Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_014_M21
(779 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 174 2e-43
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 174 2e-43
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 173 5e-43
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 169 6e-42
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 167 3e-41
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 162 7e-40
sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (C... 161 2e-39
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 160 5e-39
sp|Q9GLE3|CATK_PIG Cathepsin K precursor 158 1e-38
sp|P55097|CATK_MOUSE Cathepsin K precursor 157 3e-38
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 174 bits (442), Expect = 2e-43
Identities = 98/211 (46%), Positives = 131/211 (62%), Gaps = 1/211 (0%)
Frame = +2
Query: 149 WEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPE 328
WE+N+K I+ HN EY GKH +++ +N F DMTNEEF+ + +G + + +G + P
Sbjct: 52 WEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPL 110
Query: 329 NIGVLPASVDWRQKGYVTPVKNQQQCGSLFGLFSATGSLEGQYFRKNNRLISFSEQQLV* 508
+ LP SVDWR+KGYVTPVKNQ+QCGS + FSATG+LEGQ FRK +L+S SEQ LV
Sbjct: 111 FLD-LPKSVDWRKKGYVTPVKNQKQCGSCWA-FSATGALEGQMFRKTGKLVSLSEQNLV- 167
Query: 509 FVVVLMEIMDVVEVLWITLFRYIKDQ-GIESEGDYPFIRPQMALCKRNPSKIVTKCTGFT 685
F+Y+K+ G++SE YP++ +CK P V TGFT
Sbjct: 168 DCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVD-EICKYRPENSVANDTGFT 226
Query: 686 DIQSQNETDLANAVATVGPVSVAIDAGHASF 778
+ E L AVATVGP+SVA+DAGH+SF
Sbjct: 227 VVAPGKEKALMKAVATVGPISVAMDAGHSSF 257
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 174 bits (441), Expect = 2e-43
Identities = 106/217 (48%), Positives = 131/217 (60%), Gaps = 7/217 (3%)
Frame = +2
Query: 149 WEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPE 328
WE+N+K I+ HN EY GKH++++ +N F DMT+EEF+ G KP +G + P
Sbjct: 52 WEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPR-KGKVFQEP- 109
Query: 329 NIGVLPASVDWRQKGYVTPVKNQQQCGSLFGLFSATGSLEGQYFRKNNRLISFSEQQLV* 508
P SVDWR+KGYVTPVKNQ QCGS + FSATG+LEGQ FRK RLIS SEQ LV
Sbjct: 110 LFYEAPRSVDWREKGYVTPVKNQGQCGSCWA-FSATGALEGQMFRKTGRLISLSEQNLVD 168
Query: 509 FVVVLME------IMDVVEVLWITLFRYIKDQ-GIESEGDYPFIRPQMALCKRNPSKIVT 667
+MD F+Y++D G++SE YP+ + + CK NP V
Sbjct: 169 CSGPQGNEGCNGGLMDYA-------FQYVQDNGGLDSEESYPYEATEES-CKYNPKYSVA 220
Query: 668 KCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 778
TGF DI Q E L AVATVGP+SVAIDAGH SF
Sbjct: 221 NDTGFVDIPKQ-EKALMKAVATVGPISVAIDAGHESF 256
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 173 bits (438), Expect = 5e-43
Identities = 101/217 (46%), Positives = 126/217 (58%), Gaps = 7/217 (3%)
Frame = +2
Query: 149 WEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPE 328
WE+N+K I+ HN EY GKH +++ +N F DMTNEEF+ G K +G + P
Sbjct: 52 WEKNMKMIELHNREYSQGKHGFTMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKMFQEPL 110
Query: 329 NIGVLPASVDWRQKGYVTPVKNQQQCGSLFGLFSATGSLEGQYFRKNNRLISFSEQQLV* 508
+P SVDWR+KGYVTPVKNQ QCGS + FSATG+LEGQ FRK +L+S SEQ LV
Sbjct: 111 -FAEIPKSVDWREKGYVTPVKNQGQCGSCWA-FSATGALEGQMFRKTGKLVSLSEQNLVD 168
Query: 509 FVVVLME------IMDVVEVLWITLFRYIKDQG-IESEGDYPFIRPQMALCKRNPSKIVT 667
+MD FRY+KD G ++SE YP++ C P
Sbjct: 169 CSRAQGNEGCNGGLMD-------NAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAA 221
Query: 668 KCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 778
TGF D+ Q E L AVAT+GP+SVAIDAGH SF
Sbjct: 222 NDTGFVDLP-QREKALMKAVATLGPISVAIDAGHQSF 257
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 169 bits (429), Expect = 6e-42
Identities = 102/211 (48%), Positives = 121/211 (57%), Gaps = 1/211 (0%)
Frame = +2
Query: 149 WEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPE 328
WE+N K I HN EY GKH + + +N F DMTNEEF+ G K +G + P
Sbjct: 52 WEKNKKIIDLHNQEYSEGKHAFRMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKLFHEPL 110
Query: 329 NIGVLPASVDWRQKGYVTPVKNQQQCGSLFGLFSATGSLEGQYFRKNNRLISFSEQQLV* 508
+ V P SVDW +KGYVTPVKNQ QCGS + FSATG+LEGQ FRK +L+S SEQ LV
Sbjct: 111 LVDV-PKSVDWTKKGYVTPVKNQGQCGSCWA-FSATGALEGQMFRKTGKLVSLSEQNLV- 167
Query: 509 FVVVLMEIMDVVEVLWITLFRYIKDQ-GIESEGDYPFIRPQMALCKRNPSKIVTKCTGFT 685
L F+YIKD G++SE YP++ C P TGF
Sbjct: 168 DCSRAQGNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFV 227
Query: 686 DIQSQNETDLANAVATVGPVSVAIDAGHASF 778
DI Q E L AVATVGP+SVAIDAGH SF
Sbjct: 228 DI-PQREKALMKAVATVGPISVAIDAGHTSF 257
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 167 bits (423), Expect = 3e-41
Identities = 100/211 (47%), Positives = 125/211 (59%), Gaps = 1/211 (0%)
Frame = +2
Query: 149 WEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPE 328
WE+N+K I+ HN EY GKH +S+ +N F DMTNEEF+ G K +G +
Sbjct: 52 WEKNMKMIELHNQEYSQGKHGFSMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKVFHESL 110
Query: 329 NIGVLPASVDWRQKGYVTPVKNQQQCGSLFGLFSATGSLEGQYFRKNNRLISFSEQQLV* 508
+ V P SVDWR+KGYVT VKNQ QCGS + FSATG+LEGQ FRK +L+S SEQ LV
Sbjct: 111 VLEV-PKSVDWREKGYVTAVKNQGQCGSCWA-FSATGALEGQMFRKTGKLVSLSEQNLV- 167
Query: 509 FVVVLMEIMDVVEVLWITLFRYIKDQG-IESEGDYPFIRPQMALCKRNPSKIVTKCTGFT 685
L F+Y+KD G +++E YP++ + C P TGF
Sbjct: 168 DCSRPQGNQGCNGGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFV 227
Query: 686 DIQSQNETDLANAVATVGPVSVAIDAGHASF 778
DI Q E L AVATVGP+SVAIDAGH+SF
Sbjct: 228 DIP-QREKALMKAVATVGPISVAIDAGHSSF 257
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 162 bits (411), Expect = 7e-40
Identities = 99/214 (46%), Positives = 124/214 (57%), Gaps = 2/214 (0%)
Frame = +2
Query: 143 LFWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGI-MKTKPTLEGSTYM 319
L WE+NLKYI HNLE LG HTY L +N DMTNEE K G+ + + T
Sbjct: 48 LIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTNEEVVQKMTGLKVPASHSRSNDTLY 107
Query: 320 APENIGVLPASVDWRQKGYVTPVKNQQQCGSLFGLFSATGSLEGQYFRKNNRLISFSEQQ 499
P+ G P SVD+R+KGYVTPVKNQ QCGS + FS+ G+LEGQ +K +L++ S Q
Sbjct: 108 IPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWA-FSSVGALEGQLKKKTGKLLNLSPQN 166
Query: 500 LV*FVVVLMEIMDVVEVLWITLFRYI-KDQGIESEGDYPFIRPQMALCKRNPSKIVTKCT 676
LV V E F+Y+ K++GI+SE YP++ Q C NP+ KC
Sbjct: 167 LVDCV---SENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYV-GQEESCMYNPTGKAAKCR 222
Query: 677 GFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 778
G+ +I NE L AVA VGPVSVAIDA SF
Sbjct: 223 GYREIPEGNEKALKRAVARVGPVSVAIDASLTSF 256
>sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (Cathepsin X) (Cathepsin O2)
Length = 329
Score = 161 bits (408), Expect = 2e-39
Identities = 99/214 (46%), Positives = 124/214 (57%), Gaps = 2/214 (0%)
Frame = +2
Query: 143 LFWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGI-MKTKPTLEGSTYM 319
L WE+NLKYI HNLE LG HTY L +N DMT+EE K G+ + + T
Sbjct: 48 LIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLY 107
Query: 320 APENIGVLPASVDWRQKGYVTPVKNQQQCGSLFGLFSATGSLEGQYFRKNNRLISFSEQQ 499
PE G P SVD+R+KGYVTPVKNQ QCGS + FS+ G+LEGQ +K +L++ S Q
Sbjct: 108 IPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWA-FSSVGALEGQLKKKTGKLLNLSPQN 166
Query: 500 LV*FVVVLMEIMDVVEVLWITLFRYI-KDQGIESEGDYPFIRPQMALCKRNPSKIVTKCT 676
LV V E F+Y+ K++GI+SE YP++ Q C NP+ KC
Sbjct: 167 LVDCV---SENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYV-GQEESCMYNPTGKAAKCR 222
Query: 677 GFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 778
G+ +I NE L AVA VGPVSVAIDA SF
Sbjct: 223 GYREIPEGNEKALKRAVARVGPVSVAIDASLTSF 256
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 160 bits (404), Expect = 5e-39
Identities = 110/266 (41%), Positives = 147/266 (55%), Gaps = 7/266 (2%)
Frame = +2
Query: 2 ILSLVVVAITAVPQKFLSKQ*IK*RMGNYKSTFWKEI**INLTLVDD----LFWEQNLKY 169
+L L VV+ P++ L Q +K T+ K+ + VD+ L WE+NLK+
Sbjct: 6 VLLLPVVSFALHPEEILDTQ-----WELWKKTYSKQY----NSKVDEISRRLIWEKNLKH 56
Query: 170 IQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGS--TYMAPENIGVL 343
I HNLE LG HTY L +N DMT+EE K G +K P+ S T P+ G
Sbjct: 57 ISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTG-LKVPPSRSHSNDTLYIPDWEGRT 115
Query: 344 PASVDWRQKGYVTPVKNQQQCGSLFGLFSATGSLEGQYFRKNNRLISFSEQQLV*FVVVL 523
P S+D+R+KGYVTPVKNQ QCGS + FS+ G+LEGQ +K +L++ S Q LV V
Sbjct: 116 PDSIDYRKKGYVTPVKNQGQCGSCWA-FSSVGALEGQLKKKTGKLLNLSPQNLVDCV--- 171
Query: 524 MEIMDVVEVLWITLFRYI-KDQGIESEGDYPFIRPQMALCKRNPSKIVTKCTGFTDIQSQ 700
E F+Y+ +++GI+SE YP++ Q C NP+ KC G+ +I
Sbjct: 172 SENYGCGGGYMTNAFQYVQRNRGIDSEDAYPYV-GQDESCMYNPTGKAAKCRGYREIPEG 230
Query: 701 NETDLANAVATVGPVSVAIDAGHASF 778
NE L AVA VGPVSVAIDA SF
Sbjct: 231 NEKALKRAVARVGPVSVAIDASLTSF 256
>sp|Q9GLE3|CATK_PIG Cathepsin K precursor
Length = 330
Score = 158 bits (400), Expect = 1e-38
Identities = 110/266 (41%), Positives = 147/266 (55%), Gaps = 7/266 (2%)
Frame = +2
Query: 2 ILSLVVVAITAVPQKFLSKQ*IK*RMGNYKSTFWKEI**INLTLVDD----LFWEQNLKY 169
+L L V++ P++ L Q +K T+ K+ + VD+ L WE+NLK+
Sbjct: 7 VLLLPVMSSALYPEEILDTQ-----WELWKKTYRKQY----NSKVDEISRRLIWEKNLKH 57
Query: 170 IQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGS--TYMAPENIGVL 343
I HNLE LG HTY L +N DMT+EE K G +K P+ S T P+ G
Sbjct: 58 ISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTG-LKVPPSHSRSNDTLYIPDWEGRT 116
Query: 344 PASVDWRQKGYVTPVKNQQQCGSLFGLFSATGSLEGQYFRKNNRLISFSEQQLV*FVVVL 523
P S+D+R+KGYVTPVKNQ QCGS + FS+ G+LEGQ +K +L++ S Q LV V
Sbjct: 117 PDSIDYRKKGYVTPVKNQGQCGSCWA-FSSVGALEGQLKKKTGKLLNLSPQNLVDCV--- 172
Query: 524 MEIMDVVEVLWITLFRYI-KDQGIESEGDYPFIRPQMALCKRNPSKIVTKCTGFTDIQSQ 700
E F+Y+ K++GI+SE YP++ Q C NP+ KC G+ +I
Sbjct: 173 SENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYV-GQDENCMYNPTGKAAKCRGYREIPEG 231
Query: 701 NETDLANAVATVGPVSVAIDAGHASF 778
NE L AVA VGPVSVAIDA SF
Sbjct: 232 NEKALKRAVARVGPVSVAIDASLTSF 257
>sp|P55097|CATK_MOUSE Cathepsin K precursor
Length = 329
Score = 157 bits (397), Expect = 3e-38
Identities = 95/214 (44%), Positives = 123/214 (57%), Gaps = 2/214 (0%)
Frame = +2
Query: 143 LFWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGI-MKTKPTLEGSTYM 319
L WE+NLK I HNLE LG HTY L +N DMT+EE K G+ + + T
Sbjct: 48 LIWEKNLKQISAHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLRIPPSRSYSNDTLY 107
Query: 320 APENIGVLPASVDWRQKGYVTPVKNQQQCGSLFGLFSATGSLEGQYFRKNNRLISFSEQQ 499
PE G +P S+D+R+KGYVTPVKNQ QCGS + FS+ G+LEGQ +K +L++ S Q
Sbjct: 108 TPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWA-FSSAGALEGQLKKKTGKLLALSPQN 166
Query: 500 LV*FVVVLMEIMDVVEVLWITLFRYIKDQ-GIESEGDYPFIRPQMALCKRNPSKIVTKCT 676
LV V E T F+Y++ GI+SE YP++ Q C N + KC
Sbjct: 167 LVDCVT---ENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYV-GQDESCMYNATAKAAKCR 222
Query: 677 GFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 778
G+ +I NE L AVA VGP+SV+IDA ASF
Sbjct: 223 GYREIPVGNEKALKRAVARVGPISVSIDASLASF 256
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,815,458
Number of Sequences: 369166
Number of extensions: 1710855
Number of successful extensions: 4311
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3864
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4003
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7308943600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)