Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_G09
(888 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q91V09|WD13_MOUSE WD-repeat protein 13 253 4e-67
sp|Q6DKP5|WDR13_PANTR WD-repeat protein 13 >gi|20140804|sp|... 250 4e-66
sp|P61964|WDR5_HUMAN WD-repeat protein 5 (BMP2-induced 3-kb... 55 3e-07
sp|P39706|SWD1_YEAST COMPASS component SWD1 (Complex protei... 52 2e-06
sp|O43017|SWD3_SCHPO Set1 complex component swd3 (Set1C com... 51 4e-06
sp|Q8C0P5|COR2A_MOUSE Coronin-2A 50 8e-06
sp|Q15291|RBBP5_HUMAN Retinoblastoma-binding protein 5 (RBB... 50 8e-06
sp|O42858|SWD1_SCHPO Set1 complex component swd1 (Set1C com... 50 8e-06
sp|P38129|TAF5_YEAST Transcription initiation factor TFIID ... 49 1e-05
sp|Q21624|CORO_CAEEL Coronin-like protein cor-1 49 2e-05
>sp|Q91V09|WD13_MOUSE WD-repeat protein 13
Length = 485
Score = 253 bits (647), Expect = 4e-67
Identities = 133/296 (44%), Positives = 195/296 (65%), Gaps = 1/296 (0%)
Frame = +2
Query: 2 TKIALASRALAGNDSVEEGYAFTGIKHIFD-HCSAGVNRIRFAHNNASRLAIGCEDGSLS 178
T +A ASRA+AG+ S+ E YAF G+ H+FD H V R+RFA+++ RLA DGS+S
Sbjct: 139 TSVAEASRAMAGDTSLSENYAFAGMYHVFDQHVDEAVPRVRFANDDRHRLACCSLDGSIS 198
Query: 179 ICCTWPFQEECVLAIMKDQHKSGITDLAWSSANDFILTASRDSTVCLWNVESASLARIYK 358
+C P VL +++ H G++D AWS +ND +++ S D+T+ +W E R
Sbjct: 199 LCQLVP-APPTVLHVLRG-HTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIREIP 256
Query: 359 ELNVGKEILTVEFQPMNNNLFVAGGSDGVIQVINLSTGKAVKSGRDKLGGMITALTFEES 538
+ + G E+L FQP+NNNL V G + + V+N+STGK VK G KL G + AL+F+ +
Sbjct: 257 DPD-GAELLCCTFQPVNNNLTVVGNAKHNVHVMNISTGKKVKGGSSKLTGRVLALSFD-A 314
Query: 539 VGECLWIGNTQGIIQSYLFEVGTGKITRAKRLTVSTKPCTISSLQSRAWINREARDPCLL 718
G LW G+ +G + S+LF++ TGK+T+AKRL V + ++S+ +R+W++REARDP LL
Sbjct: 315 PGRLLWAGDDRGSVFSFLFDMATGKLTKAKRLVVH-EGSPVTSISARSWVSREARDPSLL 373
Query: 719 VNASINSLLFFRIASSDGQIVLKNKFPIRHTEKIIHSSFCPLISFRQGACVVTGSE 886
+NA +N LL +R+ ++G + LK FPI + + S FCPL+SFRQGACVVTGSE
Sbjct: 374 INACLNKLLLYRVVDNEGALQLKRSFPIEQSSHPVRSIFCPLMSFRQGACVVTGSE 429
>sp|Q6DKP5|WDR13_PANTR WD-repeat protein 13
sp|Q9H1Z4|WD13_HUMAN WD-repeat protein 13
Length = 485
Score = 250 bits (638), Expect = 4e-66
Identities = 132/296 (44%), Positives = 193/296 (65%), Gaps = 1/296 (0%)
Frame = +2
Query: 2 TKIALASRALAGNDSVEEGYAFTGIKHIFD-HCSAGVNRIRFAHNNASRLAIGCEDGSLS 178
T A ASRA+AG+ S+ E YAF G+ H+FD H V R+RFA+++ RLA DGS+S
Sbjct: 139 TSAAEASRAMAGDTSLSENYAFAGMYHVFDQHVDEAVPRVRFANDDRHRLACCSLDGSIS 198
Query: 179 ICCTWPFQEECVLAIMKDQHKSGITDLAWSSANDFILTASRDSTVCLWNVESASLARIYK 358
+C P VL +++ H G++D AWS +ND +++ S D+T+ +W E R
Sbjct: 199 LCQLVP-APPTVLRVLRG-HTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIREIP 256
Query: 359 ELNVGKEILTVEFQPMNNNLFVAGGSDGVIQVINLSTGKAVKSGRDKLGGMITALTFEES 538
+ + E+L FQP+NNNL V G + + V+N+STGK VK G KL G + AL+F+ +
Sbjct: 257 DPD-SAELLCCTFQPVNNNLTVVGNAKHNVHVMNISTGKKVKGGSSKLTGRVLALSFD-A 314
Query: 539 VGECLWIGNTQGIIQSYLFEVGTGKITRAKRLTVSTKPCTISSLQSRAWINREARDPCLL 718
G LW G+ +G + S+LF++ TGK+T+AKRL V + ++S+ +R+W++REARDP LL
Sbjct: 315 PGRLLWAGDDRGSVFSFLFDMATGKLTKAKRLVVH-EGSPVTSISARSWVSREARDPSLL 373
Query: 719 VNASINSLLFFRIASSDGQIVLKNKFPIRHTEKIIHSSFCPLISFRQGACVVTGSE 886
+NA +N LL +R+ ++G + LK FPI + + S FCPL+SFRQGACVVTGSE
Sbjct: 374 INACLNKLLLYRVVDNEGTLQLKRSFPIEQSSHPVRSIFCPLMSFRQGACVVTGSE 429
>sp|P61964|WDR5_HUMAN WD-repeat protein 5 (BMP2-induced 3-kb gene protein)
sp|P61965|WDR5_MOUSE WD-repeat protein 5 (BMP2-induced 3-kb gene protein) (WD-repeat
protein BIG-3)
Length = 334
Score = 55.1 bits (131), Expect = 3e-07
Identities = 28/84 (33%), Positives = 49/84 (58%)
Frame = +2
Query: 236 HKSGITDLAWSSANDFILTASRDSTVCLWNVESASLARIYKELNVGKEILTVEFQPMNNN 415
HK GI+D+AWSS ++ +++AS D T+ +W+V S + K + F P +N
Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK--GHSNYVFCCNFNP-QSN 142
Query: 416 LFVAGGSDGVIQVINLSTGKAVKS 487
L V+G D +++ ++ TGK +K+
Sbjct: 143 LIVSGSFDESVRIWDVKTGKCLKT 166
Score = 39.3 bits (90), Expect = 0.015
Identities = 26/114 (22%), Positives = 45/114 (39%), Gaps = 7/114 (6%)
Frame = +2
Query: 164 DGSL-------SICCTWPFQEECVLAIMKDQHKSGITDLAWSSANDFILTASRDSTVCLW 322
DGSL +C W L + D ++ + +S +IL A+ D+T+ LW
Sbjct: 182 DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Query: 323 NVESASLARIYKELNVGKEILTVEFQPMNNNLFVAGGSDGVIQVINLSTGKAVK 484
+ + Y K + F V+G D ++ + NL T + V+
Sbjct: 242 DYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295
>sp|P39706|SWD1_YEAST COMPASS component SWD1 (Complex proteins associated with SET1
protein SWD1) (Set1C component SWD1)
Length = 426
Score = 52.0 bits (123), Expect = 2e-06
Identities = 43/162 (26%), Positives = 69/162 (42%), Gaps = 12/162 (7%)
Frame = +2
Query: 146 LAIGCEDGSLSICCTWPFQEECVLAIMKDQHKSGITDLAWSSANDFILTASRDSTVCLWN 325
LA+GC +G+L I F+ CV M H IT +AWS +LT+SRD ++ LW+
Sbjct: 41 LALGCANGALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWD 100
Query: 326 VESASLARIYKELNVGKEILTVEFQPMNNNLFVAG------------GSDGVIQVINLST 469
+ S + KE+ I ++ L VA +D V +++ S
Sbjct: 101 LSKPS--KPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSD 158
Query: 470 GKAVKSGRDKLGGMITALTFEESVGECLWIGNTQGIIQSYLF 595
K + S D G + T + +G ++G + Y F
Sbjct: 159 EKQLSSTPDH--GYVLVCTVHTKHPNIIIVGTSKGWLDFYKF 198
>sp|O43017|SWD3_SCHPO Set1 complex component swd3 (Set1C component swd3) (COMPASS
component swd3) (Complex proteins associated with set1
protein swd3)
Length = 380
Score = 51.2 bits (121), Expect = 4e-06
Identities = 30/117 (25%), Positives = 56/117 (47%)
Frame = +2
Query: 134 NASRLAIGCEDGSLSICCTWPFQEECVLAIMKDQHKSGITDLAWSSANDFILTASRDSTV 313
N +A DG++ I F+ EC L H GI+ + W++ + ++ +AS D T+
Sbjct: 65 NKRWIATSSSDGTIKIWSALTFRLECTLF----GHYRGISQVKWATGSKYLASASDDKTI 120
Query: 314 CLWNVESASLARIYKELNVGKEILTVEFQPMNNNLFVAGGSDGVIQVINLSTGKAVK 484
+W+ E R K + +++F P+ L V+G D +++ NL G ++
Sbjct: 121 RIWDFEKRCSVRCLK--GHTNYVSSIDFNPL-GTLLVSGSWDETVRIWNLQDGTCLR 174
>sp|Q8C0P5|COR2A_MOUSE Coronin-2A
Length = 524
Score = 50.1 bits (118), Expect = 8e-06
Identities = 28/91 (30%), Positives = 48/91 (52%), Gaps = 6/91 (6%)
Frame = +2
Query: 236 HKSGITDLAWSSANDF-ILTASRDSTVCLWNVESASLAR---IYKELNVG--KEILTVEF 397
H+ + D+ W+ NDF I + S D+T+ +WN+ L R Y++ +G + + VE+
Sbjct: 81 HRGNVLDIKWNPFNDFEIASCSEDATIKIWNIPKQLLTRNLTTYRKELIGHARRVGLVEW 140
Query: 398 QPMNNNLFVAGGSDGVIQVINLSTGKAVKSG 490
P N+ + G D + V NL T +V +G
Sbjct: 141 HPTTANILFSAGYDYKVMVWNLDTKDSVIAG 171
>sp|Q15291|RBBP5_HUMAN Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding
protein RBQ-3)
Length = 538
Score = 50.1 bits (118), Expect = 8e-06
Identities = 43/179 (24%), Positives = 73/179 (40%), Gaps = 11/179 (6%)
Frame = +2
Query: 146 LAIGCEDGSLSICCTWPFQEECVLAIMKDQHKSGITDLAWSSANDFILTASRDSTVCLWN 325
LA+GC DG + I W F + I+ H + L WS +++AS D+ V W+
Sbjct: 39 LAVGCNDGRIVI---WDFLTRGIAKIIS-AHIHPVCSLCWSRDGHKLVSASTDNIVSQWD 94
Query: 326 VESASLARIYKELNVGKEILTVEFQPMNNNLFVAGGSDGVIQVINLSTGKAVKSGRDKLG 505
V S + ++ IL V++ P + N + ++ LS K V D
Sbjct: 95 VLSGDCDQRFR---FPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDS 151
Query: 506 GMITALTFEESVGECLWIGNTQG-----------IIQSYLFEVGTGKITRAKRLTVSTK 649
+ +F+ GE ++ GN +G ++ S+ GT T K + + K
Sbjct: 152 DLNVVASFDRR-GEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARK 209
>sp|O42858|SWD1_SCHPO Set1 complex component swd1 (Set1C component swd1) (COMPASS
component swd1) (Complex proteins associated with set1
protein swd1)
Length = 398
Score = 50.1 bits (118), Expect = 8e-06
Identities = 50/187 (26%), Positives = 78/187 (41%), Gaps = 13/187 (6%)
Frame = +2
Query: 116 IRFAHNNASRLAIGCEDGSLSICCTWPFQEECVLAIMKDQHKSGITDLAWSSANDFILTA 295
IRF+ N LA G +GS+ I W V ++ H I + WSS + F+LTA
Sbjct: 30 IRFS-TNGYHLASGLVNGSVVI---WDLSTFSVSRVLTG-HTRAIQSVCWSSCDRFLLTA 84
Query: 296 SRDSTVCLWNVESASLARIYKELNVGKEILTVEFQPMNNNLFVAGGSDGVIQVINLSTG- 472
SRD LW++ S I ++ + + + P N FVA D Q+I + G
Sbjct: 85 SRDWKCILWDLRDGS---IVYQVVLSAPVWSASLHPHKINTFVASLLDESPQLIIVDDGI 141
Query: 473 ------------KAVKSGRDKLGGMITALTFEESVGECLWIGNTQGIIQSYLFEVGTGKI 616
S R +T ++F GE + G ++G ++ + T KI
Sbjct: 142 PKHKYLPTNPDIDENYSDRRNRSKHVTLVSFFHPSGEYILSGTSKGWF--HVIDASTTKI 199
Query: 617 TRAKRLT 637
+ R+T
Sbjct: 200 RSSHRIT 206
>sp|P38129|TAF5_YEAST Transcription initiation factor TFIID subunit 5 (TBP-associated
factor 5) (TBP-associated factor 90 kDa) (TAFII-90)
Length = 798
Score = 49.3 bits (116), Expect = 1e-05
Identities = 55/203 (27%), Positives = 88/203 (43%), Gaps = 1/203 (0%)
Frame = +2
Query: 26 ALAGNDSVEEGYAFTGIKHIFDHCSAGVNRIRFAHNNASRLAIGCEDGSLSICCTWPFQE 205
AL ND E+ T + H S V F+ +N L+ G ED ++ + W
Sbjct: 506 ALNNNDKDEDPTCKTLVGH-----SGTVYSTSFSPDNKYLLS-GSEDKTVRL---WSMDT 556
Query: 206 ECVLAIMKDQHKSGITDLAWSSANDFILTASRDSTVCLWNVESASLARIYK-ELNVGKEI 382
L K H + D+++S + TAS D T LW+ + RI+ LN ++
Sbjct: 557 HTALVSYKG-HNHPVWDVSFSPLGHYFATASHDQTARLWSCDHIYPLRIFAGHLN---DV 612
Query: 383 LTVEFQPMNNNLFVAGGSDGVIQVINLSTGKAVKSGRDKLGGMITALTFEESVGECLWIG 562
V F P N G SD ++ ++STG +V+ +I+ + G L G
Sbjct: 613 DCVSFHP-NGCYVFTGSSDKTCRMWDVSTGDSVRLFLGHTAPVISIAVCPD--GRWLSTG 669
Query: 563 NTQGIIQSYLFEVGTGKITRAKR 631
+ GII ++++GTGK + R
Sbjct: 670 SEDGIIN--VWDIGTGKRLKQMR 690
Score = 37.0 bits (84), Expect = 0.074
Identities = 22/100 (22%), Positives = 47/100 (47%)
Frame = +2
Query: 236 HKSGITDLAWSSANDFILTASRDSTVCLWNVESASLARIYKELNVGKEILTVEFQPMNNN 415
H + + +++ ++ T S D T +W+V + R++ L ++++ P +
Sbjct: 608 HLNDVDCVSFHPNGCYVFTGSSDKTCRMWDVSTGDSVRLF--LGHTAPVISIAVCP-DGR 664
Query: 416 LFVAGGSDGVIQVINLSTGKAVKSGRDKLGGMITALTFEE 535
G DG+I V ++ TGK +K R I +L++ +
Sbjct: 665 WLSTGSEDGIINVWDIGTGKRLKQMRGHGKNAIYSLSYSK 704
>sp|Q21624|CORO_CAEEL Coronin-like protein cor-1
Length = 605
Score = 48.9 bits (115), Expect = 2e-05
Identities = 26/90 (28%), Positives = 47/90 (52%), Gaps = 6/90 (6%)
Frame = +2
Query: 230 DQHKSGITDLAWSSANDFILTASRDSTVC-LWNVESASLARIYKELNVG-----KEILTV 391
D HK+ ++AWS ND ++ + + T C +W + L R E V K + T+
Sbjct: 76 DAHKAPCLEVAWSPFNDNVIASCSEDTTCKVWVIPDRGLNRNLSEPAVELTGHQKRVNTI 135
Query: 392 EFQPMNNNLFVAGGSDGVIQVINLSTGKAV 481
+ P+ NN+ + G + V+ + N+ TG+A+
Sbjct: 136 AWHPVANNVLLTAGGENVMFMWNVGTGEAL 165
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,034,800
Number of Sequences: 369166
Number of extensions: 1989413
Number of successful extensions: 5708
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4991
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5597
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8886314050
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)