Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_014_E03
(402 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma p... 87 9e-18
sp|P14272|KLKB1_RAT Plasma kallikrein precursor (Plasma pre... 82 3e-16
sp|Q9DBI0|TMPS6_MOUSE Transmembrane protease, serine 6 (Mat... 81 7e-16
sp|P03952|KLKB1_HUMAN Plasma kallikrein precursor (Plasma p... 79 3e-15
sp|P98074|ENTK_PIG Enteropeptidase precursor (Enterokinase)... 77 1e-14
sp|P98072|ENTK_BOVIN Enteropeptidase precursor (Enterokinas... 75 6e-14
sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinas... 74 8e-14
sp|P03951|FA11_HUMAN Coagulation factor XI precursor (Plasm... 74 8e-14
sp|P98064|MASP1_MOUSE Complement-activating component of Ra... 73 2e-13
sp|O08762|NETR_MOUSE Neurotrypsin precursor (Motopsin) (Bra... 73 2e-13
>sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 87.4 bits (215), Expect = 9e-18
Identities = 50/105 (47%), Positives = 64/105 (60%), Gaps = 3/105 (2%)
Frame = +1
Query: 25 WRKNKSQ-KNSNILQEVEIPLVNFELCQKRYRIFNLNKEIHICAGSRR--KDTCRGDSGG 195
W K Q + NILQ+ IPLV E CQK+YR + +NK++ ICAG + D C+GDSGG
Sbjct: 522 WGYTKEQGETQNILQKATIPLVPNEECQKKYRDYVINKQM-ICAGYKEGGTDACKGDSGG 580
Query: 196 GLFCLDPSTNRWQLYGITNFGSARGCGTSYGVYTRVPEVSNWIKE 330
L C + RWQL GIT++G G GVYT+V E +WI E
Sbjct: 581 PLVC--KHSGRWQLVGITSWGEGCGRKDQPGVYTKVSEYMDWILE 623
>sp|P14272|KLKB1_RAT Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 82.4 bits (202), Expect = 3e-16
Identities = 49/110 (44%), Positives = 64/110 (58%), Gaps = 3/110 (2%)
Frame = +1
Query: 25 WRKNKSQ-KNSNILQEVEIPLVNFELCQKRYRIFNLNKEIHICAGSRRK--DTCRGDSGG 195
W K + + NILQ+ IPLV E CQK+YR + + K++ ICAG + D C+GDSGG
Sbjct: 522 WGYTKERGETQNILQKATIPLVPNEECQKKYRDYVITKQM-ICAGYKEGGIDACKGDSGG 580
Query: 196 GLFCLDPSTNRWQLYGITNFGSARGCGTSYGVYTRVPEVSNWIKEIISKS 345
L C + RWQL GIT++G GVYT+V E +WI E I S
Sbjct: 581 PLVC--KHSGRWQLVGITSWGEGCARKEQPGVYTKVAEYIDWILEKIQSS 628
>sp|Q9DBI0|TMPS6_MOUSE Transmembrane protease, serine 6 (Matriptase-2)
Length = 799
Score = 81.3 bits (199), Expect = 7e-16
Identities = 43/98 (43%), Positives = 65/98 (66%), Gaps = 2/98 (2%)
Frame = +1
Query: 52 SNILQEVEIPLVNFELCQKRYRIFNLNKEIHICAGSRR--KDTCRGDSGGGLFCLDPSTN 225
SN LQ+V++ LV +LC + YR + ++ + +CAG R+ KD C+GDSGG L C +PS
Sbjct: 705 SNTLQKVDVQLVPQDLCSEAYR-YQVSPRM-LCAGYRKGKKDACQGDSGGPLVCREPS-G 761
Query: 226 RWQLYGITNFGSARGCGTSYGVYTRVPEVSNWIKEIIS 339
RW L G+ ++G G +GVYTRV V NWI+++++
Sbjct: 762 RWFLAGLVSWGLGCGRPNFFGVYTRVTRVINWIQQVLT 799
>sp|P03952|KLKB1_HUMAN Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 79.3 bits (194), Expect = 3e-15
Identities = 43/94 (45%), Positives = 57/94 (60%), Gaps = 2/94 (2%)
Frame = +1
Query: 55 NILQEVEIPLVNFELCQKRYRIFNLNKEIHICAGSRR--KDTCRGDSGGGLFCLDPSTNR 228
NILQ+V IPLV E CQKRY+ + + + + +CAG + KD C+GDSGG L C
Sbjct: 533 NILQKVNIPLVTNEECQKRYQDYKITQRM-VCAGYKEGGKDACKGDSGGPLVC--KHNGM 589
Query: 229 WQLYGITNFGSARGCGTSYGVYTRVPEVSNWIKE 330
W+L GIT++G GVYT+V E +WI E
Sbjct: 590 WRLVGITSWGEGCARREQPGVYTKVAEYMDWILE 623
>sp|P98074|ENTK_PIG Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic mini chain; Enteropeptidase non-catalytic
heavy chain; Enteropeptidase catalytic light chain]
Length = 1034
Score = 77.4 bits (189), Expect = 1e-14
Identities = 39/97 (40%), Positives = 61/97 (62%), Gaps = 2/97 (2%)
Frame = +1
Query: 52 SNILQEVEIPLVNFELCQKRYRIFNLNKEIHICAGSRRK--DTCRGDSGGGLFCLDPSTN 225
++ILQE ++PL++ E CQ++ +N+ + + +CAG D+C+GDSGG L CL+ N
Sbjct: 940 ADILQEADVPLLSNEKCQQQMPEYNITENM-MCAGYEEGGIDSCQGDSGGPLMCLE--NN 996
Query: 226 RWQLYGITNFGSARGCGTSYGVYTRVPEVSNWIKEII 336
RW L G+T+FG GVY RVP+ + WI+ +
Sbjct: 997 RWLLAGVTSFGYQCALPNRPGVYARVPKFTEWIQSFL 1033
>sp|P98072|ENTK_BOVIN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1035
Score = 74.7 bits (182), Expect = 6e-14
Identities = 37/97 (38%), Positives = 59/97 (60%), Gaps = 2/97 (2%)
Frame = +1
Query: 52 SNILQEVEIPLVNFELCQKRYRIFNLNKEIHICAGSRRK--DTCRGDSGGGLFCLDPSTN 225
+++LQE ++PL++ E CQ++ +N+ + + +CAG D+C+GDSGG L C + N
Sbjct: 941 ADVLQEADVPLLSNEKCQQQMPEYNITENM-VCAGYEAGGVDSCQGDSGGPLMCQE--NN 997
Query: 226 RWQLYGITNFGSARGCGTSYGVYTRVPEVSNWIKEII 336
RW L G+T+FG GVY RVP + WI+ +
Sbjct: 998 RWLLAGVTSFGYQCALPNRPGVYARVPRFTEWIQSFL 1034
>sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1019
Score = 74.3 bits (181), Expect = 8e-14
Identities = 39/97 (40%), Positives = 58/97 (59%), Gaps = 2/97 (2%)
Frame = +1
Query: 52 SNILQEVEIPLVNFELCQKRYRIFNLNKEIHICAGSRRK--DTCRGDSGGGLFCLDPSTN 225
+NILQE ++PL++ E CQ++ +N+ + + ICAG D+C+GDSGG L C + N
Sbjct: 925 ANILQEADVPLLSNERCQQQMPEYNITENM-ICAGYEEGGIDSCQGDSGGPLMCQE--NN 981
Query: 226 RWQLYGITNFGSARGCGTSYGVYTRVPEVSNWIKEII 336
RW L G+T+FG GVY RV + WI+ +
Sbjct: 982 RWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFL 1018
>sp|P03951|FA11_HUMAN Coagulation factor XI precursor (Plasma thromboplastin antecedent)
(PTA) (FXI) [Contains: Coagulation factor XIa heavy
chain; Coagulation factor XIa light chain]
Length = 625
Score = 74.3 bits (181), Expect = 8e-14
Identities = 45/97 (46%), Positives = 54/97 (55%), Gaps = 2/97 (2%)
Frame = +1
Query: 46 KNSNILQEVEIPLVNFELCQKRYRIFNLNKEIHICAGSRR--KDTCRGDSGGGLFCLDPS 219
K N LQ+ +IPLV E CQKRYR + ++ ICAG R KD C+GDSGG L C
Sbjct: 527 KIQNTLQKAKIPLVTNEECQKRYRGHKITHKM-ICAGYREGGKDACKGDSGGPLSC--KH 583
Query: 220 TNRWQLYGITNFGSARGCGTSYGVYTRVPEVSNWIKE 330
W L GIT++G GVYT V E +WI E
Sbjct: 584 NEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILE 620
>sp|P98064|MASP1_MOUSE Complement-activating component of Ra-reactive factor precursor
(Ra-reactive factor serine protease p100) (RaRF)
(Mannan-binding lectin serine protease 1) [Contains:
Complement-activating component of Ra-reactive factor
heavy chain; Complement-activating component of
Ra-reactive factor light chain]
Length = 704
Score = 72.8 bits (177), Expect = 2e-13
Identities = 40/112 (35%), Positives = 60/112 (53%), Gaps = 5/112 (4%)
Frame = +1
Query: 13 VLERWRKNKSQKNSNILQEVEIPLVNFELCQKRYRIFNLNKEIH---ICAGSRR--KDTC 177
++ W K Q+ L E+EIP+VN + CQ+ Y L K++ ICAG + KD C
Sbjct: 590 IVSGWGKQFLQRFPENLMEIEIPIVNSDTCQEAYT--PLKKKVTKDMICAGEKEGGKDAC 647
Query: 178 RGDSGGGLFCLDPSTNRWQLYGITNFGSARGCGTSYGVYTRVPEVSNWIKEI 333
GDSGG + D ++W L G+ ++G G YGVY+ + +WI+ I
Sbjct: 648 AGDSGGPMVTKDAERDQWYLVGVVSWGEDCGKKDRYGVYSYIYPNKDWIQRI 699
>sp|O08762|NETR_MOUSE Neurotrypsin precursor (Motopsin) (Brain-specific serine protease
3) (BSSP-3)
Length = 761
Score = 72.8 bits (177), Expect = 2e-13
Identities = 40/100 (40%), Positives = 57/100 (57%), Gaps = 4/100 (4%)
Frame = +1
Query: 52 SNILQEVEIPLVNFELCQKRYRIFNLNKEIHICAGS----RRKDTCRGDSGGGLFCLDPS 219
S LQ+ +PL+ C++RY+ L +CAG+ R D+C+GDSGG L C P
Sbjct: 664 SRTLQQAAVPLLPKRFCKERYK--GLFTGRMLCAGNLQEDNRVDSCQGDSGGPLMCEKPD 721
Query: 220 TNRWQLYGITNFGSARGCGTSYGVYTRVPEVSNWIKEIIS 339
+ W +YG+T++G G + GVYTRVP WIK + S
Sbjct: 722 ES-WVVYGVTSWGYGCGVKDTPGVYTRVPAFVPWIKSVTS 760
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,608,173
Number of Sequences: 369166
Number of extensions: 965500
Number of successful extensions: 3304
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2788
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2850
length of database: 68,354,980
effective HSP length: 98
effective length of database: 50,250,950
effective search space used: 1758783250
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)