Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_014_I01
(807 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 216 8e-56
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 209 5e-54
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 209 5e-54
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 206 6e-53
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 204 2e-52
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 204 2e-52
sp|O35186|CATK_RAT Cathepsin K precursor 204 2e-52
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 203 4e-52
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 203 5e-52
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 202 7e-52
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 216 bits (549), Expect = 8e-56
Identities = 106/224 (47%), Positives = 145/224 (64%), Gaps = 5/224 (2%)
Frame = +1
Query: 34 PNNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIID 213
P + LP S DWR+KG V+PV NQ+ +AF+A GALEGQ F T L LS+Q ++D
Sbjct: 109 PLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVD 168
Query: 214 CSIYYGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNSNCKYDKSLATVKPYGFKYV 390
CS GN GC GG +++A+ Y+ + G + +E YP+V + CKY + GF V
Sbjct: 169 CSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVV 228
Query: 391 SRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEES 570
+ GKE LM AV +GPIS A+DA +SF+ YK+GIY + CSS N++H VLV+GYG E
Sbjct: 229 APGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEG 288
Query: 571 GQS----FWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVP 690
S +W++KNSWG +WG GY+K+++D NN CGIA+ AS P
Sbjct: 289 ANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYP 332
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 209 bits (533), Expect = 5e-54
Identities = 95/221 (42%), Positives = 145/221 (65%), Gaps = 2/221 (0%)
Frame = +1
Query: 34 PNNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIID 213
P ++ +P S DWRE GAV+ V +Q + +AF++ GALEGQ+F L LS+Q ++D
Sbjct: 117 PAHVTVPKSVDWREHGAVTGVKDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVD 176
Query: 214 CSIYYGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNSNCKYDKSLATVKPYGFKYV 390
CS YGN+GC GG++ A+ Y+ D G + ++ YP+ G + +C ++K+ GF +
Sbjct: 177 CSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDI 236
Query: 391 SRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLVIGYG-EE 567
G E + AV +GP+S AIDAS SF+ Y G+Y++ C N++H VLV+GYG +E
Sbjct: 237 PEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVGYGTDE 296
Query: 568 SGQSFWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVP 690
SG +W++KNSWG+ WG +GY+K++R+ NN CGIA+ +S P
Sbjct: 297 SGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIATASSYP 337
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 209 bits (533), Expect = 5e-54
Identities = 95/224 (42%), Positives = 148/224 (66%), Gaps = 2/224 (0%)
Frame = +1
Query: 31 TPNNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQII 210
+P ++ LP S DWR KGAV+ V +Q + +AF++ GALEGQ+F + L LS+Q ++
Sbjct: 118 SPAHVTLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLV 177
Query: 211 DCSIYYGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNSNCKYDKSLATVKPYGFKY 387
DCS YGN+GC GG++ A+ Y+ D G + ++ YP+ + +C ++K GF
Sbjct: 178 DCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTD 237
Query: 388 VSRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLVIGYG-E 564
+ +G E + AV +GP+S AIDAS SF+ Y G+Y++ C + N++H VLV+G+G +
Sbjct: 238 IPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTD 297
Query: 565 ESGQSFWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVPLL 696
ESG+ +W++KNSWG+ WG KG++K+ R+ N CGIAS +S PL+
Sbjct: 298 ESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 206 bits (524), Expect = 6e-53
Identities = 93/222 (41%), Positives = 137/222 (61%)
Frame = +1
Query: 37 NNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDC 216
NN +PD DWRE G V+ V +Q N +AF+ G +EGQ +T S+QQ++DC
Sbjct: 104 NNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDC 163
Query: 217 SIYYGNSGCYGGILSKAYAYLADYGSELDEDYPFVGCNSNCKYDKSLATVKPYGFKYVSR 396
S +GN+GC GG++ AY YL +G E + YP+ C+Y+K L K G+ V
Sbjct: 164 SGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGYYTVHS 223
Query: 397 GKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEESGQ 576
G E +L N V P + A+D + F Y++GIY +CS VNHAVL +GYG + G
Sbjct: 224 GSEVELKNLVGARRPAAVAVDVE-SDFMMYRSGIYQSQTCSPLRVNHAVLAVGYGTQGGT 282
Query: 577 SFWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVPLLKK 702
+WI+KNSWG+ WG +GY++++R+ N+CGIAS+AS+P++ +
Sbjct: 283 DYWIVKNSWGTYWGERGYIRMARNRGNMCGIASLASLPMVAR 324
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 204 bits (520), Expect = 2e-52
Identities = 101/226 (44%), Positives = 148/226 (65%), Gaps = 5/226 (2%)
Frame = +1
Query: 34 PNNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIID 213
P +K+P S DWREKG V+PV NQ +AF+A+G LEGQ F T L LS+Q ++D
Sbjct: 109 PLMLKIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVD 168
Query: 214 CSIYYGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNSNCKYDKSLATVKPYGFKYV 390
CS GN GC GG++ A+ Y+ + G + +E YP+ + +CKY A GF +
Sbjct: 169 CSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDI 228
Query: 391 SRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEES 570
+ ++A LM AV +GPIS A+DAS S + Y +GIY + +CSS N++H VL++GYG E
Sbjct: 229 PQQEKA-LMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEG 287
Query: 571 GQS----FWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVPLL 696
S +W++KNSWGS+WGM+GY+K+++D +N CG+A+ AS P++
Sbjct: 288 TDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 204 bits (520), Expect = 2e-52
Identities = 105/220 (47%), Positives = 141/220 (64%), Gaps = 5/220 (2%)
Frame = +1
Query: 46 KLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIY 225
++P S DWREKG V+PV NQ +AF+A GALEGQ F T L LS+Q ++DCS
Sbjct: 113 EIPKSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRA 172
Query: 226 YGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNS-NCKYDKSLATVKPYGFKYVSRG 399
GN GC GG++ A+ Y+ D G + +E YP++G ++ C Y + GF + +
Sbjct: 173 QGNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQ- 231
Query: 400 KEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEE---S 570
+E LM AV +GPIS AIDA SF+ YK+GIY D CSS +++H VLV+GYG E S
Sbjct: 232 REKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDS 291
Query: 571 GQSFWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVP 690
FWI+KNSWG +WG GY+K+++D NN CGIA+ AS P
Sbjct: 292 NNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYP 331
>sp|O35186|CATK_RAT Cathepsin K precursor
Length = 329
Score = 204 bits (519), Expect = 2e-52
Identities = 105/227 (46%), Positives = 143/227 (62%), Gaps = 2/227 (0%)
Frame = +1
Query: 16 NDFITTPN-NIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEIL 192
ND + TP ++PDS D+R+KG V+PV NQ +AF++AGALEGQ T L L
Sbjct: 103 NDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLAL 162
Query: 193 SKQQIIDCSIYYGNSGCYGGILSKAYAYLADYGSELDED-YPFVGCNSNCKYDKSLATVK 369
S Q ++DC N GC GG ++ A+ Y+ G ED YP+VG + +C Y+ + K
Sbjct: 163 SPQNLVDC--VSENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAK 220
Query: 370 PYGFKYVSRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLV 549
G++ + G E L AV +GP+S +IDAS TSF+ Y G+Y D +C +NVNHAVLV
Sbjct: 221 CRGYREIPVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLV 280
Query: 550 IGYGEESGQSFWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVP 690
+GYG + G +WIIKNSWG WG KGY+ L+R+ NN CGI ++AS P
Sbjct: 281 VGYGTQKGNKYWIIKNSWGESWGNKGYVLLARNKNNACGITNLASFP 327
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 203 bits (517), Expect = 4e-52
Identities = 104/218 (47%), Positives = 139/218 (63%), Gaps = 5/218 (2%)
Frame = +1
Query: 52 PDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSIYYG 231
P S DWREKG V+PV NQ +AF+A GALEGQ F T L LS+Q ++DCS G
Sbjct: 115 PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQG 174
Query: 232 NSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNSNCKYDKSLATVKPYGFKYVSRGKEA 408
N GC GG++ A+ Y+ D G + +E YP+ +CKY+ + GF + + ++A
Sbjct: 175 NEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKA 234
Query: 409 DLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEESGQS--- 579
LM AV +GPIS AIDA SF YK GIY + CSS +++H VLV+GYG ES +S
Sbjct: 235 -LMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNN 293
Query: 580 -FWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVP 690
+W++KNSWG +WGM GY+K+++D N CGIAS AS P
Sbjct: 294 KYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYP 331
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 203 bits (516), Expect = 5e-52
Identities = 104/222 (46%), Positives = 142/222 (63%), Gaps = 6/222 (2%)
Frame = +1
Query: 43 IKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIIDCSI 222
+++P S DWREKG V+ V NQ +AF+A GALEGQ F T L LS+Q ++DCS
Sbjct: 112 LEVPKSVDWREKGYVTAVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSR 171
Query: 223 YYGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNSN-CKYDKSLATVKPYGFKYVSR 396
GN GC GG++ A+ Y+ D G + +E YP++G +N C Y + GF + +
Sbjct: 172 PQGNQGCNGGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDIPQ 231
Query: 397 GKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEESGQ 576
+E LM AV +GPIS AIDA +SF+ YK+GIY D CSS +++H VLV+GYG E
Sbjct: 232 -REKALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTD 290
Query: 577 S----FWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVP 690
S FWI+KNSWG +WG GY+K+++D NN CGI++ AS P
Sbjct: 291 SNSSKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGISTAASYP 332
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 202 bits (515), Expect = 7e-52
Identities = 104/225 (46%), Positives = 141/225 (62%), Gaps = 6/225 (2%)
Frame = +1
Query: 34 PNNIKLPDSWDWREKGAVSPVGNQRNNSCGYAFAAAGALEGQNFNLTKTLEILSKQQIID 213
P + +P S DW +KG V+PV NQ +AF+A GALEGQ F T L LS+Q ++D
Sbjct: 109 PLLVDVPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVD 168
Query: 214 CSIYYGNSGCYGGILSKAYAYLADYGS-ELDEDYPFVGCNSN-CKYDKSLATVKPYGFKY 387
CS GN GC GG++ A+ Y+ D G + +E YP++ ++N C Y + GF
Sbjct: 169 CSRAQGNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVD 228
Query: 388 VSRGKEADLMNAVYNIGPISAAIDASPTSFKQYKTGIYDDTSCSSNNVNHAVLVIGYGEE 567
+ + +E LM AV +GPIS AIDA TSF+ YK+GIY D CS +++H VLV+GYG E
Sbjct: 229 IPQ-REKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLVVGYGFE 287
Query: 568 SGQS----FWIIKNSWGSKWGMKGYMKLSRDTNNLCGIASMASVP 690
S FWI+KNSWG +WG GY+K+++D NN CGIA+ AS P
Sbjct: 288 GTDSNNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYP 332
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,878,167
Number of Sequences: 369166
Number of extensions: 1679176
Number of successful extensions: 5274
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4695
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4847
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7666799535
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)