Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_D12
(809 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P33527|MRP1_HUMAN Multidrug resistance-associated protei... 323 4e-88
sp|O88563|MRP3_RAT Canalicular multispecific organic anion ... 319 6e-87
sp|O35379|MRP1_MOUSE Multidrug resistance-associated protei... 316 4e-86
sp|O15438|MRP3_HUMAN Canalicular multispecific organic anio... 314 2e-85
sp|Q8VI47|MRP2_MOUSE Canalicular multispecific organic anio... 313 3e-85
sp|Q63120|MRP2_RAT Canalicular multispecific organic anion ... 311 2e-84
sp|Q28689|MRP2_RABIT Canalicular multispecific organic anio... 311 2e-84
sp|P39109|YCFI_YEAST Metal resistance protein YCF1 (Yeast c... 308 1e-83
sp|Q92887|MRP2_HUMAN Canalicular multispecific organic anio... 305 7e-83
sp|P14772|BPT1_YEAST Bile pigment transporter 1 293 4e-79
>sp|P33527|MRP1_HUMAN Multidrug resistance-associated protein 1 (ATP-binding cassette
sub-family C member 1)
Length = 1531
Score = 323 bits (827), Expect = 4e-88
Identities = 161/269 (59%), Positives = 210/269 (78%), Gaps = 1/269 (0%)
Frame = +2
Query: 2 VSYALSITQTLNWLVRMXXXXXXXXXXXXRIQEYSQMTPEAPWEIPDKKPDEKWP-LGYI 178
VSY+L +T LNWLVRM R++EYS+ EAPW+I + P WP +G +
Sbjct: 1234 VSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRV 1293
Query: 179 KFANYSTKYREGLDDVLKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEIII 358
+F NY +YRE LD VL+++N IN EKVGIVGRTG+GKSSL L LFRI E + GEIII
Sbjct: 1294 EFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIII 1353
Query: 359 DGLPIHELGLHDVRGRLTIIPQDPVLFSGTLRRNLDPFNKHTDDEIWKVLTMSNLKTFVE 538
DG+ I ++GLHD+R ++TIIPQDPVLFSG+LR NLDPF++++D+E+W L +++LK FV
Sbjct: 1354 DGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFV- 1412
Query: 539 NSGSEQLQMTISEGGENLSVGQRQLMCLARALLRRTNILVLDEATAAVDLDTDVLIQNTI 718
++ ++L +EGGENLSVGQRQL+CLARALLR+T ILVLDEATAAVDL+TD LIQ+TI
Sbjct: 1413 SALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTI 1472
Query: 719 RQEFKDCTILTIAHRLNTVLDYDQILVLD 805
R +F+DCT+LTIAHRLNT++DY +++VLD
Sbjct: 1473 RTQFEDCTVLTIAHRLNTIMDYTRVIVLD 1501
Score = 60.8 bits (146), Expect = 4e-09
Identities = 52/202 (25%), Positives = 92/202 (45%), Gaps = 10/202 (4%)
Frame = +2
Query: 227 LKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEIIIDGLPIHELGLHDVRGR 406
L + F I V +VG+ G GKSSL+ AL +++ G + I +G
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI-------------KGS 707
Query: 407 LTIIPQDPVLFSGTLRRNL-------DPFNKHTDDEIWKVLTMSNLKTFVENSGSEQLQM 565
+ +PQ + + +LR N+ +P+ + I + +L+ +E
Sbjct: 708 VAYVPQQAWIQNDSLRENILFGCQLEEPYYRSV---IQACALLPDLEILPSGDRTE---- 760
Query: 566 TISEGGENLSVGQRQLMCLARALLRRTNILVLDEATAAVDLDTDV-LIQNTI--RQEFKD 736
I E G NLS GQ+Q + LARA+ +I + D+ +AVD + +N I + K+
Sbjct: 761 -IGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKN 819
Query: 737 CTILTIAHRLNTVLDYDQILVL 802
T + + H ++ + D I+V+
Sbjct: 820 KTRILVTHSMSYLPQVDVIIVM 841
>sp|O88563|MRP3_RAT Canalicular multispecific organic anion transporter 2 (Multidrug
resistance-associated protein 3) (MRP-like protein 2)
(MLP-2)
Length = 1522
Score = 319 bits (817), Expect = 6e-87
Identities = 156/269 (57%), Positives = 203/269 (75%), Gaps = 1/269 (0%)
Frame = +2
Query: 2 VSYALSITQTLNWLVRMXXXXXXXXXXXXRIQEYSQMTPEAPWEIPDKKPDEKWPL-GYI 178
VSYAL +T +LNW++R R++EYS+ EAPW + + E WP G +
Sbjct: 1225 VSYALQVTLSLNWMIRTLSDLESNIIAVERVKEYSKTETEAPWVLESNRAPEGWPRSGVV 1284
Query: 179 KFANYSTKYREGLDDVLKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEIII 358
+F NYS +YR GL+ VLKN+ + EKVGIVGRTG+GKSS+ L LFRILE + GEI I
Sbjct: 1285 EFRNYSVRYRPGLELVLKNLTLHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIFI 1344
Query: 359 DGLPIHELGLHDVRGRLTIIPQDPVLFSGTLRRNLDPFNKHTDDEIWKVLTMSNLKTFVE 538
DGL + +GLHD+R +LTIIPQDP+LFSGTLR NLDPF +++D++IW+ L +S+L FV
Sbjct: 1345 DGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSDEDIWRTLELSHLSAFV- 1403
Query: 539 NSGSEQLQMTISEGGENLSVGQRQLMCLARALLRRTNILVLDEATAAVDLDTDVLIQNTI 718
+S L SEGG+NLSVGQRQL+CLARALLR++ +LVLDEATAA+DL+TD LIQ TI
Sbjct: 1404 SSQPTGLDFQCSEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTI 1463
Query: 719 RQEFKDCTILTIAHRLNTVLDYDQILVLD 805
R +F+DCT+LTIAHRLNT++DY+++LVLD
Sbjct: 1464 RTQFEDCTVLTIAHRLNTIMDYNRVLVLD 1492
Score = 65.9 bits (159), Expect = 1e-10
Identities = 54/174 (31%), Positives = 82/174 (47%), Gaps = 4/174 (2%)
Frame = +2
Query: 176 IKFANYSTKYREGLDDVLKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEII 355
I N + + + L L ++N +I V +VG G GKSSLV AL +E+ G +
Sbjct: 625 ITIHNGTFSWSKDLPPTLHSINIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGAV- 683
Query: 356 IDGLPIHELGLHDVRGRLTIIPQDPVLFSGTLRRNL---DPFN-KHTDDEIWKVLTMSNL 523
V+G + +PQ + + TL+ N+ P N K + +++L
Sbjct: 684 ------------SVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADL 731
Query: 524 KTFVENSGSEQLQMTISEGGENLSVGQRQLMCLARALLRRTNILVLDEATAAVD 685
G +Q + I E G NLS GQRQ + LARA+ NI +LD+ +AVD
Sbjct: 732 DVL---PGGDQTE--IGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVD 780
>sp|O35379|MRP1_MOUSE Multidrug resistance-associated protein 1 (ATP-binding cassette
sub-family C member 1)
Length = 1528
Score = 316 bits (810), Expect = 4e-86
Identities = 160/269 (59%), Positives = 208/269 (77%), Gaps = 1/269 (0%)
Frame = +2
Query: 2 VSYALSITQTLNWLVRMXXXXXXXXXXXXRIQEYSQMTPEAPWEIPDKKPDEKWP-LGYI 178
VSY+L IT LNWLVRM R++EYS+ EAPW+I + P WP G +
Sbjct: 1231 VSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSTWPHSGRV 1290
Query: 179 KFANYSTKYREGLDDVLKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEIII 358
+F +Y +YRE LD VLK++N I EKVGIVGRTG+GKSSL L LFRI E + GEIII
Sbjct: 1291 EFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIII 1350
Query: 359 DGLPIHELGLHDVRGRLTIIPQDPVLFSGTLRRNLDPFNKHTDDEIWKVLTMSNLKTFVE 538
DG+ I ++GLH++R ++TIIPQDPVLFSG+LR NLDPF++++D+E+W L +++LK FV
Sbjct: 1351 DGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFV- 1409
Query: 539 NSGSEQLQMTISEGGENLSVGQRQLMCLARALLRRTNILVLDEATAAVDLDTDVLIQNTI 718
++ ++L +EGGENLSVGQRQL+CLARALLR+T ILVLDEATAAVDL+TD LIQ+TI
Sbjct: 1410 SALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTI 1469
Query: 719 RQEFKDCTILTIAHRLNTVLDYDQILVLD 805
R +F+DCT+LTIAHRLNT++DY +++VLD
Sbjct: 1470 RTQFEDCTVLTIAHRLNTIMDYTRVIVLD 1498
Score = 60.1 bits (144), Expect = 7e-09
Identities = 53/217 (24%), Positives = 95/217 (43%), Gaps = 8/217 (3%)
Frame = +2
Query: 176 IKFANYSTKYREGLDDVLKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEII 355
I N + + G L + F I V +VG+ G GKSSL+ AL +++ G +
Sbjct: 644 ITVKNATFTWARGEPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVT 703
Query: 356 IDGLPIHELGLHDVRGRLTIIPQDPVLFSGTLRRNLDPFNKHTDDEIWKVL-----TMSN 520
+ +G + +PQ + + +LR N+ F + +K + + +
Sbjct: 704 L-------------KGSVAYVPQQAWIQNDSLRENI-LFGHPLQENYYKAVMEACALLPD 749
Query: 521 LKTFVENSGSEQLQMTISEGGENLSVGQRQLMCLARALLRRTNILVLDEATAAVDLDTDV 700
L+ +E I E G NLS GQ+Q + LARA+ ++I + D+ +AVD
Sbjct: 750 LEILPSGDRTE-----IGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGK 804
Query: 701 LIQNTI---RQEFKDCTILTIAHRLNTVLDYDQILVL 802
I + K+ T + + H ++ + D I+V+
Sbjct: 805 HIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVM 841
>sp|O15438|MRP3_HUMAN Canalicular multispecific organic anion transporter 2 (Multidrug
resistance-associated protein 3) (Multi-specific organic
anion tranporter-D) (MOAT-D)
Length = 1527
Score = 314 bits (805), Expect = 2e-85
Identities = 157/269 (58%), Positives = 203/269 (75%), Gaps = 1/269 (0%)
Frame = +2
Query: 2 VSYALSITQTLNWLVRMXXXXXXXXXXXXRIQEYSQMTPEAPWEIPDKKPDEKWP-LGYI 178
VSY+L +T LNW++RM R++EYS+ EAPW + +P E WP G +
Sbjct: 1230 VSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEV 1289
Query: 179 KFANYSTKYREGLDDVLKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEIII 358
+F NYS +YR GLD VL++++ ++ EKVGIVGRTG+GKSS+ L LFRILE + GEI I
Sbjct: 1290 EFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRI 1349
Query: 359 DGLPIHELGLHDVRGRLTIIPQDPVLFSGTLRRNLDPFNKHTDDEIWKVLTMSNLKTFVE 538
DGL + ++GLHD+R +LTIIPQDP+LFSGTLR NLDPF +++++IW L +S+L TFV
Sbjct: 1350 DGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFV- 1408
Query: 539 NSGSEQLQMTISEGGENLSVGQRQLMCLARALLRRTNILVLDEATAAVDLDTDVLIQNTI 718
+S L SEGGENLSVGQRQL+CLARALLR++ ILVLDEATAA+DL+TD LIQ TI
Sbjct: 1409 SSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATI 1468
Query: 719 RQEFKDCTILTIAHRLNTVLDYDQILVLD 805
R +F CT+LTIAHRLNT++DY ++LVLD
Sbjct: 1469 RTQFDTCTVLTIAHRLNTIMDYTRVLVLD 1497
Score = 57.4 bits (137), Expect = 5e-08
Identities = 49/163 (30%), Positives = 82/163 (50%), Gaps = 2/163 (1%)
Frame = +2
Query: 203 YREGLDDVLKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEIIIDGLPIHEL 382
+ + L L +++ ++ V +VG G GKSSLV AL +E+ G++
Sbjct: 636 WAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKV---------- 685
Query: 383 GLHDVRGRLTIIPQDPVLFSGTLRRNLDPFNKHTDDEIWK-VLTMSNLKTFVEN-SGSEQ 556
++G + +PQ + + TL+ N+ F K + + ++ L L +E G +Q
Sbjct: 686 ---HMKGSVAYVPQQAWIQNCTLQENV-LFGKALNPKRYQQTLEACALLADLEMLPGGDQ 741
Query: 557 LQMTISEGGENLSVGQRQLMCLARALLRRTNILVLDEATAAVD 685
+ I E G NLS GQRQ + LARA+ +I +LD+ +AVD
Sbjct: 742 TE--IGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVD 782
>sp|Q8VI47|MRP2_MOUSE Canalicular multispecific organic anion transporter 1 (ATP-binding
cassette sub-family C member 2)
Length = 1543
Score = 313 bits (803), Expect = 3e-85
Identities = 161/270 (59%), Positives = 201/270 (74%), Gaps = 1/270 (0%)
Frame = +2
Query: 2 VSYALSITQTLNWLVRMXXXXXXXXXXXXRIQEYSQMTPEAPWEIPDKKPDEKWP-LGYI 178
+S AL+ITQTLNWLVRM RI EY + EAPW + DKKP WP G I
Sbjct: 1240 LSNALNITQTLNWLVRMTSEVETNIVAVERINEYINVDNEAPW-VTDKKPPADWPKKGEI 1298
Query: 179 KFANYSTKYREGLDDVLKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEIII 358
+F NY +YR LD VLK + I EKVG+VGRTG+GKSSL LFRILE + G+III
Sbjct: 1299 QFNNYQVRYRPELDLVLKGITCNIKSTEKVGVVGRTGAGKSSLTNCLFRILESAGGQIII 1358
Query: 359 DGLPIHELGLHDVRGRLTIIPQDPVLFSGTLRRNLDPFNKHTDDEIWKVLTMSNLKTFVE 538
DG+ I +GLHD+RGRLTIIPQDP+LFSG LR NLDPFNK++D+EIW+ L +++LK+FV
Sbjct: 1359 DGIDIASIGLHDLRGRLTIIPQDPILFSGNLRMNLDPFNKYSDEEIWRALELAHLKSFVA 1418
Query: 539 NSGSEQLQMTISEGGENLSVGQRQLMCLARALLRRTNILVLDEATAAVDLDTDVLIQNTI 718
L ++EGG+NLS+GQRQL+CL RA+LR++ ILVLDEATAAVDL+TD LIQ TI
Sbjct: 1419 GLQLGLLH-EVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTI 1477
Query: 719 RQEFKDCTILTIAHRLNTVLDYDQILVLDN 808
R EF CT++TIAHRL+T++D D+I+VLD+
Sbjct: 1478 RNEFSQCTVITIAHRLHTIMDSDKIMVLDS 1507
Score = 80.5 bits (197), Expect = 5e-15
Identities = 59/213 (27%), Positives = 106/213 (49%), Gaps = 4/213 (1%)
Frame = +2
Query: 176 IKFANYSTKYREGLDDVLKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEII 355
++F+ S + L+ +++VN +I P + V +VG GSGKSSL+ A+ +E HG I
Sbjct: 635 VQFSEASFTWDRDLEATIQDVNLDIKPGQLVAVVGTVGSGKSSLISAMLGEMENVHGHIT 694
Query: 356 IDGLPIHELGLHDVRGRLTIIPQDPVLFSGTLRRNLDPFNKHTDDEIWKVLTMSNLKTFV 535
I +G + +PQ + +GT++ N+ +++ + + +V+ L +
Sbjct: 695 I-------------KGSIAYVPQQAWIQNGTIKDNILFGSEYDEKKYQRVIEACALLPDL 741
Query: 536 EN-SGSEQLQMTISEGGENLSVGQRQLMCLARALLRRTNILVLDEATAAVDLDTDVLIQN 712
E G + + I E G NLS GQ+ + LARA + +I +LD+ +AVD I N
Sbjct: 742 EMLPGGDMAE--IGEKGINLSGGQKHRVSLARATYQDADIYILDDPLSAVDTHVGKHIFN 799
Query: 713 TI---RQEFKDCTILTIAHRLNTVLDYDQILVL 802
+ T + + H ++ + D+I+VL
Sbjct: 800 KVVGPNGLLSGKTRILVTHGIHFLPQVDEIVVL 832
>sp|Q63120|MRP2_RAT Canalicular multispecific organic anion transporter 1 (ATP-binding
cassette sub-family C member 2) (Multidrug
resistance-associated protein 2) (Canalicular multidrug
resistance protein)
Length = 1541
Score = 311 bits (796), Expect = 2e-84
Identities = 159/271 (58%), Positives = 205/271 (75%), Gaps = 2/271 (0%)
Frame = +2
Query: 2 VSYALSITQTLNWLVRMXXXXXXXXXXXXRIQEYSQMTPEAPWEIPDKKPDEKWPL-GYI 178
+S AL+ITQTLNWLVRM RI EY + EAPW + DK+P WP G I
Sbjct: 1238 LSNALNITQTLNWLVRMTSEAETNIVAVERISEYINVENEAPW-VTDKRPPADWPRHGEI 1296
Query: 179 KFANYSTKYREGLDDVLKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEIII 358
+F NY +YR LD VLK + I EKVG+VGRTG+GKSSL LFRILE + G+III
Sbjct: 1297 QFNNYQVRYRPELDLVLKGITCNIKSGEKVGVVGRTGAGKSSLTNCLFRILESAGGQIII 1356
Query: 359 DGLPIHELGLHDVRGRLTIIPQDPVLFSGTLRRNLDPFNKHTDDEIWKVLTMSNLKTFVE 538
DG+ + +GLHD+R RLTIIPQDP+LFSG+LR NLDPFNK++D+E+W+ L +++L++FV
Sbjct: 1357 DGIDVASIGLHDLRERLTIIPQDPILFSGSLRMNLDPFNKYSDEEVWRALELAHLRSFV- 1415
Query: 539 NSGSE-QLQMTISEGGENLSVGQRQLMCLARALLRRTNILVLDEATAAVDLDTDVLIQNT 715
SG + L ++EGG+NLS+GQRQL+CL RA+LR++ ILVLDEATAAVDL+TD LIQ T
Sbjct: 1416 -SGLQLGLLSEVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTT 1474
Query: 716 IRQEFKDCTILTIAHRLNTVLDYDQILVLDN 808
IR+EF CT++TIAHRL+T++D D+I+VLDN
Sbjct: 1475 IRKEFSQCTVITIAHRLHTIMDSDKIMVLDN 1505
Score = 82.0 bits (201), Expect = 2e-15
Identities = 63/213 (29%), Positives = 106/213 (49%), Gaps = 4/213 (1%)
Frame = +2
Query: 176 IKFANYSTKYREGLDDVLKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEII 355
+KF+ S + L+ +++VN +I P + V +VG GSGKSSLV A+ +E HG I
Sbjct: 633 VKFSEASFTWDPDLEATIQDVNLDIKPGQLVAVVGTVGSGKSSLVSAMLGEMENVHGHIT 692
Query: 356 IDGLPIHELGLHDVRGRLTIIPQDPVLFSGTLRRNLDPFNKHTDDEIWKVLTMSNLKTFV 535
I +G +PQ + +GT++ N+ +++ + + +VL L +
Sbjct: 693 I-------------QGSTAYVPQQSWIQNGTIKDNILFGSEYNEKKYQQVLKACALLPDL 739
Query: 536 E-NSGSEQLQMTISEGGENLSVGQRQLMCLARALLRRTNILVLDEATAAVDLDTDVLIQN 712
E G + + I E G NLS GQ+Q + LARA + +I +LD+ +AVD I N
Sbjct: 740 EILPGGDMAE--IGEKGINLSGGQKQRVSLARAAYQDADIYILDDPLSAVDAHVGKHIFN 797
Query: 713 TI---RQEFKDCTILTIAHRLNTVLDYDQILVL 802
+ T + + H ++ + D+I+VL
Sbjct: 798 KVVGPNGLLAGKTRIFVTHGIHFLPQVDEIVVL 830
>sp|Q28689|MRP2_RABIT Canalicular multispecific organic anion transporter 1 (ATP-binding
cassette sub-family C member 2) (Multidrug
resistance-associated protein 2) (Canalicular multidrug
resistance protein) (Epithelial basolateral chloride
conductance regulator)
Length = 1564
Score = 311 bits (796), Expect = 2e-84
Identities = 159/270 (58%), Positives = 201/270 (74%), Gaps = 1/270 (0%)
Frame = +2
Query: 2 VSYALSITQTLNWLVRMXXXXXXXXXXXXRIQEYSQMTPEAPWEIPDKKPDEKWP-LGYI 178
+S AL+ITQTLNWLVRM RI EY ++ EAPW + DK+P WP G I
Sbjct: 1240 LSNALNITQTLNWLVRMTSETETNIVAVERITEYIKVENEAPW-VTDKRPPAGWPHKGEI 1298
Query: 179 KFANYSTKYREGLDDVLKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEIII 358
+F+NY +YR LD VLK +N +I EK+G+VGRTG+GKSSL LFRILE + G I I
Sbjct: 1299 QFSNYQVRYRPELDLVLKGINCDIKSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGHITI 1358
Query: 359 DGLPIHELGLHDVRGRLTIIPQDPVLFSGTLRRNLDPFNKHTDDEIWKVLTMSNLKTFVE 538
DG+ I +GLHD+RG+LTIIPQDPVLFSG+LR NLDPFN ++D+EIW+ L +++LK+FV
Sbjct: 1359 DGIDIASIGLHDLRGKLTIIPQDPVLFSGSLRMNLDPFNNYSDEEIWRALELAHLKSFVA 1418
Query: 539 NSGSEQLQMTISEGGENLSVGQRQLMCLARALLRRTNILVLDEATAAVDLDTDVLIQNTI 718
L +SE +NLS+GQRQL+CL RALLR++ ILVLDEATAAVDL+TD LIQ TI
Sbjct: 1419 GL-QHGLSREVSEAEDNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDHLIQTTI 1477
Query: 719 RQEFKDCTILTIAHRLNTVLDYDQILVLDN 808
R EF CT++TIAHRL+T++D D+I+VLDN
Sbjct: 1478 RNEFSHCTVITIAHRLHTIMDSDKIMVLDN 1507
Score = 85.1 bits (209), Expect = 2e-16
Identities = 64/214 (29%), Positives = 104/214 (48%), Gaps = 3/214 (1%)
Frame = +2
Query: 176 IKFANYSTKYREGLDDVLKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEII 355
++F+ S + L+ ++NVN +I P + V +VG GSGKSSL+ A+ +E HG I
Sbjct: 635 VQFSEASFTWDRNLEPTIRNVNLDIMPGQLVAVVGTVGSGKSSLMSAMLGEMENVHGHIT 694
Query: 356 IDGLPIHELGLHDVRGRLTIIPQDPVLFSGTLRRNLDPFNKHTDDEIWKVLTMSNLKTFV 535
I +G +PQ + +GT++ N+ + + +VL L +
Sbjct: 695 I-------------KGTTAYVPQQSWIQNGTIKDNILFGAEFDERRYQRVLEACALLPDL 741
Query: 536 ENSGSEQLQMTISEGGENLSVGQRQLMCLARALLRRTNILVLDEATAAVDLDTDVLIQNT 715
E L I E G NLS GQ+Q + LARA + ++I +LD+ +AVD I N
Sbjct: 742 EILPGGDL-AEIGEKGINLSGGQKQRISLARASYQNSDIYILDDPLSAVDAHVGKHIFNK 800
Query: 716 I---RQEFKDCTILTIAHRLNTVLDYDQILVLDN 808
+ T L + H L+ + D+I+V++N
Sbjct: 801 VLGPNGLLNGKTRLLVTHSLHFLPQVDEIVVVEN 834
>sp|P39109|YCFI_YEAST Metal resistance protein YCF1 (Yeast cadmium factor 1)
Length = 1515
Score = 308 bits (789), Expect = 1e-83
Identities = 155/270 (57%), Positives = 203/270 (75%), Gaps = 1/270 (0%)
Frame = +2
Query: 2 VSYALSITQTLNWLVRMXXXXXXXXXXXXRIQEYSQMTPEAPWEIPDKKPDEKWPL-GYI 178
+SYAL ITQTLNW+VRM RI+EY+ + EAP + +P ++WP G I
Sbjct: 1213 LSYALQITQTLNWIVRMTVEVETNIVSVERIKEYADLKSEAPLIVEGHRPPKEWPSQGDI 1272
Query: 179 KFANYSTKYREGLDDVLKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEIII 358
KF NYST+YR LD VLK++N I P EKVGIVGRTG+GKSSL LALFR++E S G I+I
Sbjct: 1273 KFNNYSTRYRPELDLVLKHINIHIKPNEKVGIVGRTGAGKSSLTLALFRMIEASEGNIVI 1332
Query: 359 DGLPIHELGLHDVRGRLTIIPQDPVLFSGTLRRNLDPFNKHTDDEIWKVLTMSNLKTFVE 538
D + I+E+GL+D+R +L+IIPQD +F GT+R N+DP N++TD+ IW+ L +S+LK V
Sbjct: 1333 DNIAINEIGLYDLRHKLSIIPQDSQVFEGTVRENIDPINQYTDEAIWRALELSHLKEHVL 1392
Query: 539 NSGSEQLQMTISEGGENLSVGQRQLMCLARALLRRTNILVLDEATAAVDLDTDVLIQNTI 718
+ ++ L ++EGG NLSVGQRQL+CLARA+L + ILVLDEATAAVD++TD ++Q TI
Sbjct: 1393 SMSNDGLDAQLTEGGGNLSVGQRQLLCLARAMLVPSKILVLDEATAAVDVETDKVVQETI 1452
Query: 719 RQEFKDCTILTIAHRLNTVLDYDQILVLDN 808
R FKD TILTIAHRLNT++D D+I+VLDN
Sbjct: 1453 RTAFKDRTILTIAHRLNTIMDSDRIIVLDN 1482
Score = 57.0 bits (136), Expect = 6e-08
Identities = 44/153 (28%), Positives = 71/153 (46%)
Frame = +2
Query: 227 LKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEIIIDGLPIHELGLHDVRGR 406
LKN+NF+ IVG+ GSGK++L+ + L R G V G
Sbjct: 646 LKNINFQAKKGNLTCIVGKVGSGKTALLSCMLGDLFRVKG-------------FATVHGS 692
Query: 407 LTIIPQDPVLFSGTLRRNLDPFNKHTDDEIWKVLTMSNLKTFVENSGSEQLQMTISEGGE 586
+ + Q P + +GT++ N+ F D E ++ + T + + + E G
Sbjct: 693 VAYVSQVPWIMNGTVKENI-LFGHRYDAEFYEKTIKACALTIDLAILMDGDKTLVGEKGI 751
Query: 587 NLSVGQRQLMCLARALLRRTNILVLDEATAAVD 685
+LS GQ+ + LARA+ R + +LD+ AAVD
Sbjct: 752 SLSGGQKARLSLARAVYARADTYLLDDPLAAVD 784
>sp|Q92887|MRP2_HUMAN Canalicular multispecific organic anion transporter 1 (ATP-binding
cassette sub-family C member 2) (Multidrug
resistance-associated protein 2) (Canalicular multidrug
resistance protein)
Length = 1545
Score = 305 bits (782), Expect = 7e-83
Identities = 157/272 (57%), Positives = 205/272 (75%), Gaps = 3/272 (1%)
Frame = +2
Query: 2 VSYALSITQTLNWLVRMXXXXXXXXXXXXRIQEYSQMTPEAPWEIPDKKPDEKWP-LGYI 178
+S AL+ITQTLNWLVRM RI EY+++ EAPW + DK+P WP G I
Sbjct: 1242 LSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPW-VTDKRPPPDWPSKGKI 1300
Query: 179 KFANYSTKYREGLDDVLKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEIII 358
+F NY +YR LD VL+ + +I EK+G+VGRTG+GKSSL LFRILE + G+III
Sbjct: 1301 QFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIII 1360
Query: 359 DGLPIHELGLHDVRGRLTIIPQDPVLFSGTLRRNLDPFNKHTDDEIWKVLTMSNLKTFVE 538
DG+ I +GLHD+R +LTIIPQDP+LFSG+LR NLDPFN ++D+EIWK L +++LK+FV
Sbjct: 1361 DGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFV- 1419
Query: 539 NSGSEQLQMT--ISEGGENLSVGQRQLMCLARALLRRTNILVLDEATAAVDLDTDVLIQN 712
S QL ++ ++E G NLS+GQRQL+CL RALLR++ ILVLDEATAAVDL+TD LIQ
Sbjct: 1420 --ASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQT 1477
Query: 713 TIRQEFKDCTILTIAHRLNTVLDYDQILVLDN 808
TI+ EF CT++TIAHRL+T++D D+++VLDN
Sbjct: 1478 TIQNEFAHCTVITIAHRLHTIMDSDKVMVLDN 1509
Score = 78.2 bits (191), Expect = 3e-14
Identities = 61/214 (28%), Positives = 101/214 (47%), Gaps = 3/214 (1%)
Frame = +2
Query: 176 IKFANYSTKYREGLDDVLKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEII 355
++F+ S + + +++VN +I + V ++G GSGKSSL+ A+ +E HG I
Sbjct: 637 MQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHIT 696
Query: 356 IDGLPIHELGLHDVRGRLTIIPQDPVLFSGTLRRNLDPFNKHTDDEIWKVLTMSNLKTFV 535
I +G +PQ + +GT++ N+ + + +VL L +
Sbjct: 697 I-------------KGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDL 743
Query: 536 ENSGSEQLQMTISEGGENLSVGQRQLMCLARALLRRTNILVLDEATAAVDLDTDVLIQNT 715
E L I E G NLS GQ+Q + LARA + +I +LD+ +AVD I N
Sbjct: 744 EMLPGGDL-AEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNK 802
Query: 716 I---RQEFKDCTILTIAHRLNTVLDYDQILVLDN 808
+ K T L + H ++ + D+I+VL N
Sbjct: 803 VLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGN 836
>sp|P14772|BPT1_YEAST Bile pigment transporter 1
Length = 1559
Score = 293 bits (750), Expect = 4e-79
Identities = 156/285 (54%), Positives = 203/285 (71%), Gaps = 17/285 (5%)
Frame = +2
Query: 2 VSYALSITQTLNWLVRMXXXXXXXXXXXXRIQEYSQMTPEAPWEIPDKKPDEKWPL-GYI 178
+SY+L +T +L W+VR RI EY ++ PEA P+K+PDE WP G I
Sbjct: 1243 MSYSLEVTGSLTWIVRTTVTIETNIVSVERIVEYCELPPEAQSINPEKRPDENWPSKGGI 1302
Query: 179 KFANYSTKYREGLDDVLKNVNFEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEIII 358
+F NYSTKYRE LD VL N+N +I P EKVGIVGRTG+GKS+L LALFRILE + G+III
Sbjct: 1303 EFKNYSTKYRENLDPVLNNINVKIEPCEKVGIVGRTGAGKSTLSLALFRILEPTEGKIII 1362
Query: 359 DGLPIHELGLHDVRGRLTIIPQDPVLFSGTLRRNLDPFNKHTDDEIWKVLTMSNLKTFVE 538
DG+ I ++GL D+R L IIPQD F GT++ NLDPFN++++DE+ + + ++LK +E
Sbjct: 1363 DGIDISDIGLFDLRSHLAIIPQDAQAFEGTVKTNLDPFNRYSEDELKRAVEQAHLKPHLE 1422
Query: 539 ----------NSGSEQ------LQMTISEGGENLSVGQRQLMCLARALLRRTNILVLDEA 670
+S E L + I+E G NLSVGQRQL+CLARALL R+ ILVLDEA
Sbjct: 1423 KMLHSKPRGDDSNEEDGNVNDILDVKINENGSNLSVGQRQLLCLARALLNRSKILVLDEA 1482
Query: 671 TAAVDLDTDVLIQNTIRQEFKDCTILTIAHRLNTVLDYDQILVLD 805
TA+VD++TD +IQ+TIR+EFKD TILTIAHR++TVLD D+I+VLD
Sbjct: 1483 TASVDMETDKIIQDTIRREFKDRTILTIAHRIDTVLDSDKIIVLD 1527
Score = 48.5 bits (114), Expect = 2e-05
Identities = 56/206 (27%), Positives = 96/206 (46%), Gaps = 12/206 (5%)
Frame = +2
Query: 227 LKNVN-FEINpreKVGIVGRTGSGKSSLVLALFRILERSHGEIIIDGLPIHELGLHDVRG 403
LKN++ FE + V +VGR G+GKS+ + A+ L G D +P + +R
Sbjct: 654 LKNIDHFEAKRGDLVCVVGRVGAGKSTFLKAILGQLPCMSGSR--DSIPPKLI----IRS 707
Query: 404 R-LTIIPQDPVLFSGTLRRNLDPFNKHTDDEIWKVLTMSNLKTFVE----NSGSEQLQMT 568
+ Q+ + + ++R N+ H D+ + LT+ + + G E L
Sbjct: 708 SSVAYCSQESWIMNASVRENI--LFGHKFDQDYYDLTIKACQLLPDLKILPDGDETL--- 762
Query: 569 ISEGGENLSVGQRQLMCLARALLRRTNILVLDEATAAVDLDTD------VLIQNTIRQEF 730
+ E G +LS GQ+ + LARA+ R +I +LD+ +AVD + VLI T
Sbjct: 763 VGEKGISLSGGQKARLSLARAVYSRADIYLLDDILSAVDAEVSKNIIEYVLIGKTAL--L 820
Query: 731 KDCTILTIAHRLNTVLDYDQILVLDN 808
K+ TI+ + ++ + I L+N
Sbjct: 821 KNKTIILTTNTVSILKHSQMIYALEN 846
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,022,956
Number of Sequences: 369166
Number of extensions: 1877571
Number of successful extensions: 8368
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6880
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7563
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7715018400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)