Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_G24
(449 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 169 3e-42
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 166 3e-41
sp|P13277|CYSP1_HOMAM Digestive cysteine proteinase 1 precu... 164 8e-41
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 160 1e-39
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 160 2e-39
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 156 2e-38
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 155 3e-38
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 155 4e-38
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 154 1e-37
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 153 2e-37
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 169 bits (427), Expect = 3e-42
Identities = 77/124 (62%), Positives = 95/124 (76%), Gaps = 1/124 (0%)
Frame = +2
Query: 11 DGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIYNE 190
D +C ++K+ + + TG+VDIP G E + A AT+GP+SVAIDAS+ SFQLY G+YNE
Sbjct: 216 DDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNE 275
Query: 191 PDCSSTQLDHGVLVVGYGT-EDGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGIATMAS 367
P+C LDHGVLVVGYGT E G +YWLVKNSWGT WG GYIKM+++ NNQCGIAT +S
Sbjct: 276 PECDEQNLDHGVLVVGYGTDESGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIATASS 335
Query: 368 YPLV 379
YP V
Sbjct: 336 YPTV 339
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 166 bits (419), Expect = 3e-41
Identities = 74/125 (59%), Positives = 92/125 (73%)
Frame = +2
Query: 5 AEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIY 184
A DG+C +D + V +C+G+ +I GSET L A +GPISV IDA++ SFQ Y SG+Y
Sbjct: 199 ARDGSCRFDSNSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVY 258
Query: 185 NEPDCSSTQLDHGVLVVGYGTEDGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGIATMA 364
EP CS + LDH VL VGYG+E G ++WLVKNSW T WG GYIKMS++ NN CGIAT+A
Sbjct: 259 YEPSCSPSYLDHAVLAVGYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNCGIATVA 318
Query: 365 SYPLV 379
SYPLV
Sbjct: 319 SYPLV 323
>sp|P13277|CYSP1_HOMAM Digestive cysteine proteinase 1 precursor
Length = 322
Score = 164 bits (415), Expect = 8e-41
Identities = 75/125 (60%), Positives = 93/125 (74%)
Frame = +2
Query: 5 AEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIY 184
A D TC ++ + + +CTGYV I GSE++L TA +GPISVAIDAS+ SFQ Y +G+Y
Sbjct: 198 ARDNTCRFNSNTIGATCTGYVGIAQGSESALKTATRDIGPISVAIDASHRSFQSYYTGVY 257
Query: 185 NEPDCSSTQLDHGVLVVGYGTEDGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGIATMA 364
EP CSS+QLDH VL VGYG+E G ++WLVKNSW T WG GYIKM+++ NN CGIAT A
Sbjct: 258 YEPSCSSSQLDHAVLAVGYGSEGGQDFWLVKNSWATSWGESGYIKMARNRNNNCGIATDA 317
Query: 365 SYPLV 379
YP V
Sbjct: 318 CYPTV 322
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 160 bits (405), Expect = 1e-39
Identities = 75/126 (59%), Positives = 92/126 (73%), Gaps = 1/126 (0%)
Frame = +2
Query: 5 AEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIY 184
A D +C ++K V + G+ DIP G E +A A ATVGP+SVAIDAS+ SFQ Y G+Y
Sbjct: 216 AIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVY 275
Query: 185 NEPDCSSTQLDHGVLVVGYGT-EDGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGIATM 361
NEP C + LDHGVLVVG+GT E G +YWLVKNSWGT WG G+IKM ++ NQCGIA+
Sbjct: 276 NEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASA 335
Query: 362 ASYPLV 379
+SYPLV
Sbjct: 336 SSYPLV 341
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 160 bits (404), Expect = 2e-39
Identities = 80/129 (62%), Positives = 94/129 (72%), Gaps = 4/129 (3%)
Frame = +2
Query: 5 AEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIY 184
A+DG+C Y V + TG+VDIP E +L A ATVGPISVA+DAS+ S Q Y SGIY
Sbjct: 206 AKDGSCKYRAEYAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIY 264
Query: 185 NEPDCSSTQLDHGVLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGI 352
EP+CSS LDHGVLVVGYG E + YWLVKNSWG WG+DGYIK++KD NN CG+
Sbjct: 265 YEPNCSSKDLDHGVLVVGYGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGL 324
Query: 353 ATMASYPLV 379
AT ASYP+V
Sbjct: 325 ATAASYPIV 333
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 156 bits (394), Expect = 2e-38
Identities = 78/130 (60%), Positives = 90/130 (69%), Gaps = 4/130 (3%)
Frame = +2
Query: 2 LAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGI 181
+A D C Y V + TG+ + G E +L A ATVGPISVA+DA + SFQ YKSGI
Sbjct: 205 VAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGI 264
Query: 182 YNEPDCSSTQLDHGVLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCG 349
Y EPDCSS LDHGVLVVGYG E + S YWLVKNSWG WG +GY+K++KD NN CG
Sbjct: 265 YFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCG 324
Query: 350 IATMASYPLV 379
IAT ASYP V
Sbjct: 325 IATAASYPNV 334
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 155 bits (393), Expect = 3e-38
Identities = 77/129 (59%), Positives = 96/129 (74%), Gaps = 4/129 (3%)
Frame = +2
Query: 5 AEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIY 184
A+DG+C Y V + TG+VDIP E +L A ATVGPISVA+DAS+ S Q Y SGIY
Sbjct: 206 AKDGSCKYRAEFAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIY 264
Query: 185 NEPDCSSTQLDHGVLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGI 352
EP+CSS LDHGVL+VGYG E + + YWLVKNSWG+ WG++GYIK++KD +N CG+
Sbjct: 265 YEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGL 324
Query: 353 ATMASYPLV 379
AT ASYP+V
Sbjct: 325 ATAASYPVV 333
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 155 bits (392), Expect = 4e-38
Identities = 79/126 (62%), Positives = 89/126 (70%), Gaps = 1/126 (0%)
Frame = +2
Query: 5 AEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIY 184
A D +C Y TG+VDIP E +L A ATVGPISVAIDA + SFQ YKSGIY
Sbjct: 93 ATDTSCNYKPEYSAAKDTGFVDIPQ-REKALMKAVATVGPISVAIDAGHSSFQFYKSGIY 151
Query: 185 NEPDCSSTQLDHGVLVVGYGTEDGSN-YWLVKNSWGTVWGIDGYIKMSKDANNQCGIATM 361
+PDCSS LDHGVLVVGYG E +N +W+VKNSWG WG GY+KM+KD NN CGIAT
Sbjct: 152 YDPDCSSKDLDHGVLVVGYGFEGTNNKFWIVKNSWGPEWGNKGYVKMAKDQNNHCGIATA 211
Query: 362 ASYPLV 379
ASYP V
Sbjct: 212 ASYPTV 217
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 154 bits (388), Expect = 1e-37
Identities = 77/128 (60%), Positives = 90/128 (70%), Gaps = 4/128 (3%)
Frame = +2
Query: 8 EDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIYN 187
E +C Y + TG+VDIP E +L A ATVGPISVAIDA + SFQ YKSGIY
Sbjct: 208 ETNSCTYKPECSAANDTGFVDIPQ-REKALMKAVATVGPISVAIDAGHSSFQFYKSGIYY 266
Query: 188 EPDCSSTQLDHGVLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGIA 355
+PDCSS LDHGVLVVGYG E + S +W+VKNSWG WG +GY+KM+KD NN CGI+
Sbjct: 267 DPDCSSKDLDHGVLVVGYGFEGTDSNSSKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIS 326
Query: 356 TMASYPLV 379
T ASYP V
Sbjct: 327 TAASYPTV 334
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 153 bits (386), Expect = 2e-37
Identities = 77/129 (59%), Positives = 90/129 (69%), Gaps = 4/129 (3%)
Frame = +2
Query: 5 AEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQLYKSGIY 184
A + +C Y+ V + TG+VDIP E +L A ATVGPISVAIDA + SF YK GIY
Sbjct: 206 ATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESFLFYKEGIY 264
Query: 185 NEPDCSSTQLDHGVLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKDANNQCGI 352
EPDCSS +DHGVLVVGYG E D + YWLVKNSWG WG+ GY+KM+KD N CGI
Sbjct: 265 FEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGI 324
Query: 353 ATMASYPLV 379
A+ ASYP V
Sbjct: 325 ASAASYPTV 333
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,258,576
Number of Sequences: 369166
Number of extensions: 1033150
Number of successful extensions: 3326
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3046
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3122
length of database: 68,354,980
effective HSP length: 100
effective length of database: 49,881,480
effective search space used: 2444192520
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)