Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_014_B11
(452 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEP... 115 6e-26
sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin... 112 3e-25
sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proep... 110 1e-24
sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEP... 109 2e-24
sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 ... 64 2e-10
sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1 59 4e-09
sp|P81013|GRN1_CYPCA Granulin-1 54 2e-07
sp|P81014|GRN2_CYPCA Granulin-2 50 2e-06
sp|P81015|GRN3_CYPCA Granulin-3 48 1e-05
sp|P25777|ORYB_ORYSA Oryzain beta chain precursor 43 4e-04
>sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Granulin-1; Granulin-2; Granulin-3; Granulin-4;
Granulin-5; Granulin-6; Granulin-7]
Length = 591
Score = 115 bits (287), Expect = 6e-26
Identities = 53/146 (36%), Positives = 74/146 (50%)
Frame = +3
Query: 6 ICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNE 185
IC + ++ C D TCC SG + CC NA+CC D LHCCP+ T CDL RC+ Q+
Sbjct: 207 ICPDSRSQCPDDTTCCLLASGEYGCCPMPNAICCSDHLHCCPQDTVCDLRQSRCLSQNK- 265
Query: 186 PIEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHY 365
+ + P +TV + ++ + +CP+G QTCC + +G +
Sbjct: 266 ---------AKTLLTKLPSWTV-------WDVECDQEVSCPEG------QTCCRLQSGKW 303
Query: 366 GCCPFSLRVCCPDLRTCCAPRYHCVT 443
GCCPF VCC D CC R+ C T
Sbjct: 304 GCCPFPKAVCCEDHVHCCPERFRCHT 329
Score = 98.2 bits (243), Expect = 7e-21
Identities = 52/143 (36%), Positives = 69/143 (48%), Gaps = 6/143 (4%)
Frame = +3
Query: 9 CQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQ-SNE 185
C G+ C D TCC G CC A CC D++HCCP G +CDLV+ RC+ +
Sbjct: 112 CPGGEFECPDSSTCCHMLDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHIRCVTALGSH 171
Query: 186 PI--EWPVVETIDSAKIETPKYT--VERSTLREFMIKIGDKNNCPDG-GQCAGLQTCCLM 350
P+ + P T + TP + + + L +I CPD QC TCCL+
Sbjct: 172 PLTTKLPAQRTNYTGAEGTPVVSPGLLPAALPTSVI-------CPDSRSQCPDDTTCCLL 224
Query: 351 YTGHYGCCPFSLRVCCPDLRTCC 419
+G YGCCP +CC D CC
Sbjct: 225 ASGEYGCCPMPNAICCSDHLHCC 247
Score = 96.7 bits (239), Expect = 2e-20
Identities = 51/142 (35%), Positives = 65/142 (45%)
Frame = +3
Query: 24 ALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPV 203
A C ++TCC GG CCQ +AVCC D HCCP G TC++ + C
Sbjct: 445 ASCPVRQTCCPKLGGGWACCQLPHAVCCEDGQHCCPAGYTCNVKARSC------------ 492
Query: 204 VETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFS 383
+ D A + P ST + GD++ C D QTCC G + CCPF
Sbjct: 493 EKAADGAHLAAP--LAVGSTGGVMDVACGDRHFCHDE------QTCCRDSRGGWACCPFH 544
Query: 384 LRVCCPDLRTCCAPRYHCVTGG 449
VCC D R CC +HC + G
Sbjct: 545 QGVCCKDQRHCCPAGFHCESQG 566
Score = 68.9 bits (167), Expect = 5e-12
Identities = 41/144 (28%), Positives = 54/144 (37%), Gaps = 1/144 (0%)
Frame = +3
Query: 9 CQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEP 188
CQ+ A C +C + +G CC +S A+ CGD HCCP G C CI +
Sbjct: 47 CQS-PANCPIGHSCVLTAAGTAACCPFSQAMACGDGHHCCPYGFHCSTDGGTCIQR---- 101
Query: 189 IEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGG-QCAGLQTCCLMYTGHY 365
P + + + + CP G +C TCC M G +
Sbjct: 102 ---PDIHLLGAVQ-------------------------CPGGEFECPDSSTCCHMLDGSW 133
Query: 366 GCCPFSLRVCCPDLRTCCAPRYHC 437
GCCP CC D CC C
Sbjct: 134 GCCPMPQASCCEDRVHCCPHGASC 157
Score = 66.6 bits (161), Expect = 2e-11
Identities = 23/51 (45%), Positives = 30/51 (58%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSN 182
C D++TCC GG CC + VCC DQ HCCP G C+ RC+H+ +
Sbjct: 524 CHDEQTCCRDSRGGWACCPFHQGVCCKDQRHCCPAGFHCESQGTRCVHKKS 574
Score = 63.5 bits (153), Expect = 2e-10
Identities = 34/123 (27%), Positives = 49/123 (39%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 209
C + +TCC +SG CC + AVCC D +HCCPE C C Q + W
Sbjct: 289 CPEGQTCCRLQSGKWGCCPFPKAVCCEDHVHCCPERFRCHTEKDTC-EQGLLQVPWAQKT 347
Query: 210 TIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLR 389
++ P + + +C + C CC + +G +GCCP S
Sbjct: 348 PAQPSRPSQPSPPGPPGPPSP-PGPLRSEISCDEVVSCRPGNICCRLASGEWGCCPSSEG 406
Query: 390 VCC 398
C
Sbjct: 407 YLC 409
Score = 43.5 bits (101), Expect = 2e-04
Identities = 32/125 (25%), Positives = 49/125 (39%), Gaps = 2/125 (1%)
Frame = +3
Query: 69 GHQCCQYSNAVCCGDQLHCCP--EGTTCDLVNKRCIHQSNEPIEWPVVETIDSAKIETPK 242
G+ CC+ ++ + CCP EG C + +RC V + + K+
Sbjct: 387 GNICCRLASG-----EWGCCPSSEGYLC-MAGERC----------QVGDRLAPEKMAAHL 430
Query: 243 YTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLRVCCPDLRTCCA 422
++ ++T +G C C QTCC G + CC VCC D + CC
Sbjct: 431 MSLSQTT------DVG----CDQHASCPVRQTCCPKLGGGWACCQLPHAVCCEDGQHCCP 480
Query: 423 PRYHC 437
Y C
Sbjct: 481 AGYTC 485
Score = 43.1 bits (100), Expect = 3e-04
Identities = 20/50 (40%), Positives = 23/50 (46%)
Frame = +3
Query: 300 NCPDGGQCAGLQTCCLMYTGHYGCCPFSLRVCCPDLRTCCAPRYHCVTGG 449
NCP G +C L G CCPFS + C D CC +HC T G
Sbjct: 52 NCPIG------HSCVLTAAGTAACCPFSQAMACGDGHHCCPYGFHCSTDG 95
>sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin; Granulin-1 (Granulin G);
Granulin-2 (Granulin F); Granulin-3 (Granulin B)
(Epithelin-2); Granulin-4 (Granulin A) (Epithelin-1);
Granulin-5 (Granulin C); Granulin-6 (Granulin D);
Granulin-7 (Granulin E)]
Length = 588
Score = 112 bits (281), Expect = 3e-25
Identities = 54/151 (35%), Positives = 72/151 (47%), Gaps = 2/151 (1%)
Frame = +3
Query: 6 ICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNE 185
+C + K C D TCC +G + CC NA+CC D LHCCP+ T CDL+ +CI +
Sbjct: 205 VCPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCISK--- 261
Query: 186 PIEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHY 365
+ + P Y V +K + +CPDG TCC + TG +
Sbjct: 262 -------DYTTDLMTKLPGYPVNE-------VKCDLEVSCPDG------YTCCRLNTGAW 301
Query: 366 GCCPFSLRVCCPDLRTCCAPRYHC--VTGGC 452
GCCPF+ VCC D CC + C TG C
Sbjct: 302 GCCPFTKAVCCEDHIHCCPAGFQCHTETGTC 332
Score = 95.9 bits (237), Expect = 4e-20
Identities = 47/137 (34%), Positives = 62/137 (45%)
Frame = +3
Query: 9 CQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEP 188
C + C D TCC G CC A CC D++HCCP G +CDLV+ RCI +
Sbjct: 125 CPGSQFECPDSATCCIMIDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCISPTG-- 182
Query: 189 IEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYG 368
P+++ + P R+ ++ K CPD TCC + TG YG
Sbjct: 183 -THPLLK-------KFPAQRTNRAVASFSVVCPDAKTQCPDD------STCCELPTGKYG 228
Query: 369 CCPFSLRVCCPDLRTCC 419
CCP +CC D CC
Sbjct: 229 CCPMPNAICCSDHLHCC 245
Score = 89.7 bits (221), Expect = 3e-18
Identities = 48/140 (34%), Positives = 62/140 (44%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 209
C +TCC S G CCQ +AVCC D+ HCCP G TC++ + C
Sbjct: 447 CPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTC-------------- 492
Query: 210 TIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLR 389
E +V+ S F K+G+ C G C Q+CC G + CCP+
Sbjct: 493 -------EKDAGSVQPSMDLTFGSKVGNV-ECGAGHFCHDNQSCCKDSQGGWACCPYVKG 544
Query: 390 VCCPDLRTCCAPRYHCVTGG 449
VCC D R CC +HC G
Sbjct: 545 VCCRDGRHCCPIGFHCSAKG 564
Score = 87.4 bits (215), Expect = 1e-17
Identities = 42/140 (30%), Positives = 63/140 (45%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 209
C D TCC +G CC ++ AVCC D +HCCP G C C ++ P ++
Sbjct: 287 CPDGYTCCRLNTGAWGCCPFTKAVCCEDHIHCCPAGFQCHTETGTC---ELGVLQVPWMK 343
Query: 210 TIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLR 389
+ +A + P + ++ + C D C TCC + +G +GCCP
Sbjct: 344 KV-TASLSLPDPQILKNDVP-----------CDDFSSCPSNNTCCRLSSGDWGCCPMPEA 391
Query: 390 VCCPDLRTCCAPRYHCVTGG 449
VCC D + CC + C+ G
Sbjct: 392 VCCLDHQHCCPQGFKCMDEG 411
Score = 75.1 bits (183), Expect = 7e-14
Identities = 43/136 (31%), Positives = 53/136 (38%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 209
C TCC SG CC AVCC D HCCP+G C ++ +
Sbjct: 369 CPSNNTCCRLSSGDWGCCPMPEAVCCLDHQHCCPQGFKC--------------MDEGYCQ 414
Query: 210 TIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLR 389
D K V ++TL ++ GD C C QTCC G + CC
Sbjct: 415 KGDRMVAGLEKMPVRQTTL----LQHGDIG-CDQHTSCPVGQTCCPSLKGSWACCQLPHA 469
Query: 390 VCCPDLRTCCAPRYHC 437
VCC D + CC Y C
Sbjct: 470 VCCEDRQHCCPAGYTC 485
Score = 73.2 bits (178), Expect = 3e-13
Identities = 40/136 (29%), Positives = 50/136 (36%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 209
C D +C + SG CC +S V C D HCCP G C K C S+ +
Sbjct: 67 CPDGYSCLLTVSGTSSCCPFSEGVSCDDGQHCCPRGFHCSADGKSCSQISDSLL------ 120
Query: 210 TIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLR 389
++ P G + CPD TCC+M G +GCCP
Sbjct: 121 ----GAVQCP----------------GSQFECPDSA------TCCIMIDGSWGCCPMPQA 154
Query: 390 VCCPDLRTCCAPRYHC 437
CC D CC C
Sbjct: 155 SCCEDRVHCCPHGASC 170
Score = 57.0 bits (136), Expect = 2e-08
Identities = 20/49 (40%), Positives = 25/49 (51%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQ 176
C D ++CC GG CC Y VCC D HCCP G C +C+ +
Sbjct: 522 CHDNQSCCKDSQGGWACCPYVKGVCCRDGRHCCPIGFHCSAKGTKCLRK 570
Score = 45.4 bits (106), Expect = 6e-05
Identities = 20/52 (38%), Positives = 27/52 (51%)
Frame = +3
Query: 294 KNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLRVCCPDLRTCCAPRYHCVTGG 449
+++CPDG +C L +G CCPFS V C D + CC +HC G
Sbjct: 64 RDHCPDG------YSCLLTVSGTSSCCPFSEGVSCDDGQHCCPRGFHCSADG 109
>sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proepithelin) (PEPI) (PC
cell-derived growth factor) (PCDGF) [Contains: Granulin
1; Granulin 2; Granulin 3; Granulin 4; Granulin 5;
Granulin 6; Granulin 7]
Length = 589
Score = 110 bits (275), Expect = 1e-24
Identities = 52/146 (35%), Positives = 73/146 (50%)
Frame = +3
Query: 6 ICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNE 185
+C + K C D TCC +G + CC NA+CC D LHCCP+ T CDL+ +C+ ++
Sbjct: 206 VCPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCLSKN-- 263
Query: 186 PIEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHY 365
T D + P Y V+ +K + +CP+G TCC + TG +
Sbjct: 264 -------YTTD-LLTKLPGYPVKE-------VKCDMEVSCPEG------YTCCRLNTGAW 302
Query: 366 GCCPFSLRVCCPDLRTCCAPRYHCVT 443
GCCPF+ VCC D CC + C T
Sbjct: 303 GCCPFAKAVCCEDHIHCCPAGFQCHT 328
Score = 96.3 bits (238), Expect = 3e-20
Identities = 47/138 (34%), Positives = 60/138 (43%), Gaps = 1/138 (0%)
Frame = +3
Query: 9 CQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEP 188
C + C D TCC G CC A CC D++HCCP G +CDLV+ RC+ +
Sbjct: 125 CPGSQFECPDSATCCIMVDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCVSPTG-- 182
Query: 189 IEWPVVETIDSAKIETPKYTVERSTLREFMIKIGD-KNNCPDGGQCAGLQTCCLMYTGHY 365
+ + P R+ F + D K CPD TCC + TG Y
Sbjct: 183 --------THTLLKKFPAQKTNRAVSLPFSVVCPDAKTQCPDD------STCCELPTGKY 228
Query: 366 GCCPFSLRVCCPDLRTCC 419
GCCP +CC D CC
Sbjct: 229 GCCPMPNAICCSDHLHCC 246
Score = 93.2 bits (230), Expect = 2e-19
Identities = 49/140 (35%), Positives = 66/140 (47%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 209
C +TCC S G CCQ +AVCC D+ HCCP G TC++ + C + + I+ PV+
Sbjct: 448 CPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTC-EKDVDFIQPPVLL 506
Query: 210 TIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLR 389
T+ K+G+ C +G C QTCC G + CCP+
Sbjct: 507 TLGP--------------------KVGNV-ECGEGHFCHDNQTCCKDSAGVWACCPYLKG 545
Query: 390 VCCPDLRTCCAPRYHCVTGG 449
VCC D R CC +HC G
Sbjct: 546 VCCRDGRHCCPGGFHCSARG 565
Score = 88.2 bits (217), Expect = 8e-18
Identities = 42/140 (30%), Positives = 60/140 (42%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 209
C + TCC +G CC ++ AVCC D +HCCP G C H E +++
Sbjct: 288 CPEGYTCCRLNTGAWGCCPFAKAVCCEDHIHCCPAGFQC--------HTEKGTCEMGILQ 339
Query: 210 TIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLR 389
K+ P + L+ C D +C TCC + +G +GCCP
Sbjct: 340 VPWMKKVIAPLRLPDPQILK-------SDTPCDDFTRCPTNNTCCKLNSGDWGCCPIPEA 392
Query: 390 VCCPDLRTCCAPRYHCVTGG 449
VCC D + CC + C+ G
Sbjct: 393 VCCSDNQHCCPQGFTCLAQG 412
Score = 79.7 bits (195), Expect = 3e-15
Identities = 41/136 (30%), Positives = 52/136 (38%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 209
C +C + SG CC +S V CGD HCCP+G C K C S+ P+
Sbjct: 67 CPAGYSCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADGKSCFQMSDNPL------ 120
Query: 210 TIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLR 389
++ P G + CPD TCC+M G +GCCP
Sbjct: 121 ----GAVQCP----------------GSQFECPDSA------TCCIMVDGSWGCCPMPQA 154
Query: 390 VCCPDLRTCCAPRYHC 437
CC D CC C
Sbjct: 155 SCCEDRVHCCPHGASC 170
Score = 79.3 bits (194), Expect = 4e-15
Identities = 46/137 (33%), Positives = 55/137 (40%), Gaps = 1/137 (0%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 209
C TCC SG CC AVCC D HCCP+G TC L C
Sbjct: 370 CPTNNTCCKLNSGDWGCCPIPEAVCCSDNQHCCPQGFTC-LAQGYC-------------- 414
Query: 210 TIDSAKIETPKYTVERSTLREFM-IKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSL 386
K +T +E+ R+ ++IGD C C QTCC G + CC
Sbjct: 415 ----QKGDTMVAGLEKIPARQTTPLQIGD-IGCDQHTSCPVGQTCCPSLKGSWACCQLPH 469
Query: 387 RVCCPDLRTCCAPRYHC 437
VCC D + CC Y C
Sbjct: 470 AVCCEDRQHCCPAGYTC 486
Score = 55.5 bits (132), Expect = 5e-08
Identities = 20/49 (40%), Positives = 25/49 (51%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQ 176
C D +TCC +G CC Y VCC D HCCP G C +C+ +
Sbjct: 523 CHDNQTCCKDSAGVWACCPYLKGVCCRDGRHCCPGGFHCSARGTKCLRK 571
Score = 45.1 bits (105), Expect = 7e-05
Identities = 19/50 (38%), Positives = 23/50 (46%)
Frame = +3
Query: 300 NCPDGGQCAGLQTCCLMYTGHYGCCPFSLRVCCPDLRTCCAPRYHCVTGG 449
+C G C +C L +G CCPFS V C D CC +HC G
Sbjct: 60 SCQTHGHCPAGYSCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADG 109
>sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Paragranulin; Granulin-1 (Granulin G); Granulin-2
(Granulin F); Granulin-3 (Granulin B); Granulin-4
(Granulin A); Granulin-5 (Granulin C); Granulin-6
(Granulin D); Granulin-7 (Granulin E)]
Length = 593
Score = 109 bits (273), Expect = 2e-24
Identities = 51/146 (34%), Positives = 72/146 (49%)
Frame = +3
Query: 6 ICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNE 185
+C + ++ C D TCC SG + CC NA CC D LHCCP+ T CDL+ +C+ + N
Sbjct: 207 MCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENA 266
Query: 186 PIEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHY 365
+ + P +TV +K + +CPDG TCC + +G +
Sbjct: 267 TTD---------LLTKLPAHTVGD-------VKCDMEVSCPDG------YTCCRLQSGAW 304
Query: 366 GCCPFSLRVCCPDLRTCCAPRYHCVT 443
GCCPF+ VCC D CC + C T
Sbjct: 305 GCCPFTQAVCCEDHIHCCPAGFTCDT 330
Score = 96.7 bits (239), Expect = 2e-20
Identities = 47/140 (33%), Positives = 61/140 (43%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 209
C D TCC +SG CC ++ AVCC D +HCCP G TCD C P + P +E
Sbjct: 290 CPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTC---EQGPHQVPWME 346
Query: 210 TIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLR 389
+ ++R C + C TCC + +G +GCCP
Sbjct: 347 KAPAHLSLPDPQALKRDV------------PCDNVSSCPSSDTCCQLTSGEWGCCPIPEA 394
Query: 390 VCCPDLRTCCAPRYHCVTGG 449
VCC D + CC Y CV G
Sbjct: 395 VCCSDHQHCCPQGYTCVAEG 414
Score = 94.4 bits (233), Expect = 1e-19
Identities = 49/138 (35%), Positives = 62/138 (44%), Gaps = 1/138 (0%)
Frame = +3
Query: 9 CQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEP 188
C + + C D TCC G CC A CC D++HCCP G CDLV+ RCI +
Sbjct: 126 CPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTG-- 183
Query: 189 IEWPVVETIDSAKIETPKYTVERSTLREFMIKIGD-KNNCPDGGQCAGLQTCCLMYTGHY 365
T AK + P R+ + D ++ CPDG TCC + +G Y
Sbjct: 184 -------THPLAK-KLPAQRTNRAVALSSSVMCPDARSRCPDG------STCCELPSGKY 229
Query: 366 GCCPFSLRVCCPDLRTCC 419
GCCP CC D CC
Sbjct: 230 GCCPMPNATCCSDHLHCC 247
Score = 87.4 bits (215), Expect = 1e-17
Identities = 45/141 (31%), Positives = 60/141 (42%), Gaps = 1/141 (0%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 209
C +TCC S G CCQ +AVCC D+ HCCP G TC++ + C
Sbjct: 450 CPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSC-------------- 495
Query: 210 TIDSAKIETPKYTVERSTLREFMIKIGDKN-NCPDGGQCAGLQTCCLMYTGHYGCCPFSL 386
E + + +T +G K+ C +G C QTCC + CCP+
Sbjct: 496 -------EKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQ 548
Query: 387 RVCCPDLRTCCAPRYHCVTGG 449
VCC D R CC + C G
Sbjct: 549 GVCCADRRHCCPAGFRCAARG 569
Score = 77.0 bits (188), Expect = 2e-14
Identities = 47/143 (32%), Positives = 57/143 (39%)
Frame = +3
Query: 9 CQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEP 188
C N + C TCC SG CC AVCC D HCCP+G TC + +C S
Sbjct: 366 CDNVSS-CPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTC-VAEGQCQRGSE-- 421
Query: 189 IEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYG 368
I + + P S R+ I +CP G QTCC G +
Sbjct: 422 --------IVAGLEKMPARRASLSHPRD--IGCDQHTSCPVG------QTCCPSLGGSWA 465
Query: 369 CCPFSLRVCCPDLRTCCAPRYHC 437
CC VCC D + CC Y C
Sbjct: 466 CCQLPHAVCCEDRQHCCPAGYTC 488
Score = 73.2 bits (178), Expect = 3e-13
Identities = 39/139 (28%), Positives = 48/139 (34%), Gaps = 1/139 (0%)
Frame = +3
Query: 24 ALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPV 203
A C +C + SG CC + AV CGD HCCP G C + C +S +
Sbjct: 65 AHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAI 124
Query: 204 VETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGG-QCAGLQTCCLMYTGHYGCCPF 380
CPD +C TCC+M G +GCCP
Sbjct: 125 --------------------------------QCPDSQFECPDFSTCCVMVDGSWGCCPM 152
Query: 381 SLRVCCPDLRTCCAPRYHC 437
CC D CC C
Sbjct: 153 PQASCCEDRVHCCPHGAFC 171
Score = 57.4 bits (137), Expect = 1e-08
Identities = 20/49 (40%), Positives = 25/49 (51%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQ 176
C D +TCC G CC Y VCC D+ HCCP G C +C+ +
Sbjct: 527 CHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRR 575
Score = 40.4 bits (93), Expect = 0.002
Identities = 16/49 (32%), Positives = 20/49 (40%)
Frame = +3
Query: 303 CPDGGQCAGLQTCCLMYTGHYGCCPFSLRVCCPDLRTCCAPRYHCVTGG 449
C C+ +C +G CCPF V C D CC +HC G
Sbjct: 61 CQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADG 109
>sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 (PMP-D1)
Length = 54
Score = 63.5 bits (153), Expect = 2e-10
Identities = 23/47 (48%), Positives = 28/47 (59%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 170
C +TCC + G CC Y VCC D +HCCP GT CD ++RCI
Sbjct: 7 CPGTETCCTTPQGEEGCCPYKEGVCCLDGIHCCPSGTVCDEDHRRCI 53
Score = 42.7 bits (99), Expect = 4e-04
Identities = 16/33 (48%), Positives = 18/33 (54%)
Frame = +3
Query: 321 CAGLQTCCLMYTGHYGCCPFSLRVCCPDLRTCC 419
C G +TCC G GCCP+ VCC D CC
Sbjct: 7 CPGTETCCTTPQGEEGCCPYKEGVCCLDGIHCC 39
>sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1
Length = 46
Score = 59.3 bits (142), Expect = 4e-09
Identities = 21/36 (58%), Positives = 23/36 (63%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEG 137
C D +TCC + GG CC YS VCC DQ HCCP G
Sbjct: 10 CHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVG 45
Score = 48.5 bits (114), Expect = 7e-06
Identities = 19/39 (48%), Positives = 21/39 (53%)
Frame = +3
Query: 303 CPDGGQCAGLQTCCLMYTGHYGCCPFSLRVCCPDLRTCC 419
C +G C QTCC G CCP+S VCC D R CC
Sbjct: 4 CGEGHFCHDXQTCCRASQGGXACCPYSQGVCCADQRHCC 42
>sp|P81013|GRN1_CYPCA Granulin-1
Length = 57
Score = 53.5 bits (127), Expect = 2e-07
Identities = 20/48 (41%), Positives = 25/48 (52%)
Frame = +3
Query: 27 LCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 170
+C D TCC S G CC +S CC D +HCC G CD + C+
Sbjct: 9 ICPDGTTCCLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHCDSTSTHCL 56
Score = 49.3 bits (116), Expect = 4e-06
Identities = 22/45 (48%), Positives = 24/45 (53%)
Frame = +3
Query: 303 CPDGGQCAGLQTCCLMYTGHYGCCPFSLRVCCPDLRTCCAPRYHC 437
CPDG TCCL G + CCPFS+ CC D CC YHC
Sbjct: 10 CPDG------TTCCLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHC 48
>sp|P81014|GRN2_CYPCA Granulin-2
Length = 57
Score = 50.1 bits (118), Expect = 2e-06
Identities = 19/52 (36%), Positives = 24/52 (46%)
Frame = +3
Query: 15 NGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 170
N + C + TCC S G CC + CC D HCC G CD + C+
Sbjct: 5 NARTTCPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRCDSTSTLCL 56
Score = 42.7 bits (99), Expect = 4e-04
Identities = 17/39 (43%), Positives = 19/39 (48%)
Frame = +3
Query: 321 CAGLQTCCLMYTGHYGCCPFSLRVCCPDLRTCCAPRYHC 437
C TCC G + CCPF + CC D R CC Y C
Sbjct: 10 CPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRC 48
>sp|P81015|GRN3_CYPCA Granulin-3
Length = 57
Score = 47.8 bits (112), Expect = 1e-05
Identities = 20/45 (44%), Positives = 22/45 (48%)
Frame = +3
Query: 303 CPDGGQCAGLQTCCLMYTGHYGCCPFSLRVCCPDLRTCCAPRYHC 437
C G C TCC G + CCPF + CC D R CC YHC
Sbjct: 4 CDAGITCPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHC 48
Score = 45.8 bits (107), Expect = 4e-05
Identities = 18/47 (38%), Positives = 21/47 (44%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 170
C TCC S G CC + CC D HCC G CD + C+
Sbjct: 10 CPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHCDSTSTLCL 56
>sp|P25777|ORYB_ORYSA Oryzain beta chain precursor
Length = 471
Score = 42.7 bits (99), Expect = 4e-04
Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 3/50 (6%)
Frame = +3
Query: 291 DKNNCPDGGQCA---GLQTCCLMYTGHYGCCPFSLRVCCPDLRTCCAPRY 431
D +CP G C G + CL++ GCCP CC D +CC P Y
Sbjct: 387 DNFSCPAGSTCCCAFGFRNLCLVW----GCCPVEGATCCKDHASCCPPDY 432
Score = 33.1 bits (74), Expect = 0.29
Identities = 17/60 (28%), Positives = 22/60 (36%), Gaps = 6/60 (10%)
Frame = +3
Query: 30 CGDQKTCCASKSGGHQC-----CQYSNAVCCGDQLHCC-PEGTTCDLVNKRCIHQSNEPI 191
C TCC + + C C A CC D CC P+ C+ C N P+
Sbjct: 391 CPAGSTCCCAFGFRNLCLVWGCCPVEGATCCKDHASCCPPDYPVCNTRAGTCSASKNSPL 450
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,644,264
Number of Sequences: 369166
Number of extensions: 1196078
Number of successful extensions: 4571
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3876
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4452
length of database: 68,354,980
effective HSP length: 101
effective length of database: 49,696,745
effective search space used: 2435140505
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)