Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_E05
(678 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O35129|PHB2_MOUSE Prohibitin-2 (B-cell receptor-associat... 254 1e-67
sp|Q5XIH7|PHB2_RAT Prohibitin-2 (B-cell receptor-associated... 254 1e-67
sp|P50093|PHB2_CAEEL Mitochondrial prohibitin complex prote... 237 2e-62
sp|P50085|PHB2_YEAST Prohibitin-2 214 2e-55
sp|P67778|PHB_MOUSE Prohibitin (B-cell receptor associated ... 189 7e-48
sp|P40961|PHB_YEAST Prohibitin 189 7e-48
sp|P35232|PHB_HUMAN Prohibitin 187 2e-47
sp|P24156|L2CC_DROME L(2)37Cc protein 177 2e-44
sp|Q9BKU4|PHB1_CAEEL Mitochondrial prohibitin complex prote... 172 6e-43
sp|O28852|Y1420_ARCFU Hypothetical protein AF1420 54 5e-07
>sp|O35129|PHB2_MOUSE Prohibitin-2 (B-cell receptor-associated protein BAP37) (Repressor
of estrogen receptor activity)
sp|Q99623|PHB2_HUMAN Prohibitin-2 (B-cell receptor-associated protein BAP37) (Repressor
of estrogen receptor activity) (D-prohibitin)
Length = 299
Score = 254 bits (650), Expect = 1e-67
Identities = 126/192 (65%), Positives = 169/192 (88%)
Frame = +3
Query: 18 NSDLQMVNISLRVLSRPDINKIPTIYKSLGEDYDERVLPSISNEVLKAVVAKFNAGQLIT 197
+ DLQMVNISLRVLSRP+ ++P++Y+ LG DY+ERVLPSI NEVLK+VVAKFNA QLIT
Sbjct: 96 SKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLIT 155
Query: 198 QREQVSLLIRKLLIERAKDFNIIVDDVSITDLSFSKQYGEAVERKQISQQEAQRAQFTVM 377
QR QVSLLIR+ L ERAKDF++I+DDV+IT+LSFS++Y AVE KQ++QQEAQRAQF V
Sbjct: 156 QRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVE 215
Query: 378 RAKQERQQKIVNAEGEAQAAILIGDALSQSSGYLKLRKIKAAEKIARTLSTAQNKAYLNA 557
+AKQE++QKIV AEGEA+AA ++G+ALS++ GY+KLRKI+AA+ I++T++T+QN+ YL A
Sbjct: 216 KAKQEQRQKIVQAEGEAEAAKMLGEALSKNPGYIKLRKIRAAQNISKTIATSQNRIYLTA 275
Query: 558 NTLMMNINDKTF 593
+ L++N+ D++F
Sbjct: 276 DNLVLNLQDESF 287
>sp|Q5XIH7|PHB2_RAT Prohibitin-2 (B-cell receptor-associated protein BAP37) (BAP-37)
Length = 299
Score = 254 bits (650), Expect = 1e-67
Identities = 126/192 (65%), Positives = 169/192 (88%)
Frame = +3
Query: 18 NSDLQMVNISLRVLSRPDINKIPTIYKSLGEDYDERVLPSISNEVLKAVVAKFNAGQLIT 197
+ DLQMVNISLRVLSRP+ ++P++Y+ LG DY+ERVLPSI NEVLK+VVAKFNA QLIT
Sbjct: 96 SKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLIT 155
Query: 198 QREQVSLLIRKLLIERAKDFNIIVDDVSITDLSFSKQYGEAVERKQISQQEAQRAQFTVM 377
QR QVSLLIR+ L ERAKDF++I+DDV+IT+LSFS++Y AVE KQ++QQEAQRAQF V
Sbjct: 156 QRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVE 215
Query: 378 RAKQERQQKIVNAEGEAQAAILIGDALSQSSGYLKLRKIKAAEKIARTLSTAQNKAYLNA 557
+AKQE++QKIV AEGEA+AA ++G+ALS++ GY+KLRKI+AA+ I++T++T+QN+ YL A
Sbjct: 216 KAKQEQRQKIVQAEGEAEAAKMLGEALSKNPGYIKLRKIRAAQNISKTIATSQNRIYLTA 275
Query: 558 NTLMMNINDKTF 593
+ L++N+ D++F
Sbjct: 276 DNLVLNLQDESF 287
>sp|P50093|PHB2_CAEEL Mitochondrial prohibitin complex protein 2 (Prohibitin-2)
Length = 286
Score = 237 bits (605), Expect = 2e-62
Identities = 122/192 (63%), Positives = 155/192 (80%)
Frame = +3
Query: 18 NSDLQMVNISLRVLSRPDINKIPTIYKSLGEDYDERVLPSISNEVLKAVVAKFNAGQLIT 197
+ DLQMVNI LRVLSRP+ + IY++LG++++ERVLPSI NEVLK VVAKFNA QLIT
Sbjct: 87 SKDLQMVNIGLRVLSRPNPEHLVHIYRTLGQNWEERVLPSICNEVLKGVVAKFNASQLIT 146
Query: 198 QREQVSLLIRKLLIERAKDFNIIVDDVSITDLSFSKQYGEAVERKQISQQEAQRAQFTVM 377
QR+QVS+L+RK LIERA DFNII+DDVS+T+L+FS QY AVE KQ++ QEAQRA F V
Sbjct: 147 QRQQVSMLVRKTLIERALDFNIILDDVSLTELAFSPQYSAAVEAKQVAAQEAQRATFYVE 206
Query: 378 RAKQERQQKIVNAEGEAQAAILIGDALSQSSGYLKLRKIKAAEKIARTLSTAQNKAYLNA 557
RAKQ++Q+KIV AEGEA++A L+G+A+ G+LKLRKI+AA+KIAR +S + NK YL
Sbjct: 207 RAKQQKQEKIVQAEGEAESAKLLGEAMKNDPGFLKLRKIRAAQKIARIVSESGNKTYLPT 266
Query: 558 NTLMMNINDKTF 593
LM+NI D +
Sbjct: 267 GGLMLNIADTDY 278
>sp|P50085|PHB2_YEAST Prohibitin-2
Length = 315
Score = 214 bits (544), Expect = 2e-55
Identities = 107/184 (58%), Positives = 149/184 (80%)
Frame = +3
Query: 24 DLQMVNISLRVLSRPDINKIPTIYKSLGEDYDERVLPSISNEVLKAVVAKFNAGQLITQR 203
DLQMVNI+ RVLSRPD+ ++PTIY++LG+DYDERVLPSI NEVLKAVVA+FNA QLITQR
Sbjct: 115 DLQMVNITCRVLSRPDVVQLPTIYRTLGQDYDERVLPSIVNEVLKAVVAQFNASQLITQR 174
Query: 204 EQVSLLIRKLLIERAKDFNIIVDDVSITDLSFSKQYGEAVERKQISQQEAQRAQFTVMRA 383
E+VS LIR+ L+ RA FNI++DDVSIT ++FS ++ AVE KQI+QQ+AQRA F V +A
Sbjct: 175 EKVSRLIRENLVRRASKFNILLDDVSITYMTFSPEFTNAVEAKQIAQQDAQRAAFVVDKA 234
Query: 384 KQERQQKIVNAEGEAQAAILIGDALSQSSGYLKLRKIKAAEKIARTLSTAQNKAYLNANT 563
+QE+Q +V A+GEA++A LIG+A+ +S Y++L+++ A IA+ L+++ N+ L+
Sbjct: 235 RQEKQGMVVRAQGEAKSAELIGEAIKKSRDYVELKRLDTARDIAKILASSPNRVILDNEA 294
Query: 564 LMMN 575
L++N
Sbjct: 295 LLLN 298
>sp|P67778|PHB_MOUSE Prohibitin (B-cell receptor associated protein 32) (BAP 32)
sp|P67779|PHB_RAT Prohibitin
Length = 272
Score = 189 bits (479), Expect = 7e-48
Identities = 98/181 (54%), Positives = 142/181 (78%), Gaps = 1/181 (0%)
Frame = +3
Query: 18 NSDLQMVNISLRVLSRPDINKIPTIYKSLGEDYDERVLPSISNEVLKAVVAKFNAGQLIT 197
+ DLQ VNI+LR+L RP +++P IY S+GEDYDERVLPSI+ E+LK+VVA+F+AG+LIT
Sbjct: 82 SKDLQNVNITLRILFRPVASQLPRIYTSIGEDYDERVLPSITTEILKSVVARFDAGELIT 141
Query: 198 QREQVSLLIRKLLIERAKDFNIIVDDVSITDLSFSKQYGEAVERKQISQQEAQRAQFTVM 377
QRE VS + L ERA F +I+DDVS+T L+F K++ EAVE KQ++QQEA+RA+F V
Sbjct: 142 QRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVE 201
Query: 378 RAKQERQQKIVNAEGEAQAAILIGDALSQS-SGYLKLRKIKAAEKIARTLSTAQNKAYLN 554
+A+Q+++ I++AEG+++AA LI ++L+ + G ++LRK++AAE IA LS ++N YL
Sbjct: 202 KAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLP 261
Query: 555 A 557
A
Sbjct: 262 A 262
>sp|P40961|PHB_YEAST Prohibitin
Length = 287
Score = 189 bits (479), Expect = 7e-48
Identities = 96/183 (52%), Positives = 142/183 (77%), Gaps = 1/183 (0%)
Frame = +3
Query: 6 TNSQNSDLQMVNISLRVLSRPDINKIPTIYKSLGEDYDERVLPSISNEVLKAVVAKFNAG 185
TN+ DLQMV+++LRVL RP++ ++P IY++LG DYDERVLPSI NEVLK++VA+F+A
Sbjct: 80 TNTGTKDLQMVSLTLRVLHRPEVLQLPAIYQNLGLDYDERVLPSIGNEVLKSIVAQFDAA 139
Query: 186 QLITQREQVSLLIRKLLIERAKDFNIIVDDVSITDLSFSKQYGEAVERKQISQQEAQRAQ 365
+LITQRE +S IRK L RA +F I ++DVSIT ++F ++ +AVE+KQI+QQ+A+RA+
Sbjct: 140 ELITQREIISQKIRKELSTRANEFGIKLEDVSITHMTFGPEFTKAVEQKQIAQQDAERAK 199
Query: 366 FTVMRAKQERQQKIVNAEGEAQAAILIGDALSQ-SSGYLKLRKIKAAEKIARTLSTAQNK 542
F V +A+QERQ ++ AEGEA++A I AL++ G L +R+++A++ IA+TL+ + N
Sbjct: 200 FLVEKAEQERQASVIRAEGEAESAEFISKALAKVGDGLLLIRRLEASKDIAQTLANSSNV 259
Query: 543 AYL 551
YL
Sbjct: 260 VYL 262
>sp|P35232|PHB_HUMAN Prohibitin
Length = 272
Score = 187 bits (475), Expect = 2e-47
Identities = 97/181 (53%), Positives = 142/181 (78%), Gaps = 1/181 (0%)
Frame = +3
Query: 18 NSDLQMVNISLRVLSRPDINKIPTIYKSLGEDYDERVLPSISNEVLKAVVAKFNAGQLIT 197
+ DLQ VNI+LR+L RP +++P I+ S+GEDYDERVLPSI+ E+LK+VVA+F+AG+LIT
Sbjct: 82 SKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDERVLPSITTEILKSVVARFDAGELIT 141
Query: 198 QREQVSLLIRKLLIERAKDFNIIVDDVSITDLSFSKQYGEAVERKQISQQEAQRAQFTVM 377
QRE VS + L ERA F +I+DDVS+T L+F K++ EAVE KQ++QQEA+RA+F V
Sbjct: 142 QRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVE 201
Query: 378 RAKQERQQKIVNAEGEAQAAILIGDALSQS-SGYLKLRKIKAAEKIARTLSTAQNKAYLN 554
+A+Q+++ I++AEG+++AA LI ++L+ + G ++LRK++AAE IA LS ++N YL
Sbjct: 202 KAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLP 261
Query: 555 A 557
A
Sbjct: 262 A 262
>sp|P24156|L2CC_DROME L(2)37Cc protein
Length = 276
Score = 177 bits (450), Expect = 2e-44
Identities = 94/189 (49%), Positives = 142/189 (75%), Gaps = 2/189 (1%)
Frame = +3
Query: 18 NSDLQMVNISLRVLSRPDINKIPTIYKSLGEDYDERVLPSISNEVLKAVVAKFNAGQLIT 197
+ DLQ VNI+LR+L RP +++P IY LG+DYDERVLPSI+ EVLKAVVA+F+AG+LIT
Sbjct: 82 SKDLQNVNITLRILYRPIPDQLPKIYTILGQDYDERVLPSIAPEVLKAVVAQFDAGELIT 141
Query: 198 QREQVSLLIRKLLIERAKDFNIIVDDVSITDLSFSKQYGEAVERKQISQQEAQRAQFTVM 377
QRE VS + + L RAK F I+DD+S+T L+F +++ AVE KQ++QQEA++A+F V
Sbjct: 142 QREMVSQRVSQELTVRAKQFGFILDDISLTHLTFGREFTLAVEMKQVAQQEAEKARFVVE 201
Query: 378 RAKQERQQKIVNAEGEAQAAILIGDALSQS-SGYLKLRKIKAAEKIARTLSTAQNKAYL- 551
+A+Q++ I++AEG+A+AA L+ + ++ G ++LR+I+AAE IA LS ++ AYL
Sbjct: 202 KAEQQKLASIISAEGDAEAAGLLAKSFGEAGDGLVELRRIEAAEDIAYQLSRSRGVAYLP 261
Query: 552 NANTLMMNI 578
+ + ++N+
Sbjct: 262 SGQSTLLNL 270
>sp|Q9BKU4|PHB1_CAEEL Mitochondrial prohibitin complex protein 1 (Prohibitin-1)
Length = 275
Score = 172 bits (437), Expect = 6e-43
Identities = 92/186 (49%), Positives = 134/186 (72%), Gaps = 1/186 (0%)
Frame = +3
Query: 6 TNSQNSDLQMVNISLRVLSRPDINKIPTIYKSLGEDYDERVLPSISNEVLKAVVAKFNAG 185
T + + DLQ VNI+LR+L RP +++P IY ++G DY ERVLPSI+NEVLKAVVA+F+A
Sbjct: 81 TITGSKDLQNVNITLRILHRPSPDRLPNIYLNIGLDYAERVLPSITNEVLKAVVAQFDAH 140
Query: 186 QLITQREQVSLLIRKLLIERAKDFNIIVDDVSITDLSFSKQYGEAVERKQISQQEAQRAQ 365
++ITQRE VS L ERA F +++DD++IT L+F +++ EAVE KQ++QQEA++A+
Sbjct: 141 EMITQREVVSQRASVALRERAAQFGLLLDDIAITHLNFGREFTEAVEMKQVAQQEAEKAR 200
Query: 366 FTVMRAKQERQQKIVNAEGEAQAAILIGDAL-SQSSGYLKLRKIKAAEKIARTLSTAQNK 542
+ V +A+Q + + AEG+AQAA L+ A S G ++LRKI+AAE+IA ++ +N
Sbjct: 201 YLVEKAEQMKIAAVTTAEGDAQAAKLLAKAFASAGDGLVELRKIEAAEEIAERMAKNKNV 260
Query: 543 AYLNAN 560
YL N
Sbjct: 261 TYLPGN 266
>sp|O28852|Y1420_ARCFU Hypothetical protein AF1420
Length = 249
Score = 53.5 bits (127), Expect = 5e-07
Identities = 37/149 (24%), Positives = 78/149 (52%), Gaps = 4/149 (2%)
Frame = +3
Query: 96 KSLGEDYD-ERVLPSISNEVLKAVVAKFNAGQLITQREQVSLLIRKLLIERAKDFNIIVD 272
K++ E +D + ++ L++++ + +++++R+++++ +++++ E + I V
Sbjct: 95 KAVTEVFDYQYATAQLAQTTLRSIIGQAELDEVLSERDKLNVKLQQIIDEETNPWGIKVT 154
Query: 273 DVSITDLSFSKQYGEAVERKQISQQEAQRAQFTVMRAKQERQQKIVNAEGEAQAAILI-- 446
V I D+ E + R Q EA+R ER+ KI+ AEGE QAA+ +
Sbjct: 155 AVEIKDVELP----EEMRRIMAMQAEAER----------ERRSKIIRAEGEYQAAMKLRE 200
Query: 447 -GDALSQSSGYLKLRKIKAAEKIARTLST 530
D L+QS G + LR ++ +I+ +T
Sbjct: 201 AADVLAQSEGAILLRYLQTLNEISAEQNT 229
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,370,144
Number of Sequences: 369166
Number of extensions: 853139
Number of successful extensions: 3084
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2952
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3072
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5733423530
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)