Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_014_C21
(513 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9GLE3|CATK_PIG Cathepsin K precursor 172 3e-43
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 172 4e-43
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 172 4e-43
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 171 9e-43
sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (C... 170 2e-42
sp|P55097|CATK_MOUSE Cathepsin K precursor 170 2e-42
sp|O35186|CATK_RAT Cathepsin K precursor 169 3e-42
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 168 6e-42
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 163 2e-40
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 163 3e-40
>sp|Q9GLE3|CATK_PIG Cathepsin K precursor
Length = 330
Score = 172 bits (437), Expect = 3e-43
Identities = 88/169 (52%), Positives = 112/169 (66%), Gaps = 3/169 (1%)
Frame = +1
Query: 13 LNEISRRLIWESNLKYIQKHNIESDLGKHTYTLGLNHFADMTNEEFRAKY--LSVPPSRK 186
++EISRRLIWE NLK+I HN+E+ LG HTY L +NH DMT+EE K L VPPS
Sbjct: 42 VDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSHS 101
Query: 187 KISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSATGSLEGQHFRKTGNLT 366
+ + P G+ PD++D+R +GYVTPVKNQ QCGSCW+FS+ G+LEGQ +KTG L
Sbjct: 102 RSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLL 161
Query: 367 SFSEQQLVDXXXXXXXXXXXXXLMDNAFEYIEK-FGIESEDAYPYTAED 510
+ S Q LVD M NAF+Y++K GI+SEDAYPY +D
Sbjct: 162 NLSPQNLVD--CVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQD 208
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 172 bits (436), Expect = 4e-43
Identities = 88/169 (52%), Positives = 112/169 (66%), Gaps = 3/169 (1%)
Frame = +1
Query: 13 LNEISRRLIWESNLKYIQKHNIESDLGKHTYTLGLNHFADMTNEEFRAKY--LSVPPSRK 186
++EISRRLIWE NLK+I HN+E+ LG HTY L +NH DMT+EE K L VPPSR
Sbjct: 41 VDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSRS 100
Query: 187 KISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSATGSLEGQHFRKTGNLT 366
+ P G+ PD++D+R +GYVTPVKNQ QCGSCW+FS+ G+LEGQ +KTG L
Sbjct: 101 HSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLL 160
Query: 367 SFSEQQLVDXXXXXXXXXXXXXLMDNAFEYIEK-FGIESEDAYPYTAED 510
+ S Q LVD M NAF+Y+++ GI+SEDAYPY +D
Sbjct: 161 NLSPQNLVD--CVSENYGCGGGYMTNAFQYVQRNRGIDSEDAYPYVGQD 207
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 172 bits (436), Expect = 4e-43
Identities = 89/169 (52%), Positives = 111/169 (65%), Gaps = 3/169 (1%)
Frame = +1
Query: 13 LNEISRRLIWESNLKYIQKHNIESDLGKHTYTLGLNHFADMTNEEFRAKY--LSVPPSRK 186
++EISRRLIWE NLKYI HN+E+ LG HTY L +NH DMTNEE K L VP S
Sbjct: 41 VDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTNEEVVQKMTGLKVPASHS 100
Query: 187 KISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSATGSLEGQHFRKTGNLT 366
+ + P G+ PD+VD+R +GYVTPVKNQ QCGSCW+FS+ G+LEGQ +KTG L
Sbjct: 101 RSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLL 160
Query: 367 SFSEQQLVDXXXXXXXXXXXXXLMDNAFEYIEK-FGIESEDAYPYTAED 510
+ S Q LVD M NAF+Y++K GI+SEDAYPY ++
Sbjct: 161 NLSPQNLVD--CVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQE 207
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 171 bits (433), Expect = 9e-43
Identities = 84/172 (48%), Positives = 111/172 (64%), Gaps = 1/172 (0%)
Frame = +1
Query: 1 KYESLNEISRRLIWESNLKYIQKHNIESDLGKHTYTLGLNHFADMTNEEFRAKYLSVPPS 180
+Y ++ RR IWE N+K+IQ+HN+ DLG TYTLGLN F DMT EEF+AKYL+
Sbjct: 31 EYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEFKAKYLTEMSR 90
Query: 181 RKKI-STVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSATGSLEGQHFRKTG 357
I S N +PD +DWR GYVT VK+Q CGSCW+FS TG++EGQ+ +
Sbjct: 91 ASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGTMEGQYMKNER 150
Query: 358 NLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYIEKFGIESEDAYPYTAEDG 513
SFSEQQLVD LM+NA++Y+++FG+E+E +YPYTA +G
Sbjct: 151 TSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYTAVEG 202
>sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (Cathepsin X) (Cathepsin O2)
Length = 329
Score = 170 bits (431), Expect = 2e-42
Identities = 88/169 (52%), Positives = 112/169 (66%), Gaps = 3/169 (1%)
Frame = +1
Query: 13 LNEISRRLIWESNLKYIQKHNIESDLGKHTYTLGLNHFADMTNEEFRAKY--LSVPPSRK 186
++EISRRLIWE NLKYI HN+E+ LG HTY L +NH DMT+EE K L VP S
Sbjct: 41 VDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHS 100
Query: 187 KISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSATGSLEGQHFRKTGNLT 366
+ + P+ G+ PD+VD+R +GYVTPVKNQ QCGSCW+FS+ G+LEGQ +KTG L
Sbjct: 101 RSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLL 160
Query: 367 SFSEQQLVDXXXXXXXXXXXXXLMDNAFEYIEK-FGIESEDAYPYTAED 510
+ S Q LVD M NAF+Y++K GI+SEDAYPY ++
Sbjct: 161 NLSPQNLVD--CVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQE 207
>sp|P55097|CATK_MOUSE Cathepsin K precursor
Length = 329
Score = 170 bits (430), Expect = 2e-42
Identities = 86/169 (50%), Positives = 112/169 (66%), Gaps = 3/169 (1%)
Frame = +1
Query: 13 LNEISRRLIWESNLKYIQKHNIESDLGKHTYTLGLNHFADMTNEEFRAKY--LSVPPSRK 186
++EISRRLIWE NLK I HN+E+ LG HTY L +NH DMT+EE K L +PPSR
Sbjct: 41 VDEISRRLIWEKNLKQISAHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLRIPPSRS 100
Query: 187 KISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSATGSLEGQHFRKTGNLT 366
+ P+ G++PD++D+R +GYVTPVKNQ QCGSCW+FS+ G+LEGQ +KTG L
Sbjct: 101 YSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLL 160
Query: 367 SFSEQQLVDXXXXXXXXXXXXXLMDNAFEYIEK-FGIESEDAYPYTAED 510
+ S Q LVD M AF+Y+++ GI+SEDAYPY +D
Sbjct: 161 ALSPQNLVD--CVTENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQD 207
>sp|O35186|CATK_RAT Cathepsin K precursor
Length = 329
Score = 169 bits (429), Expect = 3e-42
Identities = 87/169 (51%), Positives = 112/169 (66%), Gaps = 3/169 (1%)
Frame = +1
Query: 13 LNEISRRLIWESNLKYIQKHNIESDLGKHTYTLGLNHFADMTNEEFRAKY--LSVPPSRK 186
++EISRRLIWE NLK I HN+E+ LG HTY L +NH DMT+EE K L VPPSR
Sbjct: 41 VDEISRRLIWEKNLKKISVHNLEASLGAHTYELAMNHLGDMTSEEVVQKMTGLRVPPSRS 100
Query: 187 KISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSATGSLEGQHFRKTGNLT 366
+ P+ G++PD++D+R +GYVTPVKNQ QCGSCW+FS+ G+LEGQ +KTG L
Sbjct: 101 FSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLL 160
Query: 367 SFSEQQLVDXXXXXXXXXXXXXLMDNAFEYIEK-FGIESEDAYPYTAED 510
+ S Q LVD M AF+Y+++ GI+SEDAYPY +D
Sbjct: 161 ALSPQNLVD--CVSENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQD 207
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 168 bits (426), Expect = 6e-42
Identities = 83/162 (51%), Positives = 103/162 (63%), Gaps = 1/162 (0%)
Frame = +1
Query: 28 RRLIWESNLKYIQKHNIESDLGKHTYTLGLNHFADMTNEEFRAKYLSVPPSRKKISTVFM 207
RR +WE N+K I+ HN E GKH +T+ +N F DMTNEEFR + K +F
Sbjct: 48 RRAVWEKNMKMIELHNREYSQGKHGFTMAMNAFGDMTNEEFRQVMNGFQNQKHKKGKMFQ 107
Query: 208 APKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSATGSLEGQHFRKTGNLTSFSEQQL 387
P ++P +VDWR +GYVTPVKNQ QCGSCW+FSATG+LEGQ FRKTG L S SEQ L
Sbjct: 108 EPL-FAEIPKSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNL 166
Query: 388 VDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPYTAED 510
VD LMDNAF Y+ + G++SE++YPY D
Sbjct: 167 VDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRD 208
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 163 bits (413), Expect = 2e-40
Identities = 85/170 (50%), Positives = 106/170 (62%), Gaps = 1/170 (0%)
Frame = +1
Query: 4 YESLNEISRRLIWESNLKYIQKHNIESDLGKHTYTLGLNHFADMTNEEFRAKYLSVPPSR 183
Y + E RR +WE N+K I+ HN E GKH +T+ +N F DMTNEEFR +
Sbjct: 40 YGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQK 99
Query: 184 KKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSATGSLEGQHFRKTGNL 363
+ VF P + LP +VDWR +GYVTPVKNQ+QCGSCW+FSATG+LEGQ FRKTG L
Sbjct: 100 FRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKL 158
Query: 364 TSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPYTAED 510
S SEQ LVD M AF+Y+ E G++SE++YPY A D
Sbjct: 159 VSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVD 208
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 163 bits (412), Expect = 3e-40
Identities = 87/171 (50%), Positives = 107/171 (62%), Gaps = 1/171 (0%)
Frame = +1
Query: 4 YESLNEISRRLIWESNLKYIQKHNIESDLGKHTYTLGLNHFADMTNEEFRAKYLSVPPSR 183
Y + E RR +WE N++ IQ HN E GKH +T+ +N F DMTNEEFR +
Sbjct: 40 YGTNEEEWRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTNEEFRQIVNGYRHQK 99
Query: 184 KKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSCWSFSATGSLEGQHFRKTGNL 363
K +F P M ++P TVDWR +G VTPVKNQ QCGSCW+FSA+G LEGQ F KTG L
Sbjct: 100 HKKGRLFQEPL-MLQIPKTVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKL 158
Query: 364 TSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIESEDAYPYTAEDG 513
S SEQ LVD LMD AF+YI E G++SE++YPY A+DG
Sbjct: 159 ISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDG 209
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.314 0.131 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,680,220
Number of Sequences: 369166
Number of extensions: 1113192
Number of successful extensions: 2652
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2406
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2458
length of database: 68,354,980
effective HSP length: 103
effective length of database: 49,327,275
effective search space used: 3304927425
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)