Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_014_F05
(743 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P51893|SAHHA_XENLA Adenosylhomocysteinase A (S-adenosyl-... 397 e-110
sp|O93477|SAHHB_XENLA Adenosylhomocysteinase B (S-adenosyl-... 396 e-110
sp|P50247|SAHH_MOUSE Adenosylhomocysteinase (S-adenosyl-L-h... 392 e-109
sp|P23526|SAHH_HUMAN Adenosylhomocysteinase (S-adenosyl-L-h... 389 e-108
sp|P10760|SAHH_RAT Adenosylhomocysteinase (S-adenosyl-L-hom... 387 e-107
sp|Q710C4|SAHH_PIG Adenosylhomocysteinase (S-adenosyl-L-hom... 386 e-107
sp|Q27580|SAHH_DROME Adenosylhomocysteinase (S-adenosyl-L-h... 380 e-105
sp|P27604|SAHH_CAEEL Adenosylhomocysteinase (S-adenosyl-L-h... 369 e-102
sp|O76757|SAHH_ANOGA Adenosylhomocysteinase (S-adenosyl-L-h... 362 e-100
sp|O13639|SAHH_SCHPO Adenosylhomocysteinase (S-adenosyl-L-h... 360 2e-99
>sp|P51893|SAHHA_XENLA Adenosylhomocysteinase A (S-adenosyl-L-homocysteine hydrolase A)
(AdoHcyase A)
Length = 433
Score = 397 bits (1019), Expect = e-110
Identities = 194/247 (78%), Positives = 210/247 (85%)
Frame = +1
Query: 1 NLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLKCPAINVNDSVTKSKFDNLYGCR 180
NLVH KYP LL GIKGISEETTTGVHNLYKM SSG L+ PAINVNDSVTKSKFDNLYGCR
Sbjct: 138 NLVHSKYPQLLKGIKGISEETTTGVHNLYKMKSSGTLQVPAINVNDSVTKSKFDNLYGCR 197
Query: 181 ESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRAYGCRVLVSEIDPINALQAAMEG 360
ESL+DGIKRATDVM+AGKVA+VAGYGDVGKGC QALRA+G RV+++EIDPINALQAAMEG
Sbjct: 198 ESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRAFGARVIITEIDPINALQAAMEG 257
Query: 361 YEVTTVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDSIVCNIGHFDIEVEAKWLYENCK 540
YEVTT++EA K+ IFVT TGC DI+ GRHFE M DDSIVCNIGHFDIE++ KWL EN
Sbjct: 258 YEVTTMDEASKEGNIFVTTTGCADIVEGRHFENMKDDSIVCNIGHFDIELDVKWLNENAV 317
Query: 541 SKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHPKFRDEQLVHKSVLAQIELWTKT 720
K IKPQVDRY LKNGRHIILLAEGRLVNLGCA GHP F V+AQIELWT T
Sbjct: 318 KKVNIKPQVDRYLLKNGRHIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTNT 377
Query: 721 DQYKVGV 741
D+Y VGV
Sbjct: 378 DKYPVGV 384
>sp|O93477|SAHHB_XENLA Adenosylhomocysteinase B (S-adenosyl-L-homocysteine hydrolase B)
(AdoHcyase B)
Length = 433
Score = 396 bits (1017), Expect = e-110
Identities = 193/247 (78%), Positives = 210/247 (85%)
Frame = +1
Query: 1 NLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLKCPAINVNDSVTKSKFDNLYGCR 180
NLVH KYP LL GIKGISEETTTGVHNLYKM SSG L+ PAINVNDSVTKSKFDNLYGCR
Sbjct: 138 NLVHTKYPQLLKGIKGISEETTTGVHNLYKMKSSGTLQVPAINVNDSVTKSKFDNLYGCR 197
Query: 181 ESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRAYGCRVLVSEIDPINALQAAMEG 360
ESL+DGIKRATDVM+AGKVA+VAGYGDVGKGC QALRA+G RVL++EIDPINALQAAMEG
Sbjct: 198 ESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRAFGARVLITEIDPINALQAAMEG 257
Query: 361 YEVTTVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDSIVCNIGHFDIEVEAKWLYENCK 540
YEVTT++EA K+ IFVT TGC DI+ GRHFE M DDSIVCNIGHFD+E++ KWL +N
Sbjct: 258 YEVTTMDEASKEGNIFVTTTGCADIVEGRHFENMKDDSIVCNIGHFDVELDVKWLNDNAA 317
Query: 541 SKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHPKFRDEQLVHKSVLAQIELWTKT 720
K IKPQVDRY LKNGRHIILLAEGRLVNLGCA GHP F V+AQIELWT T
Sbjct: 318 KKINIKPQVDRYLLKNGRHIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTNT 377
Query: 721 DQYKVGV 741
D+Y VGV
Sbjct: 378 DKYPVGV 384
>sp|P50247|SAHH_MOUSE Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase) (Liver copper binding protein) (CUBP)
Length = 432
Score = 392 bits (1007), Expect = e-109
Identities = 190/247 (76%), Positives = 210/247 (85%)
Frame = +1
Query: 1 NLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLKCPAINVNDSVTKSKFDNLYGCR 180
NL+H KYP LL GI+GISEETTTGVHNLYKMMS+G LK PAINVNDSVTKSKFDNLYGCR
Sbjct: 137 NLIHTKYPQLLSGIRGISEETTTGVHNLYKMMSNGILKVPAINVNDSVTKSKFDNLYGCR 196
Query: 181 ESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRAYGCRVLVSEIDPINALQAAMEG 360
ESL+DGIKRATDVM+AGKVA+VAGYGDVGKGC QALR +G RV+++EIDPINALQAAMEG
Sbjct: 197 ESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEG 256
Query: 361 YEVTTVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDSIVCNIGHFDIEVEAKWLYENCK 540
YEVTT++EA K+ IFVT TGC DII+GRHFEQM DD+IVCNIGHFD+E++ KWL EN
Sbjct: 257 YEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAV 316
Query: 541 SKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHPKFRDEQLVHKSVLAQIELWTKT 720
K IKPQVDRY LKNGR IILLAEGRLVNLGCA GHP F V+AQIELWT
Sbjct: 317 EKVNIKPQVDRYWLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHP 376
Query: 721 DQYKVGV 741
D+Y VGV
Sbjct: 377 DKYPVGV 383
>sp|P23526|SAHH_HUMAN Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 432
Score = 389 bits (999), Expect = e-108
Identities = 188/247 (76%), Positives = 210/247 (85%)
Frame = +1
Query: 1 NLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLKCPAINVNDSVTKSKFDNLYGCR 180
NL+H KYP LL GI+GISEETTTGVHNLYKMM++G LK PAINVNDSVTKSKFDNLYGCR
Sbjct: 137 NLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCR 196
Query: 181 ESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRAYGCRVLVSEIDPINALQAAMEG 360
ESL+DGIKRATDVM+AGKVA+VAGYGDVGKGC QALR +G RV+++EIDPINALQAAMEG
Sbjct: 197 ESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEG 256
Query: 361 YEVTTVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDSIVCNIGHFDIEVEAKWLYENCK 540
YEVTT++EA ++ IFVT TGC DII+GRHFEQM DD+IVCNIGHFD+E++ KWL EN
Sbjct: 257 YEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAV 316
Query: 541 SKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHPKFRDEQLVHKSVLAQIELWTKT 720
K IKPQVDRY LKNGR IILLAEGRLVNLGCA GHP F V+AQIELWT
Sbjct: 317 EKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHP 376
Query: 721 DQYKVGV 741
D+Y VGV
Sbjct: 377 DKYPVGV 383
>sp|P10760|SAHH_RAT Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 432
Score = 387 bits (995), Expect = e-107
Identities = 187/247 (75%), Positives = 209/247 (84%)
Frame = +1
Query: 1 NLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLKCPAINVNDSVTKSKFDNLYGCR 180
NL+H K+P LL GI+GISEETTTGVHNLYKMM++G LK PAINVNDSVTKSKFDNLYGCR
Sbjct: 137 NLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCR 196
Query: 181 ESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRAYGCRVLVSEIDPINALQAAMEG 360
ESL+DGIKRATDVM+AGKVA+VAGYGDVGKGC QALR +G RV+++EIDPINALQAAMEG
Sbjct: 197 ESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEG 256
Query: 361 YEVTTVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDSIVCNIGHFDIEVEAKWLYENCK 540
YEVTT++EA K+ IFVT TGC DII+GRHFEQM DD+IVCNIGHFD+E++ KWL EN
Sbjct: 257 YEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAV 316
Query: 541 SKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHPKFRDEQLVHKSVLAQIELWTKT 720
K IKPQVDRY LKNG IILLAEGRLVNLGCA GHP F V+AQIELWT
Sbjct: 317 EKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHP 376
Query: 721 DQYKVGV 741
D+Y VGV
Sbjct: 377 DKYPVGV 383
>sp|Q710C4|SAHH_PIG Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 432
Score = 386 bits (992), Expect = e-107
Identities = 188/247 (76%), Positives = 208/247 (84%)
Frame = +1
Query: 1 NLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLKCPAINVNDSVTKSKFDNLYGCR 180
NLVH KYP LL GI+GISEETTTGVHNLYKM ++G LK PAINVNDSVTKSKFDNLYGCR
Sbjct: 137 NLVHTKYPELLSGIRGISEETTTGVHNLYKMKANGILKVPAINVNDSVTKSKFDNLYGCR 196
Query: 181 ESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRAYGCRVLVSEIDPINALQAAMEG 360
ESL+DGIKRATDVM+AGKVA+VAGYGDVGKGC QALR +G RV+++EIDPINALQAAMEG
Sbjct: 197 ESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEG 256
Query: 361 YEVTTVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDSIVCNIGHFDIEVEAKWLYENCK 540
YEVTT++EA ++ IFVT TGC DII+GRHFEQM DD+IVCNIGHFD+E++ KWL EN
Sbjct: 257 YEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAV 316
Query: 541 SKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHPKFRDEQLVHKSVLAQIELWTKT 720
K IKPQVDRY LKNG IILLAEGRLVNLGCA GHP F VLAQIELWT
Sbjct: 317 EKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVLAQIELWTHP 376
Query: 721 DQYKVGV 741
D+Y VGV
Sbjct: 377 DKYPVGV 383
>sp|Q27580|SAHH_DROME Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 432
Score = 380 bits (975), Expect = e-105
Identities = 182/247 (73%), Positives = 206/247 (83%)
Frame = +1
Query: 1 NLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLKCPAINVNDSVTKSKFDNLYGCR 180
NLVHEK+P L IKG+SEETTTGVHNLYKM G+L PAINVNDSVTKSKFDNLYGCR
Sbjct: 137 NLVHEKFPQYLKNIKGLSEETTTGVHNLYKMFKEGRLGVPAINVNDSVTKSKFDNLYGCR 196
Query: 181 ESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRAYGCRVLVSEIDPINALQAAMEG 360
ESL+DGIKRATDVM+AGKV VAGYGDVGKGC QAL+ +G RV+V+E+DPINALQAAMEG
Sbjct: 197 ESLIDGIKRATDVMIAGKVCCVAGYGDVGKGCAQALKGFGGRVIVTEVDPINALQAAMEG 256
Query: 361 YEVTTVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDSIVCNIGHFDIEVEAKWLYENCK 540
YEVTT+EEA K+A IFVT TGC+DII H +QM DD+IVCNIGHFDIE++ WL N K
Sbjct: 257 YEVTTMEEASKEASIFVTTTGCRDIITSVHLQQMPDDAIVCNIGHFDIEIDVDWLNANAK 316
Query: 541 SKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHPKFRDEQLVHKSVLAQIELWTKT 720
K +KPQVDRYT+++G+HIILLAEGRLVNLGCAHGHP F VLAQIELWTK+
Sbjct: 317 EKVNVKPQVDRYTMQSGKHIILLAEGRLVNLGCAHGHPSFVMSNSFTNQVLAQIELWTKS 376
Query: 721 DQYKVGV 741
D+Y VGV
Sbjct: 377 DKYAVGV 383
>sp|P27604|SAHH_CAEEL Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase) (Dumpy-14 protein)
Length = 437
Score = 369 bits (946), Expect = e-102
Identities = 181/250 (72%), Positives = 205/250 (82%), Gaps = 3/250 (1%)
Frame = +1
Query: 1 NLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLKCPAINVNDSVTKSKFDNLYGCR 180
NLVH KYP L GI+G+SEETTTGVHNL KM++ G LK PAINVNDSVTKSKFDNLYG R
Sbjct: 139 NLVHAKYPQYLAGIRGLSEETTTGVHNLAKMLAKGDLKVPAINVNDSVTKSKFDNLYGIR 198
Query: 181 ESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRAYGCRVLVSEIDPINALQAAMEG 360
ESL DGIKRATDVMLAGKVA+VAGYGDVGKG +L+A+G RV+V+EIDPINALQAAMEG
Sbjct: 199 ESLPDGIKRATDVMLAGKVAVVAGYGDVGKGSAASLKAFGSRVIVTEIDPINALQAAMEG 258
Query: 361 YEVTTVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDSIVCNIGHFDIEVEAKWLYENCK 540
YEVTT+EEA KA I VT TGCKDI+ G+HFE + +D+IVCN+GHFD E++ KWL N
Sbjct: 259 YEVTTLEEAAPKANIIVTTTGCKDIVTGKHFELLPNDAIVCNVGHFDCEIDVKWLNTNAT 318
Query: 541 SKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHPKFRDEQLVHKSVLAQIELWTK- 717
KDTIKPQVDRYTLKNGRH+ILLAEGRLVNLGCA GHP F VLAQ+ELWTK
Sbjct: 319 KKDTIKPQVDRYTLKNGRHVILLAEGRLVNLGCATGHPSFVMSNSFTNQVLAQVELWTKF 378
Query: 718 --TDQYKVGV 741
+YK+G+
Sbjct: 379 GTPQEYKLGL 388
>sp|O76757|SAHH_ANOGA Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 432
Score = 362 bits (928), Expect = e-100
Identities = 180/247 (72%), Positives = 197/247 (79%)
Frame = +1
Query: 1 NLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLKCPAINVNDSVTKSKFDNLYGCR 180
NLVH ++P LL I+G+SEETTTGVHNLYKM G+L PAINVNDSVTKSKFDNLYGCR
Sbjct: 137 NLVHAEHPELLKEIRGLSEETTTGVHNLYKMFREGRLGMPAINVNDSVTKSKFDNLYGCR 196
Query: 181 ESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRAYGCRVLVSEIDPINALQAAMEG 360
ESL+DGIKRATDVM+AGKV +VAGYGDVGKGC QALR G RVL++EIDPINALQAAMEG
Sbjct: 197 ESLLDGIKRATDVMIAGKVCVVAGYGDVGKGCAQALRGSGGRVLITEIDPINALQAAMEG 256
Query: 361 YEVTTVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDSIVCNIGHFDIEVEAKWLYENCK 540
EVTT+EEA K+A+IFVT TGC DII+G HF M DDSIVCNIGHFD E+ WL EN
Sbjct: 257 KEVTTMEEASKEAQIFVTTTGCTDIIMGEHFLNMKDDSIVCNIGHFDCEINVTWLQENAV 316
Query: 541 SKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHPKFRDEQLVHKSVLAQIELWTKT 720
K IKPQVDRY L NG HIILLAEGRLVNLGCA GH F VLAQIELWT
Sbjct: 317 EKVNIKPQVDRYRLANGNHIILLAEGRLVNLGCAMGHSSFVMSNSFTNQVLAQIELWTNR 376
Query: 721 DQYKVGV 741
+QY +GV
Sbjct: 377 EQYAIGV 383
>sp|O13639|SAHH_SCHPO Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 433
Score = 360 bits (924), Expect = 2e-99
Identities = 175/246 (71%), Positives = 201/246 (81%)
Frame = +1
Query: 4 LVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLKCPAINVNDSVTKSKFDNLYGCRE 183
LVHE++P LL I+GISEETTTGVHNLYKM KLK PAINVNDSVTKSKFDNL+GC+E
Sbjct: 139 LVHERHPELLVDIRGISEETTTGVHNLYKMFKENKLKVPAINVNDSVTKSKFDNLFGCKE 198
Query: 184 SLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRAYGCRVLVSEIDPINALQAAMEGY 363
SLVDGIKRATDVM+AGKVA+VAG+GDVGKGC +LR+ G RV+V+E+DPINALQAAM+G+
Sbjct: 199 SLVDGIKRATDVMIAGKVAVVAGFGDVGKGCSTSLRSQGARVIVTEVDPINALQAAMDGF 258
Query: 364 EVTTVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDSIVCNIGHFDIEVEAKWLYENCKS 543
EVTT+EEAVK+ +IFVT TGC+DII G HF +M +DSIVCNIGHFD+E++ WL N K
Sbjct: 259 EVTTMEEAVKEGQIFVTTTGCRDIIRGEHFNEMKEDSIVCNIGHFDVEIDVAWLKANAKD 318
Query: 544 KDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHPKFRDEQLVHKSVLAQIELWTKTD 723
IKPQVDRY LKNGRHIILLA+GRLVNLGCA GHP F VLAQI LWT
Sbjct: 319 VVNIKPQVDRYELKNGRHIILLADGRLVNLGCATGHPSFVMSCSFTNQVLAQIALWTDNT 378
Query: 724 QYKVGV 741
Y +GV
Sbjct: 379 SYPLGV 384
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,485,486
Number of Sequences: 369166
Number of extensions: 1706815
Number of successful extensions: 5226
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4943
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5088
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6728100400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)