Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_F11
(873 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q920M5|CORO6_MOUSE Coronin-6 (Clipin E) 191 3e-48
sp|Q920J3|CORO6_RAT Coronin-6 187 3e-47
sp|Q92828|COR2A_HUMAN Coronin-2A (WD repeat-containing prot... 180 5e-45
sp|Q9BR76|CO1B_HUMAN Coronin-1B (Coronin-2) 180 5e-45
sp|Q9ULV4|COR1C_HUMAN Coronin-1C (Coronin-3) (hCRNN4) 177 3e-44
sp|Q9WUM3|COR1B_MOUSE Coronin-1B (Coronin-2) 176 6e-44
sp|Q9XS70|COR1B_RABIT Coronin-1B (Coroninse) (Coronin-like ... 176 8e-44
sp|Q9WUM4|COR1C_MOUSE Coronin-1C (Coronin-3) 176 1e-43
sp|O89046|COR1B_RAT Coronin-1B (Coronin-2) 175 2e-43
sp|Q8C0P5|COR2A_MOUSE Coronin-2A 171 3e-42
>sp|Q920M5|CORO6_MOUSE Coronin-6 (Clipin E)
Length = 471
Score = 191 bits (484), Expect = 3e-48
Identities = 101/268 (37%), Positives = 157/268 (58%), Gaps = 1/268 (0%)
Frame = +2
Query: 71 WHPTVGNAVLTSCGSKFAGAGSSADTHLILWDTVKTEKLLEIK-LNNCYLTSLSFNYNGS 247
WHPT N +L++ G D +I+W+ E LL + ++ + S+ +N NGS
Sbjct: 139 WHPTARNVLLSAGG----------DNVIIIWNVGTGEVLLSLDDIHPDVIHSVCWNSNGS 188
Query: 248 KVVCTDNSHITRIIDLRSSEPVLQEAMLHKKARRQNTVYLKNGLIFSTGYSSTTIREYAL 427
+ T RIID R S+ V + A H+ AR V+ +G + STG+S + R+ AL
Sbjct: 189 LLATTCKDKTLRIIDPRKSQVVAERARPHEGARPLRAVFTADGKLLSTGFSRMSERQLAL 248
Query: 428 WDENDLSNPIELIDLDANSGVLYPIYDADINVIYVWGKGDSIMSFFEVVYEPKPTIQYLC 607
WD N+ P+ L ++D ++GVL P YD D +++Y+ GKGDS + +FE+ EP P + YL
Sbjct: 249 WDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITEEP-PFVHYLN 307
Query: 608 CYQSAKPQNGVIAMPKLGVNVAANELTRLFKFYANGFCEVIPIICPRREQGFSEEVYPPT 787
+ S +PQ G+ MPK G++V+ E+ R +K + CE I + PR+ F +++YP T
Sbjct: 308 TFSSKEPQRGMGFMPKRGLDVSKCEIARFYKLHERK-CEPIIMTVPRKSDLFQDDLYPDT 366
Query: 788 PSRVPSLTIDEWINGADADPILISLETG 871
P P+L DEW++G DA+P+LISL+ G
Sbjct: 367 PGPEPALEADEWLSGQDAEPVLISLKEG 394
>sp|Q920J3|CORO6_RAT Coronin-6
Length = 472
Score = 187 bits (476), Expect = 3e-47
Identities = 99/268 (36%), Positives = 155/268 (57%), Gaps = 1/268 (0%)
Frame = +2
Query: 71 WHPTVGNAVLTSCGSKFAGAGSSADTHLILWDTVKTEKLLEIK-LNNCYLTSLSFNYNGS 247
WHPT N +L++ G D +I+W+ E LL + ++ + S+ +N NGS
Sbjct: 139 WHPTARNVLLSAGG----------DNVIIIWNVGTGEVLLSLDDIHPDVIHSVCWNSNGS 188
Query: 248 KVVCTDNSHITRIIDLRSSEPVLQEAMLHKKARRQNTVYLKNGLIFSTGYSSTTIREYAL 427
+ T RIID R S+ V + H+ R V+ + G IF+TG++ + RE L
Sbjct: 189 LLATTCKDKTLRIIDPRKSQVVAERFAAHEGMRPMRAVFTRLGHIFTTGFTRMSQRELGL 248
Query: 428 WDENDLSNPIELIDLDANSGVLYPIYDADINVIYVWGKGDSIMSFFEVVYEPKPTIQYLC 607
WD N+ P+ L ++D ++GVL P YD D +++Y+ GKGDS + +FE+ EP P + YL
Sbjct: 249 WDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEP-PFVHYLN 307
Query: 608 CYQSAKPQNGVIAMPKLGVNVAANELTRLFKFYANGFCEVIPIICPRREQGFSEEVYPPT 787
+ S +PQ G+ MPK G++V+ E+ R +K + CE I + PR+ F +++YP T
Sbjct: 308 TFSSKEPQRGMGFMPKRGLDVSKCEIARFYKLHERK-CEPIVMTVPRKSDLFQDDLYPDT 366
Query: 788 PSRVPSLTIDEWINGADADPILISLETG 871
P P+L DEW++G DA+P+LISL+ G
Sbjct: 367 PGPEPALEADEWLSGQDAEPVLISLKEG 394
>sp|Q92828|COR2A_HUMAN Coronin-2A (WD repeat-containing protein 2) (IR10)
Length = 525
Score = 180 bits (456), Expect = 5e-45
Identities = 108/269 (40%), Positives = 156/269 (57%), Gaps = 2/269 (0%)
Frame = +2
Query: 71 WHPTVGNAVLTSCGSKFAGAGSSADTHLILWDTVKTEKLLEIKLNNCYLTSLSFNYNGSK 250
WHPT N +L S G + + DT ++V T + I + + S+SFN NGS
Sbjct: 140 WHPTAAN-ILFSAGYDYKVMIWNLDTK----ESVITSPMSTISCHQDVILSMSFNTNGSL 194
Query: 251 VVCTDNSHITRIIDLRSSEPVLQEAMLHKKARRQNTVYLKN-GLIFSTGYSSTTIREYAL 427
+ T R+ID R+ VLQEA +K R ++L N + STG S R+ AL
Sbjct: 195 LATTCKDRKIRVIDPRAGT-VLQEAS-YKGHRASKVLFLGNLKKLMSTGTSRWNNRQVAL 252
Query: 428 WDENDLSNPIELIDLDANSGVLYPIYDADINVIYVWGKGDSIMSFFEVVYEPKPTIQYLC 607
WD+++LS P+ DLD +SGVL+P YDAD +++YV GKGD + ++EV + KP + YL
Sbjct: 253 WDQDNLSVPLMEEDLDGSSGVLFPFYDADTSMLYVVGKGDGNIRYYEVSAD-KPHLSYLT 311
Query: 608 CYQSAKPQNGVIAMPKLGVNVAANELTRLFKFY-ANGFCEVIPIICPRREQGFSEEVYPP 784
Y+S PQ G+ MPK G++V++ E+ R +K E I +I PRR + + E++YPP
Sbjct: 312 EYRSYNPQKGIGVMPKRGLDVSSCEIFRFYKLITTKSLIEPISMIVPRRSESYQEDIYPP 371
Query: 785 TPSRVPSLTIDEWINGADADPILISLETG 871
T PSLT EW++G + DPIL+SL G
Sbjct: 372 TAGAQPSLTAQEWLSGMNRDPILVSLRPG 400
>sp|Q9BR76|CO1B_HUMAN Coronin-1B (Coronin-2)
Length = 489
Score = 180 bits (456), Expect = 5e-45
Identities = 96/265 (36%), Positives = 151/265 (56%), Gaps = 1/265 (0%)
Frame = +2
Query: 71 WHPTVGNAVLTSCGSKFAGAGSSADTHLILWDTVKTEKLLEI-KLNNCYLTSLSFNYNGS 247
WHPT N +L++ D +++W+ E+L + L+ + ++S+N+NGS
Sbjct: 140 WHPTARNVLLSA----------GCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGS 189
Query: 248 KVVCTDNSHITRIIDLRSSEPVLQEAMLHKKARRQNTVYLKNGLIFSTGYSSTTIREYAL 427
RIID R V + H+ AR ++L +G +F+TG+S + R+ AL
Sbjct: 190 LFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFSRMSERQLAL 249
Query: 428 WDENDLSNPIELIDLDANSGVLYPIYDADINVIYVWGKGDSIMSFFEVVYEPKPTIQYLC 607
WD +L P+ L +LD+++G L P YD D +V+YV GKGDS + +FE+ EP P I +L
Sbjct: 250 WDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEP-PYIHFLN 308
Query: 608 CYQSAKPQNGVIAMPKLGVNVAANELTRLFKFYANGFCEVIPIICPRREQGFSEEVYPPT 787
+ S +PQ G+ +MPK G+ V+ E+ R +K + CE I + PR+ F +++YP T
Sbjct: 309 TFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERK-CEPIVMTVPRKSDLFQDDLYPDT 367
Query: 788 PSRVPSLTIDEWINGADADPILISL 862
+L +EW++G DADPILISL
Sbjct: 368 AGPEAALEAEEWVSGRDADPILISL 392
>sp|Q9ULV4|COR1C_HUMAN Coronin-1C (Coronin-3) (hCRNN4)
Length = 474
Score = 177 bits (450), Expect = 3e-44
Identities = 94/268 (35%), Positives = 152/268 (56%), Gaps = 1/268 (0%)
Frame = +2
Query: 71 WHPTVGNAVLTSCGSKFAGAGSSADTHLILWDTVKTEKLLEIK-LNNCYLTSLSFNYNGS 247
WHPT N +L++ D +I+W+ E L+ + +++ + ++S+N NGS
Sbjct: 138 WHPTARNVLLSA----------GCDNAIIIWNVGTGEALINLDDMHSDMIYNVSWNRNGS 187
Query: 248 KVVCTDNSHITRIIDLRSSEPVLQEAMLHKKARRQNTVYLKNGLIFSTGYSSTTIREYAL 427
+ R+ID R E V ++ H+ AR ++L +G +F+TG+S + R+ AL
Sbjct: 188 LICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRMSERQLAL 247
Query: 428 WDENDLSNPIELIDLDANSGVLYPIYDADINVIYVWGKGDSIMSFFEVVYEPKPTIQYLC 607
W+ ++ PI L ++D ++GVL P YD D ++IY+ GKGDS + +FE+ E P + YL
Sbjct: 248 WNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDE-SPYVHYLN 306
Query: 608 CYQSAKPQNGVIAMPKLGVNVAANELTRLFKFYANGFCEVIPIICPRREQGFSEEVYPPT 787
+ S +PQ G+ MPK G++V E+ R FK + CE I + PR+ F +++YP T
Sbjct: 307 TFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERK-CEPIIMTVPRKSDLFQDDLYPDT 365
Query: 788 PSRVPSLTIDEWINGADADPILISLETG 871
+L +EW G +ADPILISL+ G
Sbjct: 366 AGPEAALEAEEWFEGKNADPILISLKHG 393
>sp|Q9WUM3|COR1B_MOUSE Coronin-1B (Coronin-2)
Length = 484
Score = 176 bits (447), Expect = 6e-44
Identities = 94/265 (35%), Positives = 151/265 (56%), Gaps = 1/265 (0%)
Frame = +2
Query: 71 WHPTVGNAVLTSCGSKFAGAGSSADTHLILWDTVKTEKLLEI-KLNNCYLTSLSFNYNGS 247
WHPT N +L++ D +++W+ E+L + L+ + ++S+N+NGS
Sbjct: 140 WHPTARNVLLSA----------GCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGS 189
Query: 248 KVVCTDNSHITRIIDLRSSEPVLQEAMLHKKARRQNTVYLKNGLIFSTGYSSTTIREYAL 427
RIID R V + H+ AR ++L +G +F+TG+S + R+ AL
Sbjct: 190 LFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFSRMSERQLAL 249
Query: 428 WDENDLSNPIELIDLDANSGVLYPIYDADINVIYVWGKGDSIMSFFEVVYEPKPTIQYLC 607
WD +L P+ L +LD+++G L P YD D +V+YV GKGDS + +FE+ EP P I +L
Sbjct: 250 WDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITDEP-PYIHFLN 308
Query: 608 CYQSAKPQNGVIAMPKLGVNVAANELTRLFKFYANGFCEVIPIICPRREQGFSEEVYPPT 787
+ S +PQ G+ +MPK G+ V+ E+ R +K + CE I + PR+ F +++YP T
Sbjct: 309 TFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERK-CEPIVMTVPRKSDLFQDDLYPDT 367
Query: 788 PSRVPSLTIDEWINGADADPILISL 862
+L ++W++G DA+PILISL
Sbjct: 368 AGPEAALEAEDWVSGQDANPILISL 392
>sp|Q9XS70|COR1B_RABIT Coronin-1B (Coroninse) (Coronin-like protein pp66)
Length = 486
Score = 176 bits (446), Expect = 8e-44
Identities = 95/265 (35%), Positives = 149/265 (56%), Gaps = 1/265 (0%)
Frame = +2
Query: 71 WHPTVGNAVLTSCGSKFAGAGSSADTHLILWDTVKTEKLLEI-KLNNCYLTSLSFNYNGS 247
WHPT N +L++ D +++W+ E+L + L+ + ++S+N NGS
Sbjct: 140 WHPTARNVLLSA----------GCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNRNGS 189
Query: 248 KVVCTDNSHITRIIDLRSSEPVLQEAMLHKKARRQNTVYLKNGLIFSTGYSSTTIREYAL 427
RIID R V + H+ AR ++L +G +F+TG+S + R+ AL
Sbjct: 190 LFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFSRMSERQLAL 249
Query: 428 WDENDLSNPIELIDLDANSGVLYPIYDADINVIYVWGKGDSIMSFFEVVYEPKPTIQYLC 607
WD +L P+ L +LD+++G L P YD D +V+YV GKGDS + +FE+ EP P I +L
Sbjct: 250 WDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITDEP-PYIHFLN 308
Query: 608 CYQSAKPQNGVIAMPKLGVNVAANELTRLFKFYANGFCEVIPIICPRREQGFSEEVYPPT 787
+ S +PQ GV +MPK G+ V+ E+ R +K + CE I + PR+ F +++YP T
Sbjct: 309 TFTSKEPQRGVGSMPKRGLEVSKCEIARFYKLHERK-CEPIVMTVPRKSDLFQDDLYPDT 367
Query: 788 PSRVPSLTIDEWINGADADPILISL 862
+L +EW++G DA P+LISL
Sbjct: 368 AGPEAALEAEEWVSGRDAGPVLISL 392
>sp|Q9WUM4|COR1C_MOUSE Coronin-1C (Coronin-3)
Length = 474
Score = 176 bits (445), Expect = 1e-43
Identities = 93/268 (34%), Positives = 152/268 (56%), Gaps = 1/268 (0%)
Frame = +2
Query: 71 WHPTVGNAVLTSCGSKFAGAGSSADTHLILWDTVKTEKLLEIK-LNNCYLTSLSFNYNGS 247
WHPT N +L++ D +I+W+ E L+ + +++ + ++S++ NGS
Sbjct: 138 WHPTARNVLLSA----------GCDNAIIIWNVGTGEALINLDDMHSDMIYNVSWSRNGS 187
Query: 248 KVVCTDNSHITRIIDLRSSEPVLQEAMLHKKARRQNTVYLKNGLIFSTGYSSTTIREYAL 427
+ R+ID R E V ++ H+ AR ++L +G +F+TG+S + R+ AL
Sbjct: 188 LICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRMSERQLAL 247
Query: 428 WDENDLSNPIELIDLDANSGVLYPIYDADINVIYVWGKGDSIMSFFEVVYEPKPTIQYLC 607
W+ ++ PI L ++D ++GVL P YD D ++IY+ GKGDS + +FE+ E P + YL
Sbjct: 248 WNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDE-SPYVHYLN 306
Query: 608 CYQSAKPQNGVIAMPKLGVNVAANELTRLFKFYANGFCEVIPIICPRREQGFSEEVYPPT 787
+ S +PQ G+ MPK G++V E+ R FK + CE I + PR+ F +++YP T
Sbjct: 307 TFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERK-CEPIIMTVPRKSDLFQDDLYPDT 365
Query: 788 PSRVPSLTIDEWINGADADPILISLETG 871
+L +EW G +ADPILISL+ G
Sbjct: 366 AGPEAALEAEEWFEGKNADPILISLKHG 393
>sp|O89046|COR1B_RAT Coronin-1B (Coronin-2)
Length = 484
Score = 175 bits (443), Expect = 2e-43
Identities = 96/267 (35%), Positives = 152/267 (56%), Gaps = 3/267 (1%)
Frame = +2
Query: 71 WHPTVGNAVLTSCGSKFAGAGSSADTHLILWDTVKTEKLLEI-KLNNCYLTSLSFNYNGS 247
WHPT N +L++ D +++W+ E+L + L+ + ++S+N+NGS
Sbjct: 140 WHPTARNVLLSA----------GCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGS 189
Query: 248 K--VVCTDNSHITRIIDLRSSEPVLQEAMLHKKARRQNTVYLKNGLIFSTGYSSTTIREY 421
C D S RIID R V + H+ AR ++L +G +F+ G+S + R+
Sbjct: 190 LFCTACKDKS--VRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTAGFSRMSERQL 247
Query: 422 ALWDENDLSNPIELIDLDANSGVLYPIYDADINVIYVWGKGDSIMSFFEVVYEPKPTIQY 601
ALWD + P+ L +LD+++G L P YD D +V+YV GKGDS + +FE+ EP P I +
Sbjct: 248 ALWDPENFEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITDEP-PYIHF 306
Query: 602 LCCYQSAKPQNGVIAMPKLGVNVAANELTRLFKFYANGFCEVIPIICPRREQGFSEEVYP 781
L + S +PQ G+ +MPK G+ V+ E+ R +K + CE I + PR+ F +++YP
Sbjct: 307 LNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERK-CEPIVMTVPRKSDLFQDDLYP 365
Query: 782 PTPSRVPSLTIDEWINGADADPILISL 862
T +L ++W++G DADPILISL
Sbjct: 366 DTAGPDAALEAEDWVSGQDADPILISL 392
>sp|Q8C0P5|COR2A_MOUSE Coronin-2A
Length = 524
Score = 171 bits (432), Expect = 3e-42
Identities = 104/275 (37%), Positives = 155/275 (56%), Gaps = 8/275 (2%)
Frame = +2
Query: 71 WHPTVGNAVLTSCGSKFAGAGSSADTHLILWDTVKTEKLLE--IKLNNCY---LTSLSFN 235
WHPT N +L S G D +++W+ + ++ +K NC+ + S+SFN
Sbjct: 140 WHPTTAN-ILFSAGY---------DYKVMVWNLDTKDSVIAGPVKTINCHQDVILSMSFN 189
Query: 236 YNGSKVVCTDNSHITRIIDLRSSEPVLQEAMLHKKARRQNTVYLKNGL--IFSTGYSSTT 409
NGS + T RI+D R VLQEA K R N V L + STG S
Sbjct: 190 TNGSLLATTCKDRKIRIVDPRLGI-VLQEASY--KGHRANKVLFLGSLKKLLSTGTSRWN 246
Query: 410 IREYALWDENDLSNPIELIDLDANSGVLYPIYDADINVIYVWGKGDSIMSFFEVVYEPKP 589
R+ ALWD+ +LS P+ DLD +SGVL+P +D+D +++Y+ GKGD + ++EV E KP
Sbjct: 247 NRQMALWDQENLSVPLTEEDLDGSSGVLFPFFDSDTSMLYIVGKGDGNIRYYEVSME-KP 305
Query: 590 TIQYLCCYQSAKPQNGVIAMPKLGVNVAANELTRLFKFY-ANGFCEVIPIICPRREQGFS 766
+ YL Y+S PQ G+ MPK G++V++ E+ R +K E + +I PRR + +
Sbjct: 306 HLTYLTEYRSYNPQKGIGIMPKRGLDVSSCEIFRFYKLITTKSLIEPVSMIVPRRSESYQ 365
Query: 767 EEVYPPTPSRVPSLTIDEWINGADADPILISLETG 871
E++YPPT + PSLT EW++G + PI++SL G
Sbjct: 366 EDIYPPTAAAQPSLTAHEWLSGMNRGPIMMSLRPG 400
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 102,927,114
Number of Sequences: 369166
Number of extensions: 2148922
Number of successful extensions: 5138
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4921
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5074
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8646143400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)