Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_014_K24
(456 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P60891|PRPS1_HUMAN Ribose-phosphate pyrophosphokinase I ... 181 9e-46
sp|Q9D7G0|PRPS1_MOUSE Ribose-phosphate pyrophosphokinase I ... 180 1e-45
sp|Q4R4R7|PRPS2_MACFA Ribose-phosphate pyrophosphokinase II... 179 2e-45
sp|P09330|PRPS2_RAT Ribose-phosphate pyrophosphokinase II (... 179 3e-45
sp|Q9CS42|PRPS2_MOUSE Ribose-phosphate pyrophosphokinase II... 179 3e-45
sp|P21108|PRPS3_HUMAN Ribose-phosphate pyrophosphokinase II... 176 3e-44
sp|P38689|KPR3_YEAST Ribose-phosphate pyrophosphokinase 3 (... 156 2e-38
sp|P46585|KPR1_CANAL Ribose-phosphate pyrophosphokinase 1 (... 152 3e-37
sp|P38063|KPR4_YEAST Probable ribose-phosphate pyrophosphok... 150 1e-36
sp|P38620|KPR2_YEAST Ribose-phosphate pyrophosphokinase 2 (... 150 1e-36
>sp|P60891|PRPS1_HUMAN Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate
synthetase I) (PRS-I) (PPRibP)
sp|P60892|PRPS1_RAT Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate
synthetase I) (PRS-I)
Length = 318
Score = 181 bits (458), Expect = 9e-46
Identities = 88/153 (57%), Positives = 122/153 (79%), Gaps = 2/153 (1%)
Frame = +2
Query: 2 LMELLIMINACKNASSARITAVLPYMPYSRQSKKDNNRVPITAKLVADLLHIAGTNHIIT 181
LMELLIMINACK AS++R+TAV+P PY+RQ KKD +R PI+AKLVA++L +AG +HIIT
Sbjct: 67 LMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIIT 126
Query: 182 MDLHASQIQGFFNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLK 361
MDLHASQIQGFF++PVDNL +E + WI++NIS+W TI S + A+RV ++A+ L
Sbjct: 127 MDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLN 186
Query: 362 VRFGLIYVEKKEASE--QIILVGDVVSRIAVIL 454
V F LI+ E+K+A+E +++LVGDV R+A+++
Sbjct: 187 VDFALIHKERKKANEVDRMVLVGDVKDRVAILV 219
>sp|Q9D7G0|PRPS1_MOUSE Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate
synthetase I) (PRS-I)
Length = 318
Score = 180 bits (457), Expect = 1e-45
Identities = 88/153 (57%), Positives = 121/153 (79%), Gaps = 2/153 (1%)
Frame = +2
Query: 2 LMELLIMINACKNASSARITAVLPYMPYSRQSKKDNNRVPITAKLVADLLHIAGTNHIIT 181
LMELLIMINACK AS++R+TAV+P PY+RQ KKD +R PI+AKLVA++L +AG +HIIT
Sbjct: 67 LMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIIT 126
Query: 182 MDLHASQIQGFFNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLK 361
MDLHASQIQGFF++PVDNL +E + WI++NIS+W TI S + A+RV ++A L
Sbjct: 127 MDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIAERLN 186
Query: 362 VRFGLIYVEKKEASE--QIILVGDVVSRIAVIL 454
V F LI+ E+K+A+E +++LVGDV R+A+++
Sbjct: 187 VDFALIHKERKKANEVDRMVLVGDVKDRVAILV 219
>sp|Q4R4R7|PRPS2_MACFA Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II)
sp|P11908|PRPS2_HUMAN Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II) (PPRibP)
Length = 318
Score = 179 bits (455), Expect = 2e-45
Identities = 87/153 (56%), Positives = 122/153 (79%), Gaps = 2/153 (1%)
Frame = +2
Query: 2 LMELLIMINACKNASSARITAVLPYMPYSRQSKKDNNRVPITAKLVADLLHIAGTNHIIT 181
LMELLIMINACK ASS+R+TAV+P PY+RQ KKD +R PI+AKLVA++L +AG +HIIT
Sbjct: 67 LMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIIT 126
Query: 182 MDLHASQIQGFFNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLK 361
MDLHASQIQGFF++PVDNL +E + WI++NI++W+ I S + A+RV ++A+ L
Sbjct: 127 MDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTSIADRLN 186
Query: 362 VRFGLIYVEKKEASE--QIILVGDVVSRIAVIL 454
V F LI+ E+K+A+E +++LVGDV R+A+++
Sbjct: 187 VEFALIHKERKKANEVDRMVLVGDVKDRVAILV 219
>sp|P09330|PRPS2_RAT Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II)
Length = 318
Score = 179 bits (454), Expect = 3e-45
Identities = 87/153 (56%), Positives = 121/153 (79%), Gaps = 2/153 (1%)
Frame = +2
Query: 2 LMELLIMINACKNASSARITAVLPYMPYSRQSKKDNNRVPITAKLVADLLHIAGTNHIIT 181
LMELLIMINACK ASS+R+TAV+P PY+RQ KKD +R PI+AKLVA++L +AG +HIIT
Sbjct: 67 LMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIIT 126
Query: 182 MDLHASQIQGFFNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLK 361
MDLHASQIQGFF++PVDNL +E + WI++NI++W I S + A+RV ++A+ L
Sbjct: 127 MDLHASQIQGFFDIPVDNLYAEPAVLQWIRENITEWRNCIIVSPDAGGAKRVTSIADRLN 186
Query: 362 VRFGLIYVEKKEASE--QIILVGDVVSRIAVIL 454
V F LI+ E+K+A+E +++LVGDV R+A+++
Sbjct: 187 VEFALIHKERKKANEVDRMVLVGDVKDRVAILV 219
>sp|Q9CS42|PRPS2_MOUSE Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II)
Length = 318
Score = 179 bits (454), Expect = 3e-45
Identities = 87/153 (56%), Positives = 121/153 (79%), Gaps = 2/153 (1%)
Frame = +2
Query: 2 LMELLIMINACKNASSARITAVLPYMPYSRQSKKDNNRVPITAKLVADLLHIAGTNHIIT 181
LMELLIMINACK ASS+R+TAV+P PY+RQ KKD +R PI+AKLVA++L +AG +HIIT
Sbjct: 67 LMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIIT 126
Query: 182 MDLHASQIQGFFNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLK 361
MDLHASQIQGFF++PVDNL +E + WI++NI++W I S + A+RV ++A+ L
Sbjct: 127 MDLHASQIQGFFDIPVDNLYAEPAVLQWIRENITEWRNCIIVSPDAGGAKRVTSIADRLN 186
Query: 362 VRFGLIYVEKKEASE--QIILVGDVVSRIAVIL 454
V F LI+ E+K+A+E +++LVGDV R+A+++
Sbjct: 187 VEFALIHKERKKANEVDRMVLVGDVKDRVAILV 219
>sp|P21108|PRPS3_HUMAN Ribose-phosphate pyrophosphokinase III (Phosphoribosyl
pyrophosphate synthetase III) (PRS-III) (Phosphoribosyl
pyrophosphate synthetase 1-like 1)
Length = 318
Score = 176 bits (445), Expect = 3e-44
Identities = 88/153 (57%), Positives = 120/153 (78%), Gaps = 2/153 (1%)
Frame = +2
Query: 2 LMELLIMINACKNASSARITAVLPYMPYSRQSKKDNNRVPITAKLVADLLHIAGTNHIIT 181
LMELLIMINACK AS++R+TAV+P PY+RQ KKD +R PI+AKLVA++L IAG +HIIT
Sbjct: 67 LMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRSPISAKLVANMLSIAGADHIIT 126
Query: 182 MDLHASQIQGFFNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLK 361
MDLHASQIQGFF++PVDNL +E + WI++NI +W+ I S + A+RV ++A+ L
Sbjct: 127 MDLHASQIQGFFDIPVDNLYAEPTVLKWIRENIPEWKNCIIVSPDAGGAKRVTSIADQLN 186
Query: 362 VRFGLIYVEKKEASEQ--IILVGDVVSRIAVIL 454
V F LI+ E+K+A+E I+LVGDV R+A+++
Sbjct: 187 VDFALIHKERKKANEVDCIVLVGDVNDRVAILV 219
>sp|P38689|KPR3_YEAST Ribose-phosphate pyrophosphokinase 3 (Phosphoribosyl pyrophosphate
synthetase 3)
Length = 320
Score = 156 bits (394), Expect = 2e-38
Identities = 80/153 (52%), Positives = 114/153 (74%), Gaps = 2/153 (1%)
Frame = +2
Query: 2 LMELLIMINACKNASSARITAVLPYMPYSRQSKKDNNRVPITAKLVADLLHIAGTNHIIT 181
++ELLIMINA K AS+ RITA++P PY+RQ +KD +R PITAKL+AD+L AG +H+IT
Sbjct: 70 VLELLIMINASKTASARRITAIIPNFPYARQDRKDKSRAPITAKLMADMLTTAGCDHVIT 129
Query: 182 MDLHASQIQGFFNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLK 361
MDLHASQIQGFF+VPVDNL +E + +IK+N++ + I I S + A+R A +A+ L
Sbjct: 130 MDLHASQIQGFFDVPVDNLYAEPSVVRYIKENVNYMDSI-IISPDAGGAKRAATLADRLD 188
Query: 362 VRFGLIYVEKKEASE--QIILVGDVVSRIAVIL 454
+ F LI+ E+ A+E +++LVGDV +I +I+
Sbjct: 189 LNFALIHKERARANEVSRMVLVGDVTDKICIIV 221
>sp|P46585|KPR1_CANAL Ribose-phosphate pyrophosphokinase 1 (Phosphoribosyl pyrophosphate
synthetase 1)
Length = 321
Score = 152 bits (385), Expect = 3e-37
Identities = 80/153 (52%), Positives = 110/153 (71%), Gaps = 2/153 (1%)
Frame = +2
Query: 2 LMELLIMINACKNASSARITAVLPYMPYSRQSKKDNNRVPITAKLVADLLHIAGTNHIIT 181
+ EL+IMINACK AS+ RIT +LP PY+RQ +KD +R PITAKL+AD+L AG +H+IT
Sbjct: 70 VFELMIMINACKTASARRITVILPNFPYARQDRKDKSRAPITAKLMADMLTTAGCDHVIT 129
Query: 182 MDLHASQIQGFFNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLK 361
MDLHASQIQGFF+VPVDNL +E + +IK+ I + E I S + A+R A +A+ L
Sbjct: 130 MDLHASQIQGFFDVPVDNLYAEPSVVRYIKETID-YSEAIIISSDAGGAKRAAGLADRLD 188
Query: 362 VRFGLIYVEKKEASE--QIILVGDVVSRIAVIL 454
+ F LI+ E+ A+E +++LV DV +I VI+
Sbjct: 189 LNFELIHKERARANEVSRMVLVVDVTDKICVIV 221
>sp|P38063|KPR4_YEAST Probable ribose-phosphate pyrophosphokinase 4 (Phosphoribosyl
pyrophosphate synthetase 4)
Length = 355
Score = 150 bits (380), Expect = 1e-36
Identities = 75/153 (49%), Positives = 115/153 (75%), Gaps = 2/153 (1%)
Frame = +2
Query: 2 LMELLIMINACKNASSARITAVLPYMPYSRQSKKDNNRVPITAKLVADLLHIAGTNHIIT 181
LMELLI+I+AC+ AS+ +IT V+P PY+RQ KKD +R PITAKLVA+LL AG +H+IT
Sbjct: 107 LMELLILIHACQIASARKITTVIPNFPYARQDKKDKSRAPITAKLVANLLQTAGADHVIT 166
Query: 182 MDLHASQIQGFFNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLK 361
MDLHASQIQGFF++PVDNL +E +++I+ + ++ + S + A+RVA +A+ L
Sbjct: 167 MDLHASQIQGFFHIPVDNLYAEPSVLNYIRARKTDFDNAILVSPDAGGAKRVAALADKLD 226
Query: 362 VRFGLIYVEKKEASE--QIILVGDVVSRIAVIL 454
+ F LI+ E+++A+E +++LVGDV ++ +++
Sbjct: 227 LNFALIHKERQKANEVSKMVLVGDVTNKSCLLV 259
>sp|P38620|KPR2_YEAST Ribose-phosphate pyrophosphokinase 2 (Phosphoribosyl pyrophosphate
synthetase 2)
Length = 318
Score = 150 bits (379), Expect = 1e-36
Identities = 77/153 (50%), Positives = 113/153 (73%), Gaps = 2/153 (1%)
Frame = +2
Query: 2 LMELLIMINACKNASSARITAVLPYMPYSRQSKKDNNRVPITAKLVADLLHIAGTNHIIT 181
LMELLI+I+ACK AS RITAV+P PY+RQ KKD +R PITAKL+A+LL AG +H+IT
Sbjct: 71 LMELLILIHACKTASVRRITAVIPNFPYARQDKKDKSRAPITAKLIANLLETAGCDHVIT 130
Query: 182 MDLHASQIQGFFNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLK 361
MDLHASQIQGFF++PVDNL E +++I+ + + + S + A+RVA++A+ L
Sbjct: 131 MDLHASQIQGFFHIPVDNLYGEPSVLNYIRTK-TDFNNAILVSPDAGGAKRVASLADKLD 189
Query: 362 VRFGLIYVEKKEASE--QIILVGDVVSRIAVIL 454
+ F LI+ E+++A+E +++LVGDV + +++
Sbjct: 190 MNFALIHKERQKANEVSRMLLVGDVAGKSCLLI 222
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,825,591
Number of Sequences: 369166
Number of extensions: 1112573
Number of successful extensions: 3078
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2853
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3034
length of database: 68,354,980
effective HSP length: 101
effective length of database: 49,696,745
effective search space used: 2484837250
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)