Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_O12
(537 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitoc... 235 4e-62
sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitoc... 234 1e-61
sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitocho... 234 1e-61
sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitoc... 215 5e-56
sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytopl... 214 1e-55
sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytopl... 214 1e-55
sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplas... 214 1e-55
sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytopl... 212 4e-55
sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytopl... 211 7e-55
sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalo... 202 3e-52
>sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 452
Score = 235 bits (600), Expect = 4e-62
Identities = 111/142 (78%), Positives = 125/142 (88%), Gaps = 1/142 (0%)
Frame = +3
Query: 3 CKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTN 182
CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTN
Sbjct: 308 CKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTN 367
Query: 183 PIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQP 362
PIASIFAWTRGLEHRGKLD NQ+LIR+ ++E+ CV+TV+SG MTKDLA CIHGL NV+
Sbjct: 368 PIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKL 427
Query: 363 N-HYLVTMDFLDAIAENFESKL 425
N H+L T DFLD I N + L
Sbjct: 428 NEHFLNTTDFLDTIKSNLDRAL 449
>sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 452
Score = 234 bits (597), Expect = 1e-61
Identities = 111/142 (78%), Positives = 124/142 (87%), Gaps = 1/142 (0%)
Frame = +3
Query: 3 CKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTN 182
CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTN
Sbjct: 308 CKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTN 367
Query: 183 PIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQP 362
PIASIFAWTRGLEHRGKLD NQ+LIR+ +E+ CV+TV+SG MTKDLA CIHGL NV+
Sbjct: 368 PIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCIHGLSNVKL 427
Query: 363 N-HYLVTMDFLDAIAENFESKL 425
N H+L T DFLD I N + L
Sbjct: 428 NEHFLNTSDFLDTIKSNLDRAL 449
>sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 421
Score = 234 bits (597), Expect = 1e-61
Identities = 111/142 (78%), Positives = 124/142 (87%), Gaps = 1/142 (0%)
Frame = +3
Query: 3 CKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTN 182
CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTSTN
Sbjct: 277 CKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTN 336
Query: 183 PIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQP 362
PIASIFAWTRGLEHRGKLD NQ+LIR+ +E+ CV+TV+SG MTKDLA CIHGL NV+
Sbjct: 337 PIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCIHGLSNVKL 396
Query: 363 N-HYLVTMDFLDAIAENFESKL 425
N H+L T DFLD I N + L
Sbjct: 397 NEHFLNTSDFLDTIKSNLDRAL 418
>sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 523
Score = 215 bits (548), Expect = 5e-56
Identities = 106/142 (74%), Positives = 117/142 (82%), Gaps = 1/142 (0%)
Frame = +3
Query: 3 CKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTN 182
CKNYDGDVQSDI+A +GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYREHQKG+PTST
Sbjct: 380 CKNYDGDVQSDILASRFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTK 439
Query: 183 PIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQP 362
IASIFAWTRGLEHRGKLD NQ+LIR+ E+ CV TV+ G MTKDLA CIHGL NV+
Sbjct: 440 GIASIFAWTRGLEHRGKLDGNQDLIRFAQTREKVCVQTVE-GAMTKDLAGCIHGLSNVKL 498
Query: 363 N-HYLVTMDFLDAIAENFESKL 425
N H+L T DFLD I N + L
Sbjct: 499 NEHFLNTTDFLDTIKSNLDRAL 520
>sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 214 bits (545), Expect = 1e-55
Identities = 99/141 (70%), Positives = 118/141 (83%)
Frame = +3
Query: 3 CKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTN 182
CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAHGTVTRHYR HQKG+ TSTN
Sbjct: 269 CKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRMHQKGQETSTN 328
Query: 183 PIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQP 362
PIASIFAW+RGL HR +LDNN EL + +E C++T+++G MTKDLAACI GL NVQ
Sbjct: 329 PIASIFAWSRGLAHRARLDNNTELSFFAKALEEVCIETIEAGFMTKDLAACIKGLPNVQR 388
Query: 363 NHYLVTMDFLDAIAENFESKL 425
+ YL T +F+D + EN ++KL
Sbjct: 389 SDYLNTFEFMDKLGENLKAKL 409
>sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 214 bits (545), Expect = 1e-55
Identities = 99/141 (70%), Positives = 118/141 (83%)
Frame = +3
Query: 3 CKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTN 182
CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAHGTVTRHYR HQKG+ TSTN
Sbjct: 269 CKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRMHQKGQETSTN 328
Query: 183 PIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQP 362
PIASIFAW+RGL HR +LDNN EL + +E C++T+++G MTKDLAACI GL NVQ
Sbjct: 329 PIASIFAWSRGLAHRARLDNNTELSFFAKALEEVCIETIEAGFMTKDLAACIKGLPNVQR 388
Query: 363 NHYLVTMDFLDAIAENFESKL 425
+ YL T +F+D + EN ++KL
Sbjct: 389 SDYLNTFEFMDKLGENLKAKL 409
>sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 214 bits (544), Expect = 1e-55
Identities = 99/141 (70%), Positives = 119/141 (84%)
Frame = +3
Query: 3 CKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTN 182
CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAHGTVTRHYR +QKG+ TSTN
Sbjct: 269 CKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRMYQKGQETSTN 328
Query: 183 PIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQP 362
PIASIFAW+RGL HR KLDNN EL + + +E C++T+++G MTKDLAACI GL NVQ
Sbjct: 329 PIASIFAWSRGLAHRAKLDNNTELSFFANALEEVCIETIEAGFMTKDLAACIKGLPNVQR 388
Query: 363 NHYLVTMDFLDAIAENFESKL 425
+ YL T +F+D + EN ++KL
Sbjct: 389 SDYLNTFEFMDKLGENLKAKL 409
>sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 212 bits (540), Expect = 4e-55
Identities = 99/141 (70%), Positives = 118/141 (83%)
Frame = +3
Query: 3 CKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTN 182
CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAHGTVTRHYR +QKG+ TSTN
Sbjct: 269 CKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRMYQKGQETSTN 328
Query: 183 PIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQP 362
PIASIFAW+RGL HR KLDNN EL + +E C++T+++G MTKDLAACI GL NVQ
Sbjct: 329 PIASIFAWSRGLAHRAKLDNNTELSFFAKALEDVCIETIEAGFMTKDLAACIKGLPNVQR 388
Query: 363 NHYLVTMDFLDAIAENFESKL 425
+ YL T +F+D + EN ++KL
Sbjct: 389 SDYLNTFEFMDKLGENLKAKL 409
>sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 211 bits (538), Expect = 7e-55
Identities = 99/141 (70%), Positives = 118/141 (83%)
Frame = +3
Query: 3 CKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTN 182
CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAHGTVTRHYR +QKG+ TSTN
Sbjct: 269 CKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTN 328
Query: 183 PIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQP 362
PIASIFAWTRGL HR KLDNN+EL + + +E ++T+++G MTKDLAACI GL NVQ
Sbjct: 329 PIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQR 388
Query: 363 NHYLVTMDFLDAIAENFESKL 425
+ YL T +F+D + EN + KL
Sbjct: 389 SDYLNTFEFMDKLGENLKIKL 409
>sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase)
(IDH) (NADP(+)-specific ICDH) (IDP)
Length = 415
Score = 202 bits (515), Expect = 3e-52
Identities = 97/141 (68%), Positives = 115/141 (81%)
Frame = +3
Query: 3 CKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVTRHYREHQKGKPTSTN 182
CKNYDGDVQSD +AQG+GSLGLMTSVL+CPDGKTIEAEAAHGTVTRHYR HQKG TSTN
Sbjct: 271 CKNYDGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYRVHQKGGETSTN 330
Query: 183 PIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDSGKMTKDLAACIHGLKNVQP 362
IASIFAWTRGL HR LDNN+ L+ + +E AC+ V+SGKMTKDLA IHG K +
Sbjct: 331 SIASIFAWTRGLAHRATLDNNERLLDFTEKLEAACIGAVESGKMTKDLALIIHGSK-LSR 389
Query: 363 NHYLVTMDFLDAIAENFESKL 425
+HYL T +F+DA+A+ +++L
Sbjct: 390 DHYLNTEEFIDAVADELKARL 410
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,171,819
Number of Sequences: 369166
Number of extensions: 1270776
Number of successful extensions: 3146
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3053
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3131
length of database: 68,354,980
effective HSP length: 103
effective length of database: 49,327,275
effective search space used: 3699545625
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)