Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_N14
(635 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P53634|CATC_HUMAN Dipeptidyl-peptidase I precursor (DPP-... 262 5e-70
sp|Q26563|CATC_SCHMA Cathepsin C precursor 262 6e-70
sp|P97821|CATC_MOUSE Dipeptidyl-peptidase I precursor (DPP-... 254 1e-67
sp|Q60HG6|CATC_MACFA Dipeptidyl-peptidase I precursor (DPP-... 253 2e-67
sp|O97578|CATC_CANFA Dipeptidyl-peptidase I precursor (DPP-... 253 4e-67
sp|P80067|CATC_RAT Dipeptidyl-peptidase I precursor (DPP-I)... 251 1e-66
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precu... 119 5e-27
sp|Q8IIJ9|CATC_PLAF7 Probable cathepsin C precursor 116 6e-26
sp|P92133|CATB3_GIALA Cathepsin B-like CP3 precursor (Cathe... 112 6e-25
sp|P92132|CATB2_GIALA Cathepsin B-like CP2 precursor (Cathe... 112 1e-24
>sp|P53634|CATC_HUMAN Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 463
Score = 262 bits (670), Expect = 5e-70
Identities = 117/187 (62%), Positives = 146/187 (78%), Gaps = 1/187 (0%)
Frame = +3
Query: 9 PILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYKGMNGKCSTTKDCKRY 188
PILSPQ+VV CS Y+QGC+GGFPYLIAGK+A+DFG+ +E+C PY G + C +DC RY
Sbjct: 281 PILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRY 340
Query: 189 FATNYKYIGGYYGATNEPLMRMELVRNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTS 368
+++ Y Y+GG+YG NE LM++ELV +GP+AV FEVYDDF+ Y G+YHH T
Sbjct: 341 YSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHH-------TGL 393
Query: 369 KFGFNPFELTNHAVLVVGYG-ETSSGEKFWIVKNSWGNGWGENGYFRIRRGNDECGIESL 545
+ FNPFELTNHAVL+VGYG +++SG +WIVKNSWG GWGENGYFRIRRG DEC IES+
Sbjct: 394 RDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESI 453
Query: 546 GVASEPI 566
VA+ PI
Sbjct: 454 AVAATPI 460
>sp|Q26563|CATC_SCHMA Cathepsin C precursor
Length = 454
Score = 262 bits (669), Expect = 6e-70
Identities = 120/190 (63%), Positives = 147/190 (77%), Gaps = 2/190 (1%)
Frame = +3
Query: 6 RPILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYKGMN-GKCSTTKDCK 182
+PILSPQ VV+CSPYS+GC+GGFP+LIAGK+ EDFG+ Q+ PY G + GKC+ +K+C
Sbjct: 269 QPILSPQTVVDCSPYSEGCNGGFPFLIAGKYGEDFGLPQKIVIPYTGEDTGKCTVSKNCT 328
Query: 183 RYFATNYKYIGGYYGATNEPLMRMELVRNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLT 362
RY+ T+Y YIGGYYGATNE LM++EL+ NGP VGFEVY+DF Y G+YHH +
Sbjct: 329 RYYTTDYSYIGGYYGATNEKLMQLELISNGPFPVGFEVYEDFQFYKEGIYHHT----TVQ 384
Query: 363 TSKFGFNPFELTNHAVLVVGYG-ETSSGEKFWIVKNSWGNGWGENGYFRIRRGNDECGIE 539
T + FNPFELTNHAVL+VGYG + SGE +W VKNSWG WGE GYFRI RG DECG+E
Sbjct: 385 TDHYNFNPFELTNHAVLLVGYGVDKLSGEPYWKVKNSWGVEWGEQGYFRILRGTDECGVE 444
Query: 540 SLGVASEPIL 569
SLGV +P+L
Sbjct: 445 SLGVRFDPVL 454
>sp|P97821|CATC_MOUSE Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 462
Score = 254 bits (650), Expect = 1e-67
Identities = 113/187 (60%), Positives = 146/187 (78%), Gaps = 1/187 (0%)
Frame = +3
Query: 9 PILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYKGMNGKCSTTKDCKRY 188
PILSPQ+VV CSPY+QGCDGGFPYLIAGK+A+DFG+ +ESC PY + C ++C RY
Sbjct: 280 PILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEESCFPYTAKDSPCKpreNCLRY 339
Query: 189 FATNYKYIGGYYGATNEPLMRMELVRNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTS 368
++++Y Y+GG+YG NE LM++ELV++GP+AV FEV+DDF+ Y G+YHH T
Sbjct: 340 YSSDYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHH-------TGL 392
Query: 369 KFGFNPFELTNHAVLVVGYG-ETSSGEKFWIVKNSWGNGWGENGYFRIRRGNDECGIESL 545
FNPFELTNHAVL+VGYG + +G ++WI+KNSWG+ WGE+GYFRIRRG DEC IES+
Sbjct: 393 SDPFNPFELTNHAVLLVGYGRDPVTGIEYWIIKNSWGSNWGESGYFRIRRGTDECAIESI 452
Query: 546 GVASEPI 566
VA+ PI
Sbjct: 453 AVAAIPI 459
>sp|Q60HG6|CATC_MACFA Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 463
Score = 253 bits (647), Expect = 2e-67
Identities = 113/187 (60%), Positives = 143/187 (76%), Gaps = 1/187 (0%)
Frame = +3
Query: 9 PILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYKGMNGKCSTTKDCKRY 188
PILS Q+VV CS Y+QGC+GGFPYL AGK+A+DFG+ +E+C PY G + C +DC RY
Sbjct: 281 PILSSQEVVSCSQYAQGCEGGFPYLTAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRY 340
Query: 189 FATNYKYIGGYYGATNEPLMRMELVRNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTS 368
+++ Y Y+GG+YG NE LM++ELV +GP+AV FEVYDDF+ Y G+YHH T
Sbjct: 341 YSSEYHYVGGFYGGCNEALMKLELVYHGPLAVAFEVYDDFLHYQNGIYHH-------TGL 393
Query: 369 KFGFNPFELTNHAVLVVGYG-ETSSGEKFWIVKNSWGNGWGENGYFRIRRGNDECGIESL 545
+ FNPFELTNHAVL+VGYG +++SG +WIVKNSWG WGE+GYFRIRRG DEC IES+
Sbjct: 394 RDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTSWGEDGYFRIRRGTDECAIESI 453
Query: 546 GVASEPI 566
VA+ PI
Sbjct: 454 AVAATPI 460
>sp|O97578|CATC_CANFA Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain 1;
Dipeptidyl-peptidase I heavy chain 2;
Dipeptidyl-peptidase I heavy chain 3;
Dipeptidyl-peptidase I heavy chain 4;
Dipeptidyl-peptidase I light chain]
Length = 435
Score = 253 bits (645), Expect = 4e-67
Identities = 115/187 (61%), Positives = 146/187 (78%), Gaps = 1/187 (0%)
Frame = +3
Query: 9 PILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYKGMNGKCSTTKDCKRY 188
PILSPQ++V CS Y+QGC+GGFPYLIAGK+A+DFG+ +E+C PY G + C DC RY
Sbjct: 254 PILSPQEIVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYAGSDSPCK-PNDCFRY 312
Query: 189 FATNYKYIGGYYGATNEPLMRMELVRNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTS 368
+++ Y Y+GG+YGA NE LM++ELVR+GP+AV FEVYDDF Y G+Y+H T
Sbjct: 313 YSSEYYYVGGFYGACNEALMKLELVRHGPMAVAFEVYDDFFHYQKGIYYH-------TGL 365
Query: 369 KFGFNPFELTNHAVLVVGYG-ETSSGEKFWIVKNSWGNGWGENGYFRIRRGNDECGIESL 545
+ FNPFELTNHAVL+VGYG +++SG +WIVKNSWG+ WGE+GYFRIRRG DEC IES+
Sbjct: 366 RDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGSRWGEDGYFRIRRGTDECAIESI 425
Query: 546 GVASEPI 566
VA+ PI
Sbjct: 426 AVAATPI 432
>sp|P80067|CATC_RAT Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 462
Score = 251 bits (640), Expect = 1e-66
Identities = 112/187 (59%), Positives = 144/187 (77%), Gaps = 1/187 (0%)
Frame = +3
Query: 9 PILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYKGMNGKCSTTKDCKRY 188
PILSPQ+VV CSPY+QGCDGGFPYLIAGK+A+DFG+ +E+C PY + C ++C RY
Sbjct: 280 PILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGVVEENCFPYTATDAPCKPKENCLRY 339
Query: 189 FATNYKYIGGYYGATNEPLMRMELVRNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTTS 368
+++ Y Y+GG+YG NE LM++ELV++GP+AV FEV+DDF+ Y G+YHH T
Sbjct: 340 YSSEYYYVGGFYGGCNEALMKLELVKHGPMAVAFEVHDDFLHYHSGIYHH-------TGL 392
Query: 369 KFGFNPFELTNHAVLVVGYG-ETSSGEKFWIVKNSWGNGWGENGYFRIRRGNDECGIESL 545
FNPFELTNHAVL+VGYG + +G +WIVKNSWG+ WGE+GYFRIRRG DEC IES+
Sbjct: 393 SDPFNPFELTNHAVLLVGYGKDPVTGLDYWIVKNSWGSQWGESGYFRIRRGTDECAIESI 452
Query: 546 GVASEPI 566
+A+ PI
Sbjct: 453 AMAAIPI 459
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor
Length = 329
Score = 119 bits (299), Expect = 5e-27
Identities = 73/207 (35%), Positives = 108/207 (52%), Gaps = 22/207 (10%)
Frame = +3
Query: 6 RPILSPQDVVEC--SPYSQGCDGGFPYLIAGKFAEDFGMAQ------ESCNPYK---GMN 152
+PI+SP D++ C S GC+GG+P + A ++ + G+ C PY +
Sbjct: 135 QPIISPDDLLSCCGSSCGNGCEGGYP-IQALRWWDSKGVVTGGDYHGAGCKPYPIAPCTS 193
Query: 153 GKCSTTK------DCKRYFATNY---KYIG--GYYGATNEPLMRMELVRNGPIAVGFEVY 299
G C +K C+ ++T Y K+ G Y N ++ E+ NGP+ F VY
Sbjct: 194 GNCPESKTPSCSMSCQSGYSTAYAKDKHFGVSAYAVPKNAASIQAEIYANGPVEAAFSVY 253
Query: 300 DDFMSYSGGVYHHNFGTRKLTTSKFGFNPFELTNHAVLVVGYGETSSGEKFWIVKNSWGN 479
+DF Y GVY H T K+ L HA+ ++G+G T SG +W+V NSWG
Sbjct: 254 EDFYKYKSGVYKH-------TAGKY------LGGHAIKIIGWG-TESGSPYWLVANSWGV 299
Query: 480 GWGENGYFRIRRGNDECGIESLGVASE 560
WGE+G+F+I RG+D+CGIES VA +
Sbjct: 300 NWGESGFFKIYRGDDQCGIESAVVAGK 326
>sp|Q8IIJ9|CATC_PLAF7 Probable cathepsin C precursor
Length = 700
Score = 116 bits (290), Expect = 6e-26
Identities = 80/252 (31%), Positives = 117/252 (46%), Gaps = 69/252 (27%)
Frame = +3
Query: 15 LSPQDVVECSPYSQGCDGGFPYLIAGKFAE----------DFGMAQESCNPYK------G 146
LS Q V+ CS Y QGC+GGFPYL++ K A+ + +E+C PY
Sbjct: 431 LSIQTVLSCSFYDQGCNGGFPYLVS-KLAKLQGIPLNVYFPYSATEETC-PYNISKHPND 488
Query: 147 MNGKCSTTK----------------------------------------DCKRYFATNYK 206
MNG + + R++A ++
Sbjct: 489 MNGSAKLREINAIFNSNNNMSTYNNINNDHHQLGVYANTASSQEQHGISEENRWYAKDFN 548
Query: 207 YIGGYYGATN---EPLMRMELVRNGPIAVGFEVYDDFMSYSGGVYH-HNFGTRKLTTSK- 371
Y+GG YG E +M E+ RNGPI FE DF Y+ GVY +F + T +
Sbjct: 549 YVGGCYGCNQCNGEKIMMNEIYRNGPIVSSFEASPDFYDYADGVYFVEDFPHARRCTIEP 608
Query: 372 -----FGFNPFELTNHAVLVVGYGETS-SGE--KFWIVKNSWGNGWGENGYFRIRRGNDE 527
+ ++ NHA++++G+GE +G+ K+WI +NSWGNGWG+ GYF+I RG +
Sbjct: 609 KNDGVYNITGWDRVNHAIVLLGWGEEEINGKLYKYWIGRNSWGNGWGKEGYFKILRGQNF 668
Query: 528 CGIESLGVASEP 563
GIES + EP
Sbjct: 669 SGIESQSLFIEP 680
>sp|P92133|CATB3_GIALA Cathepsin B-like CP3 precursor (Cathepsin B-like protease B3)
Length = 299
Score = 112 bits (281), Expect = 6e-25
Identities = 66/178 (37%), Positives = 81/178 (45%), Gaps = 4/178 (2%)
Frame = +3
Query: 18 SPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYK----GMNGKCSTTKDCKR 185
SPQ VV C CDGG+ + +F G + C PY+ G G C T
Sbjct: 126 SPQYVVSCDRGDMACDGGWLPSV-WRFLTKTGTTTDECVPYQSGSTGARGTCPTKCADGS 184
Query: 186 YFATNYKYIGGYYGATNEPLMRMELVRNGPIAVGFEVYDDFMSYSGGVYHHNFGTRKLTT 365
YK + P + L GP+ F VY DFM Y GVY H +G +
Sbjct: 185 DLPHLYKATKAVDYGLDAPAIMKALATGGPLQTAFTVYSDFMYYESGVYQHTYGRVE--- 241
Query: 366 SKFGFNPFELTNHAVLVVGYGETSSGEKFWIVKNSWGNGWGENGYFRIRRGNDECGIE 539
HAV +VGYG G +WI+KNSWG WGE+GYFRI R +ECGIE
Sbjct: 242 ----------GGHAVDMVGYGTDDDGVDYWIIKNSWGPDWGEDGYFRIIRMTNECGIE 289
>sp|P92132|CATB2_GIALA Cathepsin B-like CP2 precursor (Cathepsin B-like protease B2)
Length = 300
Score = 112 bits (279), Expect = 1e-24
Identities = 69/188 (36%), Positives = 89/188 (47%), Gaps = 9/188 (4%)
Frame = +3
Query: 18 SPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGMAQESCNPYKG----MNGKCST-----T 170
SPQ VV C C+GG+ + KF G + C PYK + G C T +
Sbjct: 127 SPQYVVSCDHGDMACNGGWLPNV-WKFLTKTGTTTDECVPYKSGSTTLRGTCPTKCADGS 185
Query: 171 KDCKRYFATNYKYIGGYYGATNEPLMRMELVRNGPIAVGFEVYDDFMSYSGGVYHHNFGT 350
AT+YK G + P M L +GP+ V F V+ DFM Y GVY H +G
Sbjct: 186 SKVHLATATSYKDYG-----LDIPAMMKALSTSGPLQVAFLVHSDFMYYESGVYQHTYGY 240
Query: 351 RKLTTSKFGFNPFELTNHAVLVVGYGETSSGEKFWIVKNSWGNGWGENGYFRIRRGNDEC 530
+ HAV +VGYG G +WI+KNSWG WGE+GYFR+ RG ++C
Sbjct: 241 ME-------------GGHAVEMVGYGTDDDGVDYWIIKNSWGPDWGEDGYFRMIRGINDC 287
Query: 531 GIESLGVA 554
IE A
Sbjct: 288 SIEEQAYA 295
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,389,434
Number of Sequences: 369166
Number of extensions: 1743682
Number of successful extensions: 5029
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4554
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4718
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5121172350
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)