Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_I19
(656 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q14764|MVP_HUMAN Major vault protein (MVP) (Lung resista... 201 1e-51
sp|Q9EQK5|MVP_MOUSE Major vault protein (MVP) 199 4e-51
sp|Q9DGM7|MVP_ICTPU Major vault protein (MVP) 199 7e-51
sp|Q62667|MVP_RAT Major vault protein (MVP) 196 3e-50
sp|Q90405|MVP_DISOM Major vault protein (MVP100) (P100) 186 5e-47
sp|P34118|MVPA_DICDI Major vault protein alpha (MVP-alpha) 175 1e-43
sp|P54659|MVPB_DICDI Major vault protein beta (MVP-beta) 154 3e-37
sp|P19934|TOLA_ECOLI Protein tolA 52 1e-06
sp|P30427|PLEC1_RAT Plectin 1 (PLTN) (PCN) 44 3e-04
sp|Q9JI55|PLEC1_CRIGR Plectin 1 (PLTN) (PCN) (300-kDa inter... 44 3e-04
>sp|Q14764|MVP_HUMAN Major vault protein (MVP) (Lung resistance-related protein)
Length = 893
Score = 201 bits (511), Expect = 1e-51
Identities = 105/173 (60%), Positives = 134/173 (77%)
Frame = +3
Query: 3 ADRIEQQAKGRLERQMITDQAEAERTRTELLQLRAASAAVESTGQAKAEAQSRAEASRIE 182
A R+EQ+A+GRLERQ I DQ+EAE+ R ELL+L A S AVESTG AKAEA+SRAEA+RIE
Sbjct: 677 AQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIE 736
Query: 183 GEANVEQAKLKAEATTIEAENELARVIAARNAEIEYSQKHNEVAETHTQKMADIEIYKFS 362
GE +V QAKLKA+A IE E EL RV R E+ Y++ E+ + Q++A++E+ KF
Sbjct: 737 GEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFK 796
Query: 363 KMVEAIGPNTLIEIAKAGPDGDVRLLQSMGLKSALITDGSTPINLFQTAHGLI 521
+M EAIGP+T+ ++A AGP+ V+LLQS+GLKS LITDGSTPINLF TA GL+
Sbjct: 797 QMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTAFGLL 849
>sp|Q9EQK5|MVP_MOUSE Major vault protein (MVP)
Length = 861
Score = 199 bits (507), Expect = 4e-51
Identities = 105/173 (60%), Positives = 132/173 (76%)
Frame = +3
Query: 3 ADRIEQQAKGRLERQMITDQAEAERTRTELLQLRAASAAVESTGQAKAEAQSRAEASRIE 182
A R+EQ+A+GRLERQ I DQ+EAE+ R ELL+L A S AVESTG AKAEA+SRAEA+RIE
Sbjct: 677 AQRLEQEARGRLERQKILDQSEAEKARKELLELEAMSMAVESTGNAKAEAESRAEAARIE 736
Query: 183 GEANVEQAKLKAEATTIEAENELARVIAARNAEIEYSQKHNEVAETHTQKMADIEIYKFS 362
GE +V QAKLKA+A IE E EL RV R E+ YS+ E+ + Q++AD+E KF
Sbjct: 737 GEGSVLQAKLKAQALAIETEAELERVKKVREMELIYSRAQLELEVSKAQQLADVEAKKFK 796
Query: 363 KMVEAIGPNTLIEIAKAGPDGDVRLLQSMGLKSALITDGSTPINLFQTAHGLI 521
+M EA+GP T+ ++A AGP+ V+LLQS+GLKS LITDGS+PINLF TA GL+
Sbjct: 797 EMTEALGPGTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSSPINLFNTAFGLL 849
>sp|Q9DGM7|MVP_ICTPU Major vault protein (MVP)
Length = 871
Score = 199 bits (505), Expect = 7e-51
Identities = 104/173 (60%), Positives = 135/173 (78%)
Frame = +3
Query: 3 ADRIEQQAKGRLERQMITDQAEAERTRTELLQLRAASAAVESTGQAKAEAQSRAEASRIE 182
A+R+EQ+A+G+LERQ ITDQAEAER R ELL+L A SAAVESTG AKAEAQSRAEA+RI+
Sbjct: 692 AERLEQEARGKLERQKITDQAEAERARKELLELEALSAAVESTGAAKAEAQSRAEAARIQ 751
Query: 183 GEANVEQAKLKAEATTIEAENELARVIAARNAEIEYSQKHNEVAETHTQKMADIEIYKFS 362
GEA V++AKLK EA IEAE E+ R+ AR E+ Y ++ + + QK+ IE +F
Sbjct: 752 GEAAVQEAKLKVEALRIEAEAEMVRLAKAREQELLYKKELDHLEVEKQQKLVTIESQRFK 811
Query: 363 KMVEAIGPNTLIEIAKAGPDGDVRLLQSMGLKSALITDGSTPINLFQTAHGLI 521
++VEAIG TL +A+AGP+ V++LQ++GLKS LITDGS+PINLF TA+GL+
Sbjct: 812 QLVEAIGSETLTAMARAGPELQVKMLQALGLKSTLITDGSSPINLFTTANGLL 864
>sp|Q62667|MVP_RAT Major vault protein (MVP)
Length = 861
Score = 196 bits (499), Expect = 3e-50
Identities = 103/173 (59%), Positives = 132/173 (76%)
Frame = +3
Query: 3 ADRIEQQAKGRLERQMITDQAEAERTRTELLQLRAASAAVESTGQAKAEAQSRAEASRIE 182
A R+EQ+A+GRLERQ I DQ+EAE+ R ELL+L A S AVESTG AKAEA+SRAEA+RIE
Sbjct: 677 AQRLEQEARGRLERQKILDQSEAEKARKELLELEAMSMAVESTGNAKAEAESRAEAARIE 736
Query: 183 GEANVEQAKLKAEATTIEAENELARVIAARNAEIEYSQKHNEVAETHTQKMADIEIYKFS 362
GE +V QAKLKA+A IE E EL RV R E+ Y++ E+ + Q++A++E KF
Sbjct: 737 GEGSVLQAKLKAQALAIETEAELERVKKVREMELIYARAQLELEVSKAQQLANVEAKKFK 796
Query: 363 KMVEAIGPNTLIEIAKAGPDGDVRLLQSMGLKSALITDGSTPINLFQTAHGLI 521
+M EA+GP T+ ++A AGP+ V+LLQS+GLKS LITDGS+PINLF TA GL+
Sbjct: 797 EMTEALGPGTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSSPINLFSTAFGLL 849
>sp|Q90405|MVP_DISOM Major vault protein (MVP100) (P100)
Length = 852
Score = 186 bits (472), Expect = 5e-47
Identities = 98/173 (56%), Positives = 129/173 (74%)
Frame = +3
Query: 3 ADRIEQQAKGRLERQMITDQAEAERTRTELLQLRAASAAVESTGQAKAEAQSRAEASRIE 182
A R+EQ+AKGRLERQ I DQAE+ER R ELL L A S AVES G A+AEA+SRAEASRIE
Sbjct: 667 AARLEQEAKGRLERQRILDQAESERARRELLLLEADSTAVESRGAARAEAESRAEASRIE 726
Query: 183 GEANVEQAKLKAEATTIEAENELARVIAARNAEIEYSQKHNEVAETHTQKMADIEIYKFS 362
GE +V QAKLKA+A IE E EL R+ AR E++Y + N + T++++++E +F
Sbjct: 727 GEGSVLQAKLKAQALDIETEAELERLTKARERELKYIAEQNRLEVEKTRQLSELESRRFQ 786
Query: 363 KMVEAIGPNTLIEIAKAGPDGDVRLLQSMGLKSALITDGSTPINLFQTAHGLI 521
+MV+AIG +T+ IA++GP+ V+LLQ +GL S LITDGSTP+NLF A G++
Sbjct: 787 EMVQAIGADTIRAIAESGPELQVKLLQGLGLNSTLITDGSTPVNLFSAAKGML 839
>sp|P34118|MVPA_DICDI Major vault protein alpha (MVP-alpha)
Length = 843
Score = 175 bits (443), Expect = 1e-43
Identities = 94/173 (54%), Positives = 128/173 (73%)
Frame = +3
Query: 3 ADRIEQQAKGRLERQMITDQAEAERTRTELLQLRAASAAVESTGQAKAEAQSRAEASRIE 182
A+R+EQ A+GRLERQ I D+A+AE R +LLQL+A SAAVESTGQA AEAQ+ AEA+ I
Sbjct: 651 AERLEQGARGRLERQKIHDEAQAELARKDLLQLQAQSAAVESTGQATAEAQATAEAANIA 710
Query: 183 GEANVEQAKLKAEATTIEAENELARVIAARNAEIEYSQKHNEVAETHTQKMADIEIYKFS 362
EANV+QA+LKA+AT I +E+E++ + A R E+ Y + +E+ T +A+IE KF
Sbjct: 711 AEANVKQAELKAQATKIRSESEISLLKAKRENELSYQKSIDELELTKQSDLAEIEASKFK 770
Query: 363 KMVEAIGPNTLIEIAKAGPDGDVRLLQSMGLKSALITDGSTPINLFQTAHGLI 521
+VE+IG +TL IA AG + +LLQ +GLKS +ITDG +P+NLF TA+G+I
Sbjct: 771 AIVESIGRDTLKSIACAGNEMQAKLLQGLGLKSFMITDGKSPLNLFDTANGII 823
>sp|P54659|MVPB_DICDI Major vault protein beta (MVP-beta)
Length = 846
Score = 154 bits (388), Expect = 3e-37
Identities = 83/173 (47%), Positives = 120/173 (69%)
Frame = +3
Query: 3 ADRIEQQAKGRLERQMITDQAEAERTRTELLQLRAASAAVESTGQAKAEAQSRAEASRIE 182
A+R+EQ A+G LERQ I D+A+ E +R++L+QL+A SAAVESTGQA AEA++RAEA+ IE
Sbjct: 663 AERLEQMARGELERQKIIDEAKNEESRSKLVQLQAQSAAVESTGQAVAEARARAEAAIIE 722
Query: 183 GEANVEQAKLKAEATTIEAENELARVIAARNAEIEYSQKHNEVAETHTQKMADIEIYKFS 362
E+ ++QA+L A IEA +E+ + A EI++ + N + ++ A IE KF
Sbjct: 723 AESEIKQARLSTRAIEIEALSEIENLKAKHIVEIQHIKSLNNLELIKAKESATIETTKFE 782
Query: 363 KMVEAIGPNTLIEIAKAGPDGDVRLLQSMGLKSALITDGSTPINLFQTAHGLI 521
VEA+G +T+ IA+A + +LL +GLKS +ITDG +P+NLF TA+GLI
Sbjct: 783 NYVEALGSDTIKSIAQAPEETKAKLLAGLGLKSFMITDGKSPLNLFDTANGLI 835
>sp|P19934|TOLA_ECOLI Protein tolA
Length = 421
Score = 52.4 bits (124), Expect = 1e-06
Identities = 37/120 (30%), Positives = 58/120 (48%)
Frame = +3
Query: 6 DRIEQQAKGRLERQMITDQAEAERTRTELLQLRAASAAVESTGQAKAEAQSRAEASRIEG 185
+R++Q K RL Q QAE + EL Q +A AA ++ AKA+A++ A+A+
Sbjct: 101 ERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQAEEAAAKAAADAKAKAEADAKAAEEAA 160
Query: 186 EANVEQAKLKAEATTIEAENELARVIAARNAEIEYSQKHNEVAETHTQKMADIEIYKFSK 365
+ AK KAEA +A E + A A ++ + E A +K A E + +K
Sbjct: 161 KKAAADAKKKAEAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAK 220
>sp|P30427|PLEC1_RAT Plectin 1 (PLTN) (PCN)
Length = 4687
Score = 44.3 bits (103), Expect = 3e-04
Identities = 43/129 (33%), Positives = 62/129 (48%), Gaps = 17/129 (13%)
Frame = +3
Query: 12 IEQQAKGRLERQMITDQAEAERTRTEL-LQLRAASAAVESTGQAKAEA-QSRA---EASR 176
+ QQ + L++ + +Q ER R+E RAA A E+ QA+ EA QSR EA R
Sbjct: 2197 VVQQREEELQQTLQQEQNMLERLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAER 2256
Query: 177 IEGEANVE-----QAKLKAEATTIEAENELARVIAARNAEIEYSQ-------KHNEVAET 320
++ A + QA+ AE EAE E AR A A ++ Q KH + AE
Sbjct: 2257 LKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQ 2316
Query: 321 HTQKMADIE 347
++ A +E
Sbjct: 2317 TLRQKAQVE 2325
Score = 36.2 bits (82), Expect = 0.077
Identities = 39/131 (29%), Positives = 55/131 (41%), Gaps = 14/131 (10%)
Frame = +3
Query: 6 DRIEQQAKGRLERQMITDQAEAERTRTELLQLRAA--SAAVESTGQAKAEAQSRAEASRI 179
D ++ QA+ E + QAEAER R + L A SA VE + + A+ A+ R
Sbjct: 1679 DELKLQAE---EAERWLCQAEAERARQVQVALETAQRSAEVELQSKRPSFAEKTAQLERT 1735
Query: 180 EGEANVEQAKLKAEA------------TTIEAENELARVIAARNAEIEYSQKHNEVAETH 323
E +V +L+ EA EAE EL R N + + EVA+
Sbjct: 1736 LQEEHVTVTQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1795
Query: 324 TQKMADIEIYK 356
+ AD E K
Sbjct: 1796 SLAQADAEKQK 1806
Score = 32.0 bits (71), Expect = 1.5
Identities = 44/154 (28%), Positives = 70/154 (45%), Gaps = 23/154 (14%)
Frame = +3
Query: 15 EQQAKGRL--ERQMITDQAEAERT--RTELLQLRAASAAVESTGQAKAEAQSRAEASRIE 182
E A+ RL E+++I +AE E+ + +LL+ A E+T + + AE +++
Sbjct: 1842 EGTAQQRLAAEQELIRLRAETEQGEHQRQLLEEELARLQHEATAATQKRQELEAELAKVR 1901
Query: 183 GEANVEQA-KLKAEATT----------IEAE----NELARVIAARNAEIEYSQKHNEVAE 317
E V A K +AE + +EAE ELA A A E +++H E+AE
Sbjct: 1902 AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEARRHRELAE 1961
Query: 318 THTQKM---AD-IEIYKFSKMVEAIGPNTLIEIA 407
+ AD + K + + EA T EIA
Sbjct: 1962 EDAARQRAEADGVLTEKLAAISEATRLKTEAEIA 1995
Score = 31.6 bits (70), Expect = 1.9
Identities = 27/91 (29%), Positives = 43/91 (47%), Gaps = 3/91 (3%)
Frame = +3
Query: 9 RIEQQAKGRLERQMITDQAEAERTRTELLQLRAASAAVESTGQAKAEAQSR---AEASRI 179
R++ +A +++ + AE + R E+ L A+ A E ++ +E + AEA R
Sbjct: 1878 RLQHEATAATQKRQELE-AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1936
Query: 180 EGEANVEQAKLKAEATTIEAENELARVIAAR 272
E E A+L+A A ELA AAR
Sbjct: 1937 R-ELAEEAARLRALAEEARRHRELAEEDAAR 1966
Score = 29.3 bits (64), Expect = 9.4
Identities = 30/115 (26%), Positives = 49/115 (42%), Gaps = 12/115 (10%)
Frame = +3
Query: 9 RIEQQAKGRLERQMITDQAEAERTRTELLQLRAASAAVESTGQAKAE---------AQSR 161
RIE + + + R Q E ++ Q+ +A + Q A AQ R
Sbjct: 2386 RIEAENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR 2445
Query: 162 AEASRIEGE---ANVEQAKLKAEATTIEAENELARVIAARNAEIEYSQKHNEVAE 317
A A ++ E A E +LKAEA ++ + ELA+ AR + + Q ++ E
Sbjct: 2446 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE-QARRLQADKEQMAQQLVE 2499
>sp|Q9JI55|PLEC1_CRIGR Plectin 1 (PLTN) (PCN) (300-kDa intermediate filament-associated
protein) (IFAP300)
Length = 4473
Score = 44.3 bits (103), Expect = 3e-04
Identities = 43/129 (33%), Positives = 62/129 (48%), Gaps = 17/129 (13%)
Frame = +3
Query: 12 IEQQAKGRLERQMITDQAEAERTRTEL-LQLRAASAAVESTGQAKAEA-QSRA---EASR 176
+ QQ + L++ + +Q+ ER R E RAA A E+ QA+ EA QSR EA R
Sbjct: 1983 VVQQREEELQQTLQQEQSMLERLRGEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAER 2042
Query: 177 IEGEANVE-----QAKLKAEATTIEAENELARVIAARNAEIEYSQ-------KHNEVAET 320
++ A + QA+ AE EAE E AR A A ++ Q KH + AE
Sbjct: 2043 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQ 2102
Query: 321 HTQKMADIE 347
++ A +E
Sbjct: 2103 TLRQKAQVE 2111
Score = 35.0 bits (79), Expect = 0.17
Identities = 34/113 (30%), Positives = 47/113 (41%), Gaps = 14/113 (12%)
Frame = +3
Query: 60 QAEAERTRTELLQLRAA--SAAVESTGQAKAEAQSRAEASRIEGEANVEQAKLK------ 215
QA+AER R + L A SA VE + + A+ A+ R E +V +L+
Sbjct: 1480 QAQAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLERTLQEEHVTVTQLREKAERR 1539
Query: 216 ------AEATTIEAENELARVIAARNAEIEYSQKHNEVAETHTQKMADIEIYK 356
AE EAE EL R N + + EVA+ + AD E K
Sbjct: 1540 AQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQRSLAQADAEKQK 1592
Score = 31.6 bits (70), Expect = 1.9
Identities = 34/126 (26%), Positives = 53/126 (42%), Gaps = 13/126 (10%)
Frame = +3
Query: 9 RIEQQAKGRLERQMITDQAEAERTRTELLQLRAASAAVESTGQAKAE---------AQSR 161
RIE + + + R Q E ++ Q+ +A + Q A AQ R
Sbjct: 2172 RIEAENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR 2231
Query: 162 AEASRIEGE---ANVEQAKLKAEATTIEAENELARVIAARNAEIEYSQKHNEVAETH-TQ 329
A A ++ E A E +LKAEA ++ + ELA+ A R E + V ET Q
Sbjct: 2232 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQ 2291
Query: 330 KMADIE 347
+ ++E
Sbjct: 2292 RTLEVE 2297
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,132,586
Number of Sequences: 369166
Number of extensions: 1039532
Number of successful extensions: 3274
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3052
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3237
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5462583840
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)