Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_014_O08
(746 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9JHU4|DYHC_MOUSE Dynein heavy chain, cytosolic (DYHC) (... 258 1e-68
sp|P37276|DYHC_DROME Dynein heavy chain, cytosolic (DYHC) 255 1e-67
sp|P38650|DYHC_RAT Dynein heavy chain, cytosolic (DYHC) (Cy... 253 3e-67
sp|Q14204|DYHC_HUMAN Dynein heavy chain, cytosolic (DYHC) (... 253 3e-67
sp|Q19020|DYHC_CAEEL Dynein heavy chain, cytosolic (DYHC) 207 2e-53
sp|P34036|DYHC_DICDI Dynein heavy chain, cytosolic (DYHC) 186 6e-47
sp|Q27171|DYHC_PARTE Dynein heavy chain, cytosolic (DYHC) (... 154 3e-37
sp|P78716|DYHC_FUSSO Dynein heavy chain, cytosolic (DYHC) 64 3e-10
sp|P45443|DYHC_NEUCR Dynein heavy chain, cytosolic (DYHC) 64 6e-10
sp|P45444|DYHC_EMENI Dynein heavy chain, cytosolic (DYHC) 53 1e-06
>sp|Q9JHU4|DYHC_MOUSE Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain)
Length = 4644
Score = 258 bits (659), Expect = 1e-68
Identities = 121/248 (48%), Positives = 168/248 (67%)
Frame = +3
Query: 3 DDKTEIVFPEFNNHGDILQWIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQ 182
D +I P+ + +QW+ LPD+QTPSWLGLPN+AE+VLLT G +I +LKMQ
Sbjct: 4287 DGHKDIQMPDGIRREEFVQWVELLPDAQTPSWLGLPNNAERVLLTTQGVDMISKMLKMQM 4346
Query: 183 TLEDDEEIVVDQRKSKRTIELGDSRPVWMRQLYQSTQTWLQLLPKVVIPLQRTTENIKDP 362
++D+ + K RT D RP WMR L+ + WL L+P+ + PL+RT ENIKDP
Sbjct: 4347 LEDEDDLAYAETEKKARTDSTSDGRPAWMRTLHTTASNWLHLIPQTLSPLKRTVENIKDP 4406
Query: 363 IYRCFEREVNSGSNLLLIVRKDLEDISEVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYP 542
++R FEREV G+ LL VR+DL D+ +VC G KK TN+ R+++ L KGI+P SW Y
Sbjct: 4407 LFRFFEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYT 4466
Query: 543 ISSGLTVIQWIHDFADRVKQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAV 722
+ +G+TVIQW+ DF++R+KQL +IS A + GA L+++ + LGGLF+ EAY TA RQ V
Sbjct: 4467 VPAGMTVIQWVSDFSERIKQLQNISQAAASGGAKELKNIHVCLGGLFVPEAYITATRQYV 4526
Query: 723 AQSNKWAL 746
AQ+N W+L
Sbjct: 4527 AQANSWSL 4534
>sp|P37276|DYHC_DROME Dynein heavy chain, cytosolic (DYHC)
Length = 4639
Score = 255 bits (651), Expect = 1e-67
Identities = 130/246 (52%), Positives = 162/246 (65%), Gaps = 3/246 (1%)
Frame = +3
Query: 18 IVFPEFNNHGDILQWIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQTLEDD 197
I P+ L+WI L D QTPSWLGLPN+AEKVLLT G L+ +LKMQQ LEDD
Sbjct: 4282 ITMPDGTRRDHFLKWIENLTDRQTPSWLGLPNNAEKVLLTTRGTDLVSKLLKMQQ-LEDD 4340
Query: 198 EEI---VVDQRKSKRTIELGDSRPVWMRQLYQSTQTWLQLLPKVVIPLQRTTENIKDPIY 368
+E+ V DQ + D RP WM+ L+ S WL+LLPK + L+RT ENIKDP+Y
Sbjct: 4341 DELAYSVEDQSEQSAVGRGEDGRPSWMKTLHNSATAWLELLPKNLQVLKRTVENIKDPLY 4400
Query: 369 RCFEREVNSGSNLLLIVRKDLEDISEVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYPIS 548
R FEREV SGS LL V DL+D+ +C G KK TNHHRSM++ L +GIIP W +Y +
Sbjct: 4401 RYFEREVTSGSRLLQTVILDLQDVVLICQGEKKQTNHHRSMLSELVRGIIPKGWKRYTVP 4460
Query: 549 SGLTVIQWIHDFADRVKQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQ 728
+G TVIQWI DF++RV+QL +S +GA L+ +WLGGL EAY TA RQ VAQ
Sbjct: 4461 AGCTVIQWITDFSNRVQQLQKVSQLVSQAGAKELQGFPVWLGGLLNPEAYITATRQCVAQ 4520
Query: 729 SNKWAL 746
+N W+L
Sbjct: 4521 ANSWSL 4526
>sp|P38650|DYHC_RAT Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain)
(MAP 1C)
Length = 4644
Score = 253 bits (647), Expect = 3e-67
Identities = 120/248 (48%), Positives = 166/248 (66%)
Frame = +3
Query: 3 DDKTEIVFPEFNNHGDILQWIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQ 182
D +I P+ + +QW+ LPD+QTPSWLGLPN+AE+VLLT G +I +LKMQ
Sbjct: 4287 DGHKDIQMPDGIRREEFVQWVELLPDAQTPSWLGLPNNAERVLLTTQGVDMISKMLKMQM 4346
Query: 183 TLEDDEEIVVDQRKSKRTIELGDSRPVWMRQLYQSTQTWLQLLPKVVIPLQRTTENIKDP 362
++D+ + K RT D RP WMR L+ + WL L+P+ + PL+RT ENIKDP
Sbjct: 4347 LEDEDDLAYAETEKKTRTDFTSDGRPAWMRTLHTTASNWLHLIPQTLSPLKRTVENIKDP 4406
Query: 363 IYRCFEREVNSGSNLLLIVRKDLEDISEVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYP 542
++R FEREV G+ LL VR+DL D+ +VC G KK TN+ R+++ L KGI+P SW Y
Sbjct: 4407 LFRFFEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYT 4466
Query: 543 ISSGLTVIQWIHDFADRVKQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAV 722
+ +G+TVIQW+ DF++R+KQL +IS A GA L+++ + LG LF+ EAY TA RQ V
Sbjct: 4467 VPAGMTVIQWVSDFSERIKQLQNISQAAAAGGAKELKNIHVCLGALFVPEAYITATRQYV 4526
Query: 723 AQSNKWAL 746
AQ+N W+L
Sbjct: 4527 AQANSWSL 4534
>sp|Q14204|DYHC_HUMAN Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain
1) (DHC1)
Length = 4646
Score = 253 bits (647), Expect = 3e-67
Identities = 120/248 (48%), Positives = 167/248 (67%)
Frame = +3
Query: 3 DDKTEIVFPEFNNHGDILQWIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQ 182
D +I P+ + +QW+ LPD+QTPSWLGLPN+AE+VLLT G +I +LKMQ
Sbjct: 4289 DGHKDIQMPDGIRREEFVQWVELLPDTQTPSWLGLPNNAERVLLTTQGVDMISKMLKMQM 4348
Query: 183 TLEDDEEIVVDQRKSKRTIELGDSRPVWMRQLYQSTQTWLQLLPKVVIPLQRTTENIKDP 362
++D+ + K RT D RP WMR L+ + WL L+P+ + L+RT ENIKDP
Sbjct: 4349 LEDEDDLAYAETEKKTRTDSTSDGRPAWMRTLHTTASNWLHLIPQTLSHLKRTVENIKDP 4408
Query: 363 IYRCFEREVNSGSNLLLIVRKDLEDISEVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYP 542
++R FEREV G+ LL VR+DL D+ +VC G KK TN+ R+++ L KGI+P SW Y
Sbjct: 4409 LFRFFEREVKMGAKLLQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYT 4468
Query: 543 ISSGLTVIQWIHDFADRVKQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAV 722
+ +G+TVIQW+ DF++R+KQL +IS A + GA L+++ + LGGLF+ EAY TA RQ V
Sbjct: 4469 VPAGMTVIQWVSDFSERIKQLQNISLAAASGGAKELKNIHVCLGGLFVPEAYITATRQYV 4528
Query: 723 AQSNKWAL 746
AQ+N W+L
Sbjct: 4529 AQANSWSL 4536
>sp|Q19020|DYHC_CAEEL Dynein heavy chain, cytosolic (DYHC)
Length = 4568
Score = 207 bits (528), Expect = 2e-53
Identities = 106/248 (42%), Positives = 150/248 (60%)
Frame = +3
Query: 3 DDKTEIVFPEFNNHGDILQWIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQ 182
D + P + ++ W+ +L + Q P+WLGLPN+AEKVLLT G+S++ N+LK+
Sbjct: 4237 DGDDSLFTPNMSKKDQMIGWVEELKNEQLPAWLGLPNNAEKVLLTKRGESMLRNMLKVT- 4295
Query: 183 TLEDDEEIVVDQRKSKRTIELGDSRPVWMRQLYQSTQTWLQLLPKVVIPLQRTTENIKDP 362
DEE+ ++ + +P WM QL + + WLQLLPK ++ ++RT ENIKDP
Sbjct: 4296 ----DEELAFNEDGKEEV------KPQWMAQLGELAKQWLQLLPKEIVKMRRTVENIKDP 4345
Query: 363 IYRCFEREVNSGSNLLLIVRKDLEDISEVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYP 542
++R FEREVN GS LL +R+DL +IS VC KK N R++ +L KG +P W +Y
Sbjct: 4346 LFRFFEREVNLGSQLLKDIRRDLNEISAVCRAEKKQNNETRALAASLQKGEVPTGWKRYT 4405
Query: 543 ISSGLTVIQWIHDFADRVKQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAV 722
+ +TV+ W+ D +R+KQLI I GA L+ WLGG F EAY TA RQ V
Sbjct: 4406 VpreVTVMDWMTDLNERLKQLIRI------GGADNLKRETFWLGGTFSPEAYITATRQQV 4459
Query: 723 AQSNKWAL 746
AQ+N W+L
Sbjct: 4460 AQANTWSL 4467
>sp|P34036|DYHC_DICDI Dynein heavy chain, cytosolic (DYHC)
Length = 4725
Score = 186 bits (472), Expect = 6e-47
Identities = 96/240 (40%), Positives = 146/240 (60%)
Frame = +3
Query: 27 PEFNNHGDILQWIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQTLEDDEEI 206
PE ++WI LP+ TP WLGLP +AE +LL+N + +I ++ KMQ + ED E+
Sbjct: 4379 PEGTTRAHFMKWIEALPEISTPIWLGLPENAESLLLSNKARKMINDLQKMQSSEEDGEDD 4438
Query: 207 VVDQRKSKRTIELGDSRPVWMRQLYQSTQTWLQLLPKVVIPLQRTTENIKDPIYRCFERE 386
V SK+ S +L + W +LLPK + L+RTT+NIKDP++RCFERE
Sbjct: 4439 QVSG-SSKKESSSSSSEDKGKAKLRATITEWTKLLPKPLKQLKRTTQNIKDPLFRCFERE 4497
Query: 387 VNSGSNLLLIVRKDLEDISEVCSGTKKPTNHHRSMMTNLAKGIIPISWIKYPISSGLTVI 566
+++G L+ + DL ++ E+ SG K TN+ RS+ T+++KGI+P W Y + +++
Sbjct: 4498 ISTGGKLVKKITNDLANLLELISGNIKSTNYLRSLTTSISKGIVPKEWKWYSVPETISLS 4557
Query: 567 QWIHDFADRVKQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQAVAQSNKWAL 746
WI DF+ R++QL IS ++ S S+++WLGGL EAY TA RQ+ +Q N W+L
Sbjct: 4558 VWISDFSKRMQQLSEISESSDYS------SIQVWLGGLLNPEAYITATRQSASQLNGWSL 4611
>sp|Q27171|DYHC_PARTE Dynein heavy chain, cytosolic (DYHC) (DHC08)
Length = 4540
Score = 154 bits (388), Expect = 3e-37
Identities = 80/249 (32%), Positives = 136/249 (54%), Gaps = 1/249 (0%)
Frame = +3
Query: 3 DDKTEIVFPEFNNHGDILQWIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQ 182
+ K I PE + D +QWI +LP +++P W GLP++ E+V L Q LI + +QQ
Sbjct: 4190 EGKEAITVPEGRTYLDFMQWIEQLPKTESPEWSGLPSNVERVQRDQLTQKLITKVQNLQQ 4249
Query: 183 TLEDD-EEIVVDQRKSKRTIELGDSRPVWMRQLYQSTQTWLQLLPKVVIPLQRTTENIKD 359
E++ +I V K+++ + W++ L + + + +LP + PL+RT ++I D
Sbjct: 4250 EGEEEITQIEVQTEKTQKKDNKKSDQVQWLQDLLEKVEKFKAILPNKISPLERTADSIND 4309
Query: 360 PIYRCFEREVNSGSNLLLIVRKDLEDISEVCSGTKKPTNHHRSMMTNLAKGIIPISWIKY 539
P++R +RE+ S LL VR+++E++ ++ G TN R + ++ I+P W KY
Sbjct: 4310 PLFRFLDREITVASKLLKAVRQNIEELIQLAQGKILATNILRQLAKDVFNNIVPAQWNKY 4369
Query: 540 PISSGLTVIQWIHDFADRVKQLIHISNTAINSGAAGLRSVKIWLGGLFMAEAYTTAIRQA 719
+ + + + W+ DF R+ Q + T + ++W GGL EAY TA RQ
Sbjct: 4370 NVIT-MPLNDWVGDFKRRIDQFDLLGKT------KDFQKGQVWFGGLLFPEAYLTATRQY 4422
Query: 720 VAQSNKWAL 746
VAQ+NKW+L
Sbjct: 4423 VAQANKWSL 4431
>sp|P78716|DYHC_FUSSO Dynein heavy chain, cytosolic (DYHC)
Length = 4349
Score = 64.3 bits (155), Expect = 3e-10
Identities = 28/66 (42%), Positives = 47/66 (71%)
Frame = +3
Query: 18 IVFPEFNNHGDILQWIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQTLEDD 197
+V P + D WI++LP+ + P++LGLP +AEK+LL LG+SLIGN+ K+ + L++
Sbjct: 4283 LVVPSGTSFQDFNAWIHRLPEREPPTYLGLPANAEKLLLGGLGRSLIGNLRKVTELLDEG 4342
Query: 198 EEIVVD 215
E++V +
Sbjct: 4343 EQLVTE 4348
>sp|P45443|DYHC_NEUCR Dynein heavy chain, cytosolic (DYHC)
Length = 4367
Score = 63.5 bits (153), Expect = 6e-10
Identities = 28/67 (41%), Positives = 46/67 (68%)
Frame = +3
Query: 15 EIVFPEFNNHGDILQWIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQTLED 194
++V P + + + WI KLP+ + P++LGLP +AEK+LL LG+SLIGN+ K+ L++
Sbjct: 4296 DLVVPSGTSLQEFMSWIQKLPEREPPTYLGLPANAEKLLLVGLGKSLIGNLKKVTDLLDE 4355
Query: 195 DEEIVVD 215
E I+ +
Sbjct: 4356 GEAIMAE 4362
>sp|P45444|DYHC_EMENI Dynein heavy chain, cytosolic (DYHC)
Length = 4344
Score = 52.8 bits (125), Expect = 1e-06
Identities = 19/54 (35%), Positives = 40/54 (74%)
Frame = +3
Query: 54 LQWIYKLPDSQTPSWLGLPNSAEKVLLTNLGQSLIGNILKMQQTLEDDEEIVVD 215
++W+ KLP+ + P++LGLP +AEK+LL G+ +I ++ ++ L++ E++++D
Sbjct: 4290 VEWVNKLPEREPPTYLGLPANAEKLLLVGHGKKMISDLARITSLLDEGEQLMID 4343
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,917,930
Number of Sequences: 369166
Number of extensions: 1644995
Number of successful extensions: 4173
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4048
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4158
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6776504000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)