Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_014_I02
(771 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 266 5e-71
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 265 1e-70
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 264 2e-70
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 261 1e-69
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 260 3e-69
sp|Q9GLE3|CATK_PIG Cathepsin K precursor 259 6e-69
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 258 1e-68
sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (C... 258 2e-68
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 257 2e-68
sp|P55097|CATK_MOUSE Cathepsin K precursor 257 3e-68
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 266 bits (680), Expect = 5e-71
Identities = 139/257 (54%), Positives = 176/257 (68%), Gaps = 1/257 (0%)
Frame = +1
Query: 4 QINEELNDEWNLYKTRYQKSYLSIGELTRRIIWEENLRYIQHHNLEYDLGKHSYYLGVNE 183
+ ++ N +W+ +K+ +++ Y + E RR +WE+N+R IQ HN EY GKH + + +N
Sbjct: 20 KFDQTFNAQWHQWKSTHRRLYGTNEEEWRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNA 79
Query: 184 YADLTHEEFKIKFLGLKPINRNYSRTIFMPPENMDNYPKSVDWRKKGYVTPVKNQGQCGS 363
+ D+T+EEF+ G + R +F P M PK+VDWR+KG VTPVKNQGQCGS
Sbjct: 80 FGDMTNEEFRQIVNGYRHQKHKKGR-LFQEPL-MLQIPKTVDWREKGCVTPVKNQGQCGS 137
Query: 364 CWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGGLMDNAFQYIQKY-GLE 540
CW+FS +G LEGQ F K +L+SLSEQ LVDCS D N GCNGGLMD AFQYI++ GL+
Sbjct: 138 CWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLD 197
Query: 541 SEADYPYTAMDGPCKYDSTKVVAHCTGFVDIKKGNEKDLTKAVATVGPISVAIDASRPSF 720
SE YPY A DG CKY + VA+ TGFVDI + EK L KAVATVGPISVA+DAS PS
Sbjct: 198 SEESYPYEAKDGSCKYRAEYAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSL 256
Query: 721 QLYKGGIYNEVNCSSNN 771
Q Y GIY E NCSS +
Sbjct: 257 QFYSSGIYYEPNCSSKD 273
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 265 bits (676), Expect = 1e-70
Identities = 135/257 (52%), Positives = 174/257 (67%), Gaps = 1/257 (0%)
Frame = +1
Query: 4 QINEELNDEWNLYKTRYQKSYLSIGELTRRIIWEENLRYIQHHNLEYDLGKHSYYLGVNE 183
+ ++ L+ +W +K +++ Y + E RR +WE+N++ I+ HN EY GKH + + +N
Sbjct: 20 KFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNA 79
Query: 184 YADLTHEEFKIKFLGLKPINRNYSRTIFMPPENMDNYPKSVDWRKKGYVTPVKNQGQCGS 363
+ D+T+EEF+ + +G + +F P +D PKSVDWRKKGYVTPVKNQ QCGS
Sbjct: 80 FGDMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGS 137
Query: 364 CWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGGLMDNAFQYIQKY-GLE 540
CW+FS TGALEGQ FRK +LVSLSEQ LVDCS+ N GCNGG M AFQY+++ GL+
Sbjct: 138 CWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLD 197
Query: 541 SEADYPYTAMDGPCKYDSTKVVAHCTGFVDIKKGNEKDLTKAVATVGPISVAIDASRPSF 720
SE YPY A+D CKY VA+ TGF + G EK L KAVATVGPISVA+DA SF
Sbjct: 198 SEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSF 257
Query: 721 QLYKGGIYNEVNCSSNN 771
Q YK GIY E +CSS N
Sbjct: 258 QFYKSGIYFEPDCSSKN 274
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 264 bits (675), Expect = 2e-70
Identities = 140/257 (54%), Positives = 175/257 (68%), Gaps = 1/257 (0%)
Frame = +1
Query: 4 QINEELNDEWNLYKTRYQKSYLSIGELTRRIIWEENLRYIQHHNLEYDLGKHSYYLGVNE 183
+ ++ + EW+ +K+ +++ Y + E RR IWE+N+R IQ HN EY G+H + + +N
Sbjct: 20 KFDQTFSAEWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNA 79
Query: 184 YADLTHEEFKIKFLGLKPINRNYSRTIFMPPENMDNYPKSVDWRKKGYVTPVKNQGQCGS 363
+ D+T+EEF+ G + R +F P M PKSVDWR+KG VTPVKNQGQCGS
Sbjct: 80 FGDMTNEEFRQVVNGYRHQKHKKGR-LFQEPL-MLKIPKSVDWREKGCVTPVKNQGQCGS 137
Query: 364 CWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGGLMDNAFQYIQKY-GLE 540
CW+FS +G LEGQ F K +L+SLSEQ LVDCS N GCNGGLMD AFQYI++ GL+
Sbjct: 138 CWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLD 197
Query: 541 SEADYPYTAMDGPCKYDSTKVVAHCTGFVDIKKGNEKDLTKAVATVGPISVAIDASRPSF 720
SE YPY A DG CKY + VA+ TGFVDI + EK L KAVATVGPISVA+DAS PS
Sbjct: 198 SEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSL 256
Query: 721 QLYKGGIYNEVNCSSNN 771
Q Y GIY E NCSS N
Sbjct: 257 QFYSSGIYYEPNCSSKN 273
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 261 bits (668), Expect = 1e-69
Identities = 134/256 (52%), Positives = 173/256 (67%), Gaps = 3/256 (1%)
Frame = +1
Query: 13 EELNDEWNLYKTRYQKSYLS-IGELTRRIIWEENLRYIQHHNLEYDLGKHSYYLGVNEYA 189
E L+ +W L+K Y K Y S + E++RR+IWE+NL++I HNLE LG H+Y L +N
Sbjct: 20 EILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLG 79
Query: 190 DLTHEEFKIKFLGLK-PINRNYSRTIFMPPENMDNYPKSVDWRKKGYVTPVKNQGQCGSC 366
D+T EE K GLK P +R++S P+ P S+D+RKKGYVTPVKNQGQCGSC
Sbjct: 80 DMTSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSC 139
Query: 367 WSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGGLMDNAFQYIQK-YGLES 543
W+FS+ GALEGQ +K +L++LS Q LVDC +N GC GG M NAFQY+Q+ G++S
Sbjct: 140 WAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVS--ENYGCGGGYMTNAFQYVQRNRGIDS 197
Query: 544 EADYPYTAMDGPCKYDSTKVVAHCTGFVDIKKGNEKDLTKAVATVGPISVAIDASRPSFQ 723
E YPY D C Y+ T A C G+ +I +GNEK L +AVA VGP+SVAIDAS SFQ
Sbjct: 198 EDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQ 257
Query: 724 LYKGGIYNEVNCSSNN 771
Y G+Y + NCSS+N
Sbjct: 258 FYSKGVYYDENCSSDN 273
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 260 bits (664), Expect = 3e-69
Identities = 134/260 (51%), Positives = 172/260 (66%), Gaps = 9/260 (3%)
Frame = +1
Query: 19 LNDEWNLYKTRYQKSYLS-IGELTRRIIWEENLRYIQHHNLEYDLGKHSYYLGVNEYADL 195
+ +EW+ YK +++K+Y + + E R I+ EN I HN + GK SY LG+N+YAD+
Sbjct: 24 IKEEWHTYKLQHRKNYANEVEERFRMKIFNENRHKIAKHNQLFAQGKVSYKLGLNKYADM 83
Query: 196 THEEFKIKFLGLKPINRNYSR-------TIFMPPENMDNYPKSVDWRKKGYVTPVKNQGQ 354
H EFK G R R ++PP ++ PKSVDWR+ G VT VK+QG
Sbjct: 84 LHHEFKETMNGYNHTLRQLMRERTGLVGATYIPPAHV-TVPKSVDWREHGAVTGVKDQGH 142
Query: 355 CGSCWSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGGLMDNAFQYIQ-KY 531
CGSCW+FS+TGALEGQHFRK LVSLSEQ LVDCS Y NNGCNGGLMDNAF+YI+
Sbjct: 143 CGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNG 202
Query: 532 GLESEADYPYTAMDGPCKYDSTKVVAHCTGFVDIKKGNEKDLTKAVATVGPISVAIDASR 711
G+++E YPY +D C ++ + A TGFVDI +G+E+ + KAVAT+GP+SVAIDAS
Sbjct: 203 GIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSVAIDASH 262
Query: 712 PSFQLYKGGIYNEVNCSSNN 771
SFQLY G+YNE C N
Sbjct: 263 ESFQLYSEGVYNEPECDEQN 282
>sp|Q9GLE3|CATK_PIG Cathepsin K precursor
Length = 330
Score = 259 bits (662), Expect = 6e-69
Identities = 133/256 (51%), Positives = 173/256 (67%), Gaps = 3/256 (1%)
Frame = +1
Query: 13 EELNDEWNLYKTRYQKSYLS-IGELTRRIIWEENLRYIQHHNLEYDLGKHSYYLGVNEYA 189
E L+ +W L+K Y+K Y S + E++RR+IWE+NL++I HNLE LG H+Y L +N
Sbjct: 21 EILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLG 80
Query: 190 DLTHEEFKIKFLGLK-PINRNYSRTIFMPPENMDNYPKSVDWRKKGYVTPVKNQGQCGSC 366
D+T EE K GLK P + + S P+ P S+D+RKKGYVTPVKNQGQCGSC
Sbjct: 81 DMTSEEVVQKMTGLKVPPSHSRSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSC 140
Query: 367 WSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGGLMDNAFQYIQKY-GLES 543
W+FS+ GALEGQ +K +L++LS Q LVDC + N+GC GG M NAFQY+QK G++S
Sbjct: 141 WAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMTNAFQYVQKNRGIDS 198
Query: 544 EADYPYTAMDGPCKYDSTKVVAHCTGFVDIKKGNEKDLTKAVATVGPISVAIDASRPSFQ 723
E YPY D C Y+ T A C G+ +I +GNEK L +AVA VGP+SVAIDAS SFQ
Sbjct: 199 EDAYPYVGQDENCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQ 258
Query: 724 LYKGGIYNEVNCSSNN 771
Y G+Y + NC+S+N
Sbjct: 259 FYSKGVYYDENCNSDN 274
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 258 bits (660), Expect = 1e-68
Identities = 137/255 (53%), Positives = 167/255 (65%), Gaps = 1/255 (0%)
Frame = +1
Query: 10 NEELNDEWNLYKTRYQKSYLSIGELTRRIIWEENLRYIQHHNLEYDLGKHSYYLGVNEYA 189
+ L +W +K + + Y E RR +WE+N++ I+ HN EY GKHS+ + +N +
Sbjct: 22 DHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFG 81
Query: 190 DLTHEEFKIKFLGLKPINRNYSRTIFMPPENMDNYPKSVDWRKKGYVTPVKNQGQCGSCW 369
D+T EEF+ G + NR + P+SVDWR+KGYVTPVKNQGQCGSCW
Sbjct: 82 DMTSEEFRQVMNGFQ--NRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCW 139
Query: 370 SFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGGLMDNAFQYIQ-KYGLESE 546
+FS TGALEGQ FRK +L+SLSEQ LVDCS N GCNGGLMD AFQY+Q GL+SE
Sbjct: 140 AFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSE 199
Query: 547 ADYPYTAMDGPCKYDSTKVVAHCTGFVDIKKGNEKDLTKAVATVGPISVAIDASRPSFQL 726
YPY A + CKY+ VA+ TGFVDI K EK L KAVATVGPISVAIDA SF
Sbjct: 200 ESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESFLF 258
Query: 727 YKGGIYNEVNCSSNN 771
YK GIY E +CSS +
Sbjct: 259 YKEGIYFEPDCSSED 273
>sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (Cathepsin X) (Cathepsin O2)
Length = 329
Score = 258 bits (658), Expect = 2e-68
Identities = 132/256 (51%), Positives = 173/256 (67%), Gaps = 3/256 (1%)
Frame = +1
Query: 13 EELNDEWNLYKTRYQKSYLS-IGELTRRIIWEENLRYIQHHNLEYDLGKHSYYLGVNEYA 189
E L+ W L+K ++K Y + + E++RR+IWE+NL+YI HNLE LG H+Y L +N
Sbjct: 20 EILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLG 79
Query: 190 DLTHEEFKIKFLGLK-PINRNYSRTIFMPPENMDNYPKSVDWRKKGYVTPVKNQGQCGSC 366
D+T EE K GLK P++ + S PE P SVD+RKKGYVTPVKNQGQCGSC
Sbjct: 80 DMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSC 139
Query: 367 WSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGGLMDNAFQYIQK-YGLES 543
W+FS+ GALEGQ +K +L++LS Q LVDC +N+GC GG M NAFQY+QK G++S
Sbjct: 140 WAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVS--ENDGCGGGYMTNAFQYVQKNRGIDS 197
Query: 544 EADYPYTAMDGPCKYDSTKVVAHCTGFVDIKKGNEKDLTKAVATVGPISVAIDASRPSFQ 723
E YPY + C Y+ T A C G+ +I +GNEK L +AVA VGP+SVAIDAS SFQ
Sbjct: 198 EDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQ 257
Query: 724 LYKGGIYNEVNCSSNN 771
Y G+Y + +C+S+N
Sbjct: 258 FYSKGVYYDESCNSDN 273
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 257 bits (657), Expect = 2e-68
Identities = 132/256 (51%), Positives = 173/256 (67%), Gaps = 3/256 (1%)
Frame = +1
Query: 13 EELNDEWNLYKTRYQKSYLS-IGELTRRIIWEENLRYIQHHNLEYDLGKHSYYLGVNEYA 189
E L+ W L+K ++K Y S + E++RR+IWE+NL+YI HNLE LG H+Y L +N
Sbjct: 20 EILDTHWELWKKTHRKQYNSKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLG 79
Query: 190 DLTHEEFKIKFLGLK-PINRNYSRTIFMPPENMDNYPKSVDWRKKGYVTPVKNQGQCGSC 366
D+T+EE K GLK P + + S P+ P SVD+RKKGYVTPVKNQGQCGSC
Sbjct: 80 DMTNEEVVQKMTGLKVPASHSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSC 139
Query: 367 WSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGGLMDNAFQYIQK-YGLES 543
W+FS+ GALEGQ +K +L++LS Q LVDC +N+GC GG M NAFQY+QK G++S
Sbjct: 140 WAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVS--ENDGCGGGYMTNAFQYVQKNRGIDS 197
Query: 544 EADYPYTAMDGPCKYDSTKVVAHCTGFVDIKKGNEKDLTKAVATVGPISVAIDASRPSFQ 723
E YPY + C Y+ T A C G+ +I +GNEK L +AVA VGP+SVAIDAS SFQ
Sbjct: 198 EDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQ 257
Query: 724 LYKGGIYNEVNCSSNN 771
Y G+Y + +C+S+N
Sbjct: 258 FYSKGVYYDESCNSDN 273
>sp|P55097|CATK_MOUSE Cathepsin K precursor
Length = 329
Score = 257 bits (656), Expect = 3e-68
Identities = 132/256 (51%), Positives = 170/256 (66%), Gaps = 3/256 (1%)
Frame = +1
Query: 13 EELNDEWNLYKTRYQKSYLS-IGELTRRIIWEENLRYIQHHNLEYDLGKHSYYLGVNEYA 189
E L+ +W L+K +QK Y S + E++RR+IWE+NL+ I HNLE LG H+Y L +N
Sbjct: 20 EMLDTQWELWKKTHQKQYNSKVDEISRRLIWEKNLKQISAHNLEASLGVHTYELAMNHLG 79
Query: 190 DLTHEEFKIKFLGLK-PINRNYSRTIFMPPENMDNYPKSVDWRKKGYVTPVKNQGQCGSC 366
D+T EE K GL+ P +R+YS PE P S+D+RKKGYVTPVKNQGQCGSC
Sbjct: 80 DMTSEEVVQKMTGLRIPPSRSYSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSC 139
Query: 367 WSFSTTGALEGQHFRKRKQLVSLSEQQLVDCSKDYQNNGCNGGLMDNAFQYIQKY-GLES 543
W+FS+ GALEGQ +K +L++LS Q LVDC +N GC GG M AFQY+Q+ G++S
Sbjct: 140 WAFSSAGALEGQLKKKTGKLLALSPQNLVDCVT--ENYGCGGGYMTTAFQYVQQNGGIDS 197
Query: 544 EADYPYTAMDGPCKYDSTKVVAHCTGFVDIKKGNEKDLTKAVATVGPISVAIDASRPSFQ 723
E YPY D C Y++T A C G+ +I GNEK L +AVA VGPISV+IDAS SFQ
Sbjct: 198 EDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPISVSIDASLASFQ 257
Query: 724 LYKGGIYNEVNCSSNN 771
Y G+Y + NC +N
Sbjct: 258 FYSRGVYYDENCDRDN 273
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.316 0.135 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,681,440
Number of Sequences: 369166
Number of extensions: 1801294
Number of successful extensions: 5503
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4872
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5055
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7163732800
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)