Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_G18
(876 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q12887|COX10_HUMAN Protoheme IX farnesyltransferase, mit... 186 6e-47
sp|P21592|COX10_YEAST Protoheme IX farnesyltransferase, mit... 177 4e-44
sp|Q04444|COXX_BACPF Protoheme IX farnesyltransferase (Heme... 93 8e-19
sp|P67054|COXX_BRUSU Protoheme IX farnesyltransferase (Heme... 93 8e-19
sp|P08301|COXX_PARDE Protoheme IX farnesyltransferase (Heme... 91 3e-18
sp|P56938|COXX_RHOSH Protoheme IX farnesyltransferase (Heme... 89 2e-17
sp|P24009|COXX_BACSU Protoheme IX farnesyltransferase (Heme... 87 6e-17
sp|Q9K9M9|COXX_BACHD Protoheme IX farnesyltransferase (Heme... 87 6e-17
sp|O31652|CTAO_BACSU Protoheme IX farnesyltransferase (Heme... 84 7e-16
sp|O66544|COXX_AQUAE Protoheme IX farnesyltransferase (Heme... 82 1e-15
>sp|Q12887|COX10_HUMAN Protoheme IX farnesyltransferase, mitochondrial precursor (Heme O
synthase)
Length = 443
Score = 186 bits (473), Expect = 6e-47
Identities = 96/213 (45%), Positives = 126/213 (59%), Gaps = 1/213 (0%)
Frame = +3
Query: 240 KLGKLRLTTLVVTSCICGFIMAPISLNLNLLFCVSTGTFLTSLAANTINQILEIPFDSQM 419
+L K++LT LVV++ GF +AP + S GT L S AAN+INQ E+PFDS M
Sbjct: 159 QLSKIKLTALVVSTTAAGFALAPGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNM 218
Query: 420 MRTRYRPLVLGKITPLHATVFAVLCASTG-SIILFSCNQXXXXXXXXXXXXXXXIYTPLK 596
RT+ RPLV G+I+PL A FA CA G +I+ N YTPLK
Sbjct: 219 NRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLK 278
Query: 597 RVSTVNTWLGAIVGGIPPLMGWAAATDHIHLGGLLMFCMLFCWQFPHFMALSWNLKSEYA 776
R+S NTW+GA+VG IPP+MGW AAT + G L+ +L+ WQFPHF ALSW L+ +Y+
Sbjct: 279 RISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYS 338
Query: 777 KAGYQMASTASPKLCRSSALHYSVLMSLLCPLA 875
+ GY M S P LCR AL + + + +L A
Sbjct: 339 RGGYCMMSVTHPGLCRRVALRHCLALLVLSAAA 371
>sp|P21592|COX10_YEAST Protoheme IX farnesyltransferase, mitochondrial precursor (Heme O
synthase)
Length = 462
Score = 177 bits (448), Expect = 4e-44
Identities = 98/227 (43%), Positives = 133/227 (58%), Gaps = 2/227 (0%)
Frame = +3
Query: 192 QSLSYLSLKHRYDM-YMKLGKLRLTTLVVTSCICGFIMAPISLNLNLLFCVSTGTFLTSL 368
+ L+ +LK + M Y++L K RLT LV+ S IC + ++P ++N L C++ GT L S
Sbjct: 134 EGLNMKTLKKKVIMPYLQLTKPRLTILVMLSAICSYALSPYPASVNELLCLTVGTTLCSG 193
Query: 369 AANTINQILEIPFDSQMMRTRYRPLVLGKITPLHATVFAVLCASTG-SIILFSCNQXXXX 545
+AN IN E FD QM+RT+ RP+V G +TP A FA L + G SI+ F N
Sbjct: 194 SANAINMGREPEFDRQMVRTQARPVVRGDVTPTQAFEFAALIGTLGVSILYFGVNPTVAI 253
Query: 546 XXXXXXXXXXXIYTPLKRVSTVNTWLGAIVGGIPPLMGWAAATDHIHLGGLLMFCMLFCW 725
YT +KR +NTWLGA+VG +PPLMGWAAA+ H G + +LF W
Sbjct: 254 LGASNIALYGWAYTSMKRKHIINTWLGALVGMVPPLMGWAAASPLSHPGSWCLAGLLFAW 313
Query: 726 QFPHFMALSWNLKSEYAKAGYQMASTASPKLCRSSALHYSVLMSLLC 866
QFPHF LS N+++EY AGY M + +P L +L YS+LM LC
Sbjct: 314 QFPHFNTLSHNIRNEYKNAGYVMTAWKNPLLNARVSLRYSILMFPLC 360
>sp|Q04444|COXX_BACPF Protoheme IX farnesyltransferase (Heme O synthase)
Length = 312
Score = 93.2 bits (230), Expect = 8e-19
Identities = 57/194 (29%), Positives = 90/194 (46%), Gaps = 7/194 (3%)
Frame = +3
Query: 234 YMKLGKLRLTTLVVTSCICGFIMAPI------SLNLNLLFCVSTGTFLTSLAANTINQIL 395
Y+ L K + T + + G +A + +++L+ + G L T+N +
Sbjct: 33 YLVLAKQGIVTSNLITTFAGIYLAIVYTGTVFTMHLDTMIFALLGAALVMAGGCTLNNYI 92
Query: 396 EIPFDSQMMRTRYRPLVLGKITPLHATVFAVLCASTGSIILFSCNQXXXXXXXXXXXXXX 575
+ D M RT+ RP V G+ + H + + A+ G I L
Sbjct: 93 DRDIDHLMERTKERPTVTGRFSAKHVLLVGLAQAALGIIFLALTTPTAAVIGLIGLFIYV 152
Query: 576 XIYTP-LKRVSTVNTWLGAIVGGIPPLMGWAAATDHIHLGGLLMFCMLFCWQFPHFMALS 752
+YT KR +T+NT +G+ G +PPL+GWAA +HL L+F ++F WQ PHF+AL+
Sbjct: 153 VLYTMWTKRTTTLNTIVGSFSGAVPPLIGWAAIDGGLHLYAWLLFFIMFLWQPPHFLALA 212
Query: 753 WNLKSEYAKAGYQM 794
EY AG M
Sbjct: 213 MKRVEEYRAAGIPM 226
>sp|P67054|COXX_BRUSU Protoheme IX farnesyltransferase (Heme O synthase)
sp|P67053|COXX_BRUME Protoheme IX farnesyltransferase (Heme O synthase)
Length = 315
Score = 93.2 bits (230), Expect = 8e-19
Identities = 68/215 (31%), Positives = 101/215 (46%), Gaps = 7/215 (3%)
Frame = +3
Query: 234 YMKLGKLRLTTLVVTSCICGFIMAPISLNLNL----LFCVSTGTFLTSLAANTINQILEI 401
Y+ L K R+ +LVV + + G ++AP +N L + C++ G A+ +N +
Sbjct: 24 YLVLLKPRVMSLVVFTGLVGLVLAPGHMNPVLAVISILCIAVGAG----ASGALNMWYDA 79
Query: 402 PFDSQMMRTRYRPLVLGKITPLHATVFAVLCASTGSIIL-FSCNQXXXXXXXXXXXXXXX 578
D+ M RTR RP+ G I P F + ++ + L N
Sbjct: 80 DIDAVMKRTRKRPIPAGIIAPNQVLAFGLTLSAFSVMTLGLMVNWLAAALLAFTIFFYAV 139
Query: 579 IYTP-LKRVSTVNTWLGAIVGGIPPLMGWAAATDHIHLGGLLMFCMLFCWQFPHFMALSW 755
IYT LKR + N +G G PP++GWAAAT I L++F ++F W PHF ALS
Sbjct: 140 IYTMWLKRSTPQNIVIGGAAGAFPPMIGWAAATGEITWDSLVLFMIIFLWTPPHFWALSL 199
Query: 756 NLKSEYAKAGYQMASTASPKL-CRSSALHYSVLMS 857
++Y A M +L R AL Y+VLM+
Sbjct: 200 FTTNDYEAARIPMMPNVKGELSTRRQALFYAVLMA 234
>sp|P08301|COXX_PARDE Protoheme IX farnesyltransferase (Heme O synthase)
Length = 298
Score = 91.3 bits (225), Expect = 3e-18
Identities = 62/211 (29%), Positives = 100/211 (47%), Gaps = 3/211 (1%)
Frame = +3
Query: 234 YMKLGKLRLTTLVVTSCICGFIMAPISLNLNLLFCVSTGTFLTSLAANTINQILEIPFDS 413
Y+ L K R+ +LVV + G +AP +N + FC L A+ +N + D+
Sbjct: 11 YVALLKPRVMSLVVFTAFVGLWIAPQPVNPFVAFCAVLFIALGGGASGALNMWYDADIDA 70
Query: 414 QMMRTRYRPLVLGKITPLHATVFAVLCASTGSIILFSC-NQXXXXXXXXXXXXXXXIYTP 590
M RT RP+ G++T + + ++L + N +YT
Sbjct: 71 VMRRTAGRPVPSGRVTSQEPLAVGIALSGLSVMMLGAGGNWFAAGFLAFTIFFYAVVYTI 130
Query: 591 -LKRVSTVNTWLGAIVGGIPPLMGWAAATDHIHLGGLLMFCMLFCWQFPHFMALSWNLKS 767
LKR + N +G G PP++GWA T I + LLMF ++F W PHF AL+ +K
Sbjct: 131 WLKRSTPQNIVIGGAAGAFPPMIGWALPTGGIGIESLLMFALIFFWTPPHFWALALFMKD 190
Query: 768 EYAKAGYQMAS-TASPKLCRSSALHYSVLMS 857
+Y+KAG M + T K+ R Y+++++
Sbjct: 191 DYSKAGVPMLTVTHGRKVTRCHIFAYTLVLA 221
>sp|P56938|COXX_RHOSH Protoheme IX farnesyltransferase (Heme O synthase)
Length = 284
Score = 88.6 bits (218), Expect = 2e-17
Identities = 60/207 (28%), Positives = 100/207 (48%), Gaps = 3/207 (1%)
Frame = +3
Query: 264 TLVVTSCICGFIMAPISLNLNLLFCVSTGTFLTSLAANTINQILEIPFDSQMMRTRYRPL 443
+LVV + + G ++AP++++ + L + A+ +N D M RTR RP+
Sbjct: 2 SLVVFTALVGLLVAPVTVHPMIALTGILFIALGAGASGALNMWSHEDIDRVMKRTRNRPV 61
Query: 444 VLGKITPLHATVFAVLCASTGSIIL-FSCNQXXXXXXXXXXXXXXXIYTP-LKRVSTVNT 617
G + P A + + ++L + N +Y+ LKR + N
Sbjct: 62 PSGTVAPGEALGIGLALSGIAVVMLGLATNLFAAGLLAFTIFFYAVVYSMWLKRTTPQNI 121
Query: 618 WLGAIVGGIPPLMGWAAATDHIHLGGLLMFCMLFCWQFPHFMALSWNLKSEYAKAGYQMA 797
+G G PP++GWA AT + + L MF ++F W PHF +L+ +KS+Y+ AG M
Sbjct: 122 VIGGAAGAFPPMIGWAVATGGVSVESLFMFALIFMWTPPHFWSLALFMKSDYSDAGVPML 181
Query: 798 S-TASPKLCRSSALHYSVLMSLLCPLA 875
+ T ++ R+ L YS+ LL PLA
Sbjct: 182 TVTHGRRVTRAHVLVYSL---LLAPLA 205
>sp|P24009|COXX_BACSU Protoheme IX farnesyltransferase (Heme O synthase)
Length = 305
Score = 87.0 bits (214), Expect = 6e-17
Identities = 51/160 (31%), Positives = 75/160 (46%), Gaps = 1/160 (0%)
Frame = +3
Query: 318 NLNLLFCVSTGTFLTSLAANTINQILEIPFDSQMMRTRYRPLVLGKITPLHATVFAVLCA 497
N+N + G+ L + IN + D M RT+ RP V GKI P A +L
Sbjct: 59 NINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVTGKIQPSQALWSGILLV 118
Query: 498 STGSIILFSCNQXXXXXXXXXXXXXXXIYTP-LKRVSTVNTWLGAIVGGIPPLMGWAAAT 674
+ G I+L +YT KR T+NT +G++ G +PPL+GW A
Sbjct: 119 ALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTVVGSVSGAVPPLIGWTAVE 178
Query: 675 DHIHLGGLLMFCMLFCWQFPHFMALSWNLKSEYAKAGYQM 794
+I + ++F +LF WQ PHF+AL+ +Y A M
Sbjct: 179 GNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM 218
>sp|Q9K9M9|COXX_BACHD Protoheme IX farnesyltransferase (Heme O synthase)
Length = 312
Score = 87.0 bits (214), Expect = 6e-17
Identities = 54/194 (27%), Positives = 87/194 (44%), Gaps = 7/194 (3%)
Frame = +3
Query: 234 YMKLGKLRLTTLVVTSCICGFIMAPISLNLNL------LFCVSTGTFLTSLAANTINQIL 395
Y+ L K + T + + G +A + ++L + G L T+N +
Sbjct: 33 YLTLAKTGIVTSNLITTFAGLFLAATYIGVSLSDYFLTIVWTMVGAALVMAGGCTLNNYI 92
Query: 396 EIPFDSQMMRTRYRPLVLGKITPLHATVFAVLCASTGSIILFSCNQXXXXXXXXXXXXXX 575
+ D M RT+ RP V G+ + H + ++ G L
Sbjct: 93 DRDIDHLMERTKDRPSVTGRFSGQHILWTGFVQSAAGIFFLLLTTPVAAVIGFIGLFVYV 152
Query: 576 XIYTP-LKRVSTVNTWLGAIVGGIPPLMGWAAATDHIHLGGLLMFCMLFCWQFPHFMALS 752
+Y+ KR +T+NT +G+I G +PPL+GW+A +H LMF ++F WQ PHF+AL+
Sbjct: 153 VLYSMWTKRTTTLNTIVGSISGAVPPLIGWSAIDGSLHSYAWLMFFIMFFWQPPHFLALA 212
Query: 753 WNLKSEYAKAGYQM 794
EY +AG M
Sbjct: 213 MKRVEEYRRAGIPM 226
>sp|O31652|CTAO_BACSU Protoheme IX farnesyltransferase (Heme O synthase)
Length = 329
Score = 83.6 bits (205), Expect = 7e-16
Identities = 50/165 (30%), Positives = 77/165 (46%), Gaps = 1/165 (0%)
Frame = +3
Query: 294 FIMAPISLNLNLLFCVSTGTFLTSLAANTINQILEIPFDSQMMRTRYRPLVLGKITPLHA 473
F+M ++ L F +++GT N + D++M RTR R V GK+ P
Sbjct: 72 FLMTMVTAMLGTAFVMASGT--------VYNNYFDRHMDAKMARTRSRASVTGKMPPAMI 123
Query: 474 TVFAVLCASTGSIILFSCNQXXXXXXXXXXXXXXXIYTP-LKRVSTVNTWLGAIVGGIPP 650
+ + G +L+S N IYT +KR S +T++G+ G PP
Sbjct: 124 LTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIYTVWVKRTSVWSTFVGSFPGAAPP 183
Query: 651 LMGWAAATDHIHLGGLLMFCMLFCWQFPHFMALSWNLKSEYAKAG 785
LMG+ A T + +L++ ++F WQ PHF A+ K EY AG
Sbjct: 184 LMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGIRRKEEYRAAG 228
>sp|O66544|COXX_AQUAE Protoheme IX farnesyltransferase (Heme O synthase)
Length = 292
Score = 82.4 bits (202), Expect = 1e-15
Identities = 51/187 (27%), Positives = 87/187 (46%), Gaps = 3/187 (1%)
Frame = +3
Query: 234 YMKLGKLRLTTLVVTSCICGFIMAPIS-LNLNLLFCVSTGTFLTSLAANTINQILEIPFD 410
Y+ L K + +LV+ + + G + L L+F GT L + + +N +++ D
Sbjct: 15 YLVLTKPGIVSLVLITTLGGMYLGSRGELQPELVFWTLLGTGLAAAGSAVLNMVIDKDID 74
Query: 411 SQMMRTRYRPLVLGKITPLHATVFAVLCASTGSIILFSCNQXXXXXXXXXXXXXXXIYTP 590
M+RT RPL G + P A +F + +I+ + I
Sbjct: 75 KLMVRTSERPLPKGTVDPTKAFIFGITLQVFSLVIMLTFVGVLPALLVALASFSYVILYS 134
Query: 591 L--KRVSTVNTWLGAIVGGIPPLMGWAAATDHIHLGGLLMFCMLFCWQFPHFMALSWNLK 764
L KR S V T +G I G +PP++G+ AA+ + + + +F ++F WQ PHF L+
Sbjct: 135 LLLKRKSPVATEIGGISGALPPVIGYVAASGSVDINAIALFLLMFMWQPPHFWVLALKYA 194
Query: 765 SEYAKAG 785
+Y +AG
Sbjct: 195 DDYKRAG 201
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,537,638
Number of Sequences: 369166
Number of extensions: 1794303
Number of successful extensions: 4351
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4233
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4336
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8694177530
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)