Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_014_H20
(818 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9C0J8|WDR33_HUMAN WD-repeat protein 33 (WD-repeat prote... 227 3e-59
sp|Q9UTN4|YAGE_SCHPO Hypothetical WD-repeat protein C12G12.... 149 7e-36
sp|P42841|YN57_YEAST Hypothetical 53.1 kDa Trp-Asp repeats ... 112 1e-24
sp|O43017|SWD3_SCHPO Set1 complex component swd3 (Set1C com... 49 2e-05
sp|P49695|PKWA_THECU Probable serine/threonine-protein kina... 48 3e-05
sp|P56093|TUP1_CANAL Transcriptional repressor TUP1 45 2e-04
sp|O88342|WDR1_MOUSE WD-repeat protein 1 (Actin-interacting... 45 2e-04
sp|P25382|YCW2_YEAST Hypothetical WD-repeat protein YCR072C 45 3e-04
sp|P38262|SIF2_YEAST SIR4-interacting protein SIF2 44 7e-04
sp|O75083|WDR1_HUMAN WD-repeat protein 1 (Actin interacting... 43 0.001
>sp|Q9C0J8|WDR33_HUMAN WD-repeat protein 33 (WD-repeat protein WDC146)
Length = 1336
Score = 227 bits (578), Expect = 3e-59
Identities = 104/162 (64%), Positives = 128/162 (79%)
Frame = +2
Query: 236 GKRMRKAVFRRTIDYNSSVALFIEQRTWKRRFSSRCAIQPDIMYQHLLTPPTDYRDNPMN 415
GKRMRKAV R+TIDYN SV ++E R W+R AIQPD Y + L PP +NPMN
Sbjct: 45 GKRMRKAVNRKTIDYNPSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMN 104
Query: 416 CVCAKHVRTSTNKNKCPIYAVCWTPDGRRLITGASSGEFTLWNGLTFNFETILQAHDTHI 595
V K VRTSTNK KCP++ V WTP+GRRL+TGASSGEFTLWNGLTFNFETILQAHD+ +
Sbjct: 105 AVTTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPV 164
Query: 596 RAMKWSNNEEWLVSADDSGFVKYWQANMNDVNVFQAHKDSVR 721
RAM WS+N+ W+++AD G+VKYWQ+NMN+V +FQAHK+++R
Sbjct: 165 RAMTWSHNDMWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIR 206
Score = 32.7 bits (73), Expect = 1.2
Identities = 20/94 (21%), Positives = 38/94 (40%), Gaps = 4/94 (4%)
Frame = +2
Query: 467 IYAVCWTPDGRRLITGASSGE--FTLWNGLTFNFETILQAHDTHIRAMKWSNNEEWLVSA 640
+ V W P +++G+ + W+ T L AH + +K + N WL++A
Sbjct: 247 VKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTA 306
Query: 641 DDSGFVKYWQAN--MNDVNVFQAHKDSVRGVRYY 736
K + ++ VF+ HK V ++
Sbjct: 307 SRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWH 340
>sp|Q9UTN4|YAGE_SCHPO Hypothetical WD-repeat protein C12G12.14c in chromosome I
Length = 509
Score = 149 bits (377), Expect = 7e-36
Identities = 72/163 (44%), Positives = 104/163 (63%)
Frame = +2
Query: 245 MRKAVFRRTIDYNSSVALFIEQRTWKRRFSSRCAIQPDIMYQHLLTPPTDYRDNPMNCVC 424
++K + RRT+DY S ++ +I R + +P+ L PP +Y+ N + +C
Sbjct: 10 IQKPMTRRTVDYGSGLSKYIVNRHLRSNRYHIHVPRPNPNQIINLYPPYEYKYNNTSSLC 69
Query: 425 AKHVRTSTNKNKCPIYAVCWTPDGRRLITGASSGEFTLWNGLTFNFETILQAHDTHIRAM 604
K++ TS NK + I V WTPDGRRL+TG+S+GEFTLWNGLTFNFE I Q+HD +R
Sbjct: 70 TKYIHTSANKARHVINVVRWTPDGRRLLTGSSTGEFTLWNGLTFNFELINQSHDYAVRCA 129
Query: 605 KWSNNEEWLVSADDSGFVKYWQANMNDVNVFQAHKDSVRGVRY 733
+WS + WL+S D G VKY++ N+N+V + QAH+ VR V +
Sbjct: 130 EWSTDGRWLISGDGGGMVKYFEPNLNNVKIVQAHEMEVRDVAF 172
>sp|P42841|YN57_YEAST Hypothetical 53.1 kDa Trp-Asp repeats containing protein in
HXT14-PHA2 intergenic region
Length = 465
Score = 112 bits (280), Expect = 1e-24
Identities = 59/160 (36%), Positives = 94/160 (58%), Gaps = 3/160 (1%)
Frame = +2
Query: 263 RRTIDYNSSVALFIEQRTWKRRFSSRCAIQPDIMYQHLLTPPTDYR--DNPMNCVCAKHV 436
RR++D +S +I +R ++P+ Y + PP YR D +N + +K
Sbjct: 30 RRSVDVSSP---YINLYYNRRHGLPNLVVEPETSYTIDIMPPNAYRGRDRVIN-LPSKFT 85
Query: 437 RTSTNKNKCPIYAVCWTPDGRRLITGASSGEFTLWNGLTFNFETILQAHDTHIRAMKWSN 616
S+NK K I A+ WTP+GRRL+ SGEF+LWN +F FET++QAHD+ + MK+S+
Sbjct: 86 HLSSNKVKHVIPAIQWTPEGRRLVVATYSGEFSLWNASSFTFETLMQAHDSAVTTMKYSH 145
Query: 617 NEEWLVSADDSGFVKYWQANMNDV-NVFQAHKDSVRGVRY 733
+ +W++S D G +K WQ N + V + AH +S+R + +
Sbjct: 146 DSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAF 185
>sp|O43017|SWD3_SCHPO Set1 complex component swd3 (Set1C component swd3) (COMPASS
component swd3) (Complex proteins associated with set1
protein swd3)
Length = 380
Score = 48.5 bits (114), Expect = 2e-05
Identities = 24/90 (26%), Positives = 41/90 (45%), Gaps = 1/90 (1%)
Frame = +2
Query: 467 IYAVCWTPDGRRLITGASSGEFTLWNGLTFNFETILQAHDTHIRAMKWSNNEEWLVSADD 646
+ V +P+ R + T +S G +W+ LTF E L H I +KW+ ++L SA D
Sbjct: 57 VTCVSVSPNKRWIATSSSDGTIKIWSALTFRLECTLFGHYRGISQVKWATGSKYLASASD 116
Query: 647 SGFVKYWQANMN-DVNVFQAHKDSVRGVRY 733
++ W V + H + V + +
Sbjct: 117 DKTIRIWDFEKRCSVRCLKGHTNYVSSIDF 146
>sp|P49695|PKWA_THECU Probable serine/threonine-protein kinase pkwA
Length = 742
Score = 48.1 bits (113), Expect = 3e-05
Identities = 26/89 (29%), Positives = 46/89 (51%)
Frame = +2
Query: 467 IYAVCWTPDGRRLITGASSGEFTLWNGLTFNFETILQAHDTHIRAMKWSNNEEWLVSADD 646
+YAV ++PDG + +G+ G LW+ T +LQA ++ ++ +S + LV D
Sbjct: 588 VYAVAFSPDGSMVASGSRDGTIRLWDVATGKERDVLQAPAENVVSLAFSPDGSMLVHGSD 647
Query: 647 SGFVKYWQANMNDVNVFQAHKDSVRGVRY 733
S + A+ ++ F+ H D VR V +
Sbjct: 648 STVHLWDVASGEALHTFEGHTDWVRAVAF 676
Score = 42.0 bits (97), Expect = 0.002
Identities = 21/82 (25%), Positives = 41/82 (50%), Gaps = 1/82 (1%)
Frame = +2
Query: 476 VCWTPDGRRLITGASSGEFTLWNGLTFNFETILQAHDTHIRAMKWSNNEEWLVSADDSGF 655
+ ++PDG + +G+ G LWN T +L+ H ++ A+ +S + + S G
Sbjct: 549 IAFSPDGSMVASGSRDGTARLWNVATGTEHAVLKGHTDYVYAVAFSPDGSMVASGSRDGT 608
Query: 656 VKYWQ-ANMNDVNVFQAHKDSV 718
++ W A + +V QA ++V
Sbjct: 609 IRLWDVATGKERDVLQAPAENV 630
Score = 37.0 bits (84), Expect = 0.065
Identities = 17/67 (25%), Positives = 31/67 (46%)
Frame = +2
Query: 467 IYAVCWTPDGRRLITGASSGEFTLWNGLTFNFETILQAHDTHIRAMKWSNNEEWLVSADD 646
+ AV ++PDG L +G+ LW+ T L+ H + ++ + L SA +
Sbjct: 671 VRAVAFSPDGALLASGSDDRTIRLWDVAAQEEHTTLEGHTEPVHSVAFHPEGTTLASASE 730
Query: 647 SGFVKYW 667
G ++ W
Sbjct: 731 DGTIRIW 737
Score = 36.6 bits (83), Expect = 0.085
Identities = 20/90 (22%), Positives = 38/90 (42%), Gaps = 1/90 (1%)
Frame = +2
Query: 467 IYAVCWTPDGRRLITGASSGEFTLWNGLTFNFETILQAHDTHIRAMKWSNNEEWLVSADD 646
+ AV ++PDG L +G+ LW+ + + H ++ + +S + + S
Sbjct: 504 VRAVAFSPDGALLASGSDDATVRLWDVAAAEERAVFEGHTHYVLDIAFSPDGSMVASGSR 563
Query: 647 SGFVKYWQ-ANMNDVNVFQAHKDSVRGVRY 733
G + W A + V + H D V V +
Sbjct: 564 DGTARLWNVATGTEHAVLKGHTDYVYAVAF 593
Score = 34.7 bits (78), Expect = 0.32
Identities = 20/91 (21%), Positives = 41/91 (45%), Gaps = 1/91 (1%)
Frame = +2
Query: 467 IYAVCWTPDGRRLITGASSGEFTLWNGLTFNFETILQAHDTHIRAMKWSNNEEWLVSADD 646
+ ++ ++PDG L+ G+ S LW+ + + H +RA+ +S + L S D
Sbjct: 630 VVSLAFSPDGSMLVHGSDS-TVHLWDVASGEALHTFEGHTDWVRAVAFSPDGALLASGSD 688
Query: 647 SGFVKYWQ-ANMNDVNVFQAHKDSVRGVRYY 736
++ W A + + H + V V ++
Sbjct: 689 DRTIRLWDVAAQEEHTTLEGHTEPVHSVAFH 719
Score = 33.9 bits (76), Expect = 0.55
Identities = 22/88 (25%), Positives = 39/88 (44%), Gaps = 1/88 (1%)
Frame = +2
Query: 473 AVCWTPDGRRLITGASSGEFTLWNGLTFNFETILQAHDTHIRAMKWSNNEEWLVSADDSG 652
AV ++P G L G+ +W+ + + L+ H +RA+ +S + L S D
Sbjct: 464 AVAFSPGGSLLAGGSGDKLIHVWDVASGDELHTLEGHTDWVRAVAFSPDGALLASGSDDA 523
Query: 653 FVKYWQ-ANMNDVNVFQAHKDSVRGVRY 733
V+ W A + VF+ H V + +
Sbjct: 524 TVRLWDVAAAEERAVFEGHTHYVLDIAF 551
>sp|P56093|TUP1_CANAL Transcriptional repressor TUP1
Length = 514
Score = 45.1 bits (105), Expect = 2e-04
Identities = 30/110 (27%), Positives = 52/110 (47%), Gaps = 9/110 (8%)
Frame = +2
Query: 425 AKHVRTSTNKNKCP---------IYAVCWTPDGRRLITGASSGEFTLWNGLTFNFETILQ 577
AK + S+N+NK I +VC++PDG+ L TGA +W+ T IL+
Sbjct: 237 AKLIDESSNENKDDNTTASGDLYIRSVCFSPDGKLLATGAEDKLIRIWDLSTKRIIKILR 296
Query: 578 AHDTHIRAMKWSNNEEWLVSADDSGFVKYWQANMNDVNVFQAHKDSVRGV 727
H+ I ++ + + + LVS V+ W + ++ + +D V V
Sbjct: 297 GHEQDIYSLDFFPDGDRLVSGSGDRSVRIWDLRTSQCSLTLSIEDGVTTV 346
Score = 31.2 bits (69), Expect = 3.6
Identities = 21/99 (21%), Positives = 47/99 (47%), Gaps = 6/99 (6%)
Frame = +2
Query: 449 NKNKCPIYAVCWTPDGRRLITGASSGEFTLWN-----GLTFNFETILQAHDTHIRAMKWS 613
N ++ +Y+V ++ +G ++ +G+ LW+ E H + ++ +
Sbjct: 386 NGHEDSVYSVAFSNNGEQIASGSLDRTVKLWHLEGKSDKKSTCEVTYIGHKDFVLSVCCT 445
Query: 614 NNEEWLVSADDSGFVKYW-QANMNDVNVFQAHKDSVRGV 727
+ E+++S V +W QA+ N + + Q H++SV V
Sbjct: 446 PDNEYILSGSKDRGVIFWDQASGNPLLMLQGHRNSVISV 484
>sp|O88342|WDR1_MOUSE WD-repeat protein 1 (Actin-interacting protein 1) (AIP1)
Length = 606
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/77 (32%), Positives = 39/77 (50%), Gaps = 3/77 (3%)
Frame = +2
Query: 467 IYAVCWTPDGRRLITGASSGEFTLWNGLTFNFETIL---QAHDTHIRAMKWSNNEEWLVS 637
+ V ++PDG R T ++ G+ +++G T L +AHD I A+ WS + L+S
Sbjct: 192 VNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALGESKAHDGGIYAISWSPDSTHLLS 251
Query: 638 ADDSGFVKYWQANMNDV 688
A K W N+N V
Sbjct: 252 ASGDKTSKIWDVNVNSV 268
>sp|P25382|YCW2_YEAST Hypothetical WD-repeat protein YCR072C
Length = 515
Score = 44.7 bits (104), Expect = 3e-04
Identities = 22/82 (26%), Positives = 38/82 (46%), Gaps = 1/82 (1%)
Frame = +2
Query: 476 VCWTPDGRRLITGASSGEFTLWNGLTFNFETILQAHDTHIRAMKWSNNEEWLVSADDSGF 655
V ++PDGR +++ + LW+G F + + H + + WS++ LVS
Sbjct: 408 VAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVASVYQVAWSSDCRLLVSCSKDTT 467
Query: 656 VKYWQANMNDVNV-FQAHKDSV 718
+K W ++V HKD V
Sbjct: 468 LKVWDVRTRKLSVDLPGHKDEV 489
Score = 33.1 bits (74), Expect = 0.94
Identities = 18/75 (24%), Positives = 31/75 (41%), Gaps = 8/75 (10%)
Frame = +2
Query: 467 IYAVCWTPDGRRLITGASSGEFTLWNGLTFN-FETILQAHDTHIRAMKWS-------NNE 622
+ V W+PDG + TG+ LW+ + L+ H I ++ W ++
Sbjct: 189 VLCVSWSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSK 248
Query: 623 EWLVSADDSGFVKYW 667
L S+ G +K W
Sbjct: 249 PRLASSSKDGTIKIW 263
Score = 33.1 bits (74), Expect = 0.94
Identities = 15/67 (22%), Positives = 28/67 (41%)
Frame = +2
Query: 467 IYAVCWTPDGRRLITGASSGEFTLWNGLTFNFETILQAHDTHIRAMKWSNNEEWLVSADD 646
+Y V W+ D R L++ + +W+ T L H + + WS + + + S
Sbjct: 447 VYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGK 506
Query: 647 SGFVKYW 667
V+ W
Sbjct: 507 DKMVRLW 513
>sp|P38262|SIF2_YEAST SIR4-interacting protein SIF2
Length = 535
Score = 43.5 bits (101), Expect = 7e-04
Identities = 21/75 (28%), Positives = 35/75 (46%)
Frame = +2
Query: 443 STNKNKCPIYAVCWTPDGRRLITGASSGEFTLWNGLTFNFETILQAHDTHIRAMKWSNNE 622
S+ K + + W+ DG ++TG +GE LWN T +L H I ++KW+ +
Sbjct: 215 SSGKTTNQVTCLAWSHDGNSIVTGVENGELRLWN-KTGALLNVLNFHRAPIVSVKWNKDG 273
Query: 623 EWLVSADDSGFVKYW 667
++S D W
Sbjct: 274 THIISMDVENVTILW 288
Score = 31.2 bits (69), Expect = 3.6
Identities = 22/81 (27%), Positives = 35/81 (43%), Gaps = 2/81 (2%)
Frame = +2
Query: 482 WTPDGRRLITGASSGEFTLWNGLTFNFET-ILQAHDTHIRAMKWSNNEEWLVSADDSGFV 658
W D + +I G F +T T L H I +++++ + L+SA D G +
Sbjct: 326 WVDDDKFVIPGPKGAIFVYQ--ITEKTPTGKLIGHHGPISVLEFNDTNKLLLSASDDGTL 383
Query: 659 KYWQ-ANMNDVNVFQAHKDSV 718
+ W N N N F H S+
Sbjct: 384 RIWHGGNGNSQNCFYGHSQSI 404
>sp|O75083|WDR1_HUMAN WD-repeat protein 1 (Actin interacting protein 1) (AIP1) (NORI-1)
Length = 606
Score = 43.1 bits (100), Expect = 0.001
Identities = 24/77 (31%), Positives = 39/77 (50%), Gaps = 3/77 (3%)
Frame = +2
Query: 467 IYAVCWTPDGRRLITGASSGEFTLWNGLTFNFETIL---QAHDTHIRAMKWSNNEEWLVS 637
+ V ++PDG R T ++ G+ +++G T L +AHD I A+ WS + L+S
Sbjct: 192 VNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLS 251
Query: 638 ADDSGFVKYWQANMNDV 688
A K W ++N V
Sbjct: 252 ASGDKTSKIWDVSVNSV 268
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,664,111
Number of Sequences: 369166
Number of extensions: 1744666
Number of successful extensions: 4718
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3921
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4644
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7859674995
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)