Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_014_B01
(745 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8MI68|MUTA_PIG Methylmalonyl-CoA mutase, mitochondrial ... 399 e-111
sp|P22033|MUTA_HUMAN Methylmalonyl-CoA mutase, mitochondria... 392 e-109
sp|Q8HXX1|MUTA_MACFA Methylmalonyl-CoA mutase, mitochondria... 391 e-108
sp|P16332|MUTA_MOUSE Methylmalonyl-CoA mutase, mitochondria... 389 e-108
sp|Q23381|MUTA_CAEEL Probable methylmalonyl-CoA mutase, mit... 380 e-105
sp|Q59677|MUTB_PORGI Methylmalonyl-CoA mutase large subunit... 322 5e-88
sp|Q05065|MUTB_STRCM Methylmalonyl-CoA mutase large subunit... 311 1e-84
sp|P11653|MUTB_PROFR Methylmalonyl-CoA mutase large subunit... 311 2e-84
sp|P65487|MUTB_MYCTU Probable methylmalonyl-CoA mutase larg... 309 4e-84
sp|O86028|MUTB_RHIME Methylmalonyl-CoA mutase (MCM) 299 6e-81
>sp|Q8MI68|MUTA_PIG Methylmalonyl-CoA mutase, mitochondrial precursor (MCM)
(Methylmalonyl-CoA isomerase)
Length = 750
Score = 399 bits (1024), Expect = e-111
Identities = 195/246 (79%), Positives = 215/246 (87%)
Frame = +3
Query: 3 PSMKIIGDIFEYTAKHMPKFNSISISGYHMQEAGANAILEMAYTIADGLEYCRTGLKAGL 182
PSMKII DIF+YTAKHMPKFNSISISGYHMQEAGA+AILE+AYTIADGLEYCRTGL+AGL
Sbjct: 237 PSMKIIADIFQYTAKHMPKFNSISISGYHMQEAGADAILELAYTIADGLEYCRTGLQAGL 296
Query: 183 HIDEFAPRLSFFWGVGMNFYMEIAKMRAARRVWAELLKSKFNSKDKKSLLLRAHSQTSGW 362
IDEFAPRLSFFWG+GMNFYMEIAKMRA RR+WA L++ F K+ KSLLLRAH QTSGW
Sbjct: 297 TIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFRRKNSKSLLLRAHCQTSGW 356
Query: 363 SLTEQDPYNNIMRTTIEAMAAVFGGTQSLHTNAFDEALGLPTKFSARIARNXXXXXXXXX 542
SLTEQDPYNNI+RTT+EAMAAVFGGTQSLHTN+FDEALGLPT SARIARN
Sbjct: 357 SLTEQDPYNNIIRTTVEAMAAVFGGTQSLHTNSFDEALGLPTVKSARIARNTQIIIQEES 416
Query: 543 XXXKVADPWAGSFMMESLTQEIYSEAIKVIEEIEAMGGMAKAVSEGIPKLKIEECAAKRQ 722
KVADPW GS+MMESLT ++Y A+K+I EIE MGGMAKAV+EGIPKL+IEECAA+RQ
Sbjct: 417 GIPKVADPWGGSYMMESLTNDVYDAALKLINEIEEMGGMAKAVAEGIPKLRIEECAARRQ 476
Query: 723 AHIDSG 740
A IDSG
Sbjct: 477 ARIDSG 482
>sp|P22033|MUTA_HUMAN Methylmalonyl-CoA mutase, mitochondrial precursor (MCM)
(Methylmalonyl-CoA isomerase)
Length = 750
Score = 392 bits (1006), Expect = e-109
Identities = 193/246 (78%), Positives = 212/246 (86%)
Frame = +3
Query: 3 PSMKIIGDIFEYTAKHMPKFNSISISGYHMQEAGANAILEMAYTIADGLEYCRTGLKAGL 182
PSMKII DIFEYTAKHMPKFNSISISGYHMQEAGA+AILE+AYT+ADGLEY RTGL+AGL
Sbjct: 237 PSMKIIADIFEYTAKHMPKFNSISISGYHMQEAGADAILELAYTLADGLEYSRTGLQAGL 296
Query: 183 HIDEFAPRLSFFWGVGMNFYMEIAKMRAARRVWAELLKSKFNSKDKKSLLLRAHSQTSGW 362
IDEFAPRLSFFWG+GMNFYMEIAKMRA RR+WA L++ F K+ KSLLLRAH QTSGW
Sbjct: 297 TIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFQPKNSKSLLLRAHCQTSGW 356
Query: 363 SLTEQDPYNNIMRTTIEAMAAVFGGTQSLHTNAFDEALGLPTKFSARIARNXXXXXXXXX 542
SLTEQDPYNNI+RT IEAMAAVFGGTQSLHTN+FDEALGLPT SARIARN
Sbjct: 357 SLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGLPTVKSARIARNTQIIIQEES 416
Query: 543 XXXKVADPWAGSFMMESLTQEIYSEAIKVIEEIEAMGGMAKAVSEGIPKLKIEECAAKRQ 722
KVADPW GS+MME LT ++Y A+K+I EIE MGGMAKAV+EGIPKL+IEECAA+RQ
Sbjct: 417 GIPKVADPWGGSYMMECLTNDVYDAALKLINEIEEMGGMAKAVAEGIPKLRIEECAARRQ 476
Query: 723 AHIDSG 740
A IDSG
Sbjct: 477 ARIDSG 482
>sp|Q8HXX1|MUTA_MACFA Methylmalonyl-CoA mutase, mitochondrial precursor (MCM)
(Methylmalonyl-CoA isomerase)
Length = 750
Score = 391 bits (1004), Expect = e-108
Identities = 192/246 (78%), Positives = 212/246 (86%)
Frame = +3
Query: 3 PSMKIIGDIFEYTAKHMPKFNSISISGYHMQEAGANAILEMAYTIADGLEYCRTGLKAGL 182
PSMKII DIF+YT+KHMPKFNSISISGYHMQEAGA+AILE+AYT+ADGLEY RTGL+AGL
Sbjct: 237 PSMKIIADIFQYTSKHMPKFNSISISGYHMQEAGADAILELAYTLADGLEYSRTGLQAGL 296
Query: 183 HIDEFAPRLSFFWGVGMNFYMEIAKMRAARRVWAELLKSKFNSKDKKSLLLRAHSQTSGW 362
IDEFAPRLSFFWG+GMNFYMEIAKMRA RR+WA L++ F K KSLLLRAH QTSGW
Sbjct: 297 TIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFQPKSSKSLLLRAHCQTSGW 356
Query: 363 SLTEQDPYNNIMRTTIEAMAAVFGGTQSLHTNAFDEALGLPTKFSARIARNXXXXXXXXX 542
SLTEQDPYNNI+RT IEAMAAVFGGTQSLHTN+FDEALGLPT SARIARN
Sbjct: 357 SLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGLPTVKSARIARNTQIIIQEES 416
Query: 543 XXXKVADPWAGSFMMESLTQEIYSEAIKVIEEIEAMGGMAKAVSEGIPKLKIEECAAKRQ 722
KVADPW GS+MMESLT ++Y A+K+I EIE MGGMAKAV+EGIPKL+IEECAA+RQ
Sbjct: 417 GIPKVADPWGGSYMMESLTNDVYDAALKLINEIEEMGGMAKAVAEGIPKLRIEECAARRQ 476
Query: 723 AHIDSG 740
A IDSG
Sbjct: 477 ARIDSG 482
>sp|P16332|MUTA_MOUSE Methylmalonyl-CoA mutase, mitochondrial precursor (MCM)
(Methylmalonyl-CoA isomerase)
Length = 748
Score = 389 bits (1000), Expect = e-108
Identities = 190/246 (77%), Positives = 212/246 (86%)
Frame = +3
Query: 3 PSMKIIGDIFEYTAKHMPKFNSISISGYHMQEAGANAILEMAYTIADGLEYCRTGLKAGL 182
PSMKII DIF+YTA+HMPKFN ISISGYHMQEAG +AILE+AYTIADGLEYCRTGL+AGL
Sbjct: 235 PSMKIIADIFQYTAQHMPKFNPISISGYHMQEAGTDAILELAYTIADGLEYCRTGLQAGL 294
Query: 183 HIDEFAPRLSFFWGVGMNFYMEIAKMRAARRVWAELLKSKFNSKDKKSLLLRAHSQTSGW 362
IDEFAPRLSFFWG+GMNFYMEIAKMRA RR+WA L++ F K+ KSLLLRAH QTSGW
Sbjct: 295 TIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFQPKNSKSLLLRAHCQTSGW 354
Query: 363 SLTEQDPYNNIMRTTIEAMAAVFGGTQSLHTNAFDEALGLPTKFSARIARNXXXXXXXXX 542
SLTEQDPYNNI+RT IEAMAAVFGGTQSLH+N+FDEALGLPT SARIARN
Sbjct: 355 SLTEQDPYNNIVRTAIEAMAAVFGGTQSLHSNSFDEALGLPTVKSARIARNTRIIIQEES 414
Query: 543 XXXKVADPWAGSFMMESLTQEIYSEAIKVIEEIEAMGGMAKAVSEGIPKLKIEECAAKRQ 722
KVADPW GS+MMESLT ++Y A+K+I E+E MGGMAKAV+EGIPKL+IEECAA+RQ
Sbjct: 415 GIPKVADPWGGSYMMESLTNDVYEAALKLIYEVEEMGGMAKAVAEGIPKLRIEECAARRQ 474
Query: 723 AHIDSG 740
A IDSG
Sbjct: 475 ARIDSG 480
>sp|Q23381|MUTA_CAEEL Probable methylmalonyl-CoA mutase, mitochondrial precursor (MCM)
Length = 744
Score = 380 bits (975), Expect = e-105
Identities = 183/247 (74%), Positives = 212/247 (85%)
Frame = +3
Query: 3 PSMKIIGDIFEYTAKHMPKFNSISISGYHMQEAGANAILEMAYTIADGLEYCRTGLKAGL 182
PSM+IIGDIF YT++ MPKFNSISISGYHMQEAGA+A+LEMA+TIADG++YC TGL AGL
Sbjct: 229 PSMRIIGDIFAYTSREMPKFNSISISGYHMQEAGADAVLEMAFTIADGIQYCETGLNAGL 288
Query: 183 HIDEFAPRLSFFWGVGMNFYMEIAKMRAARRVWAELLKSKFNSKDKKSLLLRAHSQTSGW 362
ID FAPRLSFFWG+ MNFYMEIAKMRAARR+WA L+K +F+ K KS++LR HSQTSGW
Sbjct: 289 TIDAFAPRLSFFWGISMNFYMEIAKMRAARRLWANLIKERFSPKSDKSMMLRTHSQTSGW 348
Query: 363 SLTEQDPYNNIMRTTIEAMAAVFGGTQSLHTNAFDEALGLPTKFSARIARNXXXXXXXXX 542
SLTEQDPYNNI+RTTIEAMA+VFGGTQSLHTN+FDEALGLPTKFSARIARN
Sbjct: 349 SLTEQDPYNNIIRTTIEAMASVFGGTQSLHTNSFDEALGLPTKFSARIARNTQIIIQEES 408
Query: 543 XXXKVADPWAGSFMMESLTQEIYSEAIKVIEEIEAMGGMAKAVSEGIPKLKIEECAAKRQ 722
VADPW GS+MMESLT EIY +A+ VI+EI+ +GGMAKAV+ G+ KLKIEE AAK+Q
Sbjct: 409 GICNVADPWGGSYMMESLTDEIYEKALAVIKEIDELGGMAKAVASGMTKLKIEEAAAKKQ 468
Query: 723 AHIDSGQ 743
A ID+G+
Sbjct: 469 ARIDAGK 475
>sp|Q59677|MUTB_PORGI Methylmalonyl-CoA mutase large subunit (MCM-alpha)
Length = 715
Score = 322 bits (826), Expect = 5e-88
Identities = 158/246 (64%), Positives = 194/246 (78%)
Frame = +3
Query: 6 SMKIIGDIFEYTAKHMPKFNSISISGYHMQEAGANAILEMAYTIADGLEYCRTGLKAGLH 185
SM+II DIFEYT+++MPKFNSISISGYHMQEAGA A +EMAYT+ADG++Y + G+ AG+
Sbjct: 212 SMRIIADIFEYTSQNMPKFNSISISGYHMQEAGATADIEMAYTLADGMQYLKAGIDAGID 271
Query: 186 IDEFAPRLSFFWGVGMNFYMEIAKMRAARRVWAELLKSKFNSKDKKSLLLRAHSQTSGWS 365
+D FAPRLSFFW +G+N +MEIAKMRAAR +WA+++KS F +K+ KSL LR HSQTSGWS
Sbjct: 272 VDAFAPRLSFFWAIGVNHFMEIAKMRAARLLWAKIVKS-FGAKNPKSLALRTHSQTSGWS 330
Query: 366 LTEQDPYNNIMRTTIEAMAAVFGGTQSLHTNAFDEALGLPTKFSARIARNXXXXXXXXXX 545
LTEQDP+NN+ RT IEAMAA G TQSLHTNA DEA+ LPT FSARIARN
Sbjct: 331 LTEQDPFNNVGRTCIEAMAAALGHTQSLHTNALDEAIALPTDFSARIARNTQIYIQEETL 390
Query: 546 XXKVADPWAGSFMMESLTQEIYSEAIKVIEEIEAMGGMAKAVSEGIPKLKIEECAAKRQA 725
K DPW GS+ +ESLT E+ +A +I+E++ MGGMAKA+ G+PKL+IEE AA+ QA
Sbjct: 391 VCKEIDPWGGSYYVESLTNELVHKAWTLIKEVQEMGGMAKAIETGLPKLRIEEAAARTQA 450
Query: 726 HIDSGQ 743
IDS Q
Sbjct: 451 RIDSHQ 456
>sp|Q05065|MUTB_STRCM Methylmalonyl-CoA mutase large subunit (MCM-alpha)
Length = 733
Score = 311 bits (797), Expect = 1e-84
Identities = 154/247 (62%), Positives = 190/247 (76%)
Frame = +3
Query: 3 PSMKIIGDIFEYTAKHMPKFNSISISGYHMQEAGANAILEMAYTIADGLEYCRTGLKAGL 182
PSM+II DIF YT++ MP++NSISISGYH+QEAGA A LE+AYT+ADG+EY R G +AGL
Sbjct: 219 PSMRIISDIFAYTSQKMPRYNSISISGYHIQEAGATADLELAYTLADGVEYLRAGQEAGL 278
Query: 183 HIDEFAPRLSFFWGVGMNFYMEIAKMRAARRVWAELLKSKFNSKDKKSLLLRAHSQTSGW 362
+D FAPRLSFFW +GMNF+ME+AK+RAAR +WA+L+K +F+ K+ KSL LR HSQTSGW
Sbjct: 279 DVDAFAPRLSFFWAIGMNFFMEVAKLRAARLLWAKLVK-QFDPKNAKSLSLRTHSQTSGW 337
Query: 363 SLTEQDPYNNIMRTTIEAMAAVFGGTQSLHTNAFDEALGLPTKFSARIARNXXXXXXXXX 542
SLT QD +NN+ RT +EAMAA G TQSLHTNA DEAL LPT FSARIARN
Sbjct: 338 SLTAQDVFNNVTRTCVEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLLIQQES 397
Query: 543 XXXKVADPWAGSFMMESLTQEIYSEAIKVIEEIEAMGGMAKAVSEGIPKLKIEECAAKRQ 722
+ DPW GS +E LT ++ A + IEE+EA GGMA+A+ GIPKL++EE AA+ Q
Sbjct: 398 GTTRTIDPWGGSAYVEKLTYDLARRAWQHIEEVEAAGGMAQAIDAGIPKLRVEEAAARTQ 457
Query: 723 AHIDSGQ 743
A IDSG+
Sbjct: 458 ARIDSGR 464
>sp|P11653|MUTB_PROFR Methylmalonyl-CoA mutase large subunit (MCM-alpha)
Length = 728
Score = 311 bits (796), Expect = 2e-84
Identities = 152/247 (61%), Positives = 193/247 (78%)
Frame = +3
Query: 3 PSMKIIGDIFEYTAKHMPKFNSISISGYHMQEAGANAILEMAYTIADGLEYCRTGLKAGL 182
PSM+II +IF YT+ +MPK+NSISISGYHMQEAGA A +EMAYT+ADG++Y R G GL
Sbjct: 216 PSMRIISEIFAYTSANMPKWNSISISGYHMQEAGATADIEMAYTLADGVDYIRAGESVGL 275
Query: 183 HIDEFAPRLSFFWGVGMNFYMEIAKMRAARRVWAELLKSKFNSKDKKSLLLRAHSQTSGW 362
++D+FAPRLSFFWG+GMNF+ME+AK+RAAR +WA+L+ +F K+ KS+ LR HSQTSGW
Sbjct: 276 NVDQFAPRLSFFWGIGMNFFMEVAKLRAARMLWAKLVH-QFGPKNPKSMSLRTHSQTSGW 334
Query: 363 SLTEQDPYNNIMRTTIEAMAAVFGGTQSLHTNAFDEALGLPTKFSARIARNXXXXXXXXX 542
SLT QD YNN++RT IEAMAA G TQSLHTN+ DEA+ LPT FSARIARN
Sbjct: 335 SLTAQDVYNNVVRTCIEAMAATQGHTQSLHTNSLDEAIALPTDFSARIARNTQLFLQQES 394
Query: 543 XXXKVADPWAGSFMMESLTQEIYSEAIKVIEEIEAMGGMAKAVSEGIPKLKIEECAAKRQ 722
+V DPW+GS +E LT ++ +A I+E+E +GGMAKA+ +GIPK++IEE AA+ Q
Sbjct: 395 GTTRVIDPWSGSAYVEELTWDLARKAWGHIQEVEKVGGMAKAIEKGIPKMRIEEAAARTQ 454
Query: 723 AHIDSGQ 743
A IDSG+
Sbjct: 455 ARIDSGR 461
>sp|P65487|MUTB_MYCTU Probable methylmalonyl-CoA mutase large subunit (MCM)
sp|P65488|MUTB_MYCBO Probable methylmalonyl-CoA mutase large subunit (MCM)
Length = 750
Score = 309 bits (792), Expect = 4e-84
Identities = 157/247 (63%), Positives = 185/247 (74%)
Frame = +3
Query: 3 PSMKIIGDIFEYTAKHMPKFNSISISGYHMQEAGANAILEMAYTIADGLEYCRTGLKAGL 182
PSM+II DIF YT+ MPKFNSISISGYH+QEAGA A LE+AYT+ADG++Y R GL AGL
Sbjct: 232 PSMRIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIRAGLNAGL 291
Query: 183 HIDEFAPRLSFFWGVGMNFYMEIAKMRAARRVWAELLKSKFNSKDKKSLLLRAHSQTSGW 362
ID FAPRLSFFWG+GMNF+ME+AK+RA R +W+EL+ ++F K KSL LR HSQTSGW
Sbjct: 292 DIDSFAPRLSFFWGIGMNFFMEVAKLRAGRLLWSELV-AQFAPKSAKSLSLRTHSQTSGW 350
Query: 363 SLTEQDPYNNIMRTTIEAMAAVFGGTQSLHTNAFDEALGLPTKFSARIARNXXXXXXXXX 542
SLT QD +NN+ RT IEAMAA G TQSLHTNA DEAL LPT FSARIARN
Sbjct: 351 SLTAQDVFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLVLQQES 410
Query: 543 XXXKVADPWAGSFMMESLTQEIYSEAIKVIEEIEAMGGMAKAVSEGIPKLKIEECAAKRQ 722
+ DPW GS+ +E LT + A I E+ GGMA+A+S+GIPKL+IEE AA+ Q
Sbjct: 411 GTTRPIDPWGGSYYVEWLTHRLARRARAHIAEVAEHGGMAQAISDGIPKLRIEEAAARTQ 470
Query: 723 AHIDSGQ 743
A IDSGQ
Sbjct: 471 ARIDSGQ 477
>sp|O86028|MUTB_RHIME Methylmalonyl-CoA mutase (MCM)
Length = 712
Score = 299 bits (765), Expect = 6e-81
Identities = 149/247 (60%), Positives = 185/247 (74%)
Frame = +3
Query: 3 PSMKIIGDIFEYTAKHMPKFNSISISGYHMQEAGANAILEMAYTIADGLEYCRTGLKAGL 182
PSM+I+ DI EYTAK MPKFNSISISGYHMQEAGA + E+A+T+ADG EY R L GL
Sbjct: 204 PSMRIVADIIEYTAKEMPKFNSISISGYHMQEAGATLVQELAFTLADGREYVRAALAKGL 263
Query: 183 HIDEFAPRLSFFWGVGMNFYMEIAKMRAARRVWAELLKSKFNSKDKKSLLLRAHSQTSGW 362
++D+FA RLSFF+ +GMNF+ME AK+RAAR +W +++ +F + SL+LR H QTSG
Sbjct: 264 NVDDFAGRLSFFFAIGMNFFMEAAKLRAARLLWTRIMQ-EFKPEKASSLMLRTHCQTSGV 322
Query: 363 SLTEQDPYNNIMRTTIEAMAAVFGGTQSLHTNAFDEALGLPTKFSARIARNXXXXXXXXX 542
SL EQDPYNNI+RT EAM+AV GGTQSLHTN+FDEA+ LPT FSARIARN
Sbjct: 323 SLQEQDPYNNIVRTAFEAMSAVLGGTQSLHTNSFDEAMALPTDFSARIARNTQLILQHET 382
Query: 543 XXXKVADPWAGSFMMESLTQEIYSEAIKVIEEIEAMGGMAKAVSEGIPKLKIEECAAKRQ 722
KV DP AGS+ +ESLT E+ +A +IEE+EA+GGM KAV+ G+PK IEE A +RQ
Sbjct: 383 GVTKVVDPLAGSYYVESLTNELAEKAWGLIEEVEALGGMTKAVNAGLPKRLIEEAATRRQ 442
Query: 723 AHIDSGQ 743
A +D +
Sbjct: 443 AAVDRAE 449
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,453,815
Number of Sequences: 369166
Number of extensions: 1326826
Number of successful extensions: 2931
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2877
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2919
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6728100400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)