Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_F21
(687 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8N474|SFRP1_HUMAN Secreted frizzled-related protein 1 p... 55 2e-07
sp|O19116|SFRP1_BOVIN Secreted frizzled-related protein 1 p... 54 3e-07
sp|Q8C4U3|SFRP1_MOUSE Secreted frizzled-related protein 1 p... 53 9e-07
sp|Q9XSC1|SFRP5_BOVIN Secreted frizzled-related protein 5 p... 52 1e-06
sp|Q5T4F7|SFRP5_HUMAN Secreted frizzled-related protein 5 p... 51 3e-06
sp|Q9DEQ4|SFRP1_CHICK Secreted frizzled-related protein 1 p... 50 4e-06
sp|Q9WU66|SFRP5_MOUSE Secreted frizzled-related protein 5 p... 50 4e-06
sp|P97299|SFRP2_MOUSE Secreted frizzled-related protein 2 p... 44 5e-04
sp|Q9R168|SFRP1_RAT Secreted frizzled-related protein 1 (sF... 43 7e-04
sp|Q96HF1|SFRP2_HUMAN Secreted frizzled-related protein 2 p... 42 0.001
>sp|Q8N474|SFRP1_HUMAN Secreted frizzled-related protein 1 precursor (sFRP-1)
(Frizzled-related protein 1) (FRP-1) (Secreted
apoptosis-related protein 2) (SARP-2)
Length = 314
Score = 55.1 bits (131), Expect = 2e-07
Identities = 41/169 (24%), Positives = 73/169 (43%), Gaps = 7/169 (4%)
Frame = +1
Query: 1 ILQCDKFPQKSAGLCI---RGTEGTVPSGVTATVASKGCNCKSMYGSVFINSNYCAATTV 171
+L+CDKFP+ + + TE + P G T C + S I + CA+
Sbjct: 154 MLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPP-----CDNELKSEAIIEHLCASEFA 208
Query: 172 IRAKISKLRDRGNSRYVMRLHKK----SKIIKANSSDLPFISSIEVPCLCDMIDSEKIRK 339
+R KI +++ + ++ KK I K + L C C +D+
Sbjct: 209 LRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDN---LS 265
Query: 340 GRWLLMGVVHGRTFTLISLIRWKKKSKDFKKVIRKLKRSEAAICGSEYR 486
+L+MG + L ++ +W KK+K+FK ++K+K E S ++
Sbjct: 266 HHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK 314
>sp|O19116|SFRP1_BOVIN Secreted frizzled-related protein 1 precursor (sFRP-1) (Frizzled in
aorta protein) (FrzA protein)
Length = 308
Score = 54.3 bits (129), Expect = 3e-07
Identities = 41/169 (24%), Positives = 72/169 (42%), Gaps = 7/169 (4%)
Frame = +1
Query: 1 ILQCDKFPQKSAGLCI---RGTEGTVPSGVTATVASKGCNCKSMYGSVFINSNYCAATTV 171
+L+CDKFP+ + + TE + P G T C + S I + CA+
Sbjct: 148 MLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPP-----CDNELKSEAIIEHLCASEFA 202
Query: 172 IRAKISKLRDRGNSRYVMRLHKK----SKIIKANSSDLPFISSIEVPCLCDMIDSEKIRK 339
+R KI +++ + ++ KK I K L C C +D+
Sbjct: 203 LRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKKLVLYLKNGADCPCHQLDN---LS 259
Query: 340 GRWLLMGVVHGRTFTLISLIRWKKKSKDFKKVIRKLKRSEAAICGSEYR 486
+L+MG + L ++ +W KK+K+FK ++K+K E S ++
Sbjct: 260 HHFLIMGRKVKSQYLLTAIHKWDKKNKEFKTFMKKMKNHECPTFQSVFK 308
>sp|Q8C4U3|SFRP1_MOUSE Secreted frizzled-related protein 1 precursor (sFRP-1)
Length = 314
Score = 52.8 bits (125), Expect = 9e-07
Identities = 40/169 (23%), Positives = 72/169 (42%), Gaps = 7/169 (4%)
Frame = +1
Query: 1 ILQCDKFPQKSAGLCI---RGTEGTVPSGVTATVASKGCNCKSMYGSVFINSNYCAATTV 171
+L+CDKFP+ + + TE + P G T C + S I + CA+
Sbjct: 154 MLKCDKFPEGDVCIAMTPPNTTEASKPQGTTVCPP-----CDNELKSEAIIEHLCASEFA 208
Query: 172 IRAKISKLRDRGNSRYVMRLHKK----SKIIKANSSDLPFISSIEVPCLCDMIDSEKIRK 339
+R KI +++ + ++ KK I K L C C +D+
Sbjct: 209 LRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKALVLFLKNGADCPCHQLDN---LS 265
Query: 340 GRWLLMGVVHGRTFTLISLIRWKKKSKDFKKVIRKLKRSEAAICGSEYR 486
+L+MG + L ++ +W KK+K+FK ++++K E S ++
Sbjct: 266 HNFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKRMKNHECPTFQSVFK 314
>sp|Q9XSC1|SFRP5_BOVIN Secreted frizzled-related protein 5 precursor (sFRP-5)
Length = 315
Score = 52.4 bits (124), Expect = 1e-06
Identities = 39/154 (25%), Positives = 73/154 (47%), Gaps = 7/154 (4%)
Frame = +1
Query: 1 ILQCDKFPQKSAGLCIRGTEGTVPSGVTATVASKGC-NCKSMYGSVFINSNYCAATTVIR 177
+L C KFP + LCI G +P+ TA +K C C+ + + + C++ V++
Sbjct: 147 MLHCHKFPLDN-DLCIAVQFGHLPA--TAPPVTKICAQCEMEHSADGLMEQMCSSDFVVK 203
Query: 178 AKISKLRDRGNSRYVMRLHKKSKIIKA------NSSDLPFISSIEVPCLCDMIDSEKIRK 339
+I +++ R ++ KK K++K+ ++ L C C +DS
Sbjct: 204 MRIKEIKIENGDRKLIGAQKKKKLLKSGPLKRKDTKRLVLHMKNSAGCPCPQLDS---LA 260
Query: 340 GRWLLMGVVHGRTFTLISLIRWKKKSKDFKKVIR 441
G +L+MG L+++ RW KK+K+ K ++
Sbjct: 261 GSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVK 294
>sp|Q5T4F7|SFRP5_HUMAN Secreted frizzled-related protein 5 precursor (sFRP-5) (Secreted
apoptosis related protein 3) (SARP-3) (Frizzled-related
protein 1b) (FRP-1b)
Length = 317
Score = 50.8 bits (120), Expect = 3e-06
Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 7/154 (4%)
Frame = +1
Query: 1 ILQCDKFPQKSAGLCIRGTEGTVPSGVTATVASKGC-NCKSMYGSVFINSNYCAATTVIR 177
+L C KFP + LCI G +P+ TA +K C C+ + + + C++ V++
Sbjct: 149 MLHCHKFPLDN-DLCIAVQFGHLPA--TAPPVTKICAQCEMEHSADGLMEQMCSSDFVVK 205
Query: 178 AKISKLRDRGNSRYVMRLHKKSKIIKA------NSSDLPFISSIEVPCLCDMIDSEKIRK 339
+I +++ R ++ KK K++K ++ L C C +DS
Sbjct: 206 MRIKEIKIENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPQLDS---LA 262
Query: 340 GRWLLMGVVHGRTFTLISLIRWKKKSKDFKKVIR 441
G +L+MG L+++ RW KK+K+ K ++
Sbjct: 263 GSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVK 296
>sp|Q9DEQ4|SFRP1_CHICK Secreted frizzled-related protein 1 precursor (sFRP-1) (CsFRP1)
Length = 314
Score = 50.4 bits (119), Expect = 4e-06
Identities = 39/169 (23%), Positives = 74/169 (43%), Gaps = 7/169 (4%)
Frame = +1
Query: 1 ILQCDKFPQKSAGLCI---RGTEGTVPSGVTATVASKGCNCKSMYGSVFINSNYCAATTV 171
+L+CD+FPQ + + TE + P G T C + S I + CA+
Sbjct: 154 MLKCDQFPQDYVCIAMTTPNATEVSRPKGTTVCPP-----CDNEMKSEAIVEHLCASEFA 208
Query: 172 IRAKISKLRDRGNSRYVMRLHKKS----KIIKANSSDLPFISSIEVPCLCDMIDSEKIRK 339
++ I +++ + ++ +K+ I K N L + C C +D+
Sbjct: 209 LKMTIKEVKKENGDKVIIPRKRKALKLGPIRKKNLKKLVLLLKNGADCPCHQLDN---LG 265
Query: 340 GRWLLMGVVHGRTFTLISLIRWKKKSKDFKKVIRKLKRSEAAICGSEYR 486
+L+MG L ++ +W KK+K+FKK ++K+K + S ++
Sbjct: 266 HHFLIMGRQVKTQHLLTAIYKWDKKNKEFKKFMKKVKAPDCPTFPSVFK 314
>sp|Q9WU66|SFRP5_MOUSE Secreted frizzled-related protein 5 precursor (sFRP-5)
Length = 314
Score = 50.4 bits (119), Expect = 4e-06
Identities = 39/154 (25%), Positives = 72/154 (46%), Gaps = 7/154 (4%)
Frame = +1
Query: 1 ILQCDKFPQKSAGLCIRGTEGTVPSGVTATVASKGC-NCKSMYGSVFINSNYCAATTVIR 177
+L C KFP + LCI G +P+ TA +K C C+ + + + C++ V++
Sbjct: 146 MLHCHKFPLDN-DLCIAVQFGHLPA--TAPPVTKICAQCEMEHSADGLMEQMCSSDFVVK 202
Query: 178 AKISKLRDRGNSRYVMRLHKKSKIIKA------NSSDLPFISSIEVPCLCDMIDSEKIRK 339
+I +++ R ++ KK K++KA ++ L C C +D+
Sbjct: 203 MRIKEIKIDNGDRKLIGAQKKKKLLKAGPLKRKDTKKLVLHMKNGASCPCPQLDN---LT 259
Query: 340 GRWLLMGVVHGRTFTLISLIRWKKKSKDFKKVIR 441
G +L+MG L ++ RW KK+K+ K ++
Sbjct: 260 GSFLVMGRKVEGQLLLTAVYRWDKKNKEMKFAVK 293
>sp|P97299|SFRP2_MOUSE Secreted frizzled-related protein 2 precursor (sFRP-2) (Secreted
apoptosis related protein 1) (SARP-1) (SDF5 protein)
Length = 295
Score = 43.5 bits (101), Expect = 5e-04
Identities = 34/159 (21%), Positives = 72/159 (45%), Gaps = 8/159 (5%)
Frame = +1
Query: 1 ILQCDKFPQKSAGLCI--RGTEGTVPSGVTATVASKGCNCKSMYGSVFINSNYCAATTVI 174
+L+CD+FPQ + LCI ++ +P+ A + C K+ + + + C +
Sbjct: 139 MLECDRFPQDN-DLCIPLASSDHLLPATEEAPKVCEACKTKNEDDNDIMET-LCKNDFAL 196
Query: 175 RAKISKLRDRGNSRYVMRLHKKSKIIKANS-SDLPFISSI-----EVPCLCDMIDSEKIR 336
+ K+ ++ ++ K I K N S+ S+ + C C+ ++
Sbjct: 197 KIKVKEITYINRDTKIILETKSKTIYKLNGVSERDLKKSVLWLKDSLQCTCEEMNDIN-- 254
Query: 337 KGRWLLMGVVHGRTFTLISLIRWKKKSKDFKKVIRKLKR 453
+L+MG G + S+ RW+K ++FK++ R +++
Sbjct: 255 -APYLVMGQKQGGELVITSVKRWQKGQREFKRISRSIRK 292
>sp|Q9R168|SFRP1_RAT Secreted frizzled-related protein 1 (sFRP-1)
Length = 158
Score = 43.1 bits (100), Expect = 7e-04
Identities = 37/150 (24%), Positives = 62/150 (41%), Gaps = 9/150 (6%)
Frame = +1
Query: 1 ILQCDKFPQKSAGLCI-----RGTEGTVPSGVTATVASKGCNCKSMYGSVFINSNYCAAT 165
+L+CDKFP+ +CI TE + P G T C + S I + CA+
Sbjct: 19 MLKCDKFPE--GDVCIAMTPPNATEASKPQGTTVCPP-----CDNELKSEAIIEHLCASE 71
Query: 166 TVIRAKISKLRDRGNSRYVMRLHKK----SKIIKANSSDLPFISSIEVPCLCDMIDSEKI 333
+R KI +++ + ++ KK I K L C C +D+
Sbjct: 72 FALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKRLVLFLKNGADCPCHQLDN--- 128
Query: 334 RKGRWLLMGVVHGRTFTLISLIRWKKKSKD 423
+L+MG + L ++ +W KK+K+
Sbjct: 129 LSHNFLIMGRKVKSQYLLTAIHKWDKKNKE 158
>sp|Q96HF1|SFRP2_HUMAN Secreted frizzled-related protein 2 precursor (sFRP-2) (Secreted
apoptosis-related protein 1) (SARP-1) (Frizzled-related
protein 2) (FRP-2)
Length = 295
Score = 42.4 bits (98), Expect = 0.001
Identities = 34/159 (21%), Positives = 72/159 (45%), Gaps = 8/159 (5%)
Frame = +1
Query: 1 ILQCDKFPQKSAGLCI--RGTEGTVPSGVTATVASKGCNCKSMYGSVFINSNYCAATTVI 174
+L+CD+FPQ + LCI ++ +P+ A + C K+ + + + C +
Sbjct: 139 MLECDRFPQDN-DLCIPLASSDHLLPATEEAPKVCEACKNKNDDDNDIMET-LCKNDFAL 196
Query: 175 RAKISKLRDRGNSRYVMRLHKKSKIIKANS-SDLPFISSI-----EVPCLCDMIDSEKIR 336
+ K+ ++ ++ K I K N S+ S+ + C C+ ++
Sbjct: 197 KIKVKEITYINRDTKIILETKSKTIYKLNGVSERDLKKSVLWLKDSLQCTCEEMNDIN-- 254
Query: 337 KGRWLLMGVVHGRTFTLISLIRWKKKSKDFKKVIRKLKR 453
+L+MG G + S+ RW+K ++FK++ R +++
Sbjct: 255 -APYLVMGQKQGGELVITSVKRWQKGQREFKRISRSIRK 292
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,901,175
Number of Sequences: 369166
Number of extensions: 1340409
Number of successful extensions: 3370
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3264
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3359
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5879188535
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)