Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_C13
(754 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P08630|BTKL_DROME Tyrosine-protein kinase Btk29A (Dsrc28C) 244 2e-64
sp|P42682|TXK_MOUSE Tyrosine-protein kinase TXK (PTK-RL-18)... 225 1e-58
sp|P42680|TEC_HUMAN Tyrosine-protein kinase Tec 224 1e-58
sp|Q8JH64|BTK_CHICK Tyrosine-protein kinase BTK (Bruton's t... 223 6e-58
sp|P24604|TEC_MOUSE Tyrosine-protein kinase Tec 222 7e-58
sp|P51813|BMX_HUMAN Cytoplasmic tyrosine-protein kinase BMX... 215 1e-55
sp|P35991|BTK_MOUSE Tyrosine-protein kinase BTK (Bruton's t... 214 2e-55
sp|Q08881|ITK_HUMAN Tyrosine-protein kinase ITK/TSK (T-cell... 213 3e-55
sp|Q06187|BTK_HUMAN Tyrosine-protein kinase BTK (Bruton's t... 213 3e-55
sp|P42681|TXK_HUMAN Tyrosine-protein kinase TXK 213 4e-55
>sp|P08630|BTKL_DROME Tyrosine-protein kinase Btk29A (Dsrc28C)
Length = 786
Score = 244 bits (623), Expect = 2e-64
Identities = 123/243 (50%), Positives = 167/243 (68%), Gaps = 2/243 (0%)
Frame = +1
Query: 1 VKKGEFR-RMPVAVKQMVEGAMNEDDFIDEAKNMRFLNHPNLVQLFGVVMKKRPIMIITE 177
V++G++R + AVK M EG M+EDDFI+EAK M L HPNLVQL+GV K RPI I+TE
Sbjct: 540 VRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTE 599
Query: 178 YMKYGSLRDFLRNRSSDYFNRPVVLADICAQVAKGMAYLECENFVHRDLAARNCLVKTVS 357
YMK+GSL ++LR +L D+C QV+KGM YLE N++HRDLAARNCLV + +
Sbjct: 600 YMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSEN 659
Query: 358 RRSVQVKVADFGMARFLLDNVYEPSAGTKFPVRWAPPEVFQ-SIYTPKADVWSFGVLMWE 534
VKVADFG+AR++LD+ Y S GTKFP++WAPPEV + ++ K+DVW++GVLMWE
Sbjct: 660 ----VVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWE 715
Query: 535 VFTCCTENPYHGKNNSQVYQYIIGGGRLTKPVVCPDRLYVLMLECWQHDPKKRPAFEYVC 714
+FT C + PY N++V + + G L KP C +Y +M CW H P++RPAF +
Sbjct: 716 IFT-CGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLM 774
Query: 715 QKI 723
++
Sbjct: 775 DQL 777
>sp|P42682|TXK_MOUSE Tyrosine-protein kinase TXK (PTK-RL-18) (Resting lymphocyte kinase)
Length = 527
Score = 225 bits (573), Expect = 1e-58
Identities = 117/241 (48%), Positives = 164/241 (68%), Gaps = 2/241 (0%)
Frame = +1
Query: 1 VKKGEFR-RMPVAVKQMVEGAMNEDDFIDEAKNMRFLNHPNLVQLFGVVMKKRPIMIITE 177
V GE+R +PVA+K + EG+M+E+DFI+EAK M L+H LVQL+GV ++++P+ I+TE
Sbjct: 285 VHLGEWRAHIPVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVTE 344
Query: 178 YMKYGSLRDFLRNRSSDYFNRPVVLADICAQVAKGMAYLECENFVHRDLAARNCLVKTVS 357
+M+ G L D+LR R + +L +C + +GMAYLE ++HRDLAARNCLV +
Sbjct: 345 FMENGCLLDYLRERKGQL--QKALLLSMCQDICEGMAYLERSCYIHRDLAARNCLVSS-- 400
Query: 358 RRSVQVKVADFGMARFLLDNVYEPSAGTKFPVRWAPPEVFQ-SIYTPKADVWSFGVLMWE 534
+ VK++DFGMAR++LD+ Y S+G KFPV+W PPEVF + Y+ K+DVWSFGVLMWE
Sbjct: 401 --ACVVKISDFGMARYVLDDEYISSSGAKFPVKWCPPEVFHFNKYSSKSDVWSFGVLMWE 458
Query: 535 VFTCCTENPYHGKNNSQVYQYIIGGGRLTKPVVCPDRLYVLMLECWQHDPKKRPAFEYVC 714
VFT + P+ K+N QV + I G RL +P + P +Y +M CW PK RP F +
Sbjct: 459 VFT-EGKMPFENKSNLQVVEAISQGFRLYRPHLAPMTIYRVMYSCWHESPKGRPTFAELL 517
Query: 715 Q 717
Q
Sbjct: 518 Q 518
>sp|P42680|TEC_HUMAN Tyrosine-protein kinase Tec
Length = 631
Score = 224 bits (572), Expect = 1e-58
Identities = 123/252 (48%), Positives = 170/252 (67%), Gaps = 2/252 (0%)
Frame = +1
Query: 1 VKKGEFR-RMPVAVKQMVEGAMNEDDFIDEAKNMRFLNHPNLVQLFGVVMKKRPIMIITE 177
V+ G++R + VA+K + EGAM E+DFI+EAK M L HP LVQL+GV +++PI I+TE
Sbjct: 384 VRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTE 443
Query: 178 YMKYGSLRDFLRNRSSDYFNRPVVLADICAQVAKGMAYLECENFVHRDLAARNCLVKTVS 357
+M+ G L +FLR R +F+R V+L+ +C V +GM YLE +F+HRDLAARNCLV
Sbjct: 444 FMERGCLLNFLRQRQG-HFSRDVLLS-MCQDVCEGMEYLERNSFIHRDLAARNCLVSEAG 501
Query: 358 RRSVQVKVADFGMARFLLDNVYEPSAGTKFPVRWAPPEVFQ-SIYTPKADVWSFGVLMWE 534
VKV+DFGMAR+ LD+ Y S+G KFPV+W PPEVF S ++ K+DVWSFGVLMWE
Sbjct: 502 ----VVKVSDFGMARYFLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWE 557
Query: 535 VFTCCTENPYHGKNNSQVYQYIIGGGRLTKPVVCPDRLYVLMLECWQHDPKKRPAFEYVC 714
VFT P+ N +V + G RL +P + + +Y +ML CWQ P+ RP+FE +
Sbjct: 558 VFT-EGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLL 616
Query: 715 QKIGDYLDQNCE 750
+ I + ++ CE
Sbjct: 617 RTIDELVE--CE 626
>sp|Q8JH64|BTK_CHICK Tyrosine-protein kinase BTK (Bruton's tyrosine kinase)
Length = 657
Score = 223 bits (567), Expect = 6e-58
Identities = 119/249 (47%), Positives = 164/249 (65%), Gaps = 2/249 (0%)
Frame = +1
Query: 1 VKKGEFR-RMPVAVKQMVEGAMNEDDFIDEAKNMRFLNHPNLVQLFGVVMKKRPIMIITE 177
VK G++R + VA+K + EG+M+ED+FIDEAK M L+H LVQL+GV K+RPI IITE
Sbjct: 414 VKYGKWRGQYNVAIKMIREGSMSEDEFIDEAKVMMNLSHEKLVQLYGVCTKQRPIFIITE 473
Query: 178 YMKYGSLRDFLRNRSSDYFNRPVVLADICAQVAKGMAYLECENFVHRDLAARNCLVKTVS 357
YM G L +FLR + +P L ++C V + M YLE + F+HRDLAARNCLV
Sbjct: 474 YMANGCLLNFLRETQRRF--QPAELLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQG 531
Query: 358 RRSVQVKVADFGMARFLLDNVYEPSAGTKFPVRWAPPEV-FQSIYTPKADVWSFGVLMWE 534
VKV+DFG++R++LD+ Y S G+KFPVRW+PPEV S ++ K+DVWSFGVLMWE
Sbjct: 532 ----IVKVSDFGLSRYVLDDEYTSSMGSKFPVRWSPPEVLLYSKFSSKSDVWSFGVLMWE 587
Query: 535 VFTCCTENPYHGKNNSQVYQYIIGGGRLTKPVVCPDRLYVLMLECWQHDPKKRPAFEYVC 714
V++ + PY NNS+ +++I G RL +P +R+Y +M CW ++RP F +
Sbjct: 588 VYS-LGKMPYERFNNSETTEHVIQGLRLYRPQQASERVYAIMYSCWHEKAEERPTFSALL 646
Query: 715 QKIGDYLDQ 741
I D D+
Sbjct: 647 GSIVDITDE 655
>sp|P24604|TEC_MOUSE Tyrosine-protein kinase Tec
Length = 630
Score = 222 bits (566), Expect = 7e-58
Identities = 121/252 (48%), Positives = 169/252 (67%), Gaps = 2/252 (0%)
Frame = +1
Query: 1 VKKGEFR-RMPVAVKQMVEGAMNEDDFIDEAKNMRFLNHPNLVQLFGVVMKKRPIMIITE 177
V+ G++R + VA+K + EGAM E+DFI+EAK M L HP LVQL+GV +++PI I+TE
Sbjct: 383 VRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTE 442
Query: 178 YMKYGSLRDFLRNRSSDYFNRPVVLADICAQVAKGMAYLECENFVHRDLAARNCLVKTVS 357
+M+ G L +FLR R +F+R ++L+ +C V +GM YLE +F+HRDLAARNCLV
Sbjct: 443 FMERGCLLNFLRQRQG-HFSRDMLLS-MCQDVCEGMEYLERNSFIHRDLAARNCLVNEAG 500
Query: 358 RRSVQVKVADFGMARFLLDNVYEPSAGTKFPVRWAPPEVFQ-SIYTPKADVWSFGVLMWE 534
VKV+DFGMAR++LD+ Y S+G KFPV+W PPEVF S ++ K+DVWSFGVLMWE
Sbjct: 501 ----VVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWE 556
Query: 535 VFTCCTENPYHGKNNSQVYQYIIGGGRLTKPVVCPDRLYVLMLECWQHDPKKRPAFEYVC 714
+FT P+ N +V + G RL +P + LY +ML CWQ P+ RP+ E +
Sbjct: 557 IFT-EGRMPFEKNTNYEVVTMVTRGHRLHRPKLATKYLYEVMLRCWQERPEGRPSLEDLL 615
Query: 715 QKIGDYLDQNCE 750
+ I + ++ CE
Sbjct: 616 RTIDELVE--CE 625
>sp|P51813|BMX_HUMAN Cytoplasmic tyrosine-protein kinase BMX (Bone marrow tyrosine kinase
gene in chromosome X protein) (Epithelial and endothelial
tyrosine kinase) (ETK) (NTK38)
Length = 675
Score = 215 bits (547), Expect = 1e-55
Identities = 112/240 (46%), Positives = 155/240 (64%), Gaps = 1/240 (0%)
Frame = +1
Query: 7 KGEFRRMPVAVKQMVEGAMNEDDFIDEAKNMRFLNHPNLVQLFGVVMKKRPIMIITEYMK 186
KG++ VAVK + EG+M+ED+F EA+ M L+HP LV+ +GV K+ PI I+TEY+
Sbjct: 437 KGQY---DVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYIS 493
Query: 187 YGSLRDFLRNRSSDYFNRPVVLADICAQVAKGMAYLECENFVHRDLAARNCLVKTVSRRS 366
G L ++LR+ P L ++C V +GMA+LE F+HRDLAARNCLV R
Sbjct: 494 NGCLLNYLRSHGKGL--EPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVD----RD 547
Query: 367 VQVKVADFGMARFLLDNVYEPSAGTKFPVRWAPPEVFQSI-YTPKADVWSFGVLMWEVFT 543
+ VKV+DFGM R++LD+ Y S GTKFPV+W+ PEVF Y+ K+DVW+FG+LMWEVF+
Sbjct: 548 LCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFS 607
Query: 544 CCTENPYHGKNNSQVYQYIIGGGRLTKPVVCPDRLYVLMLECWQHDPKKRPAFEYVCQKI 723
+ PY +NSQV + G RL +P + D +Y +M CW P+KRP F+ + I
Sbjct: 608 -LGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSI 666
>sp|P35991|BTK_MOUSE Tyrosine-protein kinase BTK (Bruton's tyrosine kinase)
(Agammaglobulinaemia tyrosine kinase) (ATK) (B cell
progenitor kinase) (BPK) (Kinase EMB)
Length = 659
Score = 214 bits (546), Expect = 2e-55
Identities = 112/249 (44%), Positives = 164/249 (65%), Gaps = 2/249 (0%)
Frame = +1
Query: 1 VKKGEFR-RMPVAVKQMVEGAMNEDDFIDEAKNMRFLNHPNLVQLFGVVMKKRPIMIITE 177
VK G++R + VA+K + EG+M+ED+FI+EAK M L+H LVQL+GV K+RPI IITE
Sbjct: 416 VKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITE 475
Query: 178 YMKYGSLRDFLRNRSSDYFNRPVVLADICAQVAKGMAYLECENFVHRDLAARNCLVKTVS 357
YM G L ++LR + + L ++C V + M YLE + F+HRDLAARNCLV
Sbjct: 476 YMANGCLLNYLREMRHRFQTQQ--LLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQG 533
Query: 358 RRSVQVKVADFGMARFLLDNVYEPSAGTKFPVRWAPPEVFQ-SIYTPKADVWSFGVLMWE 534
VKV+DFG++R++LD+ Y S G+KFPVRW+PPEV S ++ K+D+W+FGVLMWE
Sbjct: 534 ----VVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWE 589
Query: 535 VFTCCTENPYHGKNNSQVYQYIIGGGRLTKPVVCPDRLYVLMLECWQHDPKKRPAFEYVC 714
+++ + PY NS+ ++I G RL +P + +R+Y +M CW +RP+F+ +
Sbjct: 590 IYS-LGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADERPSFKILL 648
Query: 715 QKIGDYLDQ 741
I D +D+
Sbjct: 649 SNILDVMDE 657
>sp|Q08881|ITK_HUMAN Tyrosine-protein kinase ITK/TSK (T-cell-specific kinase)
(Tyrosine-protein kinase Lyk) (Kinase EMT)
Length = 620
Score = 213 bits (543), Expect = 3e-55
Identities = 112/234 (47%), Positives = 158/234 (67%), Gaps = 1/234 (0%)
Frame = +1
Query: 31 VAVKQMVEGAMNEDDFIDEAKNMRFLNHPNLVQLFGVVMKKRPIMIITEYMKYGSLRDFL 210
VA+K + EGAM+E+DFI+EA+ M L+HP LVQL+GV +++ PI ++ E+M++G L D+L
Sbjct: 388 VAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYL 447
Query: 211 RNRSSDYFNRPVVLADICAQVAKGMAYLECENFVHRDLAARNCLVKTVSRRSVQVKVADF 390
R + + L +C V +GMAYLE +HRDLAARNCLV + +KV+DF
Sbjct: 448 RTQRGLF--AAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLV----GENQVIKVSDF 501
Query: 391 GMARFLLDNVYEPSAGTKFPVRWAPPEVFQ-SIYTPKADVWSFGVLMWEVFTCCTENPYH 567
GM RF+LD+ Y S GTKFPV+WA PEVF S Y+ K+DVWSFGVLMWEVF+ + PY
Sbjct: 502 GMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFS-EGKIPYE 560
Query: 568 GKNNSQVYQYIIGGGRLTKPVVCPDRLYVLMLECWQHDPKKRPAFEYVCQKIGD 729
++NS+V + I G RL KP + +Y +M CW+ P+ RPAF + +++ +
Sbjct: 561 NRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAE 614
>sp|Q06187|BTK_HUMAN Tyrosine-protein kinase BTK (Bruton's tyrosine kinase)
(Agammaglobulinaemia tyrosine kinase) (ATK) (B cell
progenitor kinase) (BPK)
Length = 659
Score = 213 bits (543), Expect = 3e-55
Identities = 111/249 (44%), Positives = 163/249 (65%), Gaps = 2/249 (0%)
Frame = +1
Query: 1 VKKGEFR-RMPVAVKQMVEGAMNEDDFIDEAKNMRFLNHPNLVQLFGVVMKKRPIMIITE 177
VK G++R + VA+K + EG+M+ED+FI+EAK M L+H LVQL+GV K+RPI IITE
Sbjct: 416 VKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITE 475
Query: 178 YMKYGSLRDFLRNRSSDYFNRPVVLADICAQVAKGMAYLECENFVHRDLAARNCLVKTVS 357
YM G L ++LR + + L ++C V + M YLE + F+HRDLAARNCLV
Sbjct: 476 YMANGCLLNYLREMRHRFQTQQ--LLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQG 533
Query: 358 RRSVQVKVADFGMARFLLDNVYEPSAGTKFPVRWAPPEVFQ-SIYTPKADVWSFGVLMWE 534
VKV+DFG++R++LD+ Y S G+KFPVRW+PPEV S ++ K+D+W+FGVLMWE
Sbjct: 534 ----VVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWE 589
Query: 535 VFTCCTENPYHGKNNSQVYQYIIGGGRLTKPVVCPDRLYVLMLECWQHDPKKRPAFEYVC 714
+++ + PY NS+ ++I G RL +P + +++Y +M CW +RP F+ +
Sbjct: 590 IYS-LGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILL 648
Query: 715 QKIGDYLDQ 741
I D +D+
Sbjct: 649 SNILDVMDE 657
>sp|P42681|TXK_HUMAN Tyrosine-protein kinase TXK
Length = 527
Score = 213 bits (542), Expect = 4e-55
Identities = 110/236 (46%), Positives = 158/236 (66%), Gaps = 2/236 (0%)
Frame = +1
Query: 1 VKKGEFR-RMPVAVKQMVEGAMNEDDFIDEAKNMRFLNHPNLVQLFGVVMKKRPIMIITE 177
V GE+R + VA+K + EG+M+E+DFI+EAK M L+H LVQL+GV ++++P+ I+TE
Sbjct: 285 VHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTE 344
Query: 178 YMKYGSLRDFLRNRSSDYFNRPVVLADICAQVAKGMAYLECENFVHRDLAARNCLVKTVS 357
+M+ G L ++LR R +L +C + +GM YLE ++HRDLAARNCLV +
Sbjct: 345 FMENGCLLNYLRENKGKL--RKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSS-- 400
Query: 358 RRSVQVKVADFGMARFLLDNVYEPSAGTKFPVRWAPPEVFQ-SIYTPKADVWSFGVLMWE 534
+ VK++DFGM R++LD+ Y S G KFP++W+PPEVF + Y+ K+DVWSFGVLMWE
Sbjct: 401 --TCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWE 458
Query: 535 VFTCCTENPYHGKNNSQVYQYIIGGGRLTKPVVCPDRLYVLMLECWQHDPKKRPAF 702
VFT + P+ K+N QV + I G RL +P + P +Y +M CW P+ RP F
Sbjct: 459 VFT-EGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTF 513
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,842,516
Number of Sequences: 369166
Number of extensions: 1996920
Number of successful extensions: 8649
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5809
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6149
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6873311200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)