Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_F19
(826 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P22757|HE_PARLI Hatching enzyme precursor (HE) (HEZ) (En... 126 6e-29
sp|Q9Y5R2|MMP24_HUMAN Matrix metalloproteinase-24 precursor... 125 1e-28
sp|Q9R0S2|MMP24_MOUSE Matrix metalloproteinase-24 precursor... 125 1e-28
sp|Q99PW6|MMP24_RAT Matrix metalloproteinase-24 precursor (... 125 1e-28
sp|Q9WTR0|MMP16_MOUSE Matrix metalloproteinase-16 precursor... 120 3e-27
sp|O35548|MMP16_RAT Matrix metalloproteinase-16 precursor (... 120 3e-27
sp|P51512|MMP16_HUMAN Matrix metalloproteinase-16 precursor... 120 6e-27
sp|Q9JHI0|MMP19_MOUSE Matrix metalloproteinase-19 precursor... 119 8e-27
sp|P91953|HE_HEMPU 50 kDa hatching enzyme precursor (HE) (H... 118 2e-26
sp|P45452|MMP13_HUMAN Collagenase 3 precursor (Matrix metal... 111 2e-24
>sp|P22757|HE_PARLI Hatching enzyme precursor (HE) (HEZ) (Envelysin)
(Sea-urchin-hatching proteinase) [Contains: Hatching
enzyme 18 kDa form]
Length = 587
Score = 126 bits (317), Expect = 6e-29
Identities = 77/181 (42%), Positives = 97/181 (53%), Gaps = 2/181 (1%)
Frame = +1
Query: 52 YVASGAKWDRG--VTYKYYLHLDWMPRTMSEAEVRRAFKVALDYWVRVSNLGFSESRDKV 225
+V S W R VTY + + + + E+RRAF+V W VS L F E D
Sbjct: 167 FVTSSITWSRNQPVTYSFGALTSDLNQNDVKDEIRRAFRV----WDDVSGLSFREVPDTT 222
Query: 226 GCKFSISFSGKDHLMYNVDNNFQSQRDPSPLDNVPGGVLAHAYFPRNGNLHCDNAETWTE 405
I F DH D D GGVLAHA+ PRNG+ H D++ETWTE
Sbjct: 223 SVDIRIKFGSYDH------------GDGISFDG-RGGVLAHAFLPRNGDAHFDDSETWTE 269
Query: 406 GKDSGINLRIVAAHEMGHAIGLHHSQDPSALMAPWYGGYISEAEYRLPNDDTLGAQSIYG 585
G SG NL VAAHE GH++GL+HS SALM P+Y GY+ +RL NDD G +S+YG
Sbjct: 270 GTRSGTNLFQVAAHEFGHSLGLYHSTVRSALMYPYYQGYV--PNFRLDNDDIAGIRSLYG 327
Query: 586 A 588
+
Sbjct: 328 S 328
>sp|Q9Y5R2|MMP24_HUMAN Matrix metalloproteinase-24 precursor (MMP-24) (Membrane-type
matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5
matrix metalloproteinase) (MT5-MMP)
Length = 645
Score = 125 bits (315), Expect = 1e-28
Identities = 83/222 (37%), Positives = 115/222 (51%), Gaps = 17/222 (7%)
Frame = +1
Query: 1 MNKGRCGGKD-----REKKNKRYVASGAKW-DRGVTYKYYLHLDWMPRTMSEAEVRRAFK 162
M K RCG D R ++NKRY +G KW + +TY + ++ P+ + E + R+A +
Sbjct: 134 MKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIH---NYTPK-VGELDTRKAIR 189
Query: 163 VALDYWVRVSNLGFSE------SRDKVGCKFSISFSGKDHLMYNVDNNFQSQRDPSPLDN 324
A D W +V+ L F E D+ I F+ H D SP D
Sbjct: 190 QAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFH------------GDSSPFDG 237
Query: 325 VPGGVLAHAYFPR---NGNLHCDNAETWTEGKDS--GINLRIVAAHEMGHAIGLHHSQDP 489
GG LAHAYFP G+ H D+ E WT G + G +L +VA HE+GHA+GL HS DP
Sbjct: 238 -EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDP 296
Query: 490 SALMAPWYGGYISEAEYRLPNDDTLGAQSIYGARGKRALPSK 615
SA+MAP+Y Y+ ++LP DD G Q IYG + P++
Sbjct: 297 SAIMAPFY-QYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTR 337
>sp|Q9R0S2|MMP24_MOUSE Matrix metalloproteinase-24 precursor (MMP-24) (Membrane-type
matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5
matrix metalloproteinase) (MT5-MMP) (MMP-21)
Length = 618
Score = 125 bits (315), Expect = 1e-28
Identities = 83/222 (37%), Positives = 115/222 (51%), Gaps = 17/222 (7%)
Frame = +1
Query: 1 MNKGRCGGKD-----REKKNKRYVASGAKW-DRGVTYKYYLHLDWMPRTMSEAEVRRAFK 162
M K RCG D R ++NKRY +G KW + +TY + ++ P+ + E + R+A +
Sbjct: 107 MKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIH---NYTPK-VGELDTRKAIR 162
Query: 163 VALDYWVRVSNLGFSE------SRDKVGCKFSISFSGKDHLMYNVDNNFQSQRDPSPLDN 324
A D W +V+ L F E D+ I F+ H D SP D
Sbjct: 163 QAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFH------------GDSSPFDG 210
Query: 325 VPGGVLAHAYFPR---NGNLHCDNAETWTEGKDS--GINLRIVAAHEMGHAIGLHHSQDP 489
GG LAHAYFP G+ H D+ E WT G + G +L +VA HE+GHA+GL HS DP
Sbjct: 211 -EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSNDP 269
Query: 490 SALMAPWYGGYISEAEYRLPNDDTLGAQSIYGARGKRALPSK 615
SA+MAP+Y Y+ ++LP DD G Q IYG + P++
Sbjct: 270 SAIMAPFY-QYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTR 310
>sp|Q99PW6|MMP24_RAT Matrix metalloproteinase-24 precursor (MMP-24) (Membrane-type
matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5
matrix metalloproteinase) (MT5-MMP)
Length = 618
Score = 125 bits (315), Expect = 1e-28
Identities = 83/222 (37%), Positives = 115/222 (51%), Gaps = 17/222 (7%)
Frame = +1
Query: 1 MNKGRCGGKD-----REKKNKRYVASGAKW-DRGVTYKYYLHLDWMPRTMSEAEVRRAFK 162
M K RCG D R ++NKRY +G KW + +TY + ++ P+ + E + R+A +
Sbjct: 107 MKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIH---NYTPK-VGELDTRKAIR 162
Query: 163 VALDYWVRVSNLGFSE------SRDKVGCKFSISFSGKDHLMYNVDNNFQSQRDPSPLDN 324
A D W +V+ L F E D+ I F+ H D SP D
Sbjct: 163 QAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFH------------GDSSPFDG 210
Query: 325 VPGGVLAHAYFPR---NGNLHCDNAETWTEGKDS--GINLRIVAAHEMGHAIGLHHSQDP 489
GG LAHAYFP G+ H D+ E WT G + G +L +VA HE+GHA+GL HS DP
Sbjct: 211 -EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSNDP 269
Query: 490 SALMAPWYGGYISEAEYRLPNDDTLGAQSIYGARGKRALPSK 615
SA+MAP+Y Y+ ++LP DD G Q IYG + P++
Sbjct: 270 SAIMAPFY-QYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTR 310
>sp|Q9WTR0|MMP16_MOUSE Matrix metalloproteinase-16 precursor (MMP-16) (Membrane-type
matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3)
(Membrane-type-3 matrix metalloproteinase) (MT3-MMP)
(MT3MMP)
Length = 607
Score = 120 bits (302), Expect = 3e-27
Identities = 81/218 (37%), Positives = 112/218 (51%), Gaps = 13/218 (5%)
Frame = +1
Query: 1 MNKGRCGGKDREK-------KNKRYVASGAKWD-RGVTYKYYLHLDWMPRTMSEAEVRRA 156
M K RCG D+ + + KRY +G KW + +TY + + + + E RRA
Sbjct: 96 MKKPRCGVPDQTRGSSKFNIRRKRYALTGQKWQHKHITYS----IKNVTPKVGDPETRRA 151
Query: 157 FKVALDYWVRVSNLGFSESRDKVGCKFSISFSGKDHLMYNVDNNFQSQRDPSPLDNVPGG 336
+ A D W V+ L F E +S +GK + + D SP D GG
Sbjct: 152 IRRAFDVWQNVTPLTFEE------VPYSELENGKRDVDITIIFASGFHGDRSPFDG-EGG 204
Query: 337 VLAHAYFPR---NGNLHCDNAETWTEGKDS--GINLRIVAAHEMGHAIGLHHSQDPSALM 501
LAHAYFP G+ H D+ E WT G + G +L +VA HE+GHA+GL HS DP+A+M
Sbjct: 205 FLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIM 264
Query: 502 APWYGGYISEAEYRLPNDDTLGAQSIYGARGKRALPSK 615
AP+Y Y+ ++LPNDD G Q IYG K P++
Sbjct: 265 APFY-QYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTR 301
>sp|O35548|MMP16_RAT Matrix metalloproteinase-16 precursor (MMP-16) (Membrane-type
matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3)
(Membrane-type-3 matrix metalloproteinase) (MT3-MMP)
(MT3MMP)
Length = 607
Score = 120 bits (302), Expect = 3e-27
Identities = 81/218 (37%), Positives = 112/218 (51%), Gaps = 13/218 (5%)
Frame = +1
Query: 1 MNKGRCGGKDREK-------KNKRYVASGAKWD-RGVTYKYYLHLDWMPRTMSEAEVRRA 156
M K RCG D+ + + KRY +G KW + +TY + + + + E RRA
Sbjct: 96 MKKPRCGVPDQTRGSSKFNIRRKRYALTGQKWQHKHITYS----IKNVTPKVGDPETRRA 151
Query: 157 FKVALDYWVRVSNLGFSESRDKVGCKFSISFSGKDHLMYNVDNNFQSQRDPSPLDNVPGG 336
+ A D W V+ L F E +S +GK + + D SP D GG
Sbjct: 152 IRRAFDVWQNVTPLTFEE------VPYSELENGKRDVDITIIFASGFHGDRSPFDG-EGG 204
Query: 337 VLAHAYFPR---NGNLHCDNAETWTEGKDS--GINLRIVAAHEMGHAIGLHHSQDPSALM 501
LAHAYFP G+ H D+ E WT G + G +L +VA HE+GHA+GL HS DP+A+M
Sbjct: 205 FLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIM 264
Query: 502 APWYGGYISEAEYRLPNDDTLGAQSIYGARGKRALPSK 615
AP+Y Y+ ++LPNDD G Q IYG K P++
Sbjct: 265 APFY-QYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTR 301
>sp|P51512|MMP16_HUMAN Matrix metalloproteinase-16 precursor (MMP-16) (Membrane-type
matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3)
(Membrane-type-3 matrix metalloproteinase) (MT3-MMP)
(MT3MMP) (MMP-X2)
Length = 607
Score = 120 bits (300), Expect = 6e-27
Identities = 80/218 (36%), Positives = 112/218 (51%), Gaps = 13/218 (5%)
Frame = +1
Query: 1 MNKGRCGGKDREK-------KNKRYVASGAKWD-RGVTYKYYLHLDWMPRTMSEAEVRRA 156
M K RCG D+ + + KRY +G KW + +TY + + + + E R+A
Sbjct: 96 MKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYS----IKNVTPKVGDPETRKA 151
Query: 157 FKVALDYWVRVSNLGFSESRDKVGCKFSISFSGKDHLMYNVDNNFQSQRDPSPLDNVPGG 336
+ A D W V+ L F E +S +GK + + D SP D GG
Sbjct: 152 IRRAFDVWQNVTPLTFEE------VPYSELENGKRDVDITIIFASGFHGDSSPFDG-EGG 204
Query: 337 VLAHAYFPR---NGNLHCDNAETWTEGKDS--GINLRIVAAHEMGHAIGLHHSQDPSALM 501
LAHAYFP G+ H D+ E WT G + G +L +VA HE+GHA+GL HS DP+A+M
Sbjct: 205 FLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIM 264
Query: 502 APWYGGYISEAEYRLPNDDTLGAQSIYGARGKRALPSK 615
AP+Y Y+ ++LPNDD G Q IYG K P++
Sbjct: 265 APFY-QYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTR 301
>sp|Q9JHI0|MMP19_MOUSE Matrix metalloproteinase-19 precursor (MMP-19) (Matrix
metalloproteinase RASI)
Length = 527
Score = 119 bits (299), Expect = 8e-27
Identities = 78/199 (39%), Positives = 107/199 (53%), Gaps = 2/199 (1%)
Frame = +1
Query: 1 MNKGRCGGKDR-EKKNKRYVASGAKWDRGVTYKYYLHLDWMPRTMSEAEVRRAFKVALDY 177
M + RCG +D +K+ +Y+ G + +T++ + +P T+S VR A A Y
Sbjct: 81 MKQPRCGLEDPFNQKSLKYLLLGHWRKKNLTFRIFN----VPSTLSLPRVRAALHQAFKY 136
Query: 178 WVRVSNLGFSESRDKVG-CKFSISFSGKDHLMYNVDNNFQSQRDPSPLDNVPGGVLAHAY 354
W V+ L F E K G +SF G+ L + N F PG VLAHA
Sbjct: 137 WSSVAPLTFREV--KAGWADIRLSFHGRQSLYCS--NTFDG----------PGKVLAHAD 182
Query: 355 FPRNGNLHCDNAETWTEGKDSGINLRIVAAHEMGHAIGLHHSQDPSALMAPWYGGYISEA 534
P G++H D E WTEG G+NLRI+AAHE+GHA+GL HS+ ALMAP Y GY +
Sbjct: 183 IPELGSIHFDKDELWTEGTYQGVNLRIIAAHEVGHALGLGHSRYTQALMAPVYAGY--QP 240
Query: 535 EYRLPNDDTLGAQSIYGAR 591
++L DD G Q++YG R
Sbjct: 241 FFKLHPDDVAGIQALYGKR 259
>sp|P91953|HE_HEMPU 50 kDa hatching enzyme precursor (HE) (HEZ) (Envelysin)
(Sea-urchin-hatching proteinase) [Contains: 38 kDa
hatching enzyme; 32 kDa hatching enzyme non-specific; 15
kDa peptide]
Length = 591
Score = 118 bits (296), Expect = 2e-26
Identities = 74/180 (41%), Positives = 95/180 (52%), Gaps = 2/180 (1%)
Frame = +1
Query: 52 YVASGAKWDRGV--TYKYYLHLDWMPRTMSEAEVRRAFKVALDYWVRVSNLGFSESRDKV 225
YV G W R V TY + + + +T + E+RRAF+V W VS+L F E D
Sbjct: 170 YVTGGIAWPRNVAVTYSFGTLSNDLSQTAIKNELRRAFQV----WDDVSSLTFREVVDSS 225
Query: 226 GCKFSISFSGKDHLMYNVDNNFQSQRDPSPLDNVPGGVLAHAYFPRNGNLHCDNAETWTE 405
I F +H +F Q GGVLAHA+ PRNG+ H D++E WT
Sbjct: 226 SVDIRIKFGSYEH---GDGISFDGQ----------GGVLAHAFLPRNGDAHFDDSERWTI 272
Query: 406 GKDSGINLRIVAAHEMGHAIGLHHSQDPSALMAPWYGGYISEAEYRLPNDDTLGAQSIYG 585
G +SG NL VAAHE GH++GL+HS SALM P+Y GY + L DD G S+YG
Sbjct: 273 GTNSGTNLFQVAAHEFGHSLGLYHSDVQSALMYPYYRGY--NPNFNLDRDDIAGITSLYG 330
>sp|P45452|MMP13_HUMAN Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 471
Score = 111 bits (278), Expect = 2e-24
Identities = 87/255 (34%), Positives = 123/255 (48%), Gaps = 4/255 (1%)
Frame = +1
Query: 1 MNKGRCGGKDREKKNKRYVASGAKWDR-GVTYKYYLHLDWMPRTMSEAEVRRAFKVALDY 177
M K RCG D + N KW + +TY+ +++ P M+ +EV +AFK A
Sbjct: 91 MKKPRCGVPDVGEYN--VFPRTLKWSKMNLTYRI---VNYTP-DMTHSEVEKAFKKAFKV 144
Query: 178 WVRVSNLGFSESRDKVGCKFSISFSGKDHLMYNVDNNFQSQRDPSPLDNVPGGVLAHAYF 357
W V+ L F+ D + ISF K+H D P D P G+LAHA+
Sbjct: 145 WSDVTPLNFTRLHDGIA-DIMISFGIKEH------------GDFYPFDG-PSGLLAHAFP 190
Query: 358 PR---NGNLHCDNAETWTEGKDSGINLRIVAAHEMGHAIGLHHSQDPSALMAPWYGGYIS 528
P G+ H D+ ETWT G NL +VAAHE GH++GL HS+DP ALM P Y Y
Sbjct: 191 PGPNYGGDAHFDDDETWTSSS-KGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIY-TYTG 248
Query: 529 EAEYRLPNDDTLGAQSIYGARGKRALPSKKRELGKIQSRLCNVKSFEDVFTFSDGKVYVL 708
++ + LP+DD G QS+YG + P + K C+ D T G+ +
Sbjct: 249 KSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDK-----CDPSLSLDAITSLRGETMIF 303
Query: 709 ADGGNLFRMNDDKVD 753
D +R++ +VD
Sbjct: 304 KD-RFFWRLHPQQVD 317
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 101,905,657
Number of Sequences: 369166
Number of extensions: 2250526
Number of successful extensions: 6482
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6091
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6323
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7956112725
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)