Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_C22
(551 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin... 112 5e-25
sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proep... 110 2e-24
sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEP... 109 4e-24
sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEP... 109 5e-24
sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 ... 63 5e-10
sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1 56 7e-08
sp|P81013|GRN1_CYPCA Granulin-1 55 9e-08
sp|P81015|GRN3_CYPCA Granulin-3 54 3e-07
sp|P81014|GRN2_CYPCA Granulin-2 49 6e-06
sp|P25777|ORYB_ORYSA Oryzain beta chain precursor 44 3e-04
>sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin; Granulin-1 (Granulin G);
Granulin-2 (Granulin F); Granulin-3 (Granulin B)
(Epithelin-2); Granulin-4 (Granulin A) (Epithelin-1);
Granulin-5 (Granulin C); Granulin-6 (Granulin D);
Granulin-7 (Granulin E)]
Length = 588
Score = 112 bits (281), Expect = 5e-25
Identities = 54/151 (35%), Positives = 72/151 (47%), Gaps = 2/151 (1%)
Frame = +1
Query: 19 ICQNGKALCGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNE 198
+C + K C TCC +G + CC NA+CC D LHCCP+ T CDL+ +CI +
Sbjct: 205 VCPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCISK--- 261
Query: 199 PIEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHY 378
+ + P Y V +K + +CPDG TCC + TG +
Sbjct: 262 -------DYTTDLMTKLPGYPVNE-------VKCDLEVSCPDG------YTCCRLNTGAW 301
Query: 379 GCCPFSLGVCCPDLRTCCAPGYHC--VTGGC 465
GCCPF+ VCC D CC G+ C TG C
Sbjct: 302 GCCPFTKAVCCEDHIHCCPAGFQCHTETGTC 332
Score = 96.7 bits (239), Expect = 3e-20
Identities = 50/140 (35%), Positives = 64/140 (45%)
Frame = +1
Query: 43 CGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 222
C +TCC S G CCQ +AVCC D+ HCCP G TC++ + C
Sbjct: 447 CPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTC-------------- 492
Query: 223 TIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLG 402
E +V+ S F K+G+ C G C Q+CC G + CCP+ G
Sbjct: 493 -------EKDAGSVQPSMDLTFGSKVGNV-ECGAGHFCHDNQSCCKDSQGGWACCPYVKG 544
Query: 403 VCCPDLRTCCAPGYHCVTGG 462
VCC D R CC G+HC G
Sbjct: 545 VCCRDGRHCCPIGFHCSAKG 564
Score = 93.2 bits (230), Expect = 4e-19
Identities = 47/143 (32%), Positives = 62/143 (43%)
Frame = +1
Query: 22 CQNGKALCGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEP 201
C + C TCC G CC A CC D++HCCP G +CDLV+ RCI +
Sbjct: 125 CPGSQFECPDSATCCIMIDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCISPTG-- 182
Query: 202 IEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYG 381
P+++ + P R+ ++ K CPD TCC + TG YG
Sbjct: 183 -THPLLK-------KFPAQRTNRAVASFSVVCPDAKTQCPDD------STCCELPTGKYG 228
Query: 382 CCPFSLGVCCPDLRTCCAPGYHC 450
CCP +CC D CC C
Sbjct: 229 CCPMPNAICCSDHLHCCPQDTVC 251
Score = 87.4 bits (215), Expect = 2e-17
Identities = 41/135 (30%), Positives = 62/135 (45%)
Frame = +1
Query: 58 TCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVETIDSA 237
TCC +G CC ++ AVCC D +HCCP G C C ++ P ++ + +A
Sbjct: 292 TCCRLNTGAWGCCPFTKAVCCEDHIHCCPAGFQCHTETGTC---ELGVLQVPWMKKV-TA 347
Query: 238 KIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPD 417
+ P + ++ + C D C TCC + +G +GCCP VCC D
Sbjct: 348 SLSLPDPQILKNDVP-----------CDDFSSCPSNNTCCRLSSGDWGCCPMPEAVCCLD 396
Query: 418 LRTCCAPGYHCVTGG 462
+ CC G+ C+ G
Sbjct: 397 HQHCCPQGFKCMDEG 411
Score = 77.8 bits (190), Expect = 2e-14
Identities = 44/136 (32%), Positives = 54/136 (39%)
Frame = +1
Query: 43 CGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 222
C TCC SG CC AVCC D HCCP+G C ++ +
Sbjct: 369 CPSNNTCCRLSSGDWGCCPMPEAVCCLDHQHCCPQGFKC--------------MDEGYCQ 414
Query: 223 TIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLG 402
D K V ++TL ++ GD C C QTCC G + CC
Sbjct: 415 KGDRMVAGLEKMPVRQTTL----LQHGD-IGCDQHTSCPVGQTCCPSLKGSWACCQLPHA 469
Query: 403 VCCPDLRTCCAPGYHC 450
VCC D + CC GY C
Sbjct: 470 VCCEDRQHCCPAGYTC 485
Score = 73.2 bits (178), Expect = 4e-13
Identities = 39/131 (29%), Positives = 49/131 (37%)
Frame = +1
Query: 58 TCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVETIDSA 237
+C + SG CC +S V C D HCCP G C K C S+ +
Sbjct: 72 SCLLTVSGTSSCCPFSEGVSCDDGQHCCPRGFHCSADGKSCSQISDSLL----------G 121
Query: 238 KIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPD 417
++ P G + CPD TCC+M G +GCCP CC D
Sbjct: 122 AVQCP----------------GSQFECPDSA------TCCIMIDGSWGCCPMPQASCCED 159
Query: 418 LRTCCAPGYHC 450
CC G C
Sbjct: 160 RVHCCPHGASC 170
Score = 53.5 bits (127), Expect = 3e-07
Identities = 19/49 (38%), Positives = 24/49 (48%)
Frame = +1
Query: 43 CGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQ 189
C ++CC GG CC Y VCC D HCCP G C +C+ +
Sbjct: 522 CHDNQSCCKDSQGGWACCPYVKGVCCRDGRHCCPIGFHCSAKGTKCLRK 570
Score = 51.6 bits (122), Expect = 1e-06
Identities = 22/52 (42%), Positives = 29/52 (55%)
Frame = +1
Query: 307 KNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 462
+++CPDG +C L +G CCPFS GV C D + CC G+HC G
Sbjct: 64 RDHCPDG------YSCLLTVSGTSSCCPFSEGVSCDDGQHCCPRGFHCSADG 109
>sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proepithelin) (PEPI) (PC
cell-derived growth factor) (PCDGF) [Contains: Granulin
1; Granulin 2; Granulin 3; Granulin 4; Granulin 5;
Granulin 6; Granulin 7]
Length = 589
Score = 110 bits (275), Expect = 2e-24
Identities = 52/146 (35%), Positives = 73/146 (50%)
Frame = +1
Query: 19 ICQNGKALCGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNE 198
+C + K C TCC +G + CC NA+CC D LHCCP+ T CDL+ +C+ ++
Sbjct: 206 VCPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCLSKN-- 263
Query: 199 PIEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHY 378
T D + P Y V+ +K + +CP+G TCC + TG +
Sbjct: 264 -------YTTD-LLTKLPGYPVKE-------VKCDMEVSCPEG------YTCCRLNTGAW 302
Query: 379 GCCPFSLGVCCPDLRTCCAPGYHCVT 456
GCCPF+ VCC D CC G+ C T
Sbjct: 303 GCCPFAKAVCCEDHIHCCPAGFQCHT 328
Score = 100 bits (248), Expect = 3e-21
Identities = 51/140 (36%), Positives = 68/140 (48%)
Frame = +1
Query: 43 CGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 222
C +TCC S G CCQ +AVCC D+ HCCP G TC++ + C + + I+ PV+
Sbjct: 448 CPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTC-EKDVDFIQPPVLL 506
Query: 223 TIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLG 402
T+ K+G+ C +G C QTCC G + CCP+ G
Sbjct: 507 TLGP--------------------KVGNV-ECGEGHFCHDNQTCCKDSAGVWACCPYLKG 545
Query: 403 VCCPDLRTCCAPGYHCVTGG 462
VCC D R CC G+HC G
Sbjct: 546 VCCRDGRHCCPGGFHCSARG 565
Score = 93.6 bits (231), Expect = 3e-19
Identities = 47/144 (32%), Positives = 60/144 (41%), Gaps = 1/144 (0%)
Frame = +1
Query: 22 CQNGKALCGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEP 201
C + C TCC G CC A CC D++HCCP G +CDLV+ RC+ +
Sbjct: 125 CPGSQFECPDSATCCIMVDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCVSPTG-- 182
Query: 202 IEWPVVETIDSAKIETPKYTVERSTLREFMIKIGD-KNNCPDGGQCAGLQTCCLMYTGHY 378
+ + P R+ F + D K CPD TCC + TG Y
Sbjct: 183 --------THTLLKKFPAQKTNRAVSLPFSVVCPDAKTQCPDD------STCCELPTGKY 228
Query: 379 GCCPFSLGVCCPDLRTCCAPGYHC 450
GCCP +CC D CC C
Sbjct: 229 GCCPMPNAICCSDHLHCCPQDTVC 252
Score = 90.1 bits (222), Expect = 3e-18
Identities = 43/140 (30%), Positives = 60/140 (42%)
Frame = +1
Query: 43 CGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 222
C TCC +G CC ++ AVCC D +HCCP G C H E +++
Sbjct: 288 CPEGYTCCRLNTGAWGCCPFAKAVCCEDHIHCCPAGFQC--------HTEKGTCEMGILQ 339
Query: 223 TIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLG 402
K+ P + L+ C D +C TCC + +G +GCCP
Sbjct: 340 VPWMKKVIAPLRLPDPQILKS-------DTPCDDFTRCPTNNTCCKLNSGDWGCCPIPEA 392
Query: 403 VCCPDLRTCCAPGYHCVTGG 462
VCC D + CC G+ C+ G
Sbjct: 393 VCCSDNQHCCPQGFTCLAQG 412
Score = 84.7 bits (208), Expect = 1e-16
Identities = 46/144 (31%), Positives = 58/144 (40%), Gaps = 1/144 (0%)
Frame = +1
Query: 22 CQ-NGKALCGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNE 198
CQ +G GY +C + SG CC +S V CGD HCCP+G C K C S+
Sbjct: 61 CQTHGHCPAGY--SCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADGKSCFQMSDN 118
Query: 199 PIEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHY 378
P+ ++ P G + CPD TCC+M G +
Sbjct: 119 PL----------GAVQCP----------------GSQFECPDSA------TCCIMVDGSW 146
Query: 379 GCCPFSLGVCCPDLRTCCAPGYHC 450
GCCP CC D CC G C
Sbjct: 147 GCCPMPQASCCEDRVHCCPHGASC 170
Score = 82.4 bits (202), Expect = 7e-16
Identities = 47/137 (34%), Positives = 56/137 (40%), Gaps = 1/137 (0%)
Frame = +1
Query: 43 CGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 222
C TCC SG CC AVCC D HCCP+G TC L C
Sbjct: 370 CPTNNTCCKLNSGDWGCCPIPEAVCCSDNQHCCPQGFTC-LAQGYC-------------- 414
Query: 223 TIDSAKIETPKYTVERSTLREFM-IKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSL 399
K +T +E+ R+ ++IGD C C QTCC G + CC
Sbjct: 415 ----QKGDTMVAGLEKIPARQTTPLQIGDIG-CDQHTSCPVGQTCCPSLKGSWACCQLPH 469
Query: 400 GVCCPDLRTCCAPGYHC 450
VCC D + CC GY C
Sbjct: 470 AVCCEDRQHCCPAGYTC 486
Score = 52.0 bits (123), Expect = 1e-06
Identities = 19/49 (38%), Positives = 24/49 (48%)
Frame = +1
Query: 43 CGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQ 189
C +TCC +G CC Y VCC D HCCP G C +C+ +
Sbjct: 523 CHDNQTCCKDSAGVWACCPYLKGVCCRDGRHCCPGGFHCSARGTKCLRK 571
Score = 51.2 bits (121), Expect = 2e-06
Identities = 21/50 (42%), Positives = 25/50 (50%)
Frame = +1
Query: 313 NCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 462
+C G C +C L +G CCPFS GV C D CC G+HC G
Sbjct: 60 SCQTHGHCPAGYSCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADG 109
>sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Paragranulin; Granulin-1 (Granulin G); Granulin-2
(Granulin F); Granulin-3 (Granulin B); Granulin-4
(Granulin A); Granulin-5 (Granulin C); Granulin-6
(Granulin D); Granulin-7 (Granulin E)]
Length = 593
Score = 109 bits (273), Expect = 4e-24
Identities = 51/146 (34%), Positives = 72/146 (49%)
Frame = +1
Query: 19 ICQNGKALCGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNE 198
+C + ++ C TCC SG + CC NA CC D LHCCP+ T CDL+ +C+ + N
Sbjct: 207 MCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENA 266
Query: 199 PIEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHY 378
+ + P +TV +K + +CPDG TCC + +G +
Sbjct: 267 TTD---------LLTKLPAHTVGD-------VKCDMEVSCPDG------YTCCRLQSGAW 304
Query: 379 GCCPFSLGVCCPDLRTCCAPGYHCVT 456
GCCPF+ VCC D CC G+ C T
Sbjct: 305 GCCPFTQAVCCEDHIHCCPAGFTCDT 330
Score = 97.1 bits (240), Expect = 3e-20
Identities = 48/141 (34%), Positives = 62/141 (43%)
Frame = +1
Query: 58 TCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVETIDSA 237
TCC +SG CC ++ AVCC D +HCCP G TCD C P + P +E +
Sbjct: 295 TCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTC---EQGPHQVPWMEKAPAH 351
Query: 238 KIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPD 417
++R C + C TCC + +G +GCCP VCC D
Sbjct: 352 LSLPDPQALKRDV------------PCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSD 399
Query: 418 LRTCCAPGYHCVTGGCA*LGS 480
+ CC GY CV G GS
Sbjct: 400 HQHCCPQGYTCVAEGQCQRGS 420
Score = 94.4 bits (233), Expect = 2e-19
Identities = 47/141 (33%), Positives = 62/141 (43%), Gaps = 1/141 (0%)
Frame = +1
Query: 43 CGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 222
C +TCC S G CCQ +AVCC D+ HCCP G TC++ + C
Sbjct: 450 CPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSC-------------- 495
Query: 223 TIDSAKIETPKYTVERSTLREFMIKIGDKN-NCPDGGQCAGLQTCCLMYTGHYGCCPFSL 399
E + + +T +G K+ C +G C QTCC + CCP+
Sbjct: 496 -------EKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQ 548
Query: 400 GVCCPDLRTCCAPGYHCVTGG 462
GVCC D R CC G+ C G
Sbjct: 549 GVCCADRRHCCPAGFRCAARG 569
Score = 91.7 bits (226), Expect = 1e-18
Identities = 49/144 (34%), Positives = 62/144 (43%), Gaps = 1/144 (0%)
Frame = +1
Query: 22 CQNGKALCGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEP 201
C + + C TCC G CC A CC D++HCCP G CDLV+ RCI +
Sbjct: 126 CPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTG-- 183
Query: 202 IEWPVVETIDSAKIETPKYTVERSTLREFMIKIGD-KNNCPDGGQCAGLQTCCLMYTGHY 378
T AK + P R+ + D ++ CPDG TCC + +G Y
Sbjct: 184 -------THPLAK-KLPAQRTNRAVALSSSVMCPDARSRCPDG------STCCELPSGKY 229
Query: 379 GCCPFSLGVCCPDLRTCCAPGYHC 450
GCCP CC D CC C
Sbjct: 230 GCCPMPNATCCSDHLHCCPQDTVC 253
Score = 79.7 bits (195), Expect = 4e-15
Identities = 46/143 (32%), Positives = 57/143 (39%)
Frame = +1
Query: 22 CQNGKALCGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEP 201
C N + C TCC SG CC AVCC D HCCP+G TC + +C S
Sbjct: 366 CDNVSS-CPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTC-VAEGQCQRGSE-- 421
Query: 202 IEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYG 381
+V ++ + R I +CP G QTCC G +
Sbjct: 422 ----IVAGLEKMPARRASLSHPRD------IGCDQHTSCPVG------QTCCPSLGGSWA 465
Query: 382 CCPFSLGVCCPDLRTCCAPGYHC 450
CC VCC D + CC GY C
Sbjct: 466 CCQLPHAVCCEDRQHCCPAGYTC 488
Score = 76.6 bits (187), Expect = 4e-14
Identities = 40/139 (28%), Positives = 49/139 (35%), Gaps = 1/139 (0%)
Frame = +1
Query: 37 ALCGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPV 216
A C +C + SG CC + AV CGD HCCP G C + C +S +
Sbjct: 65 AHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAI 124
Query: 217 VETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGG-QCAGLQTCCLMYTGHYGCCPF 393
CPD +C TCC+M G +GCCP
Sbjct: 125 --------------------------------QCPDSQFECPDFSTCCVMVDGSWGCCPM 152
Query: 394 SLGVCCPDLRTCCAPGYHC 450
CC D CC G C
Sbjct: 153 PQASCCEDRVHCCPHGAFC 171
Score = 53.9 bits (128), Expect = 3e-07
Identities = 19/49 (38%), Positives = 24/49 (48%)
Frame = +1
Query: 43 CGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQ 189
C +TCC G CC Y VCC D+ HCCP G C +C+ +
Sbjct: 527 CHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRR 575
Score = 43.9 bits (102), Expect = 3e-04
Identities = 17/49 (34%), Positives = 21/49 (42%)
Frame = +1
Query: 316 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 462
C C+ +C +G CCPF V C D CC G+HC G
Sbjct: 61 CQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADG 109
>sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Granulin-1; Granulin-2; Granulin-3; Granulin-4;
Granulin-5; Granulin-6; Granulin-7]
Length = 591
Score = 109 bits (272), Expect = 5e-24
Identities = 51/146 (34%), Positives = 72/146 (49%)
Frame = +1
Query: 19 ICQNGKALCGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNE 198
IC + ++ C TCC SG + CC NA+CC D LHCCP+ T CDL RC+ Q+
Sbjct: 207 ICPDSRSQCPDDTTCCLLASGEYGCCPMPNAICCSDHLHCCPQDTVCDLRQSRCLSQNK- 265
Query: 199 PIEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHY 378
+ + P +TV + ++ + +CP+G QTCC + +G +
Sbjct: 266 ---------AKTLLTKLPSWTV-------WDVECDQEVSCPEG------QTCCRLQSGKW 303
Query: 379 GCCPFSLGVCCPDLRTCCAPGYHCVT 456
GCCPF VCC D CC + C T
Sbjct: 304 GCCPFPKAVCCEDHVHCCPERFRCHT 329
Score = 103 bits (257), Expect = 3e-22
Identities = 53/142 (37%), Positives = 67/142 (47%)
Frame = +1
Query: 37 ALCGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPV 216
A C ++TCC GG CCQ +AVCC D HCCP G TC++ + C
Sbjct: 445 ASCPVRQTCCPKLGGGWACCQLPHAVCCEDGQHCCPAGYTCNVKARSC------------ 492
Query: 217 VETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFS 396
+ D A + P ST + GD++ C D QTCC G + CCPF
Sbjct: 493 EKAADGAHLAAP--LAVGSTGGVMDVACGDRHFCHDE------QTCCRDSRGGWACCPFH 544
Query: 397 LGVCCPDLRTCCAPGYHCVTGG 462
GVCC D R CC G+HC + G
Sbjct: 545 QGVCCKDQRHCCPAGFHCESQG 566
Score = 95.5 bits (236), Expect = 8e-20
Identities = 52/149 (34%), Positives = 69/149 (46%), Gaps = 6/149 (4%)
Frame = +1
Query: 22 CQNGKALCGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQ-SNE 198
C G+ C TCC G CC A CC D++HCCP G +CDLV+ RC+ +
Sbjct: 112 CPGGEFECPDSSTCCHMLDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHIRCVTALGSH 171
Query: 199 PI--EWPVVETIDSAKIETPKYT--VERSTLREFMIKIGDKNNCPDG-GQCAGLQTCCLM 363
P+ + P T + TP + + + L +I CPD QC TCCL+
Sbjct: 172 PLTTKLPAQRTNYTGAEGTPVVSPGLLPAALPTSVI-------CPDSRSQCPDDTTCCLL 224
Query: 364 YTGHYGCCPFSLGVCCPDLRTCCAPGYHC 450
+G YGCCP +CC D CC C
Sbjct: 225 ASGEYGCCPMPNAICCSDHLHCCPQDTVC 253
Score = 73.2 bits (178), Expect = 4e-13
Identities = 42/144 (29%), Positives = 55/144 (38%), Gaps = 1/144 (0%)
Frame = +1
Query: 22 CQNGKALCGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEP 201
CQ+ A C +C + +G CC +S A+ CGD HCCP G C CI +
Sbjct: 47 CQS-PANCPIGHSCVLTAAGTAACCPFSQAMACGDGHHCCPYGFHCSTDGGTCIQR---- 101
Query: 202 IEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGG-QCAGLQTCCLMYTGHY 378
P + + + + CP G +C TCC M G +
Sbjct: 102 ---PDIHLLGAVQ-------------------------CPGGEFECPDSSTCCHMLDGSW 133
Query: 379 GCCPFSLGVCCPDLRTCCAPGYHC 450
GCCP CC D CC G C
Sbjct: 134 GCCPMPQASCCEDRVHCCPHGASC 157
Score = 65.1 bits (157), Expect = 1e-10
Identities = 35/123 (28%), Positives = 49/123 (39%)
Frame = +1
Query: 43 CGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 222
C +TCC +SG CC + AVCC D +HCCPE C C Q + W
Sbjct: 289 CPEGQTCCRLQSGKWGCCPFPKAVCCEDHVHCCPERFRCHTEKDTC-EQGLLQVPWAQKT 347
Query: 223 TIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLG 402
++ P + + +C + C CC + +G +GCCP S G
Sbjct: 348 PAQPSRPSQPSPPGPPGPPSP-PGPLRSEISCDEVVSCRPGNICCRLASGEWGCCPSSEG 406
Query: 403 VCC 411
C
Sbjct: 407 YLC 409
Score = 63.9 bits (154), Expect = 2e-10
Identities = 22/61 (36%), Positives = 33/61 (54%)
Frame = +1
Query: 13 LNICQNGKALCGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQS 192
+++ + C ++TCC GG CC + VCC DQ HCCP G C+ RC+H+
Sbjct: 514 MDVACGDRHFCHDEQTCCRDSRGGWACCPFHQGVCCKDQRHCCPAGFHCESQGTRCVHKK 573
Query: 193 N 195
+
Sbjct: 574 S 574
Score = 47.0 bits (110), Expect = 3e-05
Identities = 33/125 (26%), Positives = 50/125 (40%), Gaps = 2/125 (1%)
Frame = +1
Query: 82 GHQCCQYSNAVCCGDQLHCCP--EGTTCDLVNKRCIHQSNEPIEWPVVETIDSAKIETPK 255
G+ CC+ ++ + CCP EG C + +RC V + + K+
Sbjct: 387 GNICCRLASG-----EWGCCPSSEGYLC-MAGERC----------QVGDRLAPEKMAAHL 430
Query: 256 YTVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCA 435
++ ++T +G C C QTCC G + CC VCC D + CC
Sbjct: 431 MSLSQTT------DVG----CDQHASCPVRQTCCPKLGGGWACCQLPHAVCCEDGQHCCP 480
Query: 436 PGYHC 450
GY C
Sbjct: 481 AGYTC 485
Score = 46.6 bits (109), Expect = 4e-05
Identities = 21/50 (42%), Positives = 24/50 (48%)
Frame = +1
Query: 313 NCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 462
NCP G +C L G CCPFS + C D CC G+HC T G
Sbjct: 52 NCPIG------HSCVLTAAGTAACCPFSQAMACGDGHHCCPYGFHCSTDG 95
>sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 (PMP-D1)
Length = 54
Score = 62.8 bits (151), Expect = 5e-10
Identities = 23/47 (48%), Positives = 28/47 (59%)
Frame = +1
Query: 43 CGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 183
C +TCC + G CC Y VCC D +HCCP GT CD ++RCI
Sbjct: 7 CPGTETCCTTPQGEEGCCPYKEGVCCLDGIHCCPSGTVCDEDHRRCI 53
Score = 48.9 bits (115), Expect = 8e-06
Identities = 19/39 (48%), Positives = 21/39 (53%)
Frame = +1
Query: 334 CAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 450
C G +TCC G GCCP+ GVCC D CC G C
Sbjct: 7 CPGTETCCTTPQGEEGCCPYKEGVCCLDGIHCCPSGTVC 45
>sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1
Length = 46
Score = 55.8 bits (133), Expect = 7e-08
Identities = 20/36 (55%), Positives = 22/36 (61%)
Frame = +1
Query: 43 CGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEG 150
C +TCC + GG CC YS VCC DQ HCCP G
Sbjct: 10 CHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVG 45
Score = 53.9 bits (128), Expect = 3e-07
Identities = 21/43 (48%), Positives = 24/43 (55%)
Frame = +1
Query: 316 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGY 444
C +G C QTCC G CCP+S GVCC D R CC G+
Sbjct: 4 CGEGHFCHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVGF 46
>sp|P81013|GRN1_CYPCA Granulin-1
Length = 57
Score = 55.5 bits (132), Expect = 9e-08
Identities = 24/45 (53%), Positives = 26/45 (57%)
Frame = +1
Query: 316 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 450
CPDG TCCL G + CCPFS+G CC D CC GYHC
Sbjct: 10 CPDG------TTCCLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHC 48
Score = 50.1 bits (118), Expect = 4e-06
Identities = 19/48 (39%), Positives = 24/48 (50%)
Frame = +1
Query: 40 LCGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 183
+C TCC S G CC +S CC D +HCC G CD + C+
Sbjct: 9 ICPDGTTCCLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHCDSTSTHCL 56
>sp|P81015|GRN3_CYPCA Granulin-3
Length = 57
Score = 53.9 bits (128), Expect = 3e-07
Identities = 22/45 (48%), Positives = 24/45 (53%)
Frame = +1
Query: 316 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 450
C G C TCC G + CCPF +G CC D R CC GYHC
Sbjct: 4 CDAGITCPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHC 48
Score = 45.1 bits (105), Expect = 1e-04
Identities = 18/47 (38%), Positives = 21/47 (44%)
Frame = +1
Query: 43 CGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 183
C TCC S G CC + CC D HCC G CD + C+
Sbjct: 10 CPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHCDSTSTLCL 56
>sp|P81014|GRN2_CYPCA Granulin-2
Length = 57
Score = 49.3 bits (116), Expect = 6e-06
Identities = 19/52 (36%), Positives = 24/52 (46%)
Frame = +1
Query: 28 NGKALCGYQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 183
N + C + TCC S G CC + CC D HCC G CD + C+
Sbjct: 5 NARTTCPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRCDSTSTLCL 56
Score = 48.9 bits (115), Expect = 8e-06
Identities = 19/39 (48%), Positives = 21/39 (53%)
Frame = +1
Query: 334 CAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 450
C TCC G + CCPF +G CC D R CC GY C
Sbjct: 10 CPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRC 48
>sp|P25777|ORYB_ORYSA Oryzain beta chain precursor
Length = 471
Score = 43.5 bits (101), Expect = 3e-04
Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 3/50 (6%)
Frame = +1
Query: 304 DKNNCPDGGQCA---GLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGY 444
D +CP G C G + CL++ GCCP CC D +CC P Y
Sbjct: 387 DNFSCPAGSTCCCAFGFRNLCLVW----GCCPVEGATCCKDHASCCPPDY 432
Score = 33.5 bits (75), Expect = 0.36
Identities = 18/65 (27%), Positives = 23/65 (35%), Gaps = 4/65 (6%)
Frame = +1
Query: 22 CQNGKALC---GYQKTCCASKSGGHQCCQYSNAVCCGDQLHCC-PEGTTCDLVNKRCIHQ 189
C G C G++ C CC A CC D CC P+ C+ C
Sbjct: 391 CPAGSTCCCAFGFRNLCLV-----WGCCPVEGATCCKDHASCCPPDYPVCNTRAGTCSAS 445
Query: 190 SNEPI 204
N P+
Sbjct: 446 KNSPL 450
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,157,122
Number of Sequences: 369166
Number of extensions: 1519556
Number of successful extensions: 5303
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4539
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5172
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3882260660
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)