Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_F08
(769 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8WMQ3|CD9_PIG CD9 antigen 82 2e-15
sp|Q922J6|TSN2_MOUSE Tetraspanin-2 (Tspan-2) 78 2e-14
sp|Q9JJW1|TSN2_RAT Tetraspanin-2 (Tspan-2) 77 4e-14
sp|O60636|TSN2_HUMAN Tetraspanin-2 (Tspan-2) 76 1e-13
sp|P40239|CD9_FELCA CD9 antigen 75 1e-13
sp|P30409|CD9_CERAE CD9 antigen (27 kDa diphtheria toxin re... 75 3e-13
sp|P21926|CD9_HUMAN CD9 antigen (p24) (Leukocyte antigen MI... 75 3e-13
sp|P30932|CD9_BOVIN CD9 antigen 74 6e-13
sp|P40240|CD9_MOUSE CD9 antigen 73 7e-13
sp|O97703|CD81_CERAE CD81 antigen 72 1e-12
>sp|Q8WMQ3|CD9_PIG CD9 antigen
Length = 226
Score = 81.6 bits (200), Expect = 2e-15
Identities = 59/220 (26%), Positives = 89/220 (40%), Gaps = 8/220 (3%)
Frame = +1
Query: 64 CIRILMMIFNFIFVLCXXXXXXXXXXXXXXXXXKNMGA---DGSAVVIAFYVTMGVGAFT 234
CI+ L+ FNFIF L K++ + S+ Y+ +G GA
Sbjct: 9 CIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQENNNSSFYTGVYILIGAGALM 68
Query: 235 LIVGACGCCGAYHESPCLLGTYXXXXXXXXXXXXXXGVLVFLYKDTVKAYVENKFEKGKN 414
++VG GCCGA ES C+LG + + + +KD V V++ + N
Sbjct: 69 MVVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDQVIKEVQDFYRDTYN 128
Query: 415 EISGDNKNNNGHWMHEAHKYLQCCGNKGPSDYSSPPKSCCLADNCENVN-----SMKGCG 579
++ G + + + H L CCG G + LAD C + MK C
Sbjct: 129 KLKGKD-DPQRETLKAIHYALDCCGLMGEVEQ-------LLADICPQRDVLSSLPMKPCP 180
Query: 580 ETWKELIQNRWILFASVXXXXXXXXXXXXXFSMCLCCTAR 699
E KE+ QN++ + +V FSM LCC R
Sbjct: 181 EAIKEVFQNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIR 220
>sp|Q922J6|TSN2_MOUSE Tetraspanin-2 (Tspan-2)
Length = 221
Score = 78.2 bits (191), Expect = 2e-14
Identities = 56/216 (25%), Positives = 89/216 (41%), Gaps = 3/216 (1%)
Frame = +1
Query: 64 CIRILMMIFNFIFVLCXXXXXXXXXXXXXXXXXKNMGADGSA---VVIAFYVTMGVGAFT 234
CI+ L++ FN +F L K++ ++ + + YV +G GA
Sbjct: 10 CIKYLLLGFNLLFWLAGSAVIAFGLWFRFGGTMKDLSSEDKSPEYFYVGLYVLVGAGALM 69
Query: 235 LIVGACGCCGAYHESPCLLGTYXXXXXXXXXXXXXXGVLVFLYKDTVKAYVENKFEKGKN 414
+ VG GCCGA ES C+LG++ GV F+ KD +V++ +E+ +
Sbjct: 70 MTVGFFGCCGAMRESQCVLGSFFTCLLVIFAAEVTTGVFAFIGKDVAIRHVQSMYEEAYS 129
Query: 415 EISGDNKNNNGHWMHEAHKYLQCCGNKGPSDYSSPPKSCCLADNCENVNSMKGCGETWKE 594
+ D NG + H QCCG K S+ P +C + + K C + +
Sbjct: 130 DYLKDRARGNG-TLITFHSAFQCCG-KESSEQVQP--TC-----PKELPGHKNCIDKIET 180
Query: 595 LIQNRWILFASVXXXXXXXXXXXXXFSMCLCCTARS 702
+I + L V FSM LCC R+
Sbjct: 181 VISAKLQLIGIVGIGIAGLTIFGMIFSMVLCCAIRN 216
>sp|Q9JJW1|TSN2_RAT Tetraspanin-2 (Tspan-2)
Length = 221
Score = 77.4 bits (189), Expect = 4e-14
Identities = 56/216 (25%), Positives = 89/216 (41%), Gaps = 3/216 (1%)
Frame = +1
Query: 64 CIRILMMIFNFIFVLCXXXXXXXXXXXXXXXXXKNMGADGSA---VVIAFYVTMGVGAFT 234
CI+ L++ FN +F L K++ ++ + + YV +G GA
Sbjct: 10 CIKYLLLGFNLLFWLAGSAVIAFGLWFRFGGTIKDLSSEEKSPEYFYVGLYVLVGAGALM 69
Query: 235 LIVGACGCCGAYHESPCLLGTYXXXXXXXXXXXXXXGVLVFLYKDTVKAYVENKFEKGKN 414
+ VG GCCGA ES C+LG++ GV F+ KD +V++ +E+ +
Sbjct: 70 MAVGFFGCCGAMRESQCVLGSFFTCLLVIFAAEVTTGVFAFIGKDVAIRHVQSMYEEAYS 129
Query: 415 EISGDNKNNNGHWMHEAHKYLQCCGNKGPSDYSSPPKSCCLADNCENVNSMKGCGETWKE 594
+ D NG + H QCCG K S+ P +C + + K C + +
Sbjct: 130 DYVRDRGRGNG-TLITFHSAFQCCG-KESSEQVQP--TC-----PKELPGHKNCIDKIET 180
Query: 595 LIQNRWILFASVXXXXXXXXXXXXXFSMCLCCTARS 702
+I + L V FSM LCC R+
Sbjct: 181 IISVKLQLIGIVGIGIAGLTIFGMIFSMVLCCAIRN 216
>sp|O60636|TSN2_HUMAN Tetraspanin-2 (Tspan-2)
Length = 221
Score = 75.9 bits (185), Expect = 1e-13
Identities = 56/216 (25%), Positives = 86/216 (39%), Gaps = 3/216 (1%)
Frame = +1
Query: 64 CIRILMMIFNFIFVLCXXXXXXXXXXXXXXXXXKNMGADGSA---VVIAFYVTMGVGAFT 234
CI+ L++ FN +F L K + ++ + + YV +G GA
Sbjct: 10 CIKYLLLGFNLLFWLAGSAVIAFGLWFRFGGAIKELSSEDKSPEYFYVGLYVLVGAGALM 69
Query: 235 LIVGACGCCGAYHESPCLLGTYXXXXXXXXXXXXXXGVLVFLYKDTVKAYVENKFEKGKN 414
+ VG GCCGA ES C+LG++ GV F+ K +V+ +E+ N
Sbjct: 70 MAVGFFGCCGAMRESQCVLGSFFTCLLVIFAAEVTTGVFAFIGKGVAIRHVQTMYEEAYN 129
Query: 415 EISGDNKNNNGHWMHEAHKYLQCCGNKGPSDYSSPPKSCCLADNCENVNSMKGCGETWKE 594
+ D NG + H QCCG K S+ P +C + + K C + +
Sbjct: 130 DYLKDRGKGNG-TLITFHSTFQCCG-KESSEQVQP--TC-----PKELLGHKNCIDEIET 180
Query: 595 LIQNRWILFASVXXXXXXXXXXXXXFSMCLCCTARS 702
+I + L V FSM LCC R+
Sbjct: 181 IISVKLQLIGIVGIGIAGLTIFGMIFSMVLCCAIRN 216
>sp|P40239|CD9_FELCA CD9 antigen
Length = 226
Score = 75.5 bits (184), Expect = 1e-13
Identities = 53/215 (24%), Positives = 86/215 (40%), Gaps = 3/215 (1%)
Frame = +1
Query: 64 CIRILMMIFNFIFVLCXXXXXXXXXXXXXXXXXKNM---GADGSAVVIAFYVTMGVGAFT 234
CI+ L+ FNFIF L K++ + S+ Y+ +G GA
Sbjct: 9 CIKYLLFGFNFIFWLAGIAVLAVGLWLRFDSQTKSIFEQDSQPSSFYTGVYILIGAGALM 68
Query: 235 LIVGACGCCGAYHESPCLLGTYXXXXXXXXXXXXXXGVLVFLYKDTVKAYVENKFEKGKN 414
++VG GCCGA ES C+LG + + + +KD V V+ ++ N
Sbjct: 69 MLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDEVIQEVQEFYKDTYN 128
Query: 415 EISGDNKNNNGHWMHEAHKYLQCCGNKGPSDYSSPPKSCCLADNCENVNSMKGCGETWKE 594
++ ++ + H L CCG G + C + + ++K C E KE
Sbjct: 129 KLKSKDEPQR-DTLKAIHYALDCCGLAGGVEQFI--SDICPQKDILSSITVKPCPEAIKE 185
Query: 595 LIQNRWILFASVXXXXXXXXXXXXXFSMCLCCTAR 699
+ N++ + +V FSM LCC R
Sbjct: 186 VFHNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIR 220
>sp|P30409|CD9_CERAE CD9 antigen (27 kDa diphtheria toxin receptor-associated protein)
(DRAP27)
Length = 228
Score = 74.7 bits (182), Expect = 3e-13
Identities = 52/217 (23%), Positives = 85/217 (39%), Gaps = 5/217 (2%)
Frame = +1
Query: 64 CIRILMMIFNFIFVLCXXXXXXXXXXXXXXXXXKNM-----GADGSAVVIAFYVTMGVGA 228
CI+ L+ FNFIF L K++ + S+ Y+ +G GA
Sbjct: 9 CIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNNNNSSFYTGVYILIGAGA 68
Query: 229 FTLIVGACGCCGAYHESPCLLGTYXXXXXXXXXXXXXXGVLVFLYKDTVKAYVENKFEKG 408
++VG GCCGA ES C+LG + + + +KD V V+ ++
Sbjct: 69 LMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDEVIKEVQEFYKDT 128
Query: 409 KNEISGDNKNNNGHWMHEAHKYLQCCGNKGPSDYSSPPKSCCLADNCENVNSMKGCGETW 588
N++ ++ + H L CCG G + C + ++K C +
Sbjct: 129 YNKLKTKDEPQR-ETLKAIHYALDCCGLAGGVEQFI--SDICPKKDVLETFTIKSCPDAI 185
Query: 589 KELIQNRWILFASVXXXXXXXXXXXXXFSMCLCCTAR 699
KE+ N++ + +V FSM LCC R
Sbjct: 186 KEVFDNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIR 222
>sp|P21926|CD9_HUMAN CD9 antigen (p24) (Leukocyte antigen MIC3) (Motility-related
protein) (MRP-1) (Tetraspanin-29) (Tspan-29)
Length = 228
Score = 74.7 bits (182), Expect = 3e-13
Identities = 52/217 (23%), Positives = 85/217 (39%), Gaps = 5/217 (2%)
Frame = +1
Query: 64 CIRILMMIFNFIFVLCXXXXXXXXXXXXXXXXXKNM-----GADGSAVVIAFYVTMGVGA 228
CI+ L+ FNFIF L K++ + S+ Y+ +G GA
Sbjct: 9 CIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNNNNSSFYTGVYILIGAGA 68
Query: 229 FTLIVGACGCCGAYHESPCLLGTYXXXXXXXXXXXXXXGVLVFLYKDTVKAYVENKFEKG 408
++VG GCCGA ES C+LG + + + +KD V V+ ++
Sbjct: 69 LMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDEVIKEVQEFYKDT 128
Query: 409 KNEISGDNKNNNGHWMHEAHKYLQCCGNKGPSDYSSPPKSCCLADNCENVNSMKGCGETW 588
N++ ++ + H L CCG G + C + ++K C +
Sbjct: 129 YNKLKTKDEPQR-ETLKAIHYALNCCGLAGGVEQFI--SDICPKKDVLETFTVKSCPDAI 185
Query: 589 KELIQNRWILFASVXXXXXXXXXXXXXFSMCLCCTAR 699
KE+ N++ + +V FSM LCC R
Sbjct: 186 KEVFDNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIR 222
>sp|P30932|CD9_BOVIN CD9 antigen
Length = 226
Score = 73.6 bits (179), Expect = 6e-13
Identities = 58/226 (25%), Positives = 95/226 (42%), Gaps = 7/226 (3%)
Frame = +1
Query: 64 CIRILMMIFNFIFVLCXXXXXXXXXXXXXXXXXKNMGA---DGSAVVIAFYVTMGVGAFT 234
CI+ L+ FNFIF L K++ + S+ Y+ +G GA
Sbjct: 9 CIKYLLFGFNFIFWLAGIAVLSVGLWLRFDSQTKSIFEQENNDSSFYTGVYILIGAGALM 68
Query: 235 LIVGACGCCGAYHESPCLLGTYXXXXXXXXXXXXXXGVLVFLYKDTVKAYVENKFEKGKN 414
++VG GCCGA ES C+LG + + + +K+ V V+ +E N
Sbjct: 69 MLVGFLGCCGAVQESQCMLGLFFSFLLVIFAIEVAAAIWGYSHKEEVIKEVQKFYEDTYN 128
Query: 415 EISGDNKNNNGHWMHEAHKYLQCCGNKG-PSDY---SSPPKSCCLADNCENVNSMKGCGE 582
++ ++ + H L CCG G P + + PPK+ L D+ + + C E
Sbjct: 129 KLKNKDEPQR-ETLKAIHIALDCCGLTGVPEQFLTDTCPPKN--LIDSLKT----RPCPE 181
Query: 583 TWKELIQNRWILFASVXXXXXXXXXXXXXFSMCLCCTARSIDYDMV 720
E+ ++++ + +V FSM LCC R + DMV
Sbjct: 182 AIDEIFRSKFHIIGAVGIGIAVVMIFGMVFSMILCCAIRR-NRDMV 226
>sp|P40240|CD9_MOUSE CD9 antigen
Length = 226
Score = 73.2 bits (178), Expect = 7e-13
Identities = 53/220 (24%), Positives = 85/220 (38%), Gaps = 8/220 (3%)
Frame = +1
Query: 64 CIRILMMIFNFIFVLCXXXXXXXXXXXXXXXXXKNMGA---DGSAVVIAFYVTMGVGAFT 234
CI+ L+ FNFIF L K++ + S+ Y+ +G GA
Sbjct: 9 CIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQENNHSSFYTGVYILIGAGALM 68
Query: 235 LIVGACGCCGAYHESPCLLGTYXXXXXXXXXXXXXXGVLVFLYKDTVKAYVENKFEKGKN 414
++VG GCCGA ES C+LG + V + +KD V ++ ++
Sbjct: 69 MLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAVWGYTHKDEVIKELQEFYKDTYQ 128
Query: 415 EISGDNKNNNGHWMHEAHKYLQCCGNKGPSDYSSPPKSCCLADNCENVN-----SMKGCG 579
++ ++ + H L CCG GP + ++D C +K C
Sbjct: 129 KLRSKDEPQR-ETLKAIHMALDCCGIAGPLEQ-------FISDTCPKKQLLESFQVKPCP 180
Query: 580 ETWKELIQNRWILFASVXXXXXXXXXXXXXFSMCLCCTAR 699
E E+ N++ + +V FSM LCC R
Sbjct: 181 EAISEVFNNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIR 220
>sp|O97703|CD81_CERAE CD81 antigen
Length = 236
Score = 72.4 bits (176), Expect = 1e-12
Identities = 54/227 (23%), Positives = 86/227 (37%), Gaps = 11/227 (4%)
Frame = +1
Query: 55 CHSCIRILMMIFNFIFVLCXXXXXXXXXXXXXXXXXKNM-------GADGSAVVIAFYVT 213
C CI+ L+ +FNF+F L N+ + + Y+
Sbjct: 6 CTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTNLLYLELGDKPAPNTFYVGIYIL 65
Query: 214 MGVGAFTLIVGACGCCGAYHESPCLLGTYXXXXXXXXXXXXXXGVLVFLYKDTVKAYVEN 393
+ VGA + VG GC GA ES CLLGT+ G+ F+ KD + V+
Sbjct: 66 IAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQ 125
Query: 394 KFEKG-KNEISGDNKNNNGHWMHEAHKYLQCCGNKGPSDYSSPPKSCCLADNCENVNS-- 564
+++ + + D+ NN + H+ L CCG+ + ++ L + N+ S
Sbjct: 126 FYDQALQQAVVDDDANNAKAVVKTFHETLDCCGSSTLAALTTSVLKNNLCPSGSNIISNL 185
Query: 565 -MKGCGETWKELIQNRWILFASVXXXXXXXXXXXXXFSMCLCCTARS 702
K C + EL + L SM LCC R+
Sbjct: 186 LKKDCHQKIDELFSGKLYLIGIAAIVVAVIMIFEMILSMVLCCGIRN 232
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,768,940
Number of Sequences: 369166
Number of extensions: 1458896
Number of successful extensions: 4068
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3874
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4004
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7115329200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)