Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_014_K09
(830 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07099|HYEP_HUMAN Epoxide hydrolase 1 (Microsomal epoxid... 170 5e-42
sp|P04068|HYEP_RABIT Epoxide hydrolase 1 (Microsomal epoxid... 169 7e-42
sp|P07687|HYEP_RAT Epoxide hydrolase 1 (Microsomal epoxide ... 167 4e-41
sp|Q9D379|HYEP_MOUSE Epoxide hydrolase 1 (Microsomal epoxid... 166 1e-40
sp|Q8MZR6|HYEP1_CTEFE Juvenile hormone epoxide hydrolase 1 ... 149 9e-36
sp|Q8MZR5|HYEP2_CTEFE Juvenile hormone epoxide hydrolase 2 ... 148 2e-35
sp|Q25489|HYEP_MANSE Juvenile hormone epoxide hydrolase (Ju... 126 6e-29
sp|Q06816|HYEP_STIAU Epoxide hydrolase (Epoxide hydratase) 70 5e-12
sp|P44248|Y1543_HAEIN Hypothetical protein HI1543 32 2.1
sp|P21358|RMAR_CANGA Mitochondrial ribosomal protein VAR1 31 4.8
>sp|P07099|HYEP_HUMAN Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide
hydratase)
Length = 455
Score = 170 bits (430), Expect = 5e-42
Identities = 89/185 (48%), Positives = 126/185 (68%), Gaps = 5/185 (2%)
Frame = +3
Query: 102 LTQRELDMVYPWSDKI-NTILSSMGYFGLQSTRPSTIGIALSDSPAGLAAYILEKFGAWS 278
LT+R+++++YP +K+ +++ GY +Q T+P T+G AL+DSP GLAAYILEKF W+
Sbjct: 274 LTERDVELLYPVKEKVFYSLMRESGYMHIQCTKPDTVGSALNDSPVGLAAYILEKFSTWT 333
Query: 279 NNNSYHLSSPNGGLEDIKITKDEMLTNVMIYYITNTISSSVRLYKEMLNE----QNHKLF 446
N +L +GGLE K + D++LTNVM+Y+ T TI SS R YKE L + Q H+
Sbjct: 334 NTEFRYLE--DGGLER-KFSLDDLLTNVMLYWTTGTIISSQRFYKENLGQGWMTQKHERM 390
Query: 447 KTPVRVPTAIAMFPNEIIQVPKPFVHFKYRNVRQFNYMPRGGHFAALEEPELLANDIRSF 626
K V VPT + FP E++ P+ +V FKY + ++YM RGGHFAA EEPELLA DIR F
Sbjct: 391 K--VYVPTGFSAFPFELLHTPEKWVRFKYPKLISYSYMVRGGHFAAFEEPELLAQDIRKF 448
Query: 627 INLME 641
++++E
Sbjct: 449 LSVLE 453
>sp|P04068|HYEP_RABIT Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide
hydratase)
Length = 455
Score = 169 bits (429), Expect = 7e-42
Identities = 94/217 (43%), Positives = 138/217 (63%), Gaps = 5/217 (2%)
Frame = +3
Query: 6 GIHINF--VETPYHDMRYLTQVFIGSMLPAKLHILTQRELDMVYPWSDKI-NTILSSMGY 176
G+H+N + ++ + L IG +L T+R+++++YP+ +K+ +++ GY
Sbjct: 245 GLHLNMALILRNHYTLTLLLGRRIGGLLG-----YTERDMELLYPFKEKVFYSLMRESGY 299
Query: 177 FGLQSTRPSTIGIALSDSPAGLAAYILEKFGAWSNNNSYHLSSPNGGLEDIKITKDEMLT 356
+++T+P T+G AL+DSP GLAAYILEKF W+N+ L +GGLE K + ++LT
Sbjct: 300 MHIRATKPDTVGCALNDSPVGLAAYILEKFSTWTNSEFRDLE--DGGLER-KFSLQDLLT 356
Query: 357 NVMIYYITNTISSSVRLYKEMLNE--QNHKLFKTPVRVPTAIAMFPNEIIQVPKPFVHFK 530
N+MIY+ T +I SS R YKE L + HK + V VPT A FP EI+ VP+ +V K
Sbjct: 357 NIMIYWTTGSIVSSQRYYKENLGQGFMAHKHERLKVHVPTGFAAFPCEIMHVPEKWVRTK 416
Query: 531 YRNVRQFNYMPRGGHFAALEEPELLANDIRSFINLME 641
Y + ++YMPRGGHFAA EEPELLA DI F+ L+E
Sbjct: 417 YPQLISYSYMPRGGHFAAFEEPELLARDICKFVGLVE 453
>sp|P07687|HYEP_RAT Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide
hydratase)
Length = 455
Score = 167 bits (422), Expect = 4e-41
Identities = 92/217 (42%), Positives = 135/217 (62%), Gaps = 5/217 (2%)
Frame = +3
Query: 6 GIHIN--FVETPYHDMRYLTQVFIGSMLPAKLHILTQRELDMVYPWSDKI-NTILSSMGY 176
G+H+N F+ ++ M L G L T+++++++YP+ +K+ +I+ GY
Sbjct: 245 GLHLNMAFISRSFYTMTPLLGQRFGRFLG-----YTEKDIELLYPYKEKVFYSIMRESGY 299
Query: 177 FGLQSTRPSTIGIALSDSPAGLAAYILEKFGAWSNNNSYHLSSPNGGLEDIKITKDEMLT 356
+Q+T+P T+G AL+DSP GLAAYILEKF W+ + L +GGLE K + D++L
Sbjct: 300 LHIQATKPDTVGCALNDSPVGLAAYILEKFSTWTKSEYRELE--DGGLER-KFSLDDLLV 356
Query: 357 NVMIYYITNTISSSVRLYKEMLNE--QNHKLFKTPVRVPTAIAMFPNEIIQVPKPFVHFK 530
N+MIY+ T TI SS R YKE L + HK V VPT + FP+E++ P+ +V K
Sbjct: 357 NIMIYWTTGTIVSSQRYYKENLGQGIMVHKHEGMKVFVPTGFSAFPSELLHAPEKWVKVK 416
Query: 531 YRNVRQFNYMPRGGHFAALEEPELLANDIRSFINLME 641
Y + ++YM RGGHFAA EEP+LLA DIR F++L E
Sbjct: 417 YPKLISYSYMERGGHFAAFEEPKLLAQDIRKFVSLAE 453
>sp|Q9D379|HYEP_MOUSE Epoxide hydrolase 1 (Microsomal epoxide hydrolase) (Epoxide
hydratase)
Length = 455
Score = 166 bits (419), Expect = 1e-40
Identities = 93/217 (42%), Positives = 134/217 (61%), Gaps = 5/217 (2%)
Frame = +3
Query: 6 GIHIN--FVETPYHDMRYLTQVFIGSMLPAKLHILTQRELDMVYPWSDKI-NTILSSMGY 176
G+H+N F+ + + L G L T+++L+++YP+ +K+ I+ GY
Sbjct: 245 GLHLNMSFISRNIYSLTPLLGQRFGRFLG-----YTEKDLELLYPFKEKVFYNIMRESGY 299
Query: 177 FGLQSTRPSTIGIALSDSPAGLAAYILEKFGAWSNNNSYHLSSPNGGLEDIKITKDEMLT 356
+Q+T+P T+G AL+DSP GLAAYILEKF W+ + L +GGLE K + +++LT
Sbjct: 300 LHIQATKPDTVGCALNDSPVGLAAYILEKFSTWTKSEYRELE--DGGLER-KFSLEDLLT 356
Query: 357 NVMIYYITNTISSSVRLYKEMLNE--QNHKLFKTPVRVPTAIAMFPNEIIQVPKPFVHFK 530
N+MIY+ T TI SS R YKE L + H+ V VPT + FP+EI+ PK +V K
Sbjct: 357 NIMIYWTTGTIVSSQRFYKENLGQGVMVHRHEGMKVFVPTGYSAFPSEILHAPKKWVKVK 416
Query: 531 YRNVRQFNYMPRGGHFAALEEPELLANDIRSFINLME 641
Y + ++YM RGGHFAA EEP+LLA DIR F++L E
Sbjct: 417 YPKLISYSYMERGGHFAAFEEPKLLAQDIRKFVSLAE 453
>sp|Q8MZR6|HYEP1_CTEFE Juvenile hormone epoxide hydrolase 1 (Juvenile hormone epoxide
hydrolase I) (Juvenile hormone-specific epoxide
hydrolase I) (JHEH I) (CfEH1)
Length = 464
Score = 149 bits (376), Expect = 9e-36
Identities = 93/208 (44%), Positives = 120/208 (57%), Gaps = 4/208 (1%)
Frame = +3
Query: 6 GIHIN--FVETPYHDMRYLTQVFIGSMLPAKLHILTQRELDMVYPWSDKINTILSSMGYF 179
G H N FV TP +++ + IGS P +YP S+ T+L MGY
Sbjct: 243 GQHSNMCFVNTPSSNIKAI----IGSFFPESF--AGTGNAHKMYPMSEHFFTLLEEMGYL 296
Query: 180 GLQSTRPSTIGIALSDSPAGLAAYILEKFGAWSNNNSYHLSSPNGGLEDIKITKDEMLTN 359
LQ+T+P T+G+AL DSPAGLAAYILEKF W+N + S G +K E+L N
Sbjct: 297 HLQATKPDTVGVALRDSPAGLAAYILEKFSTWTNRS---WRSVKDGNLLLKYNIPELLDN 353
Query: 360 VMIYYITNTISSSVRLYKEMLNEQNHKLFKTPVR--VPTAIAMFPNEIIQVPKPFVHFKY 533
VMIYY+T++I++S+RLY E + + L VR VP A A FPNE+ V + KY
Sbjct: 354 VMIYYVTDSITTSMRLYAESFTKAHLALNLDRVRNHVPAACAKFPNELAYVTDCQLAEKY 413
Query: 534 RNVRQFNYMPRGGHFAALEEPELLANDI 617
+ + Q N MP GGHFAA EEP LLA DI
Sbjct: 414 KTLLQSNDMPSGGHFAAFEEPGLLAEDI 441
>sp|Q8MZR5|HYEP2_CTEFE Juvenile hormone epoxide hydrolase 2 (Juvenile hormone epoxide
hydrolase II) (Juvenile hormone-specific epoxide
hydrolase II) (JHEH II) (CfEH2)
Length = 465
Score = 148 bits (374), Expect = 2e-35
Identities = 86/190 (45%), Positives = 118/190 (62%), Gaps = 2/190 (1%)
Frame = +3
Query: 66 FIGSMLPAKLHILTQRELDMVYPWSDKINTILSSMGYFGLQSTRPSTIGIALSDSPAGLA 245
F+GS+ P ++ + +YP S+ T+L GYF +Q+T+P T+G+AL DSPAGLA
Sbjct: 261 FVGSLFPE--WFAGKQNVHKIYPLSEHFFTLLEESGYFHIQATKPDTVGVALRDSPAGLA 318
Query: 246 AYILEKFGAWSNNNSYHLSSPNGGLEDIKITKDEMLTNVMIYYITNTISSSVRLYKEMLN 425
AYILEKF + N S+ +G L+ K T E+L NVMIYY+T +I++S+R+Y E +
Sbjct: 319 AYILEKFS--TGTNKAWRSAKDGNLQS-KFTFTELLDNVMIYYVTGSITTSMRIYAESYS 375
Query: 426 EQNHKL--FKTPVRVPTAIAMFPNEIIQVPKPFVHFKYRNVRQFNYMPRGGHFAALEEPE 599
+ L + P VPTA A FP+EI + KY+ + Q MPRGGHFAALEEP
Sbjct: 376 WDHLSLNMDRVPTIVPTACAKFPHEIAYKTDFQLAEKYKTLLQSTIMPRGGHFAALEEPL 435
Query: 600 LLANDIRSFI 629
LLA DI S +
Sbjct: 436 LLAEDIFSAV 445
>sp|Q25489|HYEP_MANSE Juvenile hormone epoxide hydrolase (Juvenile hormone-specific
epoxide hydrolase) (JHEH)
Length = 462
Score = 126 bits (317), Expect = 6e-29
Identities = 73/187 (39%), Positives = 114/187 (60%), Gaps = 1/187 (0%)
Frame = +3
Query: 60 QVFIGSMLPAKLHILTQRELDMVYPWSDKINTILSSMGYFGLQSTRPSTIGIALSDSPAG 239
++FIG++ P+ I+ + +D +YP + + IL GYF +Q+T+P TIG+AL+DSPAG
Sbjct: 262 KLFIGALFPSL--IVDAKYMDRIYPLKNLFSYILRETGYFHIQATKPDTIGVALTDSPAG 319
Query: 240 LAAYILEKFGAWSNNNSYHLSSPNGGLEDIKITKDEMLTNVMIYYITNTISSSVRLYKEM 419
LA Y++EK SN + L +P+GGLE++ + D++L V I +I N I +S RLY E
Sbjct: 320 LAGYLIEKMAICSNRD--QLDTPHGGLENLNL--DDVLDTVTINWINNCIVTSTRLYAEG 375
Query: 420 LN-EQNHKLFKTPVRVPTAIAMFPNEIIQVPKPFVHFKYRNVRQFNYMPRGGHFAALEEP 596
+ + + + P VPTA F E++ P + K+ N+ + + GGHFAAL P
Sbjct: 376 FSWPEVLIVHRIPSMVPTAGINFKYEVLYQPDWILRDKFPNLVRSTVLDFGGHFAALHTP 435
Query: 597 ELLANDI 617
+ LA+DI
Sbjct: 436 QALADDI 442
>sp|Q06816|HYEP_STIAU Epoxide hydrolase (Epoxide hydratase)
Length = 232
Score = 70.5 bits (171), Expect = 5e-12
Identities = 36/98 (36%), Positives = 59/98 (60%), Gaps = 2/98 (2%)
Frame = +3
Query: 333 ITKDEMLTNVMIYYITNTISSSVRLYKEML--NEQNHKLFKTPVRVPTAIAMFPNEIIQV 506
+++DEML N+ +Y++T+T +SS R+Y E N KL +P +++FP E+ +
Sbjct: 131 LSQDEMLDNISLYWLTDTAASSARIYWENAGSNFSGGKL-----DLPVGVSVFpreLFRA 185
Query: 507 PKPFVHFKYRNVRQFNYMPRGGHFAALEEPELLANDIR 620
PK + Y + +N RGGHFAA E+P L A+++R
Sbjct: 186 PKRWAEQTYSKLIYWNEPDRGGHFAAFEQPALFAHELR 223
>sp|P44248|Y1543_HAEIN Hypothetical protein HI1543
Length = 184
Score = 32.0 bits (71), Expect = 2.1
Identities = 23/66 (34%), Positives = 35/66 (53%)
Frame = +3
Query: 390 SSSVRLYKEMLNEQNHKLFKTPVRVPTAIAMFPNEIIQVPKPFVHFKYRNVRQFNYMPRG 569
S V++ +LNE+ KLF T +V TAI+ + ++ + FV+F R VR +
Sbjct: 59 SLQVKIDLNLLNEEYQKLFATNGKVMTAISAYGIDV----EEFVNF--RLVRNMPEVESA 112
Query: 570 GHFAAL 587
HFA L
Sbjct: 113 DHFALL 118
>sp|P21358|RMAR_CANGA Mitochondrial ribosomal protein VAR1
Length = 339
Score = 30.8 bits (68), Expect = 4.8
Identities = 18/53 (33%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Frame = -2
Query: 805 INKQIYKDYIVKNN-LVIYVSLHCVTQKT-KLMFWYYSDKLISYLNGIYKISL 653
INK +YK +KNN ++I L+ + + F+YY+ +Y N IY I++
Sbjct: 85 INKLLYKLMSLKNNKIIISKPLYKINMNVINIRFYYYNMNNYNYNNNIYYINM 137
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,521,534
Number of Sequences: 369166
Number of extensions: 1904009
Number of successful extensions: 4417
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4277
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4399
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8052550455
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)