Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_M10
(789 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P54578|UBP14_HUMAN Ubiquitin carboxyl-terminal hydrolase... 202 8e-52
sp|P60051|UBP14_PANTR Ubiquitin carboxyl-terminal hydrolase... 202 8e-52
sp|P40826|UBP14_RABIT Ubiquitin carboxyl-terminal hydrolase... 201 2e-51
sp|Q9JMA1|UBP14_MOUSE Ubiquitin carboxyl-terminal hydrolase... 200 4e-51
sp|Q17361|UBP14_CAEEL Ubiquitin carboxyl-terminal hydrolase... 121 2e-27
sp|Q92353|UBP6_SCHPO Probable ubiquitin carboxyl-terminal h... 106 6e-23
sp|P43593|UBP6_YEAST Ubiquitin carboxyl-terminal hydrolase ... 86 1e-16
sp|Q9BXU7|UBP26_HUMAN Ubiquitin carboxyl-terminal hydrolase... 44 4e-04
sp|Q9P275|UBP36_HUMAN Ubiquitin carboxyl-terminal hydrolase... 43 9e-04
sp|Q09931|UBPY_CAEEL Probable ubiquitin carboxyl-terminal h... 42 0.002
>sp|P54578|UBP14_HUMAN Ubiquitin carboxyl-terminal hydrolase 14 (Ubiquitin thiolesterase
14) (Ubiquitin-specific processing protease 14)
(Deubiquitinating enzyme 14)
Length = 494
Score = 202 bits (514), Expect = 8e-52
Identities = 111/268 (41%), Positives = 160/268 (59%), Gaps = 9/268 (3%)
Frame = +3
Query: 12 MPVYKVNIKWQKEKFNDIECDTDQPPEIFKALIFSLSGVTPDRQKVMMPGGTLKNT-WDG 188
MP+Y V +KW KEKF +E +TD+PP +FKA +F+L+GV P RQKVM+ GGTLK+ W
Sbjct: 1 MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGN 60
Query: 189 IRLKDGITIMMMGTCDDLSVGEINKPKFIEDMTESQITKALKLPQGLKNIGNTCYLNATI 368
I++K+G+T++MMG+ D L K F+EDMTE Q+ A++LP GL N+GNTCY+NAT+
Sbjct: 61 IKIKNGMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATV 120
Query: 369 QCLRTIPELYKAIKNSP----KTNESDPHSRFVLSLGRLILSMETAEVPIAPIIPLKHLH 536
QC+R++PEL A+K + E +L L SM+ I PII L+ LH
Sbjct: 121 QCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLH 180
Query: 537 EMCPQFATTQVAAPEQGGGSVLMQQDANECWAEIVRSLQKAVYIPQNVDFSDLPESFGS- 713
PQFA E+G +QQDANECW +++R LQ+ + ++ + S S
Sbjct: 181 MAFPQFA-------EKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASA 233
Query: 714 ---NGNLNFVDQFLTGKFDVKTVNTENE 788
+ + +DQF +F+ TE+E
Sbjct: 234 ATPSKKKSLIDQFFGVEFETTMKCTESE 261
>sp|P60051|UBP14_PANTR Ubiquitin carboxyl-terminal hydrolase 14 (Ubiquitin thiolesterase
14) (Ubiquitin-specific processing protease 14)
(Deubiquitinating enzyme 14)
Length = 493
Score = 202 bits (514), Expect = 8e-52
Identities = 111/268 (41%), Positives = 160/268 (59%), Gaps = 9/268 (3%)
Frame = +3
Query: 12 MPVYKVNIKWQKEKFNDIECDTDQPPEIFKALIFSLSGVTPDRQKVMMPGGTLKNT-WDG 188
MP+Y V +KW KEKF +E +TD+PP +FKA +F+L+GV P RQKVM+ GGTLK+ W
Sbjct: 1 MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGN 60
Query: 189 IRLKDGITIMMMGTCDDLSVGEINKPKFIEDMTESQITKALKLPQGLKNIGNTCYLNATI 368
I++K+G+T++MMG+ D L K F+EDMTE Q+ A++LP GL N+GNTCY+NAT+
Sbjct: 61 IKIKNGMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATV 120
Query: 369 QCLRTIPELYKAIKNSP----KTNESDPHSRFVLSLGRLILSMETAEVPIAPIIPLKHLH 536
QC+R++PEL A+K + E +L L SM+ I PII L+ LH
Sbjct: 121 QCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLH 180
Query: 537 EMCPQFATTQVAAPEQGGGSVLMQQDANECWAEIVRSLQKAVYIPQNVDFSDLPESFGS- 713
PQFA E+G +QQDANECW +++R LQ+ + ++ + S S
Sbjct: 181 MAFPQFA-------EKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASA 233
Query: 714 ---NGNLNFVDQFLTGKFDVKTVNTENE 788
+ + +DQF +F+ TE+E
Sbjct: 234 ATPSKKKSLIDQFFGVEFETTMKCTESE 261
>sp|P40826|UBP14_RABIT Ubiquitin carboxyl-terminal hydrolase 14 (Ubiquitin thiolesterase
14) (Ubiquitin-specific processing protease 14)
(Deubiquitinating enzyme 14)
Length = 493
Score = 201 bits (511), Expect = 2e-51
Identities = 110/267 (41%), Positives = 160/267 (59%), Gaps = 8/267 (2%)
Frame = +3
Query: 12 MPVYKVNIKWQKEKFNDIECDTDQPPEIFKALIFSLSGVTPDRQKVMMPGGTLKNT-WDG 188
MP+Y V +KW KEKF +E +TD+PP +FKA +F+L+GV P RQ+VM+ GGTLK+ W
Sbjct: 1 MPLYSVTVKWGKEKFGGVELNTDEPPMVFKAQLFALTGVQPARQRVMVKGGTLKDDDWGN 60
Query: 189 IRLKDGITIMMMGTCDDLSVGEINKPKFIEDMTESQITKALKLPQGLKNIGNTCYLNATI 368
I++K+G+TI+MMG+ D L K F+EDMTE Q+ A++LP GL N+GNTCY+NAT+
Sbjct: 61 IKIKNGMTILMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATV 120
Query: 369 QCLRTIPELYKAIKNSP----KTNESDPHSRFVLSLGRLILSMETAEVPIAPIIPLKHLH 536
QC+R++PEL A+K + E +L L SM+ I PII L+ LH
Sbjct: 121 QCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLH 180
Query: 537 EMCPQFATTQVAAPEQGGGSVLMQQDANECWAEIVRSLQKAVYIPQNVDFSDLPESFGS- 713
PQFA E+G +QQDANECW +++R LQ+ + ++ + S +
Sbjct: 181 MAFPQFA-------EKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSAAAV 233
Query: 714 --NGNLNFVDQFLTGKFDVKTVNTENE 788
+ + +DQF +F+ TE+E
Sbjct: 234 APSKKKSLIDQFFGVEFETTMKCTESE 260
>sp|Q9JMA1|UBP14_MOUSE Ubiquitin carboxyl-terminal hydrolase 14 (Ubiquitin thiolesterase
14) (Ubiquitin-specific processing protease 14)
(Deubiquitinating enzyme 14)
Length = 493
Score = 200 bits (508), Expect = 4e-51
Identities = 112/269 (41%), Positives = 160/269 (59%), Gaps = 10/269 (3%)
Frame = +3
Query: 12 MPVYKVNIKWQKEKFNDIECDTDQPPEIFKALIFSLSGVTPDRQKVMMPGGTLKNT-WDG 188
MP+Y V +KW KEKF +E +TD+PP +FKA +F+L+GV P RQKVM+ GGTLK+ W
Sbjct: 1 MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGN 60
Query: 189 IRLKDGITIMMMGTCDDLSVGEINKPKFIEDMTESQITKALKLPQGLKNIGNTCYLNATI 368
I++K+G+T++MMG+ D L K F+EDMTE Q+ A++LP GL N+GNTCY+NAT+
Sbjct: 61 IKMKNGMTVLMMGSADALPEEPSAKTVFVEDMTEEQLATAMELPCGLTNLGNTCYMNATV 120
Query: 369 QCLRTIPELYKAIKNSP----KTNESDPHSRFVLSLGRLILSMETAEVPIAPIIPLKHLH 536
QC+R++PEL A+K + E +L L SM+ I PII L+ LH
Sbjct: 121 QCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLH 180
Query: 537 EMCPQFATTQVAAPEQGGGSVLMQQDANECWAEIVRSLQKAVYIPQN-----VDFSDLPE 701
PQFA E+G +QQDANECW +++R LQ+ + ++ D S P
Sbjct: 181 MAFPQFA-------EKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSGRETDSSSAPA 233
Query: 702 SFGSNGNLNFVDQFLTGKFDVKTVNTENE 788
S + +DQ+ +F+ TE+E
Sbjct: 234 VTPSK-KKSLIDQYFGVEFETTMKCTESE 261
>sp|Q17361|UBP14_CAEEL Ubiquitin carboxyl-terminal hydrolase 14 (Ubiquitin thiolesterase
14) (Ubiquitin-specific processing protease 14)
(Deubiquitinating enzyme 14)
Length = 489
Score = 121 bits (304), Expect = 2e-27
Identities = 81/228 (35%), Positives = 121/228 (53%), Gaps = 13/228 (5%)
Frame = +3
Query: 12 MPVYKVNIKWQKEKFNDIECDTDQPPEIFKALIFSLSGVTPDRQKVMMPGGTL-KNTWDG 188
MP+ VN+KWQKEK+ +E DT PP +FKA +F+L+ V P+RQKV++ G TL + W+G
Sbjct: 1 MPI--VNVKWQKEKYV-VEVDTSAPPMVFKAQLFALTQVVPERQKVVIMGRTLGDDDWEG 57
Query: 189 IRLKDGITIMMMGTCDDLSVGEINKPKFIEDMTESQITKALK-----LPQGLKNIGNTCY 353
I +K+ +TIMMMG SVGEI KP + + ++ K + P GL N+GNTCY
Sbjct: 58 ITIKENMTIMMMG-----SVGEIPKPPTVLEKKQANRDKQAEEISALYPCGLANLGNTCY 112
Query: 354 LNATIQCLRTIPELYKAIKNSPKTNESDPHSRFVLSLGRLILSMETAE-------VPIAP 512
N+ +Q L+ + EL +K + + + + R +L L S+ + PI P
Sbjct: 113 FNSCVQMLKEVNEL--VLKPAEEMRIREHNDRLCHNLATLFNSLRDKDRALRSKGEPIKP 170
Query: 513 IIPLKHLHEMCPQFATTQVAAPEQGGGSVLMQQDANECWAEIVRSLQK 656
+ L + PQF QQDANEC I+ ++ +
Sbjct: 171 FAAILTLSDSFPQF-------------EKFKQQDANECLVSIMSNVTR 205
>sp|Q92353|UBP6_SCHPO Probable ubiquitin carboxyl-terminal hydrolase 6 (Ubiquitin
thiolesterase 6) (Ubiquitin-specific processing protease
6) (Deubiquitinating enzyme 6)
Length = 467
Score = 106 bits (265), Expect = 6e-23
Identities = 74/219 (33%), Positives = 116/219 (52%), Gaps = 7/219 (3%)
Frame = +3
Query: 27 VNIKWQKEKFNDIECDTDQPPEIFKALIFSLSGVTPDRQKVMMPGGTLKNT--WDGIRLK 200
+ I+WQ +K+ D+E + ++ K ++SL+ V P+RQKV++ GG LK+ + +K
Sbjct: 4 IAIRWQGKKY-DLEIEPNETGSTLKHQLYSLTQVPPERQKVIVKGGQLKDDVLLGSVGIK 62
Query: 201 DGITIMMMGTCDDLSVGEINKPKFIEDMTESQITKALKLPQGLKNIGNTCYLNATIQCLR 380
T++MMGT +L P + E + ++ P GL N+GNTCY+N+T+Q LR
Sbjct: 63 PNATLLMMGTAGELPTA---MPIPAVESVEQEESEDDGYPSGLINLGNTCYMNSTVQMLR 119
Query: 381 TIPELYKAIKNSPKTNESDPHSRFVLSLG-----RLILSMETAEVPIAPIIPLKHLHEMC 545
IPEL SD S+F S G R +L+ + P+ P+ L+ L
Sbjct: 120 AIPEL------------SDAVSQFNSSGGLVAEYRTLLNSMQSNAPVTPMRFLQSLRMEY 167
Query: 546 PQFATTQVAAPEQGGGSVLMQQDANECWAEIVRSLQKAV 662
PQFA + E GG QQDA ECW+ ++ LQ+++
Sbjct: 168 PQFAE---MSRETGG---YAQQDAEECWSFLLSVLQRSL 200
>sp|P43593|UBP6_YEAST Ubiquitin carboxyl-terminal hydrolase 6 (Ubiquitin thiolesterase 6)
(Ubiquitin-specific processing protease 6)
(Deubiquitinating enzyme 6)
Length = 499
Score = 85.9 bits (211), Expect = 1e-16
Identities = 73/229 (31%), Positives = 108/229 (47%), Gaps = 13/229 (5%)
Frame = +3
Query: 3 SGEMPVYKVNIKWQKEKFNDIECDTDQPPEIFKALIFSLSGVTPDRQKVMMPGGTLKNTW 182
SGE ++ NI+ K I TD K+ L+ V RQK M+ GG
Sbjct: 2 SGE--TFEFNIR-HSGKVYPITLSTDATSADLKSKAEELTQVPSARQKYMVKGGLSGEES 58
Query: 183 DGIR--LKDGITIMMMGTCD-DLSVGEINKPKFIEDMT-ESQITKALKLPQGLKNIGNTC 350
I +K G T+M++GT D +L K FIED+ E Q+ + +LP G KN+GNTC
Sbjct: 59 IKIYPLIKPGSTVMLLGTPDANLISKPAKKNNFIEDLAPEQQVQQFAQLPVGFKNMGNTC 118
Query: 351 YLNATIQCLRTIPELYKAIKN--------SPKTNESDPHSRFVLSLGRLILSMETAEV-P 503
YLNAT+Q L + +L I N + + + H + V+ + R +++
Sbjct: 119 YLNATLQALYRVNDLRDMILNYNPSQGVSNSGAQDEEIHKQIVIEMKRCFENLQNKSFKS 178
Query: 504 IAPIIPLKHLHEMCPQFATTQVAAPEQGGGSVLMQQDANECWAEIVRSL 650
+ PI+ L L + PQFA QGG QQDA E + ++ S+
Sbjct: 179 VLPIVLLNTLRKCYPQFAERD----SQGG--FYKQQDAEELFTQLFHSM 221
>sp|Q9BXU7|UBP26_HUMAN Ubiquitin carboxyl-terminal hydrolase 26 (Ubiquitin thiolesterase
26) (Ubiquitin-specific processing protease 26)
(Deubiquitinating enzyme 26)
Length = 913
Score = 44.3 bits (103), Expect = 4e-04
Identities = 23/71 (32%), Positives = 36/71 (50%)
Frame = +3
Query: 312 KLPQGLKNIGNTCYLNATIQCLRTIPELYKAIKNSPKTNESDPHSRFVLSLGRLILSMET 491
K+ GL N+GNTCY+NA +Q L +IP + N P + + L RL+ +T
Sbjct: 292 KICHGLPNLGNTCYMNAVLQSLLSIPSFADDLLNQSFPWGKIPLNALTMCLARLLFFKDT 351
Query: 492 AEVPIAPIIPL 524
+ I ++ L
Sbjct: 352 YNIEIKEMLLL 362
>sp|Q9P275|UBP36_HUMAN Ubiquitin carboxyl-terminal hydrolase 36 (Ubiquitin thiolesterase
36) (Ubiquitin-specific processing protease 36)
(Deubiquitinating enzyme 36)
Length = 1121
Score = 43.1 bits (100), Expect = 9e-04
Identities = 30/121 (24%), Positives = 52/121 (42%), Gaps = 2/121 (1%)
Frame = +3
Query: 303 KALKLPQGLKNIGNTCYLNATIQCLRTIPEL--YKAIKNSPKTNESDPHSRFVLSLGRLI 476
+ ++ GL N+GNTC+LNATIQCL P L Y K ++ + ++
Sbjct: 116 RVFRVGAGLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGSFCMLCVMQNHIV 175
Query: 477 LSMETAEVPIAPIIPLKHLHEMCPQFATTQVAAPEQGGGSVLMQQDANECWAEIVRSLQK 656
+ + I P+ ++ L ++ F Q+DA+E + ++QK
Sbjct: 176 QAFANSGNAIKPVSFIRDLKKIARHFRFGN-------------QEDAHEFLRYTIDAMQK 222
Query: 657 A 659
A
Sbjct: 223 A 223
>sp|Q09931|UBPY_CAEEL Probable ubiquitin carboxyl-terminal hydrolase K02C4.3 (Ubiquitin
thiolesterase) (Ubiquitin-specific processing protease)
(Deubiquitinating enzyme)
Length = 1302
Score = 42.0 bits (97), Expect = 0.002
Identities = 38/164 (23%), Positives = 70/164 (42%), Gaps = 15/164 (9%)
Frame = +3
Query: 255 INKPKFIEDMTESQITKALKLPQGLKNIGNTCYLNATIQCLRTIPELYKAI--------K 410
I++P + E + GL N GNTC+LN Q L +IP+ +
Sbjct: 178 ISRPTMLMSNLEDMVRNP-NFSTGLYNSGNTCWLNCLSQVLYSIPKFRSILYHCAPLSWH 236
Query: 411 NSPKTN---ESDPHSRFVLSLGRLILSMETAEVPIAPIIPLKHLHEMCPQFATTQVAAPE 581
P TN E+ H+ ++ L ++ +E+ + PL ++ +++
Sbjct: 237 EQPITNVKIENQQHAELLMLFRGLFAELQFSEMKYIEVGPLINM--------VDKLSKSS 288
Query: 582 QGGGSVLMQQDANECWAEIVRSLQK----AVYIPQNVDFSDLPE 701
+G ++ QQDA E I LQ+ A++ N +FS++ +
Sbjct: 289 KGPSTIGTQQDATEMLTLIFDWLQRAFDAALHAQLNPEFSNVSD 332
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,064,994
Number of Sequences: 369166
Number of extensions: 1860048
Number of successful extensions: 4472
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4325
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4452
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7454154400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)