Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_H13
(862 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q92673|SORL_HUMAN Sortilin-related receptor precursor (S... 59 2e-08
sp|O75074|LRP3_HUMAN Low-density lipoprotein receptor-relat... 58 3e-08
sp|O88204|LRP3_RAT Low-density lipoprotein receptor-related... 58 3e-08
sp|Q9NZR2|LRP1B_HUMAN Low-density lipoprotein receptor-rela... 58 3e-08
sp|Q8VI56|LRP4_MOUSE Low-density lipoprotein receptor-relat... 58 4e-08
sp|Q9QYP1|LRP4_RAT Low-density lipoprotein receptor-related... 57 5e-08
sp|O75096|LRP4_HUMAN Low-density lipoprotein receptor-relat... 57 7e-08
sp|O75581|LRP6_HUMAN Low-density lipoprotein receptor-relat... 55 2e-07
sp|Q9JI18|LRP1B_MOUSE Low-density lipoprotein receptor-rela... 55 2e-07
sp|O88572|LRP6_MOUSE Low-density lipoprotein receptor-relat... 55 2e-07
>sp|Q92673|SORL_HUMAN Sortilin-related receptor precursor (Sorting protein-related receptor
containing LDLR class A repeats) (SorLA) (SorLA-1)
(Low-density lipoprotein receptor relative with 11
ligand-binding repeats) (LDLR relative with 11
ligand-binding repeats) (LR11)
Length = 2214
Score = 58.9 bits (141), Expect = 2e-08
Identities = 28/67 (41%), Positives = 38/67 (56%)
Frame = +3
Query: 3 PTIECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTIT 182
P C + CDG DC +DE +C+P+ C H F+C+ +C+ S+ CDG I
Sbjct: 1245 PNGTCIPSSKHCDGLRDCSDGSDEQHCEPL-C-THFMDFVCKN-RQQCLFHSMVCDGIIQ 1301
Query: 183 CRDGSDE 203
CRDGSDE
Sbjct: 1302 CRDGSDE 1308
Score = 52.0 bits (123), Expect = 2e-06
Identities = 27/67 (40%), Positives = 32/67 (47%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C + CDG DC+ +DE DPV C F C CI S CDG C DG
Sbjct: 1211 CIPQRWACDGDTDCQDGSDE---DPVNCEKKCNGFRCPN--GTCIPSSKHCDGLRDCSDG 1265
Query: 195 SDEHNCD 215
SDE +C+
Sbjct: 1266 SDEQHCE 1272
Score = 48.1 bits (113), Expect = 3e-05
Identities = 26/69 (37%), Positives = 36/69 (52%), Gaps = 3/69 (4%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYC---DPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITC 185
C + +RCDG+ DC+ DE C + C ++ F C+ CI+ S RCDG + C
Sbjct: 1484 CIPNWKRCDGHQDCQDGRDEANCPTHSTLTC--MSREFQCEDGEA-CIVLSERCDGFLDC 1540
Query: 186 RDGSDEHNC 212
D SDE C
Sbjct: 1541 SDESDEKAC 1549
Score = 46.6 bits (109), Expect = 9e-05
Identities = 28/70 (40%), Positives = 32/70 (45%), Gaps = 11/70 (15%)
Frame = +3
Query: 36 CDGYADCESLADEMYCD----------PVQCGAHNK-TFLCQTFPTRCIIESLRCDGTIT 182
CDGY DC +DE C P Q G ++ F C P CI RCDG
Sbjct: 1438 CDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQ-PKTCIPNWKRCDGHQD 1496
Query: 183 CRDGSDEHNC 212
C+DG DE NC
Sbjct: 1497 CQDGRDEANC 1506
Score = 46.2 bits (108), Expect = 1e-04
Identities = 26/69 (37%), Positives = 33/69 (47%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C +CD DC +DE +C+ QC + + C + CI S CDG CRD
Sbjct: 1131 CIPLSYKCDLEDDCGDNSDESHCEMHQC--RSDEYNCSS--GMCIRSSWVCDGDNDCRDW 1186
Query: 195 SDEHNCDMI 221
SDE NC I
Sbjct: 1187 SDEANCTAI 1195
Score = 45.4 bits (106), Expect = 2e-04
Identities = 24/69 (34%), Positives = 30/69 (43%), Gaps = 2/69 (2%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C CDG DC +DE C + F C+ CI + CDG C+DG
Sbjct: 1170 CIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRN--GHCIPQRWACDGDTDCQDG 1227
Query: 195 SDEH--NCD 215
SDE NC+
Sbjct: 1228 SDEDPVNCE 1236
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/61 (39%), Positives = 30/61 (49%)
Frame = +3
Query: 36 CDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDEHNCD 215
CD DC ++DE C C + F CQ T CI S +CD C D SDE +C+
Sbjct: 1097 CDFDNDCGDMSDERNCPTTICDLDTQ-FRCQESGT-CIPLSYKCDLEDDCGDNSDESHCE 1154
Query: 216 M 218
M
Sbjct: 1155 M 1155
Score = 37.4 bits (85), Expect = 0.054
Identities = 20/76 (26%), Positives = 31/76 (40%), Gaps = 7/76 (9%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPT-------RCIIESLRCDG 173
C ++ +CD DC +DE C + P C++++ CDG
Sbjct: 1381 CIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDG 1440
Query: 174 TITCRDGSDEHNCDMI 221
C DGSDE C ++
Sbjct: 1441 YRDCADGSDEEACPLL 1456
>sp|O75074|LRP3_HUMAN Low-density lipoprotein receptor-related protein 3 precursor
(hLRp105)
Length = 770
Score = 58.2 bits (139), Expect = 3e-08
Identities = 31/71 (43%), Positives = 36/71 (50%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
CY+ RC+ C ADE C Q G TF C T CI E+ RCDG C+DG
Sbjct: 430 CYTPADRCNNQKSCPDGADEKNCFSCQPG----TFHCGT--NLCIFETWRCDGQEDCQDG 483
Query: 195 SDEHNCDMILP 227
SDEH C +P
Sbjct: 484 SDEHGCLAAVP 494
Score = 38.1 bits (87), Expect = 0.032
Identities = 24/73 (32%), Positives = 31/73 (42%), Gaps = 6/73 (8%)
Frame = +3
Query: 12 ECYSHKQRCDGYADCESLADEMYC-----DPVQCGAHNKTFLCQ-TFPTRCIIESLRCDG 173
+C +C+ +C +DE C +P TF C TRC+ RCDG
Sbjct: 177 KCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDG 236
Query: 174 TITCRDGSDEHNC 212
C DGSDE C
Sbjct: 237 LQDCGDGSDEAGC 249
Score = 31.6 bits (70), Expect = 3.0
Identities = 13/35 (37%), Positives = 18/35 (51%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTF 119
C ++RCDG DC +DE C + CG +F
Sbjct: 227 CLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSF 261
>sp|O88204|LRP3_RAT Low-density lipoprotein receptor-related protein 3 precursor
(rLRp105)
Length = 770
Score = 58.2 bits (139), Expect = 3e-08
Identities = 31/71 (43%), Positives = 36/71 (50%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
CY+ RC+ C ADE C Q G TF C T CI E+ RCDG C+DG
Sbjct: 430 CYAPADRCNNQKSCPDGADEKNCFSCQPG----TFHCGT--NLCIFETWRCDGQEDCQDG 483
Query: 195 SDEHNCDMILP 227
SDEH C +P
Sbjct: 484 SDEHGCLAAVP 494
Score = 40.0 bits (92), Expect = 0.008
Identities = 25/73 (34%), Positives = 32/73 (43%), Gaps = 6/73 (8%)
Frame = +3
Query: 12 ECYSHKQRCDGYADCESLADEMYC-----DPVQCGAHNKTFLCQ-TFPTRCIIESLRCDG 173
+C +C+ +C +DE C +P TF C TRC+ RCDG
Sbjct: 177 KCLPGPWQCNMVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDG 236
Query: 174 TITCRDGSDEHNC 212
T C DGSDE C
Sbjct: 237 TQDCGDGSDEAGC 249
Score = 32.3 bits (72), Expect = 1.7
Identities = 21/72 (29%), Positives = 29/72 (40%), Gaps = 2/72 (2%)
Frame = +3
Query: 18 YSHKQRCDGYADCESLADEMYCDPVQ--CGAHNKTFLCQTFPTRCIIESLRCDGTITCRD 191
Y + R G+ + + YC P + CG+ ++ T C E RCDG C
Sbjct: 347 YHARARSAGHGFNATYQVKGYCLPWEQPCGSSSEGDDGSTGEQGCFSEPQRCDGWWHCAS 406
Query: 192 GSDEHNCDMILP 227
G DE C P
Sbjct: 407 GRDEQGCPACPP 418
Score = 31.2 bits (69), Expect = 3.9
Identities = 13/35 (37%), Positives = 18/35 (51%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTF 119
C ++RCDG DC +DE C + CG +F
Sbjct: 227 CLPVERRCDGTQDCGDGSDEAGCPDLACGRRLGSF 261
>sp|Q9NZR2|LRP1B_HUMAN Low-density lipoprotein receptor-related protein 1B precursor
(Low-density lipoprotein receptor-related protein-deleted
in tumor) (LRP-DIT)
Length = 4599
Score = 58.2 bits (139), Expect = 3e-08
Identities = 25/67 (37%), Positives = 38/67 (56%)
Frame = +3
Query: 12 ECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRD 191
+C K +CDG+ DC+ DE C+P ++ ++C + CI SL+C+G C D
Sbjct: 3564 QCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICAS--DGCISASLKCNGEYDCAD 3621
Query: 192 GSDEHNC 212
GSDE +C
Sbjct: 3622 GSDEMDC 3628
Score = 54.7 bits (130), Expect = 3e-07
Identities = 30/75 (40%), Positives = 38/75 (50%), Gaps = 1/75 (1%)
Frame = +3
Query: 3 PTIECYSHKQRCDGYADCESLADEMYCD-PVQCGAHNKTFLCQTFPTRCIIESLRCDGTI 179
P C RCDG DCE +DE C+ ++ H F C + RCI ++ CDG I
Sbjct: 1062 PDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWS-TGRCINKAWVCDGDI 1120
Query: 180 TCRDGSDEHNCDMIL 224
C D SDE +CD L
Sbjct: 1121 DCEDQSDEDDCDSFL 1135
Score = 53.5 bits (127), Expect = 7e-07
Identities = 27/67 (40%), Positives = 30/67 (44%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C RCD DC +DE C P C K FLC C+ CDG C DG
Sbjct: 3488 CIPDHWRCDSQNDCSDNSDEENCKPQTCTL--KDFLCANGD--CVSSRFWCDGDFDCADG 3543
Query: 195 SDEHNCD 215
SDE NC+
Sbjct: 3544 SDERNCE 3550
Score = 53.1 bits (126), Expect = 1e-06
Identities = 28/69 (40%), Positives = 31/69 (44%)
Frame = +3
Query: 6 TIECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITC 185
T C S CD DC +DE CD CG H F C+ CI + RCD C
Sbjct: 3446 TKHCISKLWVCDEDPDCADASDEANCDKKTCGPHE--FQCKN--NNCIPDHWRCDSQNDC 3501
Query: 186 RDGSDEHNC 212
D SDE NC
Sbjct: 3502 SDNSDEENC 3510
Score = 48.5 bits (114), Expect = 2e-05
Identities = 26/67 (38%), Positives = 31/67 (46%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C H + CDG DC +DE+ C C F C CI S RC+ I C D
Sbjct: 2564 CIPHGKLCDGENDCGDNSDELDCKVSTCATVE--FRCAD--GTCIPRSARCNQNIDCADA 2619
Query: 195 SDEHNCD 215
SDE NC+
Sbjct: 2620 SDEKNCN 2626
Score = 47.0 bits (110), Expect = 7e-05
Identities = 26/62 (41%), Positives = 32/62 (51%), Gaps = 2/62 (3%)
Frame = +3
Query: 36 CDGYADCESLADEMYCDPVQCG--AHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDEHN 209
CDG DC +DE+ C PVQ F C + RCI+ + CDG C DG DE +
Sbjct: 2659 CDGSNDCGDYSDELKC-PVQNKHKCEENYFSCPS--GRCILNTWICDGQKDCEDGRDEFH 2715
Query: 210 CD 215
CD
Sbjct: 2716 CD 2717
Score = 45.1 bits (105), Expect = 3e-04
Identities = 26/67 (38%), Positives = 32/67 (47%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C S +C+G DC +DEM C +C F C+ CI CDG C DG
Sbjct: 3606 CISASLKCNGEYDCADGSDEMDC-VTEC--KEDQFRCKN-KAHCIPIRWLCDGIHDCVDG 3661
Query: 195 SDEHNCD 215
SDE NC+
Sbjct: 3662 SDEENCE 3668
Score = 44.7 bits (104), Expect = 3e-04
Identities = 26/71 (36%), Positives = 32/71 (45%), Gaps = 1/71 (1%)
Frame = +3
Query: 6 TIECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITC 185
T C + CDG DCE +DE CD CG C + C+ C+G C
Sbjct: 1106 TGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHP--CANDTSVCLQPEKLCNGKKDC 1163
Query: 186 RDGSDE-HNCD 215
DGSDE + CD
Sbjct: 1164 PDGSDEGYLCD 1174
Score = 44.7 bits (104), Expect = 3e-04
Identities = 24/69 (34%), Positives = 32/69 (46%), Gaps = 2/69 (2%)
Frame = +3
Query: 12 ECYSHKQRCDGYADCESLADE--MYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITC 185
EC ++ CDG C+ +DE +YC+ C K + RCI CDG C
Sbjct: 2522 ECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKP----CYNRRCIPHGKLCDGENDC 2577
Query: 186 RDGSDEHNC 212
D SDE +C
Sbjct: 2578 GDNSDELDC 2586
Score = 43.9 bits (102), Expect = 6e-04
Identities = 24/59 (40%), Positives = 31/59 (52%)
Frame = +3
Query: 36 CDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDEHNC 212
CDG DC +DE+ CD C + F C T +CI +LRC+G C D DE +C
Sbjct: 3376 CDGENDCGDNSDELNCDTHVCLSGQ--FKC-TKNQKCIPVNLRCNGQDDCGDEEDERDC 3431
Score = 43.1 bits (100), Expect = 0.001
Identities = 25/67 (37%), Positives = 31/67 (46%)
Frame = +3
Query: 3 PTIECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTIT 182
P+ C + CDG DCE DE +CD C + F C +CI + CDG
Sbjct: 2690 PSGRCILNTWICDGQKDCEDGRDEFHCDS-SCSWNQ--FACSA--QKCISKHWICDGEDD 2744
Query: 183 CRDGSDE 203
C DG DE
Sbjct: 2745 CGDGLDE 2751
Score = 42.7 bits (99), Expect = 0.001
Identities = 23/64 (35%), Positives = 30/64 (46%), Gaps = 4/64 (6%)
Frame = +3
Query: 33 RCDGYADCESLADEM----YCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSD 200
+CDG DC +DE C + ++ F+C+ RCI CD C DGSD
Sbjct: 2864 QCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKN--GRCIPSGGLCDNKDDCGDGSD 2921
Query: 201 EHNC 212
E NC
Sbjct: 2922 ERNC 2925
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/68 (36%), Positives = 29/68 (42%)
Frame = +3
Query: 12 ECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRD 191
+C RC+G DC DE C C F C+T CI + CD C D
Sbjct: 3408 KCIPVNLRCNGQDDCGDEEDERDCPENSCSPDY--FQCKT-TKHCISKLWVCDEDPDCAD 3464
Query: 192 GSDEHNCD 215
SDE NCD
Sbjct: 3465 ASDEANCD 3472
Score = 42.4 bits (98), Expect = 0.002
Identities = 23/72 (31%), Positives = 32/72 (44%)
Frame = +3
Query: 12 ECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRD 191
+C S + CDG DC +DE C+ F C +CI +CDG C+
Sbjct: 3526 DCVSSRFWCDGDFDCADGSDERNCET---SCSKDQFRCSN--GQCIPAKWKCDGHEDCKY 3580
Query: 192 GSDEHNCDMILP 227
G DE +C+ P
Sbjct: 3581 GEDEKSCEPASP 3592
Score = 41.6 bits (96), Expect = 0.003
Identities = 21/72 (29%), Positives = 30/72 (41%), Gaps = 6/72 (8%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQC------GAHNKTFLCQTFPTRCIIESLRCDGT 176
C RC+ DC +DE C+ C G F+ + C++ + CDG+
Sbjct: 2603 CIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGS 2662
Query: 177 ITCRDGSDEHNC 212
C D SDE C
Sbjct: 2663 NDCGDYSDELKC 2674
Score = 40.0 bits (92), Expect = 0.008
Identities = 25/68 (36%), Positives = 30/68 (44%), Gaps = 3/68 (4%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHN---KTFLCQTFPTRCIIESLRCDGTITC 185
C + +CDG DC +DE D V C H+ F CQ RCI + CDG C
Sbjct: 857 CIQARWKCDGDDDCLDGSDE---DSVNCFNHSCPDDQFKCQN--NRCIPKRWLCDGANDC 911
Query: 186 RDGSDEHN 209
DE N
Sbjct: 912 GSNEDESN 919
Score = 38.9 bits (89), Expect = 0.019
Identities = 25/66 (37%), Positives = 28/66 (42%), Gaps = 2/66 (3%)
Frame = +3
Query: 12 ECYSHKQRCDGYADCESLADEM--YCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITC 185
+C S CDG DC DE C + C A F CQ C+ CDG C
Sbjct: 2731 KCISKHWICDGEDDCGDGLDESDSICGAITCAAD--MFSCQG-SRACVPRHWLCDGERDC 2787
Query: 186 RDGSDE 203
DGSDE
Sbjct: 2788 PDGSDE 2793
Score = 38.9 bits (89), Expect = 0.019
Identities = 22/70 (31%), Positives = 29/70 (41%), Gaps = 4/70 (5%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQC----GAHNKTFLCQTFPTRCIIESLRCDGTIT 182
C +Q C+G +C +DE +C F C +CI L+CD
Sbjct: 3729 CLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSN--KKCIPMDLQCDRLDD 3786
Query: 183 CRDGSDEHNC 212
C DGSDE C
Sbjct: 3787 CGDGSDEQGC 3796
Score = 38.1 bits (87), Expect = 0.032
Identities = 24/67 (35%), Positives = 29/67 (43%), Gaps = 1/67 (1%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMY-CDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRD 191
C CD DC DEM C+ C + F+C++ RCI CD C D
Sbjct: 939 CIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQ-FVCKS--GRCISSKWHCDSDDDCGD 995
Query: 192 GSDEHNC 212
GSDE C
Sbjct: 996 GSDEVGC 1002
Score = 37.7 bits (86), Expect = 0.041
Identities = 25/71 (35%), Positives = 31/71 (43%), Gaps = 1/71 (1%)
Frame = +3
Query: 6 TIECYSHKQRCDGYADCESLADEMY-CDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTIT 182
T +C +CD DC +DE C +C F C T C + + CDG
Sbjct: 3326 TDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGR--FQCGT--GLCALPAFICDGEND 3381
Query: 183 CRDGSDEHNCD 215
C D SDE NCD
Sbjct: 3382 CGDNSDELNCD 3392
Score = 36.2 bits (82), Expect = 0.12
Identities = 28/79 (35%), Positives = 32/79 (40%), Gaps = 7/79 (8%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLC-QTFPTRC------IIESLRCDG 173
C H CDG DC +DE P C FLC T P RC + C+G
Sbjct: 3686 CKLHFWVCDGEDDCGDNSDEA---PDMC----VKFLCPSTRPHRCRNNRICLQSEQMCNG 3738
Query: 174 TITCRDGSDEHNCDMILPY 230
C D SDE +C L Y
Sbjct: 3739 IDECGDNSDEDHCGGKLTY 3757
Score = 35.8 bits (81), Expect = 0.16
Identities = 23/63 (36%), Positives = 27/63 (42%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C S K CD DC +DE+ C + F C + RCI CDG C D
Sbjct: 980 CISSKWHCDSDDDCGDGSDEVGCVH---SCFDNQFRCSS--GRCIPGHWACDGDNDCGDF 1034
Query: 195 SDE 203
SDE
Sbjct: 1035 SDE 1037
Score = 34.7 bits (78), Expect = 0.35
Identities = 22/67 (32%), Positives = 27/67 (40%), Gaps = 4/67 (5%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHN----KTFLCQTFPTRCIIESLRCDGTIT 182
C CDG DC +DE+ C +N F+C CI + CD
Sbjct: 2774 CVPRHWLCDGERDCPDGSDEL--STAGCAPNNTCDENAFMCHN--KVCIPKQFVCDHDDD 2829
Query: 183 CRDGSDE 203
C DGSDE
Sbjct: 2830 CGDGSDE 2836
Score = 32.7 bits (73), Expect = 1.3
Identities = 18/45 (40%), Positives = 22/45 (48%)
Frame = +3
Query: 69 DEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDE 203
D+ CDP + FLC T C+ +S CDG C D SDE
Sbjct: 28 DQQLCDPGE-------FLCHDHVT-CVSQSWLCDGDPDCPDDSDE 64
Score = 32.7 bits (73), Expect = 1.3
Identities = 21/70 (30%), Positives = 31/70 (44%), Gaps = 5/70 (7%)
Frame = +3
Query: 9 IECYSHKQRCDGYADCESLADEMY--CDP---VQCGAHNKTFLCQTFPTRCIIESLRCDG 173
+ C S CDG DC +DE C ++C ++ L +C+ S C+G
Sbjct: 43 VTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTN---KCVHLSQLCNG 99
Query: 174 TITCRDGSDE 203
+ C DG DE
Sbjct: 100 VLDCPDGYDE 109
>sp|Q8VI56|LRP4_MOUSE Low-density lipoprotein receptor-related protein 4 precursor (LDLR
dan)
Length = 1905
Score = 57.8 bits (138), Expect = 4e-08
Identities = 29/67 (43%), Positives = 36/67 (53%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C + RCDG ADC+ +DE C C A F C++ RC+ S RCDG C D
Sbjct: 243 CINSGWRCDGDADCDDQSDERNCTTSMCTAEQ--FRCRS--GRCVRLSWRCDGEDDCADN 298
Query: 195 SDEHNCD 215
SDE NC+
Sbjct: 299 SDEENCE 305
Score = 50.4 bits (119), Expect = 6e-06
Identities = 28/71 (39%), Positives = 34/71 (47%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C CDG DC +DE CD +C +K F C CI E CDG C+DG
Sbjct: 122 CIRSLWHCDGDNDCGDNSDEQ-CDMRKCS--DKEFRCSD--GSCIAEHWYCDGDTDCKDG 176
Query: 195 SDEHNCDMILP 227
SDE +C +P
Sbjct: 177 SDEESCPSAVP 187
Score = 47.0 bits (110), Expect = 7e-05
Identities = 28/69 (40%), Positives = 31/69 (44%)
Frame = +3
Query: 12 ECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRD 191
+C CDG DCE +DE C P +C F CQ CI CDG C D
Sbjct: 82 KCIRRSWVCDGDNDCEDDSDEQDCPpreC--EEDEFPCQN--GYCIRSLWHCDGDNDCGD 137
Query: 192 GSDEHNCDM 218
SDE CDM
Sbjct: 138 NSDE-QCDM 145
Score = 42.0 bits (97), Expect = 0.002
Identities = 23/71 (32%), Positives = 29/71 (40%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C + CDG DC+ +DE C Q RCI++ CDG C D
Sbjct: 160 CIAEHWYCDGDTDCKDGSDEESCPSAVPSPPCNLEEFQCAYGRCILDIYHCDGDDDCGDW 219
Query: 195 SDEHNCDMILP 227
SDE +C P
Sbjct: 220 SDESDCSSHQP 230
Score = 41.2 bits (95), Expect = 0.004
Identities = 24/66 (36%), Positives = 30/66 (45%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C + +CDG DC +DE C C + F C +CI S CDG C D
Sbjct: 44 CIPAQWQCDGDNDCGDHSDEDGCTLPTCSPLD--FHCDN--GKCIRRSWVCDGDNDCEDD 99
Query: 195 SDEHNC 212
SDE +C
Sbjct: 100 SDEQDC 105
Score = 40.4 bits (93), Expect = 0.006
Identities = 27/72 (37%), Positives = 33/72 (45%), Gaps = 6/72 (8%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPV---QCGAHNKTFLCQTFPTRCIIESLRCDGTITC 185
C RCDG DC +DE C+ QC + FLC + RCI + C+G C
Sbjct: 282 CVRLSWRCDGEDDCADNSDEENCENTGSPQCASDQ--FLC--WNGRCIGQRKLCNGINDC 337
Query: 186 RDGSDE---HNC 212
D SDE NC
Sbjct: 338 GDSSDESPQQNC 349
>sp|Q9QYP1|LRP4_RAT Low-density lipoprotein receptor-related protein 4 precursor
(Multiple epidermal growth factor-like domains 7)
Length = 1905
Score = 57.4 bits (137), Expect = 5e-08
Identities = 29/67 (43%), Positives = 36/67 (53%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C + RCDG ADC+ +DE C C A F C++ RC+ S RCDG C D
Sbjct: 243 CVNAGWRCDGDADCDDQSDERNCTTSMCTAEQ--FRCRS--GRCVRLSWRCDGEDDCADN 298
Query: 195 SDEHNCD 215
SDE NC+
Sbjct: 299 SDEENCE 305
Score = 50.4 bits (119), Expect = 6e-06
Identities = 28/71 (39%), Positives = 34/71 (47%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C CDG DC +DE CD +C +K F C CI E CDG C+DG
Sbjct: 122 CIRSLWHCDGDNDCGDNSDEQ-CDMRKCS--DKEFRCSD--GSCIAEHWYCDGDTDCKDG 176
Query: 195 SDEHNCDMILP 227
SDE +C +P
Sbjct: 177 SDEESCPSAVP 187
Score = 47.0 bits (110), Expect = 7e-05
Identities = 28/69 (40%), Positives = 31/69 (44%)
Frame = +3
Query: 12 ECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRD 191
+C CDG DCE +DE C P +C F CQ CI CDG C D
Sbjct: 82 KCIRRSWVCDGDNDCEDDSDEQDCPpreC--EEDEFPCQN--GYCIRSLWHCDGDNDCGD 137
Query: 192 GSDEHNCDM 218
SDE CDM
Sbjct: 138 NSDE-QCDM 145
Score = 42.0 bits (97), Expect = 0.002
Identities = 23/71 (32%), Positives = 29/71 (40%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C + CDG DC+ +DE C Q RCI++ CDG C D
Sbjct: 160 CIAEHWYCDGDTDCKDGSDEESCPSAVPSPPCNLEEFQCAYGRCILDIYHCDGDDDCGDW 219
Query: 195 SDEHNCDMILP 227
SDE +C P
Sbjct: 220 SDESDCSSHQP 230
Score = 41.2 bits (95), Expect = 0.004
Identities = 24/66 (36%), Positives = 30/66 (45%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C + +CDG DC +DE C C + F C +CI S CDG C D
Sbjct: 44 CIPAQWQCDGDNDCGDHSDEDGCTLPTCSPLD--FHCDN--GKCIRRSWVCDGDNDCEDD 99
Query: 195 SDEHNC 212
SDE +C
Sbjct: 100 SDEQDC 105
Score = 40.8 bits (94), Expect = 0.005
Identities = 27/72 (37%), Positives = 33/72 (45%), Gaps = 6/72 (8%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPV---QCGAHNKTFLCQTFPTRCIIESLRCDGTITC 185
C RCDG DC +DE C+ QC + FLC + RCI + C+G C
Sbjct: 282 CVRLSWRCDGEDDCADNSDEENCENTGSPQCASDQ--FLC--WNGRCIGQRKLCNGVNDC 337
Query: 186 RDGSDE---HNC 212
D SDE NC
Sbjct: 338 GDNSDESPQQNC 349
>sp|O75096|LRP4_HUMAN Low-density lipoprotein receptor-related protein 4 precursor
(Multiple epidermal growth factor-like domains 7)
Length = 1950
Score = 57.0 bits (136), Expect = 7e-08
Identities = 29/67 (43%), Positives = 35/67 (52%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C + RCDG ADC+ +DE C C A F C + RC+ S RCDG C D
Sbjct: 288 CINAGWRCDGDADCDDQSDERNCTTSMCTAEQ--FRCHS--GRCVRLSWRCDGEDDCADN 343
Query: 195 SDEHNCD 215
SDE NC+
Sbjct: 344 SDEENCE 350
Score = 52.4 bits (124), Expect = 2e-06
Identities = 29/71 (40%), Positives = 34/71 (47%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C CDG DC +DE CD +C +K F C CI E CDG C+DG
Sbjct: 167 CIRSLWHCDGDNDCGDNSDEQ-CDMRKCS--DKEFRCSD--GSCIAEHWYCDGDTDCKDG 221
Query: 195 SDEHNCDMILP 227
SDE NC +P
Sbjct: 222 SDEENCPSAVP 232
Score = 47.0 bits (110), Expect = 7e-05
Identities = 28/69 (40%), Positives = 31/69 (44%)
Frame = +3
Query: 12 ECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRD 191
+C CDG DCE +DE C P +C F CQ CI CDG C D
Sbjct: 127 KCIRRSWVCDGDNDCEDDSDEQDCPpreC--EEDEFPCQN--GYCIRSLWHCDGDNDCGD 182
Query: 192 GSDEHNCDM 218
SDE CDM
Sbjct: 183 NSDE-QCDM 190
Score = 42.0 bits (97), Expect = 0.002
Identities = 23/71 (32%), Positives = 29/71 (40%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C + CDG DC+ +DE C Q RCI++ CDG C D
Sbjct: 205 CIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDW 264
Query: 195 SDEHNCDMILP 227
SDE +C P
Sbjct: 265 SDESDCSSHQP 275
Score = 40.4 bits (93), Expect = 0.006
Identities = 24/66 (36%), Positives = 30/66 (45%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C + +CDG DC +DE C C + F C +CI S CDG C D
Sbjct: 89 CIPAQWQCDGDNDCGDHSDEDGCILPTCSPLD--FHCDN--GKCIRRSWVCDGDNDCEDD 144
Query: 195 SDEHNC 212
SDE +C
Sbjct: 145 SDEQDC 150
Score = 40.0 bits (92), Expect = 0.008
Identities = 27/72 (37%), Positives = 32/72 (44%), Gaps = 6/72 (8%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPV---QCGAHNKTFLCQTFPTRCIIESLRCDGTITC 185
C RCDG DC +DE C+ QC FLC + RCI + C+G C
Sbjct: 327 CVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQ--FLC--WNGRCIGQRKLCNGVNDC 382
Query: 186 RDGSDE---HNC 212
D SDE NC
Sbjct: 383 GDNSDESPQQNC 394
>sp|O75581|LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 precursor
Length = 1613
Score = 55.5 bits (132), Expect = 2e-07
Identities = 28/71 (39%), Positives = 41/71 (57%)
Frame = +3
Query: 9 IECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCR 188
I+C RCDG+ +CE +DE+ C PV F C + +CI +LRC+G C+
Sbjct: 1261 IDCIPVAWRCDGFTECEDHSDELNC-PV---CSESQFQCAS--GQCIDGALRCNGDANCQ 1314
Query: 189 DGSDEHNCDMI 221
D SDE NC+++
Sbjct: 1315 DKSDEKNCEVL 1325
Score = 40.4 bits (93), Expect = 0.006
Identities = 23/67 (34%), Positives = 34/67 (50%)
Frame = +3
Query: 12 ECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRD 191
+C RC+G A+C+ +DE C+ V C F C +CI + +CD + C D
Sbjct: 1299 QCIDGALRCNGDANCQDKSDEKNCE-VLCLIDQ--FRCAN--GQCIGKHKKCDHNVDCSD 1353
Query: 192 GSDEHNC 212
SDE +C
Sbjct: 1354 KSDELDC 1360
Score = 39.7 bits (91), Expect = 0.011
Identities = 24/61 (39%), Positives = 27/61 (44%), Gaps = 1/61 (1%)
Frame = +3
Query: 33 RCDGYADCESLADEMYC-DPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDEHN 209
RC L DE+ C +P C F C T CI + RCDG C D SDE N
Sbjct: 1227 RCSCPMHLVLLQDELSCGEPPTCSPQQ--FTCFTGEIDCIPVAWRCDGFTECEDHSDELN 1284
Query: 210 C 212
C
Sbjct: 1285 C 1285
>sp|Q9JI18|LRP1B_MOUSE Low-density lipoprotein receptor-related protein 1B precursor
(Low-density lipoprotein receptor-related protein-deleted
in tumor) (LRP-DIT)
Length = 4599
Score = 55.5 bits (132), Expect = 2e-07
Identities = 29/75 (38%), Positives = 38/75 (50%), Gaps = 1/75 (1%)
Frame = +3
Query: 3 PTIECYSHKQRCDGYADCESLADEMYCD-PVQCGAHNKTFLCQTFPTRCIIESLRCDGTI 179
P C RCDG DCE +DE C+ ++ H F C++ RCI + CDG +
Sbjct: 1062 PDGNCIPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCRS-TGRCINNAWVCDGDV 1120
Query: 180 TCRDGSDEHNCDMIL 224
C D SDE +CD L
Sbjct: 1121 DCEDQSDEEDCDSFL 1135
Score = 55.1 bits (131), Expect = 3e-07
Identities = 25/67 (37%), Positives = 38/67 (56%)
Frame = +3
Query: 12 ECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRD 191
+C S K +CDG+ DC+ DE C+P + ++C + C+ SL+C+G C D
Sbjct: 3564 QCLSAKWKCDGHEDCKYGEDEKNCEPAFPVCSSSEYMCAS--GGCLSASLKCNGEPDCVD 3621
Query: 192 GSDEHNC 212
GSDE +C
Sbjct: 3622 GSDEMDC 3628
Score = 53.1 bits (126), Expect = 1e-06
Identities = 27/67 (40%), Positives = 30/67 (44%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C RCD DC +DE C P C K FLC C+ CDG C DG
Sbjct: 3488 CIPDHWRCDNQNDCSDNSDEDNCKPQTCTL--KDFLCSNGD--CVSSRFWCDGEFDCADG 3543
Query: 195 SDEHNCD 215
SDE NC+
Sbjct: 3544 SDEKNCE 3550
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/69 (40%), Positives = 31/69 (44%)
Frame = +3
Query: 6 TIECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITC 185
T C S CD DC +DE CD CG H F C+ CI + RCD C
Sbjct: 3446 TKHCISKLWVCDEDPDCADASDEANCDKKTCGPHE--FQCKN--NNCIPDHWRCDNQNDC 3501
Query: 186 RDGSDEHNC 212
D SDE NC
Sbjct: 3502 SDNSDEDNC 3510
Score = 47.0 bits (110), Expect = 7e-05
Identities = 26/71 (36%), Positives = 34/71 (47%), Gaps = 1/71 (1%)
Frame = +3
Query: 6 TIECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITC 185
T C ++ CDG DCE +DE CD CG + C + C+ C+G C
Sbjct: 1106 TGRCINNAWVCDGDVDCEDQSDEEDCDSFLCGP--PKYPCANDTSVCLQPEKLCNGRKDC 1163
Query: 186 RDGSDEHN-CD 215
DGSDE + CD
Sbjct: 1164 PDGSDEGDLCD 1174
Score = 45.4 bits (106), Expect = 2e-04
Identities = 24/67 (35%), Positives = 30/67 (44%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C H + CDG DC +DE+ C C F C CI S RC+ + C D
Sbjct: 2564 CVPHGKLCDGTNDCGDSSDELDCKVSTCSTVE--FRCAD--GTCIPRSARCNQNMDCSDA 2619
Query: 195 SDEHNCD 215
SDE C+
Sbjct: 2620 SDEKGCN 2626
Score = 45.1 bits (105), Expect = 3e-04
Identities = 23/69 (33%), Positives = 33/69 (47%), Gaps = 2/69 (2%)
Frame = +3
Query: 12 ECYSHKQRCDGYADCESLADE--MYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITC 185
+C + CDG C+ +DE +YC+ C + K + RC+ CDGT C
Sbjct: 2522 DCVDYVLTCDGIPHCKDKSDEKLLYCENRSCRSGFKP----CYNRRCVPHGKLCDGTNDC 2577
Query: 186 RDGSDEHNC 212
D SDE +C
Sbjct: 2578 GDSSDELDC 2586
Score = 45.1 bits (105), Expect = 3e-04
Identities = 26/62 (41%), Positives = 32/62 (51%), Gaps = 2/62 (3%)
Frame = +3
Query: 36 CDGYADCESLADEMYCDPVQCG--AHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDEHN 209
CDG DC +DE+ C PVQ F C + RCI+ + CDG C DG DE +
Sbjct: 2659 CDGSNDCGDYSDELKC-PVQNKHKCEENYFGCPS--GRCILNTWVCDGQKDCEDGLDELH 2715
Query: 210 CD 215
CD
Sbjct: 2716 CD 2717
Score = 45.1 bits (105), Expect = 3e-04
Identities = 23/72 (31%), Positives = 32/72 (44%)
Frame = +3
Query: 12 ECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRD 191
+C S + CDG DC +DE C+ F C +C+ +CDG C+
Sbjct: 3526 DCVSSRFWCDGEFDCADGSDEKNCET---SCSKDQFQCSN--GQCLSAKWKCDGHEDCKY 3580
Query: 192 GSDEHNCDMILP 227
G DE NC+ P
Sbjct: 3581 GEDEKNCEPAFP 3592
Score = 44.7 bits (104), Expect = 3e-04
Identities = 25/59 (42%), Positives = 31/59 (52%)
Frame = +3
Query: 36 CDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDEHNC 212
CDG DC +DE+ CD C A F C T +CI +LRC+G C D DE +C
Sbjct: 3376 CDGENDCGDNSDELNCDTHVCLAGQ--FKC-TKNKKCIPVNLRCNGQDDCGDEEDEKDC 3431
Score = 43.1 bits (100), Expect = 0.001
Identities = 22/72 (30%), Positives = 31/72 (43%), Gaps = 6/72 (8%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQC------GAHNKTFLCQTFPTRCIIESLRCDGT 176
C RC+ DC +DE C+ C G + F+ + C++ S CDG+
Sbjct: 2603 CIPRSARCNQNMDCSDASDEKGCNNTDCTHFYKLGVKSTGFIRCNSTSLCVLPSWICDGS 2662
Query: 177 ITCRDGSDEHNC 212
C D SDE C
Sbjct: 2663 NDCGDYSDELKC 2674
Score = 43.1 bits (100), Expect = 0.001
Identities = 25/66 (37%), Positives = 31/66 (46%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C S +C+G DC +DEM C ++C F C+ CI CDG C DG
Sbjct: 3606 CLSASLKCNGEPDCVDGSDEMDC-VIEC--KEDQFQCKN-KAYCIPIRWLCDGIYDCVDG 3661
Query: 195 SDEHNC 212
SDE C
Sbjct: 3662 SDEETC 3667
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/68 (36%), Positives = 29/68 (42%)
Frame = +3
Query: 12 ECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRD 191
+C RC+G DC DE C C F C+T CI + CD C D
Sbjct: 3408 KCIPVNLRCNGQDDCGDEEDEKDCPENSCSPDY--FQCKT-TKHCISKLWVCDEDPDCAD 3464
Query: 192 GSDEHNCD 215
SDE NCD
Sbjct: 3465 ASDEANCD 3472
Score = 42.4 bits (98), Expect = 0.002
Identities = 24/73 (32%), Positives = 31/73 (42%), Gaps = 6/73 (8%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQ------CGAHNKTFLCQTFPTRCIIESLRCDGT 176
C CDG DC +DE + + + G F C+ CI + RCDG
Sbjct: 1018 CIPGHWACDGDNDCGDFSDETHINCTKEEARSPAGCIGNEFQCRP-DGNCIPDLWRCDGE 1076
Query: 177 ITCRDGSDEHNCD 215
C DGSDE C+
Sbjct: 1077 KDCEDGSDEKGCN 1089
Score = 41.6 bits (96), Expect = 0.003
Identities = 24/67 (35%), Positives = 31/67 (46%)
Frame = +3
Query: 3 PTIECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTIT 182
P+ C + CDG DCE DE++CD C + F C +CI + CDG
Sbjct: 2690 PSGRCILNTWVCDGQKDCEDGLDELHCDS-SCSWNQ--FACSV--KKCISKHWICDGEDD 2744
Query: 183 CRDGSDE 203
C D DE
Sbjct: 2745 CGDSLDE 2751
Score = 40.4 bits (93), Expect = 0.006
Identities = 26/66 (39%), Positives = 29/66 (43%), Gaps = 2/66 (3%)
Frame = +3
Query: 12 ECYSHKQRCDGYADCESLADEM--YCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITC 185
+C S CDG DC DE C V C A F CQ C+ + CDG C
Sbjct: 2731 KCISKHWICDGEDDCGDSLDESDSICGAVTCAAD--MFSCQGSHA-CVPQHWLCDGERDC 2787
Query: 186 RDGSDE 203
DGSDE
Sbjct: 2788 PDGSDE 2793
Score = 40.4 bits (93), Expect = 0.006
Identities = 23/64 (35%), Positives = 31/64 (48%), Gaps = 4/64 (6%)
Frame = +3
Query: 33 RCDGYADCESLADEMYCDP----VQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSD 200
+CDG DC +DE +P + ++ F+C+ RCI CD C DGSD
Sbjct: 2864 QCDGDFDCPDSSDEAPINPRCRSAEHSCNSSFFMCKN--GRCIPSDGLCDIRDDCGDGSD 2921
Query: 201 EHNC 212
E NC
Sbjct: 2922 ETNC 2925
Score = 39.7 bits (91), Expect = 0.011
Identities = 25/68 (36%), Positives = 30/68 (44%), Gaps = 3/68 (4%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHN---KTFLCQTFPTRCIIESLRCDGTITC 185
C + +CDG DC +DE D V C H+ F CQ RCI + CDG C
Sbjct: 857 CIQARWKCDGDDDCLDGSDE---DSVTCFNHSCPDDQFKCQN--NRCIPKRWLCDGANDC 911
Query: 186 RDGSDEHN 209
DE N
Sbjct: 912 GSNEDESN 919
Score = 38.1 bits (87), Expect = 0.032
Identities = 22/70 (31%), Positives = 28/70 (40%), Gaps = 4/70 (5%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQC----GAHNKTFLCQTFPTRCIIESLRCDGTIT 182
C ++ C+G DC +DE +C F C CI L+CD
Sbjct: 3729 CLQLEKICNGINDCGDNSDEEHCSGKLSLKSKPCKKDEFTCSN--RNCIPMELQCDSLDD 3786
Query: 183 CRDGSDEHNC 212
C DGSDE C
Sbjct: 3787 CGDGSDEQGC 3796
Score = 37.7 bits (86), Expect = 0.041
Identities = 25/71 (35%), Positives = 31/71 (43%), Gaps = 1/71 (1%)
Frame = +3
Query: 6 TIECYSHKQRCDGYADCESLADEMY-CDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTIT 182
T +C +CD DC +DE C +C F C T C + + CDG
Sbjct: 3326 TDKCIPFWWKCDTVDDCGDGSDEPDDCPEFKCQPGR--FQCGT--GLCALPAFICDGEND 3381
Query: 183 CRDGSDEHNCD 215
C D SDE NCD
Sbjct: 3382 CGDNSDELNCD 3392
Score = 36.2 bits (82), Expect = 0.12
Identities = 24/77 (31%), Positives = 34/77 (44%), Gaps = 4/77 (5%)
Frame = +3
Query: 9 IECYSHKQRCDGYADCESLADEMY--C-DPVQCGAHNKTFLCQTFPTRCIIESLRCDGTI 179
+ C S CDG DC +DE C + V+ C + C+ S C+G +
Sbjct: 43 VTCVSQSWLCDGDPDCPDQSDESLDTCPEEVEIKCPLNHIACHG-SSACVHLSKLCNGVV 101
Query: 180 TCRDGSDE-HNCDMILP 227
C DG DE +C +LP
Sbjct: 102 DCPDGFDEGGHCQELLP 118
Score = 36.2 bits (82), Expect = 0.12
Identities = 21/63 (33%), Positives = 26/63 (41%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C + CDG DC +DE C + FLC + C + CDG C D
Sbjct: 3645 CIPIRWLCDGIYDCVDGSDEETCGRGGSICRDDEFLCNN--SLCKLHFWVCDGEDDCGDN 3702
Query: 195 SDE 203
SDE
Sbjct: 3703 SDE 3705
Score = 35.4 bits (80), Expect = 0.21
Identities = 23/63 (36%), Positives = 28/63 (44%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDG 194
C S+K CD DC +DE+ C + F C + RCI CDG C D
Sbjct: 980 CISNKWHCDTDDDCGDRSDEVGC---VHSCLDDQFRCSS--GRCIPGHWACDGDNDCGDF 1034
Query: 195 SDE 203
SDE
Sbjct: 1035 SDE 1037
Score = 34.7 bits (78), Expect = 0.35
Identities = 22/67 (32%), Positives = 27/67 (40%), Gaps = 4/67 (5%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADEMYCDPVQCGAHN----KTFLCQTFPTRCIIESLRCDGTIT 182
C CDG DC +DE+ C +N F+C CI + CD
Sbjct: 2774 CVPQHWLCDGERDCPDGSDEL--SSAGCAPNNTCDENAFMCHN--KVCIPKQFVCDHDDD 2829
Query: 183 CRDGSDE 203
C DGSDE
Sbjct: 2830 CGDGSDE 2836
Score = 32.3 bits (72), Expect = 1.7
Identities = 21/60 (35%), Positives = 27/60 (45%), Gaps = 1/60 (1%)
Frame = +3
Query: 36 CDGYADCESLADEMY-CDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDEHNC 212
CD DC DE+ C+ C + F+C++ RCI CD C D SDE C
Sbjct: 946 CDREDDCGDQTDEVASCEFPTCEPLTQ-FICKS--GRCISNKWHCDTDDDCGDRSDEVGC 1002
Score = 31.6 bits (70), Expect = 3.0
Identities = 18/45 (40%), Positives = 22/45 (48%)
Frame = +3
Query: 69 DEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDE 203
D+ CDP + FLC T C+ +S CDG C D SDE
Sbjct: 28 DQHLCDPGE-------FLCHDHVT-CVSQSWLCDGDPDCPDQSDE 64
Score = 30.8 bits (68), Expect = 5.1
Identities = 23/65 (35%), Positives = 26/65 (40%), Gaps = 2/65 (3%)
Frame = +3
Query: 15 CYSHKQRCDGYADCESLADE--MYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCR 188
C + CDG DC S DE C C A F C RCI + CD C
Sbjct: 898 CIPKRWLCDGANDCGSNEDESNQTCTARTCQADQ--FSCGN--GRCIPTAWLCDREDDCG 953
Query: 189 DGSDE 203
D +DE
Sbjct: 954 DQTDE 958
>sp|O88572|LRP6_MOUSE Low-density lipoprotein receptor-related protein 6 precursor
Length = 1613
Score = 55.5 bits (132), Expect = 2e-07
Identities = 28/71 (39%), Positives = 41/71 (57%)
Frame = +3
Query: 9 IECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCR 188
I+C RCDG+ +CE +DE+ C PV F C + +CI +LRC+G C+
Sbjct: 1261 IDCIPVAWRCDGFTECEDHSDELNC-PV---CSESQFQCAS--GQCIDGALRCNGDANCQ 1314
Query: 189 DGSDEHNCDMI 221
D SDE NC+++
Sbjct: 1315 DKSDEKNCEVL 1325
Score = 40.4 bits (93), Expect = 0.006
Identities = 22/67 (32%), Positives = 35/67 (52%)
Frame = +3
Query: 12 ECYSHKQRCDGYADCESLADEMYCDPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRD 191
+C RC+G A+C+ +DE C+ V C F C +C+ + +CD ++ C D
Sbjct: 1299 QCIDGALRCNGDANCQDKSDEKNCE-VLCLIDQ--FRCAN--GQCVGKHKKCDHSVDCSD 1353
Query: 192 GSDEHNC 212
SDE +C
Sbjct: 1354 RSDELDC 1360
Score = 39.7 bits (91), Expect = 0.011
Identities = 24/61 (39%), Positives = 27/61 (44%), Gaps = 1/61 (1%)
Frame = +3
Query: 33 RCDGYADCESLADEMYC-DPVQCGAHNKTFLCQTFPTRCIIESLRCDGTITCRDGSDEHN 209
RC L DE+ C +P C F C T CI + RCDG C D SDE N
Sbjct: 1227 RCSCPMHLVLLQDELSCGEPPTCSPQQ--FTCFTGDIDCIPVAWRCDGFTECEDHSDELN 1284
Query: 210 C 212
C
Sbjct: 1285 C 1285
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,231,124
Number of Sequences: 369166
Number of extensions: 2064998
Number of successful extensions: 6921
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5483
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6382
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8534739105
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)