Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_014_G23
(763 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q24799|MYPH_ECHGR Myophilin 125 1e-28
sp|P26932|CNN1_CHICK Calponin-1 (Calponin, smooth muscle) 125 1e-28
sp|Q08092|CNN1_PIG Calponin-1 (Calponin H1, smooth muscle) ... 120 4e-27
sp|P37397|CNN3_RAT Calponin-3 (Calponin, acidic isoform) (C... 120 4e-27
sp|Q15417|CNN3_HUMAN Calponin-3 (Calponin, acidic isoform) 120 5e-27
sp|Q08290|CNN1_RAT Calponin-1 (Calponin H1, smooth muscle) ... 120 5e-27
sp|Q08091|CNN1_MOUSE Calponin-1 (Calponin H1, smooth muscle... 120 5e-27
sp|Q9DAW9|CNN3_MOUSE Calponin-3 (Calponin, acidic isoform) 120 5e-27
sp|Q08093|CNN2_MOUSE Calponin-2 (Calponin H2, smooth muscle... 119 7e-27
sp|P51911|CNN1_HUMAN Calponin-1 (Calponin H1, smooth muscle... 117 3e-26
>sp|Q24799|MYPH_ECHGR Myophilin
Length = 190
Score = 125 bits (314), Expect = 1e-28
Identities = 64/107 (59%), Positives = 78/107 (72%), Gaps = 1/107 (0%)
Frame = +1
Query: 4 MENIQLFLKAAEAYGVPRASLFQTVDLFESRNMAQVLNTLLQLGTECQRN-EFKGPVCGP 180
MENI FL+A + YGVP A LFQTVDLFE +++AQV TL LG CQ + E+ GPV GP
Sbjct: 84 MENISAFLEAMKGYGVPVADLFQTVDLFEKKDIAQVTRTLFALGRTCQTHPEYSGPVLGP 143
Query: 181 KPTYENKREFSEEQLRASQGIIGLQAGSNKGASQSGMSMGGVRHIAD 321
K ENKREF+E+QLR Q ++ LQ GSNKGASQ+G++MG R I D
Sbjct: 144 KLATENKREFTEQQLREGQNVVSLQYGSNKGASQAGINMGKQRMIMD 190
Score = 42.7 bits (99), Expect = 0.001
Identities = 19/31 (61%), Positives = 25/31 (80%)
Frame = +1
Query: 466 EGKSVIGLQAGSNKGASQSGMRIGTQRFIND 558
EG++V+ LQ GSNKGASQ+G+ +G QR I D
Sbjct: 160 EGQNVVSLQYGSNKGASQAGINMGKQRMIMD 190
>sp|P26932|CNN1_CHICK Calponin-1 (Calponin, smooth muscle)
Length = 292
Score = 125 bits (314), Expect = 1e-28
Identities = 81/189 (42%), Positives = 113/189 (59%), Gaps = 3/189 (1%)
Frame = +1
Query: 1 QMENIQLFLKAAEAYGVPRASLFQTVDLFESRNMAQVLNTLLQLGTECQRNEFKGPVCGP 180
++ENI FL+A + YGV +F+ DLFE+ N QV +TL+ L ++ + + G
Sbjct: 84 KLENIGNFLRAIKHYGVKPHDIFEANDLFENTNHTQVQSTLIALASQA-KTKGNNVGLGV 142
Query: 181 KPTYENKREFSEEQLRASQGIIGLQAGSNKGASQSGMSMGGV-RHIADIKVDEMSDEAKG 357
K + +R F E+LR + IIGLQ G+NK ASQ GM+ G RH+ D K+ +
Sbjct: 143 KYAEKQQRRFQPEKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQA 202
Query: 358 IVGLQAGSNKGASQSGMRI-GTQRFINDVSTGVEMTDEGKSVIGLQAGSNKGASQSGMRI 534
+ LQ G+NKGASQ+GM GT+R I + S G+E D ++IGLQ GSNKGASQ GM +
Sbjct: 203 TISLQMGTNKGASQAGMTAPGTKRQIFEPSLGMERCD--TNIIGLQMGSNKGASQQGMTV 260
Query: 535 -GTQRFIND 558
G R + D
Sbjct: 261 YGLPRQVYD 269
>sp|Q08092|CNN1_PIG Calponin-1 (Calponin H1, smooth muscle) (Basic calponin)
Length = 297
Score = 120 bits (301), Expect = 4e-27
Identities = 82/189 (43%), Positives = 109/189 (57%), Gaps = 3/189 (1%)
Frame = +1
Query: 1 QMENIQLFLKAAEAYGVPRASLFQTVDLFESRNMAQVLNTLLQLGTECQRNEFKGPVCGP 180
Q+ENI F+KA YGV +F+ DLFE+ N QV +TLL L + + K V G
Sbjct: 84 QLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNV-GV 142
Query: 181 KPTYENKREFSEEQLRASQGIIGLQAGSNKGASQSGMSMGGV-RHIADIKVDEMSDEAKG 357
K + +R+F E+LR + IIGLQ G+NK ASQ GM+ G RH+ D K+ +
Sbjct: 143 KYAEKQERKFEPEKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQA 202
Query: 358 IVGLQAGSNKGASQSGMRI-GTQRFINDVSTGVEMTDEGKSVIGLQAGSNKGASQSGMRI 534
+ LQ G+NKGASQ+GM GT+R I + G+E D + LQ GSNKGASQ GM +
Sbjct: 203 TISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLN--VSLQMGSNKGASQRGMTV 260
Query: 535 -GTQRFIND 558
G R + D
Sbjct: 261 YGLPRQVYD 269
>sp|P37397|CNN3_RAT Calponin-3 (Calponin, acidic isoform) (Calponin, non-muscle
isoform)
Length = 330
Score = 120 bits (301), Expect = 4e-27
Identities = 77/181 (42%), Positives = 105/181 (58%), Gaps = 3/181 (1%)
Frame = +1
Query: 1 QMENIQLFLKAAEAYGVPRASLFQTVDLFESRNMAQVLNTLLQLGTECQRNEFKGPV-CG 177
Q+ENI F+KA +AYG+ +F+ DLFE+ NM QV TL+ L + F + G
Sbjct: 82 QLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDIG 141
Query: 178 PKPTYENKREFSEEQLRASQGIIGLQAGSNKGASQSGMSMGGV-RHIADIKVDEMSDEAK 354
K + R F E +L+A Q +IGLQ G+NK ASQ+GM+ G RH+ D K+ +
Sbjct: 142 VKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQ 201
Query: 355 GIVGLQAGSNKGASQSGMRI-GTQRFINDVSTGVEMTDEGKSVIGLQAGSNKGASQSGMR 531
+ LQ G+NKGASQ+GM GT+R I D ++ D S I LQ G+NK ASQ GM
Sbjct: 202 TTISLQMGTNKGASQAGMSAPGTRRDIYDQKLTLQPVD--NSTISLQMGTNKVASQKGMS 259
Query: 532 I 534
+
Sbjct: 260 V 260
Score = 47.0 bits (110), Expect = 6e-05
Identities = 28/57 (49%), Positives = 38/57 (66%), Gaps = 1/57 (1%)
Frame = +1
Query: 469 GKSVIGLQAGSNKGASQSGMRI-GTQRFINDVSTGVEMSDEGKTVIGLQAGSNKGAT 636
G+SVIGLQ G+NK ASQ+GM GT+R + D + + +T I LQ G+NKGA+
Sbjct: 160 GQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFD-QTTISLQMGTNKGAS 215
>sp|Q15417|CNN3_HUMAN Calponin-3 (Calponin, acidic isoform)
Length = 329
Score = 120 bits (300), Expect = 5e-27
Identities = 77/181 (42%), Positives = 105/181 (58%), Gaps = 3/181 (1%)
Frame = +1
Query: 1 QMENIQLFLKAAEAYGVPRASLFQTVDLFESRNMAQVLNTLLQLGTECQRNEFKGPV-CG 177
Q+ENI F+KA +AYG+ +F+ DLFE+ NM QV TL+ L + F + G
Sbjct: 82 QLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDIG 141
Query: 178 PKPTYENKREFSEEQLRASQGIIGLQAGSNKGASQSGMSMGGV-RHIADIKVDEMSDEAK 354
K + R F E +L+A Q +IGLQ G+NK ASQ+GM+ G RH+ D K+ +
Sbjct: 142 VKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQ 201
Query: 355 GIVGLQAGSNKGASQSGMRI-GTQRFINDVSTGVEMTDEGKSVIGLQAGSNKGASQSGMR 531
+ LQ G+NKGASQ+GM GT+R I D ++ D S I LQ G+NK ASQ GM
Sbjct: 202 TTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPVD--NSTISLQMGTNKVASQKGMS 259
Query: 532 I 534
+
Sbjct: 260 V 260
Score = 47.0 bits (110), Expect = 6e-05
Identities = 28/57 (49%), Positives = 38/57 (66%), Gaps = 1/57 (1%)
Frame = +1
Query: 469 GKSVIGLQAGSNKGASQSGMRI-GTQRFINDVSTGVEMSDEGKTVIGLQAGSNKGAT 636
G+SVIGLQ G+NK ASQ+GM GT+R + D + + +T I LQ G+NKGA+
Sbjct: 160 GQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFD-QTTISLQMGTNKGAS 215
>sp|Q08290|CNN1_RAT Calponin-1 (Calponin H1, smooth muscle) (Basic calponin)
Length = 297
Score = 120 bits (300), Expect = 5e-27
Identities = 82/189 (43%), Positives = 108/189 (57%), Gaps = 3/189 (1%)
Frame = +1
Query: 1 QMENIQLFLKAAEAYGVPRASLFQTVDLFESRNMAQVLNTLLQLGTECQRNEFKGPVCGP 180
Q+ENI F+KA YGV +F+ DLFE+ N QV +TLL L + + K V G
Sbjct: 84 QLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNV-GV 142
Query: 181 KPTYENKREFSEEQLRASQGIIGLQAGSNKGASQSGMSMGGV-RHIADIKVDEMSDEAKG 357
K + +R F E+LR + IIGLQ G+NK ASQ GM+ G RH+ D K+ +
Sbjct: 143 KYAEKQERRFEPEKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQA 202
Query: 358 IVGLQAGSNKGASQSGMRI-GTQRFINDVSTGVEMTDEGKSVIGLQAGSNKGASQSGMRI 534
+ LQ G+NKGASQ+GM GT+R I + G+E D + LQ GSNKGASQ GM +
Sbjct: 203 TISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLN--VSLQMGSNKGASQRGMTV 260
Query: 535 -GTQRFIND 558
G R + D
Sbjct: 261 YGLPRQVYD 269
>sp|Q08091|CNN1_MOUSE Calponin-1 (Calponin H1, smooth muscle) (Basic calponin)
Length = 297
Score = 120 bits (300), Expect = 5e-27
Identities = 82/189 (43%), Positives = 108/189 (57%), Gaps = 3/189 (1%)
Frame = +1
Query: 1 QMENIQLFLKAAEAYGVPRASLFQTVDLFESRNMAQVLNTLLQLGTECQRNEFKGPVCGP 180
Q+ENI F+KA YGV +F+ DLFE+ N QV +TLL L + + K V G
Sbjct: 84 QLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNV-GV 142
Query: 181 KPTYENKREFSEEQLRASQGIIGLQAGSNKGASQSGMSMGGV-RHIADIKVDEMSDEAKG 357
K + +R F E+LR + IIGLQ G+NK ASQ GM+ G RH+ D K+ +
Sbjct: 143 KYAEKQERRFEPEKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQA 202
Query: 358 IVGLQAGSNKGASQSGMRI-GTQRFINDVSTGVEMTDEGKSVIGLQAGSNKGASQSGMRI 534
+ LQ G+NKGASQ+GM GT+R I + G+E D + LQ GSNKGASQ GM +
Sbjct: 203 TISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLN--VSLQMGSNKGASQRGMTV 260
Query: 535 -GTQRFIND 558
G R + D
Sbjct: 261 YGLPRQVYD 269
>sp|Q9DAW9|CNN3_MOUSE Calponin-3 (Calponin, acidic isoform)
Length = 330
Score = 120 bits (300), Expect = 5e-27
Identities = 77/181 (42%), Positives = 105/181 (58%), Gaps = 3/181 (1%)
Frame = +1
Query: 1 QMENIQLFLKAAEAYGVPRASLFQTVDLFESRNMAQVLNTLLQLGTECQRNEFKGPV-CG 177
Q+ENI F+KA +AYG+ +F+ DLFE+ NM QV TL+ L + F + G
Sbjct: 82 QLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDIG 141
Query: 178 PKPTYENKREFSEEQLRASQGIIGLQAGSNKGASQSGMSMGGV-RHIADIKVDEMSDEAK 354
K + R F E +L+A Q +IGLQ G+NK ASQ+GM+ G RH+ D K+ +
Sbjct: 142 VKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQ 201
Query: 355 GIVGLQAGSNKGASQSGMRI-GTQRFINDVSTGVEMTDEGKSVIGLQAGSNKGASQSGMR 531
+ LQ G+NKGASQ+GM GT+R I D ++ D S I LQ G+NK ASQ GM
Sbjct: 202 TTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPVD--NSTISLQMGTNKVASQKGMS 259
Query: 532 I 534
+
Sbjct: 260 V 260
Score = 47.0 bits (110), Expect = 6e-05
Identities = 28/57 (49%), Positives = 38/57 (66%), Gaps = 1/57 (1%)
Frame = +1
Query: 469 GKSVIGLQAGSNKGASQSGMRI-GTQRFINDVSTGVEMSDEGKTVIGLQAGSNKGAT 636
G+SVIGLQ G+NK ASQ+GM GT+R + D + + +T I LQ G+NKGA+
Sbjct: 160 GQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFD-QTTISLQMGTNKGAS 215
>sp|Q08093|CNN2_MOUSE Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin)
Length = 305
Score = 119 bits (299), Expect = 7e-27
Identities = 83/218 (38%), Positives = 115/218 (52%), Gaps = 3/218 (1%)
Frame = +1
Query: 1 QMENIQLFLKAAEAYGVPRASLFQTVDLFESRNMAQVLNTLLQLGTECQRNEFKGPV-CG 177
Q+EN+ F+KA +YG+ LF+ DLFES NM QV +LL L + + + V G
Sbjct: 84 QLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKAKTKGLQSGVDIG 143
Query: 178 PKPTYENKREFSEEQLRASQGIIGLQAGSNKGASQSGMSMGGV-RHIADIKVDEMSDEAK 354
K + + +R F + ++A Q +IGLQ G+NK ASQSGM+ G RH+ D K +
Sbjct: 144 VKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQSGMTAYGTRRHLYDPKNHILPPMDH 203
Query: 355 GIVGLQAGSNKGASQSGMRI-GTQRFINDVSTGVEMTDEGKSVIGLQAGSNKGASQSGMR 531
+ LQ G+NK ASQ GM GT+R I D G + D S + LQ G +GA+QSG
Sbjct: 204 CTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKCD--NSSMSLQMGYTQGANQSGQV 261
Query: 532 IGTQRFINDVSTGVEMSDEGKTVIGLQAGSNKGATPSW 645
G R I D + +G G AG +G P +
Sbjct: 262 FGLGRQIYD----PKYCPQGSAADGAPAGDGQGEAPEY 295
>sp|P51911|CNN1_HUMAN Calponin-1 (Calponin H1, smooth muscle) (Basic calponin)
Length = 297
Score = 117 bits (294), Expect = 3e-26
Identities = 81/189 (42%), Positives = 108/189 (57%), Gaps = 3/189 (1%)
Frame = +1
Query: 1 QMENIQLFLKAAEAYGVPRASLFQTVDLFESRNMAQVLNTLLQLGTECQRNEFKGPVCGP 180
Q+ENI F+KA YGV +F+ DLFE+ N QV +TLL L + + K V G
Sbjct: 84 QLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNV-GV 142
Query: 181 KPTYENKREFSEEQLRASQGIIGLQAGSNKGASQSGMSMGGV-RHIADIKVDEMSDEAKG 357
K + +R+F +LR + IIGLQ G+NK ASQ GM+ G RH+ D K+ +
Sbjct: 143 KYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQA 202
Query: 358 IVGLQAGSNKGASQSGMRI-GTQRFINDVSTGVEMTDEGKSVIGLQAGSNKGASQSGMRI 534
+ LQ G+NKGASQ+GM GT+R I + G+E D + LQ GSNKGASQ GM +
Sbjct: 203 TISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLN--VSLQMGSNKGASQRGMTV 260
Query: 535 -GTQRFIND 558
G R + D
Sbjct: 261 YGLPRQVYD 269
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,723,584
Number of Sequences: 369166
Number of extensions: 1848736
Number of successful extensions: 5041
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4278
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4883
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7018522000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)