: 115 PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQG 174
Query: 255 NSNCYSGCILSKAYAYLADYGS-ELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVSRGKE 431
N C +G ++ A+ Y+ D G + +E YP+ +CKY+ + GF + + ++
Sbjct: 175 NEGC-NGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEK 233
Query: 432 ADLMNAVYNIGPISAAIDASPNTFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEESGQS-- 605
A LM AV +GPIS AIDA +F YK GIY + CSS +++H VLV+GYG ES +S
Sbjct: 234 A-LMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDN 292
Query: 606 --FWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVP 716
+W++KNSWG +WGM GY+K+++D N CGIAS AS P
Sbjct: 293 NKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYP 331
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 192 bits (487), Expect = 1e-48
Identities = 101/223 (45%), Positives = 141/223 (63%), Gaps = 6/223 (2%)
Frame = +3
Query: 66 IKLPDSWDWREKGAVSPVGNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSI 245
+++P S DWREKG V+ V NQ +AF+A GALEGQ F T L LS+Q ++DCS
Sbjct: 112 LEVPKSVDWREKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSR 171
Query: 246 YYGNSNCYSGCILSKAYAYLADYGS-ELDEDYPFVGYNSN-CKYDKSLATVKPYGFKYVS 419
GN C G ++ A+ Y+ D G + +E YP++G +N C Y + GF +
Sbjct: 172 PQGNQGCNGG-LMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDIP 230
Query: 420 RGKEADLMNAVYNIGPISAAIDASPNTFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEESG 599
+ ++A LM AV +GPIS AIDA ++F+ YK+GIY D CSS +++H VLV+GYG E
Sbjct: 231 QREKA-LMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGT 289
Query: 600 QS----FWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVP 716
S FWI+KNSWG +WG GY+K+++D NN CGI++ AS P
Sbjct: 290 DSNSSKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGISTAASYP 332
>sp|O35186|CATK_RAT Cathepsin K precursor
Length = 329
Score = 192 bits (487), Expect = 1e-48
Identities = 102/229 (44%), Positives = 141/229 (61%), Gaps = 3/229 (1%)
Frame = +3
Query: 39 NDFITTPN-NIKLPDSWDWREKGAVSPVGNQRNNCCGYAFAAAGALEGQNFNLTKTLEIL 215
ND + TP ++PDS D+R+KG V+PV NQ +AF++AGALEGQ T L L
Sbjct: 103 NDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLAL 162
Query: 216 SKQQIIDC-SIYYGNSNCYSGCILSKAYAYLADYGSELDED-YPFVGYNSNCKYDKSLAT 389
S Q ++DC S YG Y ++ A+ Y+ G ED YP+VG + +C Y+ +
Sbjct: 163 SPQNLVDCVSENYGCGGGY----MTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKA 218
Query: 390 VKPYGFKYVSRGKEADLMNAVYNIGPISAAIDASPNTFKQYKTGIYDDTSCSSNNVNHAV 569
K G++ + G E L AV +GP+S +IDAS +F+ Y G+Y D +C +NVNHAV
Sbjct: 219 AKCRGYREIPVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAV 278
Query: 570 LVIGYGEESGQSFWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVP 716
LV+GYG + G +WIIKNSWG WG KGY+ L+R+ NN CGI ++AS P
Sbjct: 279 LVVGYGTQKGNKYWIIKNSWGESWGNKGYVLLARNKNNACGITNLASFP 327
>sp|Q9R014|CATJ_MOUSE Cathepsin J precursor (Cathepsin P) (Catlrp-p)
Length = 333
Score = 192 bits (487), Expect = 1e-48
Identities = 105/222 (47%), Positives = 137/222 (61%), Gaps = 4/222 (1%)
Frame = +3
Query: 63 NIKLPDSWDWREKGAVSPVGNQRNNCCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCS 242
+I LPD DWRE+G V+PV NQ +AFAAAGA+EGQ F T L LS Q ++DCS
Sbjct: 110 SIGLPDYKDWREEGYVTPVRNQGKCGSCWAFAAAGAIEGQMFWKTGNLTPLSVQNLLDCS 169
Query: 243 IYYGNSNCYSGCILSKAYAYLADYGSELDEDYPFVGYNSNCKYDKSLATVKPYGFKYVSR 422
GN C SG L + G E + YP+ G + C+Y A+ + +
Sbjct: 170 KTVGNKGCQSGTAHQAFEYVLKNKGLEAEATYPYEGKDGPCRYRSENASANITDYVNLP- 228
Query: 423 GKEADLMNAVYNIGPISAAIDASPNTFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEE--- 593
E L AV +IGP+SAAIDAS ++F+ Y GIY + +CSS VNHAVLV+GYG E
Sbjct: 229 PNELYLWVAVASIGPVSAAIDASHDSFRFYNGGIYYEPNCSSYFVNHAVLVVGYGSEGDV 288
Query: 594 -SGQSFWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVP 716
G ++W+IKNSWG +WGM GYM++++D NN CGIAS+AS P
Sbjct: 289 KDGNNYWLIKNSWGEEWGMNGYMQIAKDHNNHCGIASLASYP 330
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,493,165
Number of Sequences: 369166
Number of extensions: 1643222
Number of successful extensions: 5115
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4579
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4728
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7763237265
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)