Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_014_G10
(669 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9EQU5|SET_MOUSE SET protein (Phosphatase 2A inhibitor I... 201 2e-51
sp|Q63945|SET_RAT SET protein (Phosphatase 2A inhibitor I2P... 199 5e-51
sp|Q01105|SET_HUMAN SET protein (Phosphatase 2A inhibitor I... 194 2e-49
sp|P53997|SET_DROME SET protein 177 2e-44
sp|Q18240|SPR2_CAEEL Suppressor of presenilin 2 162 1e-39
sp|Q9UJ04|TSYL4_HUMAN Testis-specific Y-encoded-like protei... 121 2e-27
sp|P13825|ASP_PLAFS Aspartic acid-rich protein precursor 120 3e-27
sp|O88852|TSYL1_MOUSE Testis-specific Y-encoded-like protei... 119 5e-27
sp|Q9H0U9|TSYL1_HUMAN Testis-specific Y-encoded-like protei... 118 1e-26
sp|Q8VD63|TSYL4_MOUSE Testis-specific Y-encoded-like protei... 113 5e-25
>sp|Q9EQU5|SET_MOUSE SET protein (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A)
(Template-activating factor I) (TAF-I)
Length = 289
Score = 201 bits (510), Expect = 2e-51
Identities = 104/224 (46%), Positives = 141/224 (62%), Gaps = 2/224 (0%)
Frame = +2
Query: 2 ASAPKIQ-KTESNGKVDQDQVLNSLIEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQP 178
A+APK++ K+ S G ++ IE IDEVQ++ID+LNEQASEEIL+VE+K+N+ RQP
Sbjct: 19 AAAPKLEDKSASPGLPKGEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQP 78
Query: 179 LFQQRANLIKTIPNFWINALSNHPQLMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIM 358
FQ+R+ LI IPNFW+ NHPQ+ L+ E DE+ L LT ++V EF+DIKSG++I
Sbjct: 79 FFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDF 138
Query: 359 TFSPNEYFNNTTITKSIHVGES-EIKTTCDPVDWKEGKNFVKSLNESLNXXXXXXXXXXX 535
F N YF N ++K H+ ES + + + WK GK+ K +++ N
Sbjct: 139 YFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQN--KASRKRQHE 196
Query: 536 XPISFMQWFTSDIANSMVELGEVIKDDLWPNPLQYYLAVEDDDD 667
P SF WFT ELGEVIKDD+WPNPLQYYL + DD+
Sbjct: 197 EPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDE 240
>sp|Q63945|SET_RAT SET protein (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A)
(Template-activating factor I) (TAF-I) (Liver
regeneration-related protein LRRGR00002)
Length = 289
Score = 199 bits (506), Expect = 5e-51
Identities = 103/223 (46%), Positives = 140/223 (62%), Gaps = 2/223 (0%)
Frame = +2
Query: 5 SAPKIQ-KTESNGKVDQDQVLNSLIEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPL 181
+APK++ K+ S G ++ IE IDEVQ++ID+LNEQASEEIL+VE+K+N+ RQP
Sbjct: 20 AAPKLEDKSASPGLPKGEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPF 79
Query: 182 FQQRANLIKTIPNFWINALSNHPQLMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMT 361
FQ+R+ LI IPNFW+ NHPQ+ L+ E DE+ L LT ++V EF+DIKSG++I
Sbjct: 80 FQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFY 139
Query: 362 FSPNEYFNNTTITKSIHVGES-EIKTTCDPVDWKEGKNFVKSLNESLNXXXXXXXXXXXX 538
F N YF N ++K H+ ES + + + WK GK+ K +++ N
Sbjct: 140 FDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQN--KASRKRQHEE 197
Query: 539 PISFMQWFTSDIANSMVELGEVIKDDLWPNPLQYYLAVEDDDD 667
P SF WFT ELGEVIKDD+WPNPLQYYL + DD+
Sbjct: 198 PESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDE 240
>sp|Q01105|SET_HUMAN SET protein (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A)
(Template-activating factor I) (TAF-I) (HLA-DR
associated protein II) (PHAPII) (Inhibitor of granzyme
A-activated DNase) (IGAAD)
Length = 290
Score = 194 bits (493), Expect = 2e-49
Identities = 97/199 (48%), Positives = 128/199 (64%), Gaps = 1/199 (0%)
Frame = +2
Query: 74 IEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALSNHPQ 253
IE IDEVQ++ID+LNEQASEEIL+VE+K+N+ RQP FQ+R+ LI IPNFW+ NHPQ
Sbjct: 45 IEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQ 104
Query: 254 LMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVGES-EI 430
+ L+ E DE+ L LT ++V EF+DIKSG++I F N YF N ++K H+ ES +
Sbjct: 105 VSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDP 164
Query: 431 KTTCDPVDWKEGKNFVKSLNESLNXXXXXXXXXXXXPISFMQWFTSDIANSMVELGEVIK 610
+ + WK GK+ K +++ N P SF WFT ELGEVIK
Sbjct: 165 SSKSTEIKWKSGKDLTKRSSQTQN--KASRKRQHEEPESFFTWFTDHSDAGADELGEVIK 222
Query: 611 DDLWPNPLQYYLAVEDDDD 667
DD+WPNPLQYYL + DD+
Sbjct: 223 DDIWPNPLQYYLVPDMDDE 241
>sp|P53997|SET_DROME SET protein
Length = 269
Score = 177 bits (450), Expect = 2e-44
Identities = 89/209 (42%), Positives = 129/209 (61%), Gaps = 11/209 (5%)
Frame = +2
Query: 74 IEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALSNHPQ 253
+E+ID Q++ID LNE+ASEEIL+VE+K+N+ R+P +++R+ L+K IPNFW+ + NHPQ
Sbjct: 33 LEQIDACQNEIDALNEKASEEILKVEQKYNKLRKPCYEKRSELVKRIPNFWVTSFINHPQ 92
Query: 254 LMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVGESEIK 433
+ ++ E +E+ L +L L+VEEF+DIKSG++I F N YF N +TK H+ +
Sbjct: 93 VSGILDEEEEECLHALNKLEVEEFEDIKSGYRINFHFDENPYFENKVLTKEFHLNSAAAS 152
Query: 434 -------TTCDPVDWKEGKNFVKSLNESLNXXXXXXXXXXXXPISFMQWFTSDIANSMVE 592
+T P+ WKEGKN +K L L +F WF+ + E
Sbjct: 153 ENGDWPASTSTPIKWKEGKNLLKLL---LTKPYGNKKKRNSEYKTFFDWFSDNTDPVNDE 209
Query: 593 LGEVIKDDLWPNPLQYYLA----VEDDDD 667
+ E+IKDDLWPNPLQYYL VE +D+
Sbjct: 210 IAELIKDDLWPNPLQYYLVPDIEVEPEDE 238
>sp|Q18240|SPR2_CAEEL Suppressor of presenilin 2
Length = 312
Score = 162 bits (409), Expect = 1e-39
Identities = 89/207 (42%), Positives = 118/207 (57%), Gaps = 5/207 (2%)
Frame = +2
Query: 59 VLNSLIEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINAL 238
V LIE +D +Q +D ++E A+EE+L+VE+ FNQKR P++++R L I NFW A
Sbjct: 27 VKEKLIE-LDAIQHQLDVMSENAAEEVLKVEQIFNQKRLPIYEKRKKLTTKIDNFWQTAF 85
Query: 239 SNHPQLMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVG 418
NH L T I E EDLL +L L+V+EF+D++SGFKIIMTF PNEYF N ITKS H+
Sbjct: 86 LNHHLLSTAIPEEQEDLLAALRDLEVQEFEDLRSGFKIIMTFDPNEYFTNEVITKSYHLQ 145
Query: 419 ESEIKTTCDPVDWKEGKNFVKSLNESLNXXXXXXXXXXXXPISFMQWFTSDIANSMVELG 598
T ++WKE K +F++W T E+
Sbjct: 146 SESPSTEITEIEWKENKK-------------PPFPEDGDSAHTFLEWLTYAALPDSDEIA 192
Query: 599 EVIKDDLWPNPLQYYL-----AVEDDD 664
EVIKDDL+ NPLQYY+ VE+DD
Sbjct: 193 EVIKDDLYVNPLQYYVMPDMQEVEEDD 219
>sp|Q9UJ04|TSYL4_HUMAN Testis-specific Y-encoded-like protein 4 (TSPY-like 4)
Length = 414
Score = 121 bits (303), Expect = 2e-27
Identities = 61/199 (30%), Positives = 103/199 (51%), Gaps = 1/199 (0%)
Frame = +2
Query: 62 LNSLIEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALS 241
+N+ ++ ++ + ++ +N QA L++E+KF + R+ Q+R+ +I+ IP FW+ A
Sbjct: 200 INNCMDSLEAIDQELSNVNAQADRAFLQLERKFGRMRRLHMQRRSFIIQNIPGFWVTAFR 259
Query: 242 NHPQLMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVGE 421
NHPQL +I+ DED+L+ + +L+VEE ++G K F N YF N + K
Sbjct: 260 NHPQLSPMISGQDEDMLRYMINLEVEELKHPRAGCKFKFIFQGNPYFRNEGLVKEYERRS 319
Query: 422 S-EIKTTCDPVDWKEGKNFVKSLNESLNXXXXXXXXXXXXPISFMQWFTSDIANSMVELG 598
S + + P+ W G++ ++ + SF WF+ +
Sbjct: 320 SGRVVSLSTPIRWHRGQDPQAHIHRNREGNTIP---------SFFNWFSDHSLLEFDRIA 370
Query: 599 EVIKDDLWPNPLQYYLAVE 655
E+IK +LWPNPLQYYL E
Sbjct: 371 EIIKGELWPNPLQYYLMGE 389
>sp|P13825|ASP_PLAFS Aspartic acid-rich protein precursor
Length = 253
Score = 120 bits (301), Expect = 3e-27
Identities = 61/195 (31%), Positives = 108/195 (55%), Gaps = 3/195 (1%)
Frame = +2
Query: 92 VQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALSNHPQLMTLIT 271
VQ DI++L+ + + E + ++K++++K++PLF++R +I+ IP FW N L HP L ++
Sbjct: 20 VQKDIEQLDIKCAHEQMNIQKQYDEKKKPLFEKRDEIIQKIPGFWANTLRKHPALSDIVP 79
Query: 272 EHDEDLLQSLTSLDVEEFDDIKSGFKIIMTF--SPNEYFNNTTITKSIHVGESEIKTT-C 442
E D D+L L LD+++ D +KI F E+ T+ K + ++ K C
Sbjct: 80 E-DIDILNHLVKLDLKDNMDNNGSYKITFIFGEKAKEFMEPLTLVKHVTFDNNQEKVVEC 138
Query: 443 DPVDWKEGKNFVKSLNESLNXXXXXXXXXXXXPISFMQWFTSDIANSMVELGEVIKDDLW 622
+ WKEGKN + ++ + + S +WFT+D ++GE+I+ ++W
Sbjct: 139 TRIKWKEGKNPIAAVTHNRSDLDNEIPKW-----SIFEWFTTDELQDKPDVGELIRREIW 193
Query: 623 PNPLQYYLAVEDDDD 667
NPL YYL +E+ D+
Sbjct: 194 HNPLSYYLGLEEFDE 208
>sp|O88852|TSYL1_MOUSE Testis-specific Y-encoded-like protein 1 (TSPY-like 1)
Length = 379
Score = 119 bits (299), Expect = 5e-27
Identities = 64/195 (32%), Positives = 101/195 (51%), Gaps = 4/195 (2%)
Frame = +2
Query: 83 IDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALSNHPQLMT 262
++ +Q ++D +N QA +E+KF + R+ ++R +I+ IP FW+ A NHPQL
Sbjct: 174 LEAIQLELDTVNAQADRAFQHLEQKFGRMRRHYLERRNYIIQNIPGFWMTAFRNHPQLSA 233
Query: 263 LITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVGES-EIKTT 439
+I D ++L+ +TSL+V+E K+G K F N YF N I K V S + +
Sbjct: 234 MIRGRDAEMLRYVTSLEVKELRHPKTGCKFKFFFRRNPYFRNKLIVKEYEVRSSGRVVSL 293
Query: 440 CDPVDWKEG---KNFVKSLNESLNXXXXXXXXXXXXPISFMQWFTSDIANSMVELGEVIK 610
P+ W+ G ++F++ + + SF WF+ + E+IK
Sbjct: 294 STPIIWRRGHEPQSFIRRNQDLI--------------CSFFTWFSDHSLPESDRIAEIIK 339
Query: 611 DDLWPNPLQYYLAVE 655
+DLWPNPLQYYL E
Sbjct: 340 EDLWPNPLQYYLCRE 354
>sp|Q9H0U9|TSYL1_HUMAN Testis-specific Y-encoded-like protein 1 (TSPY-like 1)
Length = 438
Score = 118 bits (296), Expect = 1e-26
Identities = 62/198 (31%), Positives = 104/198 (52%), Gaps = 4/198 (2%)
Frame = +2
Query: 74 IEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALSNHPQ 253
++ ++ +Q ++D +N QA ++E KF + R+ ++R +I+ IP FW+ A NHPQ
Sbjct: 230 MDPLEAIQLELDTVNAQADRAFQQLEHKFGRMRRHYLERRNYIIQNIPGFWMTAFRNHPQ 289
Query: 254 LMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVGES-EI 430
L +I D ++L+ +T+L+V+E ++G K F N YF N I K V S +
Sbjct: 290 LSAMIRGQDAEMLRYITNLEVKELRHPRTGCKFKFFFRRNPYFRNKLIVKEYEVRSSGRV 349
Query: 431 KTTCDPVDWKEG---KNFVKSLNESLNXXXXXXXXXXXXPISFMQWFTSDIANSMVELGE 601
+ P+ W+ G ++F++ + + SF WF+ ++ E
Sbjct: 350 VSLSTPIIWRRGHEPQSFIRRNQDLI--------------CSFFTWFSDHSLPESDKIAE 395
Query: 602 VIKDDLWPNPLQYYLAVE 655
+IK+DLWPNPLQYYL E
Sbjct: 396 IIKEDLWPNPLQYYLLRE 413
>sp|Q8VD63|TSYL4_MOUSE Testis-specific Y-encoded-like protein 4 (TSPY-like 4)
Length = 406
Score = 113 bits (282), Expect = 5e-25
Identities = 57/192 (29%), Positives = 96/192 (50%), Gaps = 1/192 (0%)
Frame = +2
Query: 74 IEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALSNHPQ 253
++ ++ + ++ +N QA L++E+KF + R+ Q+R+ +I+ IP FW+ A NHPQ
Sbjct: 196 MDSLEAIDQELSNVNAQADRAFLQLERKFGRMRRLHMQRRSFIIQNIPGFWVTAFRNHPQ 255
Query: 254 LMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVGES-EI 430
L +I+ DED+++ + +L+VEE + G K F N YF N + K S +
Sbjct: 256 LSPMISGQDEDMMRYMINLEVEELKQPRVGCKFKFIFQSNPYFRNEGLVKEYERRSSGRV 315
Query: 431 KTTCDPVDWKEGKNFVKSLNESLNXXXXXXXXXXXXPISFMQWFTSDIANSMVELGEVIK 610
+ P+ W G+ ++ + SF WF+ + E+IK
Sbjct: 316 VSLSTPIRWHRGQEPQAHIHRNREGNTIP---------SFFNWFSDHSLLEFDRIAEIIK 366
Query: 611 DDLWPNPLQYYL 646
+LW NPLQYYL
Sbjct: 367 GELWSNPLQYYL 378
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,843,427
Number of Sequences: 369166
Number of extensions: 1356534
Number of successful extensions: 4858
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4630
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4820
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5657676120
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)